Patents Examined by R. Gallagher
  • Patent number: 4097669
    Abstract: 2-Substituted-5-trifluoromethyl-1,3,4-thiadiazoles of the formula ##STR1## in which R is substituted alkyl, phenyl monosubstituted in the o- or m- position, polysubstituted phenyl, substituted phenylalkyl, phenylalkenyl, substituted phenylalkenyl, an optionally substituted 5-membered or 6-membered heterocyclic radical with 1 to 4 hetero-atoms selected from N and S atoms, optionally substituted benzimidazolyl or benzthiazolyl, optionally substituted naphthyl, quinolyl, cyano or one of the groups ##STR2## wherein R.sup.1 and R.sup.2 conjointly are a trimethylene, tetramethylene or pentamethylene group,X is oxygen or sulfur,R' and R" each independently is alkyl or, together with the nitrogen atom and optionally further hetero-atoms selected from O and N atoms, form an optionally substituted 6-membered or 7-membered ring, andN is 0, 1 or 2,Which possess fungicidal, bactericidal, arthropodicidal and insecticidal properties.
    Type: Grant
    Filed: July 14, 1976
    Date of Patent: June 27, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Josef Helmut Reisdorff, Wilhelm Brandes, Hans Scheinpflug, Bernhard Homeyer, Peter Roessler
  • Patent number: 4096255
    Abstract: N.sup.2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
    Type: Grant
    Filed: September 14, 1976
    Date of Patent: June 20, 1978
    Assignees: Mitsubishi Chemical Industries Limited, Shosuke Okamoto
    Inventors: Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura, Shosuke Okamoto, Akiko Hijikata
  • Patent number: 4093729
    Abstract: The compounds are N-oxy and N-amino guanidines which are histamine H.sub.2 -antagonists. A compound of this invention is N-hydroxy-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidi ne.
    Type: Grant
    Filed: April 11, 1977
    Date of Patent: June 6, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Geoffrey Robert Owen
  • Patent number: 4091027
    Abstract: 6'-Amino-spiro[cycloalkane-1,2'-penam]-3'-carboxylic acids of the formula ##STR1## WHEREIN Z is a hydrogen or an alkali metal atom, or a protective group, and n a whole number of from 3 to 6, and process of preparing the same.These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to the penicillins.
    Type: Grant
    Filed: May 24, 1977
    Date of Patent: May 23, 1978
    Assignee: U C B Societe Anonyme
    Inventors: Ludovic Rodriguez, Jacques Leclercq
  • Patent number: 4089865
    Abstract: 1-Amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and/or substituted amino derivatives thereof; 3-(4- or 5-substituted thiazol-2-oxy)-1,2-epoxypropane and 5-(4- or 5-substituted thiazol-2-oxymethylene)-oxazolidine and/or N- and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds are characterized by an aminocarbonyl or carbonylamino type substituent at the 5- or 4-position on the thiazole ring. The above 1-amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and derivatives exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The 3-(4- or 5-substituted thiazol-2-oxy)-1,2-epoxypropanes are useful as intermediates for the aforementioned cardiovascular agents.
    Type: Grant
    Filed: August 27, 1976
    Date of Patent: May 16, 1978
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: John A. Edwards
  • Patent number: 4086240
    Abstract: This invention discloses new compounds of the formula ##STR1## WHEREIN X is selected from the group consisting of halogen and alkylsulfonyl; R.sup.1 is selected from the group consisting of alkyl, alkenyl, haloalkyl and alkynyl; m is an integer from 1 to 3; Y is selected from the group consisting of oxygen and sulfur; Z is selected from the group consisting of alkyl, alkenyl, halogen, haloalkyl, alkoxy, alkylthio, nitro and cyano; and n is an integer from 0 to 3.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: April 25, 1978
    Assignee: Velsicol Chemical Corporation
    Inventors: Chin Ching Wu, John Krenzer
  • Patent number: 4085103
    Abstract: 6-Dimethylamino-4-hydroxycinnolin-3-yl carboxylic acid; ethyl 6-n-but-2-ylamino-4-hydroxycinnolin-3-yl carboxylate or the pharmaceutically-acceptable acid-addition salts thereof. The compounds are active as inhibitors of effects following the combination of reagin-like antibodies and their antigens.
