Abstract: A new class of herbicidal compounds consisting of 1-alkyl- and 1,1-dialkyl-3-(3-substituted-4-nitro-5-iso-thiazolyl)ureas in which the 3-substituent consists of alkyl, alkoxy, alkylamino, alkylthio, alkylsulfinyl, and alkylsulfonyl exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of a representative member of this class is described in detail, and its utility is exemplified.

Abstract: 1,2-Benzoisothiazole-3-on-1, 1-dioxide having the formula ##STR1## wherein X represents hydrogen, halogen, nitro, lower alkyl or lower alkoxy and Y represents hydrogen, halogen, lower alkyl, or lower alkoxy is prepared by reacting phosgene with an o-sulfobenzoic acid compound having the formula: ##STR2## or an alkali metal salt or alkaline earth metal salt thereof in the presence of dimethylformamide, thereby producing a mixture of a dichlorotolylsultone and a chlorosulfonylbenzoylchloride; (b) reacting the reaction products of step (a) with an alcohol of the formula ROH wherein R represents a lower alkyl group; and then (c) reacting the product of step (b) with ammonia.

Abstract: The invention provides novel 5-nitrothiazolylimidazoline derivatives, useful as chemotherapeutic agents.

Abstract: Disclosed are certain novel 3-alkoxyisothiazoles. The 3-alkoxyisothiazoles and compositions containing them exhibit useful biocidal properties.

Abstract: Novel 2-hydroxyimino-1,2,3,4,6,7-hexahydro-11bH-benzo [a] quinolisine derivatives are prepared by reacting substituted 2-oxo-benzo[a]quinolisine compounds with hydroxylamine or an acid addition salt thereof. The described compounds and their acid addition salts and quaternary onium derivatives evidence psychopharmacological properties in the absence of adverse side effects.

Abstract: A ketonic heterocyclic compound having at least two heteroatoms in the ring is prepared by reacting a difunctional compound having the general formula ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are members of the group consisting of aliphatic, aromatic, cycloaliphatic and heterocyclic hydrocarbons which may contain functional groups selected from --OH, --OR.sub.5, --COOH, --COOR.sub.5, --CN, --Cl, --Br, --I, --F, and --CO--R.sub.5, wherein R.sub.5 is an aliphatic, aromatic, cycloaliphatic or heterocyclic hydrocarbon; X is oxygen or sulphur; Y is sulphur or nitrogen; n is an integer ranging from 1 to 3, or zero; R.sub.6 is a hydrogen or a hydrocarbon radical included in the above definition of R.sub.1 R.sub.2 R.sub.3 and R.sub.4 ; and m is the valence of Y, with carbon monoxide and oxygen in the presence of a catalyst selected from selenium, selenium compounds and complexes of copper, in the temperature range of from room temperature to 80.degree.

Abstract: The compounds are heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene which are histamine H.sub.2 -antagonists or are converted into histamine H.sub.2 -antagonists in the animal body. Two specific compounds of the present invention are 1-nitro-2-[2-((2-thiazolyl)methylsulphinyl)ethylamino]-2-[2-((2-thiazolyl) methylthio)ethylamino]ethylene and 1-nitro-2,2-bis-[2-((2-thiazolyl)methylsulphinyl)ethylamino]ethylene.

Abstract: Water-insoluble styryl dyestuffs of the formula ##STR1## in which X represents a cyano, carbo-lower alkoxy or phenylsulphone group, Y.sub.1 and Y.sub.2 each represents a hydrogen atom, an lower alkyl or lower alkoxy or phenoxy group, R represents a lower alkyl, phenyl-lower-alkyl, cyano-lower-alkyl, lower alkoxyalkyl or acyloxyalkyl group or a radical of the formula --A--S--B, and A represent a lower alkylene group that may be substituted by a lower alkanoyloxy or a benzoyloxy group and B represents a heterocyclic radical.

Abstract: 2-Nitroimidazolyl-4-thiomorpholinoiminoalkyl thiazoles are useful as anti-parasitic agents, being active against Trypanosomidae, and may be prepared by reaction of novel 2-nitroimidazolyl-4-acylthiazoles with an N-aminothiomorpholine.

Abstract: Selected 3,4-disubstituted-1,3,4-thiadiazoline-2,5-diones are prostaglandin mimics or antagonists, and have uses typical of such compounds, such as inhibitors of gastric secretion, labor inducers, bronchodilators, topical antiinflammatory agents, etc.

