Patents Examined by Rebecca M Giere
  • Patent number: 10725033
    Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: July 28, 2020
    Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin, Li Zhan
  • Patent number: 10718762
    Abstract: Herein is reported a method for the determination of the simultaneous binding of a bispecific antibody to a first and a second antigen comprising the steps of a) incubating a cell expressing cell-membrane bound FRET-donor-tagged first antigen and FRET-acceptor-tagged second antigen with the bispecific antibody, and b) determining the simultaneous binding of the bispecific antibody by determining the energy transfer from the FRET-donor to the FRET-acceptor.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: July 21, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stefan Seeber, Jens Fischer, Georg Fertig
  • Patent number: 10718768
    Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: July 21, 2020
    Assignee: The University of British Columbia
    Inventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
  • Patent number: 10712282
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: July 14, 2020
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Ian Gibbons, Timothy M. Kemp, John Howard, Shaunak Roy
  • Patent number: 10705085
    Abstract: Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: July 7, 2020
    Assignee: Ohio State Innovation Foundation
    Inventors: Ly James Lee, Kwang Joo Kwak, Bo Yu, Yun Wu, Andrew Lee
  • Patent number: 10697962
    Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: June 30, 2020
    Assignee: The University of British Columbia
    Inventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
  • Patent number: 10677732
    Abstract: A detection chip includes: a liquid container; and a light-transmitting substrate in which one of two surfaces facing each other faces an inside of the liquid container and an LSPR structure that generates localized surface plasmon resonance by light irradiation is disposed on the other surface of the two surfaces or in a region sandwiched between the one surface and the other surface.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: June 9, 2020
    Assignee: KONICA MINOLTA, INC.
    Inventors: Chie Osawa, Akihiro Maezawa, Makoto Mochizuki