Abstract: Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable compositions include whole coffee fruit extracts and powders that are orally administered at relatively low dosages.

Abstract: The invention relates to a soybean seed extract, method for producing the same and uses of the extract of soybean seeds in promoting wound healing, promoting neuron cell proliferation and/or treating brain diseases and/or neurodegenerative diseases, treating breast cancer, reducing side effects of interfering with DNA and/or RNA replication drugs and/or enhancing pharmaceutical effects of interfering with DNA and/or RNA replication drugs.

Abstract: A composition, a health functional food or a treatment method of the present invention has a remarkable cranial nerve cell protection effect and simultaneously has a sensorimotor function recovery promotion effect and a body weight increasing effect. Accordingly, the present invention has effects of preventing stroke or neurodegenerative diseases, protecting cranial nerve cell cells over the mid to long term immediately after the onset of disease, promoting the recovery of a sensorimotor function reduced by stroke and neurodegenerative diseases, and increasing a reduced body weight. Therefore, the present invention can be used for effectively preventing, treating or managing stroke and neurodegenerative diseases.

Abstract: The present invention relates to the use of an Angiotensin II type 1 (AT1) receptor blocker for promoting sleep and/or the treatment of insomnia. It is based, at least in part, on the results of experiments performed using a validated rat model of stress-induced insomnia in which candesartan was found to ameliorate sleep disturbances induced by stress. Further, it was observed that this effect seems to be caused by blockade of AT1 receptors located in several brain regions that are key components of the neural circuitry activated during insomnia. In contrast to currently marketed treatments for insomnia, the AT1 receptor blocker was found to restore normal sleep without inhibiting REM sleep and/or inducing atypical wave components in the EEG.

Abstract: A method for decreasing proliferation of cancer cells comprises the steps of administering a sensitizer. Sensitizers can include selenium, fish oil, and a combination of selenium and fish oil to a cancer cell. The method contemplates that the selenium and fish oil are administered in an amount effective to respectively increase the sensitivity of the cancer cells, and the administration of the combination of selenium and fish oil are administered in an amount effective to synergistically increase the sensitivity of the cancer cells more than the selenium or the fish oil alone. The method additionally exposes cancer cells to temperatures in excess of 37° C.

Abstract: Disclosed here are compositions and methods for preventing or treating certain health conditions associated with inflammation or oxidative stress. These compositions are prepared from ingredients containing phytochemicals that activate the Nrf2 pathways. Synergistic effects of the different phytochemicals are also disclosed.

Abstract: A human oral at least partly enteric formulation comprising one or more jojoba components, for controlling, stimulating or modulating functions for patients suffering from a degenerative disease, or for patients at risk from suffering from a degenerative disease, or for patients under therapeutic treatment of a degenerative disease.

Abstract: A method of treating skin is disclosed. The method can include topically applying to skin an effective amount of a composition that includes water, a Crithmum maritimum extract, and an Ulva lactuca extract.

Abstract: The invention relates to a soybean seed extract, method for producing the same and uses of the extract of soybean seeds in promoting wound healing, promoting neuron cell proliferation and/or treating brain diseases and/or neurodegenerative diseases, treating breast cancer, reducing side effects of interfering with DNA and/or RNA replication drugs and/or enhancing pharmaceutical effects of interfering with DNA and/or RNA replication drugs.

Abstract: The present invention relates generally to methods of use and compositions useful for treating skin. The composition includes a combination of Argania spinosa kernel extract, dill extract, Myrciaria dubia fruit extract, and Croton lechleri extract and/or Morus alba fruit extract. This combination can be used to create topical skin compositions that reduce the appearance of loose, sagging, and/or flaccid skin, and/or improve facial contouring.

Abstract: A diketopiperazine mixture suitable for mixing with a food or drink and a method for producing the mixture. High-temperature and high-pressure treatment of plant peptides in a liquid allows production of a plant extract containing a high concentration of diketopiperazines including cyclo-leucyl-leucine and cyclo-leucyl-phenylalanine. Diketopiperazines having excellent flavor derived from a plant natural product and can produce a food or drink provided with the functions of the diketopiperazines by directly mixing the diketopiperazines with the food or drink.

Abstract: To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1? released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.

Abstract: Compositions including herbal extracts, such as a Vitex negundo extract, a Cardiospermum halicacabum extract, and a Bambusa arundinacea extract, and methods using such compositions are disclosed. For example, compositions and methods may be used to improve joint health.

Abstract: Methods of treatment for atopic dermatitis in a human subject or animal, the methods comprising administering topically to the human subject or animal an active ingredient obtained from Ophiopogon japonicus.

Abstract: In various implementations, a skin therapeutic may be topically applied to improve skin health. The skin therapeutic may decrease inflammation, decrease redness, and/or decrease health times. The skin therapeutic may include a composition that includes two or more of Brassica olearacea italica Seed Oil, bisabolol, and/or Zingiber officinales.

Abstract: A process is provided for improving the water solubility of cannabinoids by combining cannabinoids with fat globules obtained from animals, plants, or synthetic chemistry. The animals can be mammals or non-mammals. The plants can be whole plants, tissue cultures, or genetically engineered plants. The fat globules can be used in their natural environment, and/or following processing, and/or as separated or purified particles.

Abstract: The invention relates to the field of polymer production, in particular to the production of chitin and chitosan from microalgae belonging to the phylum Haptophyta to the phylum Chlorophyta, or to the phylum Heterokontophyta, particularly from microalgae of the genus Isochrysis, Chlorella, Bracteacoccus, Chlorococcum, Scenedesmns, Desmodesmus, Haematococcus, Thalassiosira and Nannochloropsis, as well as to microalgal extracts thereof and their uses.

Abstract: The present disclosure relates to methods of administering a composition to a patient, particularly in the form of a dietary supplement, which addresses immune system deficiencies and promotes healthy immune system functioning. The present disclosure also related to compositions and methods for improving or boosting immune system functioning. The present disclosure further provides novel compositions for balancing immune response in human subjects.

Abstract: Exemplary embodiments provide oat fractions, and methods of producing the oat fractions, of the species Avena Sativa that has a concentration of total Avenanthramides that is from about 2 to about 25 wt. %, and up to about 30 wt. % or more, higher than the concentration before treatment with infrared energy. The higher concentration is achieved without treatment with enzymes or exposure to fungal agents to increase the concentration of total Avenanthramides. Instead, the enhanced concentration of Avenanthramides is achieved through exposure to infrared energy for a selected period of time.

Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.