Patents Examined by Randeep Singh
  • MetAP-2 inhibitor polymersomes for therapeutic administration
    Patent number: 9782489
    Abstract: The present invention provides methods to treating inflammation related disease and disorders such as an autoimmune disease and autoimmune related uveitis by administering compositions and formulations comprising MetAP-2 inhibitors as disclosed herein. The composition comprises a formulation of a fumagillol derivative that retains anti-inflammation activity and is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: October 10, 2017
    Assignee: Children's Medical Center Corporation
    Inventors: Ofra Benny-Ratsaby, Robert D'Amato, Takeru Yoshimura
  • Stabilized active compound
    Patent number: 9757331
    Abstract: Stable solid compositions have a first carrier and an adsorbate having at least one active component, such as, a vitamin D derivative and a hydrophobic stabilizer thereof, wherein the first carrier is a calcium phosphate or derivatives thereof having a solubility in water lower than 0.1 wt % at room temperature.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 12, 2017
    Assignee: PRAYON SA
    Inventors: Khadija Tantaoui Elaraqi, Guy Broze, Audrey Leruite
  • Fermented infant formula with non digestible oligosaccharides
    Patent number: 9717270
    Abstract: The present invention relates to a fermented infant formulae comprising non digestible oligosaccharides for improving intestinal tract health by decreasing protein digestive effort, by decreasing the amount of endogenously formed proteases concomitant with an increased protein digestion, and a reduced protein fermentation.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: August 1, 2017
    Assignee: N.V. Nutricia
    Inventors: Thomas Ludwig, Sylvie Huybers, Evan Abrahamse, Houkje Bouritius
  • Drug-containing implants and methods of use thereof
    Patent number: 9717799
    Abstract: The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: August 1, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Steven Siegel, Karen Winey
  • Method of treating inflammation
    Patent number: 9717755
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: August 1, 2017
    Assignee: Cytosorbents Corporation
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Robert H. Bartlett, Humayra Begum Ali
  • Synthesis of rutin nanotubes
    Patent number: 9713624
    Abstract: The synthesis of rutin nanotubes includes the steps of providing rutin powder; mixing the rutin powder with a solvent mixture of methanol, dimethyl sulfoxide, and hydrochloric acid to prepare a rutin solution; adding the rutin solution to boiling water dropwise; maintaining the rutin solution and water under ultrasonic conditions at room temperature for about 20 minutes; continuously stirring the solution until rutin nanoparticles are formed; and isolating the rutin nanotubes by centrifugation. A method of controlling the metastatic activity of cancer cells includes administering an effective amount of rutin nanotubes and nanoparticles prepared as described above to a site of metastatic activity in a mammal.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: July 25, 2017
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Mohamed Mahmoud Hafez Ahmed, Othman A. Al-Shabanah, Zeinab Korany Mohamed Hassan
  • Device and method for treating neuropathy
    Patent number: 9707172
    Abstract: Device and method for treating hyperhidrosis, neuropathy, skin, circulation, muscle stimulation, by application of a fabric including an elemental zinc particle deposition to a treatment area of the skin.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: July 18, 2017
    Inventors: Scott Sheftel, Stanley N. Sheftel
  • Rodenticide bait comprising difenacoum and method for controlling target rodent pests
    Patent number: 9706770
    Abstract: Disclosed is a rodenticide bait including: difenacoum in the form of trans-difenacoum of formula 3-(biphenyl-4-yl)-1 -(4-hydroxycoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in wherein carbons 1 and 3 of group 1,2,3,4-tetrahydronaphthalene of the trans-difenacoum have the same absolute configuration; and an edible excipient for target rodent pests. The bait includes trans-difenacoum at a concentration above a minimum trans-difenacoum concentration lethal to female adults of the target rodents, but below a minimum trans-difenacoum concentration lethal to adult males of the target rodents, the minimum concentration lethal to female adults being less than the minimum concentration lethal to male adults. Also disclosed is a method for selectively controlling a population of target rodent pests.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: July 18, 2017
    Assignees: LIPHATECH, VETAGRO SUP
    Inventors: Herve Caruel, Bernadette Espana, Stephane Besse, Virginie Lattard, Etienne Benoit
  • Composition for enhancing transdermal absorption of a drug and patch preparation
    Patent number: 9707187
    Abstract: The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug. A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms and a polyvalent alcohol having 3-8 carbon atoms. A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms, a polyvalent alcohol having 3-8 carbon atoms and an organic amine having 2-9 carbon atoms.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: July 18, 2017
    Assignee: NITTO DENKO CORPORATION
    Inventors: Arimichi Okazaki, Tsuyoshi Mukobata, Sachiko Sakamoto, Akinori Hanatani
  • Formulas for diagnosing and treating hormone-dependent cancers and cancers of the organs responsible for steroid hormone synthesis
    Patent number: 9707305
    Abstract: The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: July 18, 2017
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Juliette Merian, Raphaël Boisgard, Bertrand Tavitian, Isabelle Texier-Nogues
  • Composition for enhancing transdermal absorption of a drug and patch preparation
    Patent number: 9707189
    Abstract: The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug. A composition for enhancing transdermal absorption of an acidic drug, comprising a polyvalent alcohol having 3-8 carbon atoms, a higher alcohol having 12-20 carbon atoms and an organic amine having 2-9 carbon atoms.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: July 18, 2017
    Assignee: NITTO DENKO CORPORATION
    Inventors: Arimichi Okazaki, Tsuyoshi Mukobata, Sachiko Sakamoto, Akinori Hanatani
  • Pharmaceutical compositions comprising hydromorphone and naloxone
    Patent number: 9700508
    Abstract: The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: July 11, 2017
    Assignee: Euro-Celtique S.A.
