Patents Examined by Rebecca M Giere
  • Patent number: 11215614
    Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: January 4, 2022
    Assignee: Zoetis Services LLC
    Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz
  • Patent number: 11209430
    Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: December 28, 2021
    Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Asher Krell
  • Patent number: 11199529
    Abstract: Contamination detection systems, kits, and techniques are described for testing surfaces for the presence of hazardous contaminants, while minimizing user exposure to these contaminants. Even trace amounts of contaminants can be detected. A collection kit provides a swab that is simple to use, easy to hold and grip, allows the user to swab large areas of a surface, and keeps the user's hands away from the surface being tested. The kit also provides open and closed fluid transfer mechanism to transfer the collected fluid to a detection device while minimizing user exposure to hazardous contaminants in the collected fluid. Contamination detection kits can rapidly collect and detect hazardous drugs, including trace amounts of antineoplastic agents, in healthcare settings at the site of contamination.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: December 14, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Weston F. Harding, Erik K. Witt, Austin Jason Mckinnon, Ray Isaacson, Bart Peterson, Marcel Arantes Souza, Matthew Oshinski
  • Patent number: 11193101
    Abstract: Methods and apparatus for detecting, quantifying, enriching, and/or separating bacterial species in fluid sample are provided. The fluid sample is provided as input to a microfluidic passage of a microfluidic device, wherein the microfluidic device comprises at least one electrode disposed adjacent to the microfluidic passage. The at least one electrode is activated to capture bacteria in the sample using dielectrophoresis, wherein the capture efficiency of bacteria is at least 99%.
    Type: Grant
    Filed: December 31, 2020
    Date of Patent: December 7, 2021
    Assignee: Fluid-Screen, Inc.
    Inventors: Monika Weber, Slawomir Antoszczyk, Robert Weber
  • Patent number: 11187702
    Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: November 30, 2021
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Darren R. Link, Michael L. Samuels
  • Patent number: 11161107
    Abstract: The present invention provides a disposable pipette tip for dispersive solid phase extraction (SPE) that allows for rapid, automatable purification of large biomolecules, such as nucleic acids, proteins and polypeptides without the need for additional tools such as centrifuges, magnetic plates or vacuum manifolds. The pipette tip is designed for optimal biomolecule isolation while maintaining sample integrity. Optimized methods of using the dispersive pipette extraction system for isolation of large biomolecules are also provided.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: November 2, 2021
    Inventors: Brian Todd Mullis, Gary Horvath, Lim Andrew Lee, Sunil Hwang, William Edward Brewer
  • Patent number: 11162962
    Abstract: An automatic analysis device and a sample analysis method. The automatic analysis device (100) comprises: a loading unit (20) for loading a sample and/or a reagent to a reaction vessel; a reaction unit (10) for incubating, and washing and separating reactants in a reaction vessel; a measurement unit (80) for measuring reaction signals in the reaction vessel; and a transferring unit (50) for transferring the reaction vessel between different locations. The device (100) realizes incubation, washing and separation of the reactants in the reaction vessel by utilizing the reaction unit (10) as a center. The measurement unit (80) independent of the reaction unit (10) measures the signals in the reaction vessel.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: November 2, 2021
    Inventor: Zhen Zhang
  • Patent number: 11162948
    Abstract: Techniques for detection of virus-antibody nanocomplexes using a chip-based pillar array are provided. In one aspect, a method for virus detection is provided. The method includes the steps of: collecting a fluid sample from a virus-bearing source; contacting the fluid sample with an antibody that binds to viruses to form a sample-antibody mixture, wherein the antibody is labeled with a fluorescent tag; separating particles including any antibody-virus complexes, if present, from the sample-antibody mixture using an assay nanopillar array; and detecting the antibody-virus complexes, if present, in the particles from the separating step using fluorescence. A virus detection chip device and a chip-based immunoassay method are also provided.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: November 2, 2021
    Assignee: International Business Machines Corporation
    Inventors: Yann Astier, Stacey M. Gifford, Benjamin H. Wunsch
  • Patent number: 11154833
    Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: October 26, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: J. Christopher Love, Hidde L. Ploegh, Jehnna Ronan
  • Patent number: 11141732
    Abstract: A detection kit for quickly detecting a lead content lead a sample is provided, and belongs to the technical field of medical in vitro immunoassay. The kit includes a detection card and a quality control; the detection card includes a bottom plate, and a sample pad, a glass fiber membrane, a nitrocellulose membrane and an absorbent paper which are arranged on the surface of the bottom plate sequentially from a loading end. The provided kit has advantages of having simple preprocessing, having no need of digestion, and being economic, fast and convenient, and the like, can realize storage at room temperature, a rapid speed, a high throughout, a low instrument cost, simple and convenient operations, single-person packaging, and detection at any time, which greatly improves the simplicity and convenience of clinical use.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: October 12, 2021
    Assignee: Beijing Diagreat Biotechnologies Co., Ltd.
