Abstract: 2-Substituted-5-trifluoromethyl-1,3,4-thiadiazoles of the formula ##STR1## in which R is substituted alkyl, phenyl monosubstituted in the o- or m- position, polysubstituted phenyl, substituted phenylalkyl, phenylalkenyl, substituted phenylalkenyl, an optionally substituted 5-membered or 6-membered heterocyclic radical with 1 to 4 hetero-atoms selected from N and S atoms, optionally substituted benzimidazolyl or benzthiazolyl, optionally substituted naphthyl, quinolyl, cyano or one of the groups ##STR2## wherein R.sup.1 and R.sup.2 conjointly are a trimethylene, tetramethylene or pentamethylene group,X is oxygen or sulfur,R' and R" each independently is alkyl or, together with the nitrogen atom and optionally further hetero-atoms selected from O and N atoms, form an optionally substituted 6-membered or 7-membered ring, andN is 0, 1 or 2,Which possess fungicidal, bactericidal, arthropodicidal and insecticidal properties.

Abstract: N.sup.2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.

Abstract: The compounds are N-oxy and N-amino guanidines which are histamine H.sub.2 -antagonists. A compound of this invention is N-hydroxy-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidi ne.

Abstract: 6'-Amino-spiro[cycloalkane-1,2'-penam]-3'-carboxylic acids of the formula ##STR1## WHEREIN Z is a hydrogen or an alkali metal atom, or a protective group, and n a whole number of from 3 to 6, and process of preparing the same.These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to the penicillins.

Abstract: 1-Amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and/or substituted amino derivatives thereof; 3-(4- or 5-substituted thiazol-2-oxy)-1,2-epoxypropane and 5-(4- or 5-substituted thiazol-2-oxymethylene)-oxazolidine and/or N- and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds are characterized by an aminocarbonyl or carbonylamino type substituent at the 5- or 4-position on the thiazole ring. The above 1-amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and derivatives exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The 3-(4- or 5-substituted thiazol-2-oxy)-1,2-epoxypropanes are useful as intermediates for the aforementioned cardiovascular agents.

Abstract: This invention discloses new compounds of the formula ##STR1## WHEREIN X is selected from the group consisting of halogen and alkylsulfonyl; R.sup.1 is selected from the group consisting of alkyl, alkenyl, haloalkyl and alkynyl; m is an integer from 1 to 3; Y is selected from the group consisting of oxygen and sulfur; Z is selected from the group consisting of alkyl, alkenyl, halogen, haloalkyl, alkoxy, alkylthio, nitro and cyano; and n is an integer from 0 to 3.

Abstract: 6-Dimethylamino-4-hydroxycinnolin-3-yl carboxylic acid; ethyl 6-n-but-2-ylamino-4-hydroxycinnolin-3-yl carboxylate or the pharmaceutically-acceptable acid-addition salts thereof. The compounds are active as inhibitors of effects following the combination of reagin-like antibodies and their antigens.

Abstract: Novel N-(3,5-dihalophenyl)cyclopropanedicarboximides of the formula: ##STR1## wherein X and Y are each a chlorine atom or a bromine atom and R.sub.1, R.sub.2 and R.sub.3 are individually a hydrogen atom or a methyl group, which show high microbicidal activities against various fungi and bacteria without any material toxicity to mammals and plants and which can be produced by reacting the corresponding cyclopropanedicarboxylic acid or its anhydride with a 3,5-dihaloaniline.

Abstract: New bis-imides and tris-imides of the formula ##STR1## in which A and A' denote aromatic radicals which are optionally substituted or interrupted by an oxygen atom, an alkylene group or a sulphonyl group, Z denotes a radical of the formulae ##STR2## D denotes an oxygen atom or sulphur atom, m denotes the number 1 or 0 and n denotes the number 2 or 3, are obtained by cyclizing dicarboxylic acid monoamide compounds of the formula ##STR3## WITH ELIMINATION OF WATER. The bis-imides and tris-imides, mixed with azomethines and optionally with curing catalysts, can be used for the manufacture of moulded materials having technically very valuable mechanical and dielectric properties.

Abstract: 4-Amino-1,8-naphthalic acid-N-arylamides are obtained by reacting 4-halo-1,8-naphthalic acid-N-arylamides with ammonia in an anhydrous polar organic solvent. The products are colorants for solvents or daylight-fluorescence pigments.

Abstract: Compounds useful as lube oil additives are prepared by reaction of phosphorus halides and piperazine derivatives.

Abstract: 3,5-Dihalo-1,2,4-thiadiazoles and their preparation from corresponding 5 alkylthio compounds, useful as intermediates for fumigants are disclosed.

Abstract: The use of dyestuffs of the formula ##STR1## wherein R represents an alkyl, aralkyl, cycloalkyl or aryl radical, an alkylene radical bonded to the naphthalene ring, or hydrogen, andX represents an electron-attracting group for dyeing textiles by transfer printing.

Abstract: Diacylapomorphines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are both acyl of 1-17 carbons are symptomatically effective agents in the treatment of motor disorders of the type associated with a dopamine deficiency of the extrapyramidal system of the central nervous system, e.g. Parkinson's disease. Pharmaceutical compositions containing these compounds as an active ingredient are described, as well as new compunds of the above formula wherein R.sub.1 and R.sub.2 are formyl or acyl of 3-17 carbon atoms.

Abstract: 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.

Abstract: Novel 1-(.beta.-aryl)ethyl-1H-1,2,4-triazole ketals useful for their antimicrobial and plant-growth regulating activities.

Abstract: The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.

Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5', R.sup.5 and R.sup.6 may be the same or different and may be the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; radical of 1-6 carbon atoms;R.sup.7 and R.sup.

Abstract: Process for the preparation of the monopotassium salt of 1,2,5-thiadiazol-3,4-dicarboxylic acid (I). Involves double-stage saponification of 3,4-dicyano-1,2,5-thiadiazole (II), 3-cyano-4-carbamoyl-1,2,5-thiadiazole (III) is obtained from an aqueous suspension of 3,4-dicyano-1,2,5-thiadiazole (II) by catalytic hydration through the addition of aqueous KOH, desirably at a temperature of from 20.degree. to 50.degree. C. and with a molar ratio of 3,4-dicyano-1,25-thiadiazole (II) to KOH of from 1:0.01 to 1:0.8. This is followed by hydrolysis, by the further addition of aqueous KOH, desirably at a temperature of from 85.degree. to 100.degree. C., until attaining an overall molar ratio of 3,4-dicyano-1,2,5-thiadiazole (II) to KOH of from about 1:2.0 to 1:2.35, a molar ratio of 3,4-dicyano-1,2,5-thiadiazole (II) to H.sub.2 O of from about 1:20 to 1:23.

Abstract: An o-sulfobenzimide having the formula: ##STR1## is prepared by reacting phosgene with a methylbenzoate-o-sulfonate having the formula: ##STR2## WHEREIN M represents potassium or calcium, n is 1 when M is K and n is 2 when M is Ca, in an inert organic solvent in the presence of dimethylformamide; and then reacting ammonia with the reaction product.