    Inventors: Helen Kathleen Danagher, Hassan Mohammad, Malcolm Walden, Geoffrey Gerard Hayes, Jonathon Oliver Whitehouse, Thinnayam Naganathan Krishnamurthy, Ricardo Alberto Vargas Rincon
  • Oral pharmaceutical composition of isotretinoin
    Patent number: 9700535
    Abstract: An oral pharmaceutical composition of isotretinoin with reduced food effect. A process for preparing the oral pharmaceutical composition of the present invention.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: July 11, 2017
    Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
    Inventors: Rajesh Rao, Anuj Kumar Fanda, Satish Kumar Jain, Romi Barat Singh
  • Personal care solid granules that sustain essential oils and or plant herbal extracts that emulsify in hot water creating therapeutic solution
    Patent number: 9693935
    Abstract: A Personal care 100% plant derived, biodegradable solid granules that sustain beneficial essential oils, and or plant/herbal extracts and emulsify in hot water to create an emulsified therapeutic solution is disclosed. This invention improves over existing liquids in that it's solid granule form is completely plant derived and biodegradable and can sustain essential oils and antioxidants without the requirement of chemical preservatives, and can be packaged in eco-friendly, compostable paper. It improves over existing solid forms in that it is a 100% water soluble granule that emulsifies easily in hot water to form an easy to use liquid product.
    Type: Grant
    Filed: January 13, 2013
    Date of Patent: July 4, 2017
    Inventor: Sarah McCoy
  • Pharmaceutical formulation containing gelling agent
    Patent number: 9693961
    Abstract: Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: July 4, 2017
    Assignees: Purdue Pharma L.P., The P.F. Laboratories, Inc., Purdue Pharmaceuticals L.P.
    Inventors: Curtis Wright, Benjamin Oshlack, Christopher Breder
  • Self-preserved oil dispersions comprising boric acid
    Patent number: 9682147
    Abstract: The present invention relates to a self-preserved oil dispersion. Especially, the present invention relates to a self-preserved oil dispersion including a dispersed oil phase, an aqueous phase and at least one surfactant, wherein said oil dispersion comprises boric acid in an amount ranging from 0.005% to 0.075% in weight of the total weight of the oil dispersion, said amount of boric acid being a preservative effective amount so that the oil dispersion has a preservative activity.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: June 20, 2017
    Assignee: SANTEN SAS
    Inventors: Jean-Sébastien Garrigue, Frédéric Lallemand, Betty Philips
  • Immediate-release tablet formulation, composition for tablets and method for manufacturing immediate-release tablet formulation
    Patent number: 9675666
    Abstract: There are provided a tablet-form immediate-release preparation that contains a high concentration of a casein and/or a casein hydrolysate as an active ingredient but has an excellent physical strength, a composition for the preparation that has an excellent tabletability, and a method for producing the preparation from the composition. Each of the preparation and the composition contains 50% by mass or more of the casein and/or the casein hydrolysate, and further contains a lactose having a volume average particle diameter of not less than 50 ?m and not more than 300 ?m. The content of the lactose is 6.0 to 100 parts by mass per 100 parts by mass of the casein and/or the casein hydrolysate. The method for producing the preparation contains the steps of: preparing a mixture as the composition; filling a mortar with the mixture and tableting the mixture; and separating the tableted mixture from the mortar.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: June 13, 2017
    Assignee: ASAHI CALPIS WELLNESS CO., LTD.
    Inventor: Akira Kubota
  • Medical balloon coated with therapeutic agent, carboxylic acid, and salt thereof
    Patent number: 9675734
    Abstract: A coated medical balloon that includes a polymeric material having a surface with a therapeutic agent-containing mixture coated thereon, wherein the mixture includes a therapeutic agent, an unsaturated carboxylic acid, and a salt of the unsaturated carboxylic acid.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: June 13, 2017
    Assignee: Invatec S.p.a.
    Inventors: Simone D'Onofrio, Federica Bellucci, Paolo Pellegrini, Piersandro Pallavicini
  • Compositions and uses thereof
    Patent number: 9663517
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: May 30, 2017
    Assignees: Plexxikon Inc., Hoffman-La Roche Inc.
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
  • Amine polymers for use as bile acid sequestrants
    Patent number: 9655920
    Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: May 23, 2017
    Assignee: Relypsa, Inc.
    Inventors: Eric Connor, Kalpesh Biyani, Scott Hecker, Inez Lees, Paul Mansky, YongQi Mu, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Grace Huynh, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang