Patents Examined by Robert H. Harrison
  • Transdermal matrix system
    Patent number: 6007835
    Abstract: A novel transdermal system for the percutaneous delivery of a hormone, including a carrier and an adhesive matrix, is disclosed. The matrix includes (a) 20-50 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer, (b) 30-60 parts by weight of a tackifyier resin, (c) 4-25 parts by weight of propylene glycol laurate, (d) 2-10 parts by weight of a compound selected from N-alkyl-2-pyrrolidones, wherein the alkyl group is a C.sub.4-- C.sub.15 group, (e) 0.01-2 parts by weight of a stabilizing agent, (f) 0.1-12 parts by weight of at least one hormone selected from the group consisting of oestrogenic and progestogenic components, and (g) 1-12 parts by weight of a vinyl acetate/N-vinyl-2-pyrrolidone copolymer. A method for preparing said system and the therapeutical use thereof are also disclosed.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: December 28, 1999
    Assignee: Laboratoires D'Hygiene Et De Dietetique
    Inventors: Chantal Bon-Lapillonne, Daniel Dhuique-Mayer, Claude Mikler
  • Insecticidal bait composition for cockroaches
    Patent number: 6007832
    Abstract: The specification discloses an insecticidal bait composition for cockroaches and a related method of its use for the control of cockroach infestations. In general, the composition contains boric acid in an amount of from about 15 to about 40 weight percent together with attractant foodbaits for attracting the roaches to the composition so they will consume it. A preferred composition effective for use by persons such as typical homeowners who are not specially trained in the use of insecticides contains between about 15 and 20 weight percent boric acid along with foodbait attractants.
    Type: Grant
    Filed: January 6, 1998
    Date of Patent: December 28, 1999
    Inventor: Billy J. Stapleton
  • Sustained release delivery system
    Patent number: 6007843
    Abstract: Sustained release compositions comprising a drug dispersed within a polymer matrix, methods of producing the same and treatments with the complex.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: December 28, 1999
    Assignee: LAM Pharmaceuticals Corp.
    Inventors: Alan Drizen, Peter Rothbart, Gary M. Nath
  • Composition for local anesthesia
    Patent number: 6008256
    Abstract: A composition for local anesthesia which comprises (A) lidocaine, (B) a catecholamine such as epinephrine in an amount of, for example, 1/200,000 (g/ml) based on the volume of the composition, and (C) one or more amino acids such as glycine, glutamic acid, and L-glutamic acid-L-lysine or one or more hydroxycarboxylic acids such as lactic acid, glycolic acid, and citric acid, which has a duration suitable for short-time dental operations such as tooth extraction and excellent storage stability.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: December 28, 1999
    Assignee: Showa Yakuhin Kako Co., Ltd.
    Inventors: Mitsuhiro Haraguchi, Kazuhiro Ono, Takashi Osada, Yukio Suzuki
  • Hydrolysis-optimized lipid emulsions and use thereof
    Patent number: 6008248
    Abstract: The present invention pertains to hydrolysis-optimized isotonic lipid emulsions comprising medium-chain triglycerides (MCT), vegetable oils and fish oil, as well as their use for parenteral nutritition.
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: December 28, 1999
    Assignee: B. Braun Melsungen AG
    Inventors: German Pscherer, Marco Junginger, Jorg Nehne, Yvon A. Carpentier
  • Dithiocarbamate fungicide compositions with improved properties
    Patent number: 6004570
    Abstract: This invention is relates to dithiocarbamate fungicide formulations having improved physical properties. The formulations comprise one or more dithiocarbamate fungicides and a water soluble polymer.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: December 21, 1999
    Assignee: Rohm and Haas Company
    Inventor: Edward Charles Kostansek
  • Antimicrobial polishing compound
    Patent number: 6004539
    Abstract: An antimicrobial, abrasive, polishing compound, colloidal suspension or gel formulated for the controlling of microbial cross-contamination in the pumicing or polishing of prosthetic and orthodontic dental appliances and related materials. The colloidal suspension provides continuous, instant access to a pre-mixed polishing compound with excellent antimicrobial activity for use by dental offices and laboratories.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: December 21, 1999
    Inventors: James Joseph Longo, Jr., James Joseph Longo, Sr., David Michael Longo
  • Liquid cleansing compositions comprising xanthan gum and cross-linked polyacrylic acid polymers for enhanced suspension of large droplet oils
    Patent number: 6001344
    Abstract: The present invention relates to a novel structuring system comprising both xanthan gum and cross-linked polyacrylic acid polymer which combination unexpectedly has been found to provide enhanced stability for large size benefit agent droplets in an amphoteric/anionic surfactant system relative to use of either structurant alone.
    Type: Grant
    Filed: March 6, 1996
    Date of Patent: December 14, 1999
    Assignee: Lever Brothers Company
    Inventors: Virgilio Villa, Richard Kolodziej, May Shana'a
  • Ophthalmic composition
    Patent number: 5998488
    Abstract: In an ophthalmic solution comprising an antimicrobial preservative having a quaternary ammonium type cationic group, there are blended a cyclodextrin, EDTA or its salt, and boric acid and/or borax. The solution has an excellent antimicrobial activity and is effective for inhibiting the antimicrobial preservative from adsorbing to contact lenses. It can be instilled to eyes with contact lenses on.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: December 7, 1999
    Assignee: Lion Corporation
    Inventors: Takashi Shinohara, Yoshikazu Kubo, Shinya Kitoh
  • Combination of atovaquone with proguanil for the treatment of protozoal infections
    Patent number: 5998449
    Abstract: The invention relates to combinations of atovaquone and proguanil, their use in the treatment and propinylaxis of parasitic infections, such as protozoal parasitic infections, e.g. malaria and toxoplasmosis, and infections caused by P.carinii and their use in the manunfacture of medicaments for the treatment and/or prophylaxis of such infections. The combinations can conveniently be administered in a single pharmaceutical formulation. Preferably, atovaquone and proguanil are administered in a potentiating ratio so that they act in synergy.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: December 7, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventors: Winston Edward Gutteridge, David Brian Ashton Hutchinson, Victoria Susan Latter, Mary Pudney
  • Adherent starch granules
    Patent number: 5997945
    Abstract: The present invention provides methods and compositions used to increase the pest resistance of living organisms. The invention especially provides adherent granules made of starch that are carriers for pest control agents. Simple and economic methods have been developed to prepare said adherent granules. Compositions and characteristics of the granules are disclosed, including their capability for sustained release of pest control agents.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: December 7, 1999
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Baruch S. Shasha, Michael R. McGuire
  • NSADI delivery employing a powdered hydrocolloid gum obtainable from higher plants
    Patent number: 5993860
    Abstract: An oral-delivery pharmaceutical composition for reducing the gastric irritation effect of an NSAID in the upper GI tract of a mammal. The composition includes (a) a mucosal protective amount of a pharmaceutically-acceptable hydrocolloid gum obtainable from higher plants, (b) a dispersion-enhancing amount of another excipient and (c) a therapeutically-effective amount of an NSAID. Also disclosed is a process for preparing the composition and a method for reducing the gastric irritation effect of the NSAID by administering the composition. Also, disclosed is a composition particularly useful for preparing an aqueous suspension.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: November 30, 1999
    Assignee: Venture Lending
    Inventors: Eric H. Kuhrts, David R. Friend, Karen Yu, Jagdish Parasrampuria
  • Ocular insert with anchoring protrusions
    Patent number: 5989579
    Abstract: A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. The sustained release mechanism may, for example, be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. The protrusions may be of various shapes such as, for example, ribs, screw threads, dimples or bumps, truncated cone-shaped segments or winding braid segments.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: November 23, 1999
    Assignee: Escalon Medical Corp.