    Type: Grant
    Filed: May 5, 1977
    Date of Patent: April 18, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventors: John Preston, Austin John Reeve
  • Patent number: 4082768
    Abstract: New bis-imides and tris-imides of the formula ##STR1## in which A and A' denote aromatic radicals which are optionally substituted or interrupted by an oxygen atom, an alkylene group or a sulphonyl group, Z denotes a radical of the formulae ##STR2## D denotes an oxygen atom or sulphur atom, m denotes the number 1 or 0 and n denotes the number 2 or 3, are obtained by cyclizing dicarboxylic acid monoamide compounds of the formula ##STR3## WITH ELIMINATION OF WATER. The bis-imides and tris-imides, mixed with azomethines and optionally with curing catalysts, can be used for the manufacture of moulded materials having technically very valuable mechanical and dielectric properties.
    Type: Grant
    Filed: May 19, 1976
    Date of Patent: April 4, 1978
    Assignee: Ciba-Geigy Corporation
    Inventors: Alfred Renner, Theobald Haug
  • Patent number: 4082849
    Abstract: Novel N-(3,5-dihalophenyl)cyclopropanedicarboximides of the formula: ##STR1## wherein X and Y are each a chlorine atom or a bromine atom and R.sub.1, R.sub.2 and R.sub.3 are individually a hydrogen atom or a methyl group, which show high microbicidal activities against various fungi and bacteria without any material toxicity to mammals and plants and which can be produced by reacting the corresponding cyclopropanedicarboxylic acid or its anhydride with a 3,5-dihaloaniline.
    Type: Grant
    Filed: October 8, 1976
    Date of Patent: April 4, 1978
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Nobuyuki Kameda, Yoshio Hisada, Toshiro Kato, Akira Fujinami
  • Patent number: 4081453
    Abstract: 3,5-Dihalo-1,2,4-thiadiazoles and their preparation from corresponding 5 alkylthio compounds, useful as intermediates for fumigants are disclosed.
    Type: Grant
    Filed: April 5, 1973
    Date of Patent: March 28, 1978
    Assignee: The O. M. Scott & Sons Company
    Inventors: Gary L. Smith, Dennis Eugene Reese
  • Patent number: 4081445
    Abstract: Compounds useful as lube oil additives are prepared by reaction of phosphorus halides and piperazine derivatives.
    Type: Grant
    Filed: November 3, 1975
    Date of Patent: March 28, 1978
    Assignee: S.A. Texaco Belgium n.v.
    Inventor: Johny C. Hermans
  • Patent number: 4081446
    Abstract: 4-Amino-1,8-naphthalic acid-N-arylamides are obtained by reacting 4-halo-1,8-naphthalic acid-N-arylamides with ammonia in an anhydrous polar organic solvent. The products are colorants for solvents or daylight-fluorescence pigments.
    Type: Grant
    Filed: October 4, 1976
    Date of Patent: March 28, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Theodor Papenfuhs
  • Patent number: 4080331
    Abstract: The use of dyestuffs of the formula ##STR1## wherein R represents an alkyl, aralkyl, cycloalkyl or aryl radical, an alkylene radical bonded to the naphthalene ring, or hydrogen, andX represents an electron-attracting group for dyeing textiles by transfer printing.
    Type: Grant
    Filed: September 25, 1974
    Date of Patent: March 21, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventor: Alfred Brack
  • Patent number: 4080456
    Abstract: Diacylapomorphines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are both acyl of 1-17 carbons are symptomatically effective agents in the treatment of motor disorders of the type associated with a dopamine deficiency of the extrapyramidal system of the central nervous system, e.g. Parkinson's disease. Pharmaceutical compositions containing these compounds as an active ingredient are described, as well as new compunds of the above formula wherein R.sub.1 and R.sub.2 are formyl or acyl of 3-17 carbon atoms.
