Abstract: Guanidine-functionalized perlite particles are provided. Nonwoven articles are also provided, including a fibrous porous matrix and guanidine-functionalized perlite particles enmeshed in the fibrous porous matrix. Laminated articles are additionally provided, including a first substrate and a second substrate sealed to the first substrate along at least a portion of a perimeter of the first substrate. The laminated article further includes guanidine-functionalized perlite particles disposed between the first substrate and the second substrate. Methods of detecting microorganisms or target cellular analytes in a fluid sample using guanidine-functionalized particles or laminated articles are also provided.
Type:
Grant
Filed:
March 15, 2016
Date of Patent:
October 1, 2019
Assignee:
3M Innovative Properties Company
Inventors:
Manjiri T. Kshirsagar, George W. Griesgraber
Abstract: A pentosidine production inhibitor including a lactic acid bacterium fermentation product as an active ingredient, which has a stronger action and a high safety as a component having an action of inhibiting production of pentosidine.
Abstract: According to the present invention, organic material is converted to biogas through anaerobic digestion and the biogas is purified to yield a combustible fluid feedstock comprising methane. A fuel production facility utilizes or arranges to utilize combustible fluid feedstock to generate renewable hydrogen that is used to hydrogenate crude oil derived hydrocarbons in a process to make transportation or heating fuel. The renewable hydrogen is combined with crude oil derived hydrocarbons that have been desulfurized under conditions to hydrogenate the liquid hydrocarbon with the renewable hydrogen or alternatively, the renewable hydrogen can be added to a reactor operated so as to simultaneously desulfurize and hydrogenate the hydrocarbons. The present invention enables a party to receive a renewable fuel credit for the transportation or heating fuel.
Abstract: Compositions and methods to treat biofilms are disclosed based on the discovery of the role of the disaccharide trehalose in microbial biofilm development. In various embodiments to treat body-borne biofilms systemically and locally, the method includes administering trehalase, the enzyme which degrades trehalose, in combination with other saccharidases for an exposition time sufficient to adequately degrade the biofilm gel matrix at the site of the biofilm. The method also includes administering a combination of other enzymes such as proteolytic, fibrinolytic, and lipolytic enzymes to break down proteins and lipids present in the biofilm, and administering antimicrobials for the specific type(s) of infectious pathogen(s) underlying the biofilm. Additionally, methods are disclosed to address degradation of biofilms on medical device surfaces and biofilms present in industrial settings.
Type:
Grant
Filed:
June 26, 2017
Date of Patent:
September 24, 2019
Assignee:
ZIOLASE, LLC
Inventors:
Svetlana A. Ivanova, Dennis W. Davis, Brad W. Arenz, Thomas K. Connellan
Abstract: Compositions comprising microbiological strains and cultures and methods of use thereof are provided herein. Certain strains, cultures, and compositions thereof are useful for the control of head blight disease, for example, of various crop plants. Biological control compositions, and methods of use thereof to prevent, inhibit or treat the development of plant pathogens or disease and for preserving plant yield, are also provided.
Type:
Grant
Filed:
December 19, 2016
Date of Patent:
September 17, 2019
Assignee:
MONSANTO TECHNOLOGY LLC
Inventors:
Christopher J. Grandlic, Wayne A. Green, Janne S. Kerovuo, Ryan T. McCann
Abstract: A method of preparing collagen active peptides with antiproliferative activity against cancer cells. The collagen active peptides are obtained by hydrolysis of papain and trypsin and a specific purifying process. The collagen active peptides have antiproliferative activity against cancer cells, such as ovarian carcinoma cells including SKOV3, OVCAR3, 436 and SRO82 and the prostate cancer cells including PC3, LnCAPC1, and LnCAPC2.
Type:
Grant
Filed:
March 15, 2017
Date of Patent:
September 17, 2019
Assignees:
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY, CHINESE ACADEMY OF SCIENCES, BAOTOU DONGBAO BIO TECH CO LTD.
Inventors:
Yanchuan Guo, Bing Zhang, Fang Liu, Furong Wang, Eric Hanxiang Sun, Jianing Wang
Abstract: A method for monitoring resistance to a Bacillus thuringiensis pesticidal crystal protein is provided, which involves the measurement of protease activity or protease expression in the gut of adult insects.
Type:
Grant
Filed:
May 27, 2014
Date of Patent:
September 17, 2019
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Manfredo Jose Seufferheld, Chia-Ching Chu
Abstract: We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
Type:
Grant
Filed:
April 21, 2017
Date of Patent:
September 10, 2019
Inventors:
David R. Hall, Dan Allen, Conrad Rosenbrock, Daniel Hendricks, Andrew Nguyen, Steven J. M. Butala, Travis Niederhauser, Terrece Pearman, Joe Fox
Abstract: Compositions comprising microbiological strains and cultures and methods of use thereof are provided herein. Certain strains, cultures, and compositions thereof are useful for the control of head blight disease, for example, of various crop plants. Biological control compositions, and methods of use thereof to prevent, inhibit or treat the development of plant pathogens or disease and for preserving plant yield, are also provided.