    Inventors: Sohrab Darougar, Alan L. Weiner, Padmanabh Pravinchandra Bhatt, Victor Albert Raul, David Clayton Gantner
  • Two-phase matrix for sustained release drug delivery device
    Patent number: 5989586
    Abstract: A two-phase hydrophilic drug-containing matrix for use in transdermal drug delivery patches in which one phase is a continuous hydrophobic polymer phase which optionally includes a hydrophobic solvent that acts as a skin permeation enhancer and the other phase is a dispersed particulate hydrated inorganic silicate in whose absorbed aqueous phase the drug is dissolved.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: November 23, 1999
    Assignee: Cygnus, Inc.
    Inventors: Tsung-Min Hsu, Tung Fen Chen
  • Composition and method of enhancing electrotransport agent delivery
    Patent number: 5990179
    Abstract: A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enhancer. Methods of enhancing transdermal electrotransport delivery and of forming a composition for the enhancement of transdermal electrotransport drug delivery, and a transdermal electrotransport delivery device (10) utilizing the compositions of the invention are disclosed.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: November 23, 1999
    Assignee: ALZA Corporation
    Inventors: J. Richard Gyory, Patricia S. Campbell
  • Leave-on oxidizing solution for permanent waving of hair and a process for permanent waving of hair
    Patent number: 5988180
    Abstract: A leave-on oxidizing solution useful for permanent waving of hair containing water, an oxidant which is capable of being left on the hair and dried on the hair without damage to the hair, and an acidic agent to provide the solution with a pH value of less than about 7. The use of the leave-on oxidizing solution decreases the amount of time required for carrying out a permanent waving of hair process.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: November 23, 1999
    Assignee: Zotos International, Inc.
    Inventor: Joan M. Bergstrom
  • Bleaching composition for human hair and process for its production
    Patent number: 5989530
    Abstract: A dustless, free-flowing powdery bleaching material for human hair which comprises a powdery composition of at least one solid peroxide compound and at least one pulverulent carrier material admixed with an oil and/or a liquid wax.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: November 23, 1999
    Assignee: Goldwell AG
    Inventors: Heribert Lorenz, Frank Kufner
  • Rapamycin formulations for oral administration
    Patent number: 5985325
    Abstract: This invention provides rapamycin solid dosage unit which comprises a core and a sugar overcoat, said sugar overcoat comprising rapamycin, one or more sugars, and one or more binders.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: November 16, 1999
    Assignee: American Home Products Corporation
    Inventor: Arwinder S. Nagi
  • Soft gelatin capsule manufacture
    Patent number: 5985321
    Abstract: Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule filling and in the capsule shell. The manufacture of said capsules is improved, if in the process for making the soft gelatin capsules the gelatin bands are cooled with a liquid, and preferably with water.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: November 16, 1999
    Assignees: Novartis AG, R.P. Scherer GmbH
    Inventors: Werner Brox, Armin Meinzer, Horst Zande
  • Thrombolytic agents and methods of treatment for thrombosis
    Patent number: 5980950
    Abstract: The foregoing invention relates to a new microbubble preparation and thrombolytic therapy which relies on microbubbles and ultrasound for its lytic activity. The pharmaceutical composition of the invention comprises a liquid solution of microbubbles with an internal atmosphere enhanced with the perfluorocarbon gas which cavitate in the presence of an ultrasound field following intravenous injection or infusion of said composition into said host. For thrombolysis the area of a thrombus is exposed to an ultrasound field in the presence of the microbubbles and significant lysis is experienced. The method and pharmaceutical composition of the invention exhibit thrombolytic properties similar to those of other thrombolytic agents such as urokinase and are less toxic and are clot specific in that they do not introduce a systemic lytic state to a said animal.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: November 9, 1999
    Assignee: The Board of Regents of the University of Nebraska
    Inventor: Thomas R. Porter