    Inventors: Jianping Zhou, Yanxin Wang, Yujun Zhou
  • Patent number: 11143650
    Abstract: Some embodiments described herein relate to systems and methods operable to combine immunoassay and Total Protein techniques in a single sample run. Some embodiments described herein allow for multiple sequential immunoassays to be performed in the same microfluidic device. Some embodiments described herein relate to stripping reagents operable to remove primary antibodies associated with immunoassays. Such stripping reagents can allow for additional immunoassays and/or Total Protein assays to be performed on the same sample.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: October 12, 2021
    Assignee: ProteinSimple
    Inventors: Irina Georgievna Kazakova, Crystal Tran, Jessica Dermody, Annegret Boge, Tom Yang
  • Patent number: 11130124
    Abstract: A fluidic device is described for locally coating an inner surface of a fluidic channel. The fluidic device comprises a first, a second and a third fluidic channel intersecting at a common junction. The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device further comprises a fluid control means configured for creating a fluidic flow path for a coating fluid at the common junction such that, when coating, a coating fluid propagates from the first to the second fluidic channel via the common junction without propagating into the third fluidic channel. A corresponding method for coating and for sensing also has been disclosed.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 28, 2021
    Assignee: IMEC VZW
    Inventors: Benjamin Jones, Tim Stakenborg, Paolo Fiorini
  • Patent number: 11112405
    Abstract: Assay devices, systems, methods, and kits useful for detection of analytes in a bodily fluid sample, such as saliva, are disclosed herein. Assay devices may include a fluid sample collector and an assessment unit to which the fluid sample collector couples. The fluid sample collector may include a cap with a plunger and absorbent member that collects a bodily fluid sample. Insertion of the plunger into the assessment unit during coupling provides pressure-driven fluid flow through a filter rapidly delivering bodily fluid filtrate to one or more test panels which provide the assay result. In embodiments, an on-board light source enables a user to readily detect changes in a test panel indicative of the presence of an analyte thus providing an opportunity for obtaining rapid results with improved confidence.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: September 7, 2021
    Assignee: Baseline Global, Inc.
    Inventors: Balwant Rai, Jeffery Floyd McAllister, Peter Andrew Smith, Jay Colton Zignego, Michael Eugene O'Donnell, Leonard Kristal, Matthew Hon Ming Kwok, Mark Kin Ming Kwok
  • Patent number: 11105820
    Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: August 31, 2021
    Assignees: University of Washington through its Center for Commercialization, Bloodworks
    Inventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
  • Patent number: 11105798
    Abstract: The present invention discloses a device and a method for capillary chemiluminescence detection. The device comprises a liquid adding device, wherein the liquid adding device comprises: a bottom end of a funnel cup connected to a top end of the capillary body; a mounting bracket with one or more grooves; a liquid reagent cup disposed in each of the one or more grooves, a reagent set in the cup body, and a sealing film disposed at the opening of the cup body, a bottom end of each of the one or more grooves is connected to a top end of the funnel cup; a puncture device disposed in an inner bottom end of each of the one or more grooves. The present invention has the advantages of reducing the cost of the instrument, improving the reliability of the operation and so on.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: August 31, 2021
    Inventors: Peng Ran, Zihua Han, Yunxuan Tang, Peng Wang
  • Patent number: 11085932
    Abstract: The present invention relates to biological markers of metabolic bone diseases or disorders such as osteoporosis and related methods using thereof. The invention further relates to the use of those biomarkers and related material and assays in the diagnosis of subjects at risk of developing such disorders or monitoring the effects of a treatment thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: August 10, 2021
    Inventors: Serge Ferrari, Nicolas Bonnet, Daniel S. Spellman
  • Patent number: 11067575
    Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: July 20, 2021
    Inventors: Axel Scherer, Samuel Njoroge, Jingqing Huang
  • Patent number: 11061021
    Abstract: Apparatus for performing an assay to detect the presence of an analyte in a test sample. A housing defines a slot for receiving a sample collector, and a capsule contains a buffer liquid, the capsule being sealed by an openable lid, and being connected to the housing such that insertion of a sample collector into the slot causes the lid to open releasing the buffer liquid into the slot. The housing further defines an incubation chamber containing or configured to receive a reagent, and an aperture permitting liquid communication between the slot and the incubation chamber. The apparatus comprises one or more test elements, a substantially liquid tight sealing member separating the incubation chamber and the test element(s), and an activation mechanism operable to open the liquid tight sealing member thereby bringing at least a portion of the or each test element into liquid communication with the incubation chamber.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: July 13, 2021
    Inventors: Alan Pang, Gordon Jowett, Barry Lillis, Jack Fairbank
  • Patent number: 11047853
    Abstract: This invention relates to an improved version of paper-based analytical device and method for chromatographic chemical or immunoassays. Particularly, this present invention discloses a device and a method for reducing smears and improving sharpness and intensity of test sample readout for a multi-step chemical assay or immunoassay by introducing two additional elements, a time-delay pad (2) and a mixer (1), to the conventional two-dimensional paper network device (2DPN).
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 29, 2021
    Assignee: Purdue Research Foundation
    Inventors: Jacqueline Callihan Linnes, Laura Mae Jamicich, Elizabeth A. Phillips, Kristin M. Byers, Anna Bird
  • Patent number: 11041848
    Abstract: There is provided a method that can recover a cell having specific cell information, of cells having cell information that changes over time, from a cell group. A cell recovery method for recovering a specific cell from a cell group including a plurality of cells having cell information that changes over time includes (a) a step of detecting or measuring a desired indicator in each cell of the cell group along a time axis, and (b) a step of recovering a cell having undergone a predetermined change in the indicator, wherein the cell is recovered at a time point after elapse of a preset time since a time point of occurrence of a predetermined change in the indicator.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: June 22, 2021
    Assignee: The University of Tokyo
    Inventors: Yoshitaka Shirasaki, Sotaro Uemura, Yumiko Tanaka, Mai Shirasaki