Abstract: The invention concerns new compounds for use in the pharmaceutical industry, its subject-matter being (thio-2-ethyl)-2 carboxy-4 thiazolidinic compounds of the general formula: ##STR1## where R is selected from hydrogen atom, alkyl, phenyl, alkylaryl and acyl radicals, heterocyclic groups such as pyridoxazole or benzimidazole, and alkyl- carboxylic groups, particularly acetic, and esters and amide derivatives thereof, and salts of addition of the compounds. These compounds are of use in the production of medicines with analgesic and mucolytic properties.

Abstract: This invention relates to new pleuromutilins of the formula: ##STR1## wherein EITHER R.sub.1 is ethyl or vinyl,n is an integer from 2 to 5,X is sulphur,A group ##STR2## or a group =N-R.sub.4.sup.I, whereinEither Y and Z are both sulphur, orOne of Y and Z is oxygen and the other is sulphur, andR.sub.4.sup.i is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above, EACH OFR.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members containing one nitrogen atom or one nitrogen atom and a further hetero member selected from sulphur, oxygen and a group =N-R.sub.5.sup.I,wherein R.sub.5.sup.I is alkyl of 1 to 5 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms, orR.sub.2 and R.sub.3 together with the nitrogen atom form a piperazinyl radical, the second nitrogen atom of which is substituted by a radical R.sub.5.sup.II,whereby R.sub.5.sup.

Abstract: 2-Amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline, prepared from 4-hydroxy-1,2,3,4-tetrahydroisoquinoline and a compound which yields the amidino group, as well as its salts, are described.

Abstract: 7-Oxo-1,2,3,3,8-pentamethyl-5-trifluoromethyl-2,3,7,8-tetrahydro-1-H-pyrrol 3,2-g] quinoline, a new compound, useful as a blue-green laser dye, is prepared from a substituted indole.

Abstract: Thiazoline derivatives represented by the general formula: ##STR1## wherein X.sub.1 represents hydrogen or methyl; Y.sub.1 and Y.sub.2 each represents hydrogen, halogen, C.sub.1.sub.-3 alkyl, C.sub.1.sub.-3 alkoxy or trifluoromethyl; R.sub.1 represents hydrogen, methyl, or ethyl; R.sub.2 represents C.sub.1.sub.-3 alkyl or C.sub.3.sub.-5 alkenyl and Z represents hydrogen, carboxy or carboxy ester group and its esters and pharmaceutically acceptable salts, synthesized by quaternization and acid-elimination reaction being useful as anti-inflammatory, anti-rheumatic, analgesic and anti-pyretic agents.

Abstract: New tricyclic fused imidazole derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##STR2## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a=C-- group, orA stands for a group of the general formula (III), ##STR3## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##STR4## wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##STR5## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(ch.sub.2).sub.m --X VI.in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen.

Abstract: The preparation of dl and l compounds of the type 6-(mono and di-substituted phenyl)-5,6-dihydro or 2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles and the pharmaceutically acceptable salts thereof, is described. The use of said compounds for treating helminthiasis in warm-blooded animals is also described.

Abstract: Substituted 1,2-dihydropyridines of the formula ##SPC1##In which R and R.sup.2 are selected from the group consisting of hydrogen, --NH.sub.2, silyl, silyl linked via oxygen, silyl linked via nitrogen, sulfamyl, organosulfonamido, nitro, organic radical, organic radical linked via oxygen, organic radical linked via sulfur, organic radical linked via nitrogen, organic radical linked via --SO-- and organic radical linked via --SO.sub.2 --; with the proviso that the R.sup.2 groupings when joined together form an ortho condensed cyclic or polycyclic hydrocarbon; R.sup.1 is a member selected from the group consisting of hydrogen, --NH.sub.2, silyl, silyl linked via oxygen, silyl linked via nitrogen, sulfamyl, organosulfonamido, nitro, organic radical, organic radical linked via oxygen, organic radical linked via sulfur, organic radical linked via nitrogen, organic radical linked via --SO-- organic radical linked via --SO.sub.2 --, mercapto, sulfino and sulfo; R.sup.

Abstract: 7[D-(-)-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido]-cephalosporanic acid and 7-D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]cephalospo ranic acid and the corresponding decephalosporanic acids and the salts thereof are new synthetic compounds of value as antibacterial agents and in the treatment of bacterial infections.

Abstract: New nematocides and plant growth regulants comprise diazoles of formula, ##STR1## in which R.sup.1 is alkyl, substituted alkyl, aryl, or substituted aryl, R.sup.2 is alkyl, alkenyl, alkynyl or substituted alkyl and X is oxygen or sulphur. .Iadd.