Type:
Grant
Filed:
July 24, 2012
Date of Patent:
September 10, 2019
Assignee:
Monsanto Technology LLC
Inventors:
Christopher J. Grandlic, Wayne A. Green, Janne S. Kerovuo, Ryan McCann
Abstract: Provided herein are urine progenitor cells and methods for producing a culture of urine progenitor cells from a urine sample. The cells may be selected based upon the use of a selective cell medium, based upon morphology, and/or by selecting cell-specific markers. Also provided is an isolated urine progenitor cell that is c-kit positive and can differentiate into urothelium, smooth muscle, endothelium or interstitial cells. Methods of use of urine progenitor cells are provided, wherein cell are seeded onto a tissue scaffold are provided. Methods of treating a subject in need thereof are also provided, including providing a bladder tissue substrate that includes differentiated UPCs and transplanting the substrate into the patient. Finally, kits are provided that include a container suitable for the transport of a urine sample; media; one or more antibiotics; a package for holding said container, media, and antibiotics; and optionally, instructions for use.
Abstract: This invention relates, e.g., to a Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of a biological fluid, such as venous blood or lymph, comprising a sheath which comprises rhythmically contracting myocytes.
Type:
Grant
Filed:
May 16, 2014
Date of Patent:
August 20, 2019
Assignee:
The George Washington University, A Congressionally Chartered Not-For-Profit Corporation
Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
Type:
Grant
Filed:
May 23, 2014
Date of Patent:
August 13, 2019
Assignee:
MiMedx Group, Inc.
Inventors:
Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
Abstract: Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device.
Abstract: Disclosed herein is a system for purifying air; for the capture of solid residues (soot), and the transformation of COx and NOx (and even methane) present in contaminated air generated by industrial combustion. The purifying air system comprises an air entrance (c); a first module (A), made up of mechanical filters; a second module (B), downwards from the first module (A), and it corresponds to a series of small reactors with molecular converters (nucleophile chemical agents) to capture and transform carbon oxides (COx) and nitrogen oxides (NOx); and an exit for decontaminated air (D).
Type:
Grant
Filed:
May 25, 2016
Date of Patent:
August 13, 2019
Assignee:
ECOLOGICAL WORLD FOR LIFE S.A.S.
Inventors:
Jorge Luis Almarza Castillo, Jhosmer Anderson Cuadros Andrade, Chucheng Zhou, Ernesto Enrique Larrazabal Mogollon
Abstract: A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
Type:
Grant
Filed:
January 21, 2016
Date of Patent:
August 13, 2019
Assignee:
3M Innovative Properties Company
Inventors:
Wensheng Xia, Patrick A. Mach, Joseph M. Beaurline, Jason W. Bjork, Jie J. Liu
Abstract: The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
August 6, 2019
Assignees:
BioSpecifics Technologies Corporation, Duke University
Inventors:
Phyllis Carolyn Leppert, Thomas L. Wegman
Abstract: Methods and devices for treating lipoaspirate for use in fat grafting procedures are provided and generally include a canister for containing lipoaspirate, a separation mechanism structured to separate both oils and other materials from cellular components of lipoaspirate contained in the canister. The separation mechanism includes filters having different filtering capacities, for example, different pore sizes.
Type:
Grant
Filed:
February 1, 2016
Date of Patent:
August 6, 2019
Assignee:
Allergan, Inc.
Inventors:
Zachary Dominguez, Justin Schwab, Tiago Bertolote, Jason Metzner, Ethan Franklin
Abstract: The present invention relates to the technical field of health care products, in particular to a composition and use thereof in the manufacture of a product for improving intestinal function. The present invention provides a composition and use thereof in the manufacture of a product for improving intestinal function. In the present invention, probiotics, prebiotics, Crataegi Fructus and Dioscoreae Rhizoma are reasonably compounded, wherein each component acts synergistically, thus allowing the obtained composition to have good effects of preventing and/or treating diarrhea as well as improving intestinal flora. The efficacy thereof is significantly superior to (P<0.05) that of the Comparative Examples.
Abstract: The invention provides a method of processing MSW comprising the steps of —providing a stream of unsorted MSW to a microbial fermentation reactor in which the MSW is fermented with agitation at a non-water content of between 10 and 50% by weight and at a temperature of between 35 and 75 degrees for a period of between 1 and 72 hours under conditions sufficient to maintain a live lactic acid bacteria concentration of at least 10.000.000.000 CFU/L, and —removing a stream of fermented unsorted MSW from the reactor and subjecting it to a separation step whereby non-degradable solids are removed to provide a slurry of bio-degradable components. Further, a slurry of bio-degradable components prepared according to said method is provided.
Type:
Grant
Filed:
December 18, 2013
Date of Patent:
July 23, 2019
Assignee:
RENESCIENCE A/S
Inventors:
Georg Ornskov Ronsch, Jacob Wagner Jensen, Sebastian Buch Antonsen
Abstract: The invention relates to a method for fermentative production, on an industrial scale, of lipid-rich biomass of microalgae of the Chlorella genus having acceptable sensory properties, characterized in that the dissolved oxygen availability in the fermenter is controlled by tracking the respiratory quotient of said microalgae.
Type:
Grant
Filed:
August 22, 2014
Date of Patent:
July 16, 2019
Assignee:
CORBION BIOTECH, INC.
Inventors:
Sylvain Delaroche, Marie Le Ruyet, Laurent Segueilha, Heike Jerosch, Amandine Druon