    Type: Grant
    Filed: November 20, 1975
    Date of Patent: March 21, 1978
    Assignee: Schering Aktiengesellschaft
    Inventors: Dieter Seidelmann, Ralph Schmiechen, Reinhard Horowski, Wolfgang Kehr, Dieter Palenschat, Gert Paschelke
  • Patent number: 4080453
    Abstract: 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.
    Type: Grant
    Filed: March 2, 1976
    Date of Patent: March 21, 1978
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Haruki Nishimura, Hitoshi Uno, Kagayaki Natsuka, Noriaki Shimokawa, Masanao Shimizu, Hideo Nakamura
  • Patent number: 4079145
    Abstract: The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.
    Type: Grant
    Filed: June 22, 1976
    Date of Patent: March 14, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter-Bernd Reuschling, Klaus Kuhlein, Bernward Scholkens, Rudolf Kunstmann, Ulrich Lerch, Wilhelm Bartmann, Hermann Teufel, Gerhard Beck
  • Patent number: 4079062
    Abstract: Novel 1-(.beta.-aryl)ethyl-1H-1,2,4-triazole ketals useful for their antimicrobial and plant-growth regulating activities.
    Type: Grant
    Filed: October 9, 1975
    Date of Patent: March 14, 1978
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gustaaf Van Reet, Jan Heeres, Lourens Wals
  • Patent number: 4078066
    Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5', R.sup.5 and R.sup.6 may be the same or different and may be the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; radical of 1-6 carbon atoms;R.sup.7 and R.sup.
    Type: Grant
    Filed: December 17, 1976
    Date of Patent: March 7, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic Peter Hauck, Joseph E. Sundeen
  • Patent number: 4077966
    Abstract: Process for the preparation of the monopotassium salt of 1,2,5-thiadiazol-3,4-dicarboxylic acid (I). Involves double-stage saponification of 3,4-dicyano-1,2,5-thiadiazole (II), 3-cyano-4-carbamoyl-1,2,5-thiadiazole (III) is obtained from an aqueous suspension of 3,4-dicyano-1,2,5-thiadiazole (II) by catalytic hydration through the addition of aqueous KOH, desirably at a temperature of from 20.degree. to 50.degree. C. and with a molar ratio of 3,4-dicyano-1,25-thiadiazole (II) to KOH of from 1:0.01 to 1:0.8. This is followed by hydrolysis, by the further addition of aqueous KOH, desirably at a temperature of from 85.degree. to 100.degree. C., until attaining an overall molar ratio of 3,4-dicyano-1,2,5-thiadiazole (II) to KOH of from about 1:2.0 to 1:2.35, a molar ratio of 3,4-dicyano-1,2,5-thiadiazole (II) to H.sub.2 O of from about 1:20 to 1:23.
    Type: Grant
    Filed: March 9, 1977
    Date of Patent: March 7, 1978
    Assignee: Montedison S.p.A.
    Inventors: Giuseppe Ribaldone, Renato Grecu
  • Patent number: 4076806
    Abstract: O-Alkyl-S-[3-oxo-1,2,4-triazolobenzopyrazin(2)yl-methyl]-(thiono)thiolphosp horic(phosphonic) acid esters of the formula ##STR1## in which R is alkyl with 1 to 4 carbon atoms,R.sub.1 is alkyl or alkoxy with 1 to 4 carbon atoms, andX is oxygen or sulfur,Which possess insecticidal properties.
    Type: Grant
    Filed: March 24, 1976
    Date of Patent: February 28, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Lorenz, deceased, Ingeborg Hammann, Bernhard Homeyer, Wilhelm Stendel