Patents Examined by Robert L. Nasser
  • Patent number: 7860545
    Abstract: An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: December 28, 2010
    Assignee: DexCom, Inc.
    Inventors: Mark C. Shults, James H. Brauker, Victoria Carr-Brendel, Mark A. Tapsak, Dubravka Markovic, Stuart J. Updike, Rathbun K. Rhodes
  • Patent number: 7857769
    Abstract: A system and method for determining a left ventricular end-diastolic pressure of blood within a left ventricle of a patient includes non-invasively measuring a plurality of cardiac parameters of the patient. The cardiac parameters may include a mitral valve area, and at least one of a stroke volume of the left ventricle, a left ventricular diastolic filling time, and a maximum velocity of blood entering the left ventricle. The systems and methods further include a step of calculating the left ventricular end-diastolic pressure using the measured cardiac parameters.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: December 28, 2010
    Inventor: Alejandro Ortiz-Burgos
  • Patent number: 7850617
    Abstract: From the global end-diastolic volume GEDV and the global ejection fraction GEF the patient monitor (4) determines a corrected global end-diastolic volume cGEDV according to cGEDV=GEDV/Ć’(GEF) which is used as a novel parameter for volume responsiveness of the patient (3). In the above formula, f(GEF) is a correction function depending on global ejection fraction GEF. Further, from the right ventricular end-diastolic volume RVEDV and the right ventricular ejection fraction RVEF the patient monitor (4) determines a corrected right ventricular end-diastolic volume cRVEDV according to cRVEDV=RVEDV1f(RVEF) which is used as another novel parameter for volume responsiveness of the patient (3). In the above formula, f(RVEF) is a correction function depending on right ventricular ejection fraction RVEF.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: December 14, 2010
    Assignee: Pulsion Medical Systems AG
    Inventors: Oliver Goedje, Manu Malbrain, Stephan Joeken, Matthias Bohn
  • Patent number: 7846105
    Abstract: The present invention discloses a non-invasive blood pressure measurement apparatus and a safety protection method. In addition to a main pressure measurement circuit and a main microprocessor circuit, the measurement apparatus also includes an independently disposed assist pressure measurement circuit and an independently disposed assist microprocessor circuit. In normal measurement, the assist microprocessor circuit periodically samples a cuff pressure via the assist pressure measurement circuit, and compares the measured cuff pressure with a specified overpressure protection value, and if the cuff pressure exceeds the specified overpressure protection value, the assist microprocessor circuit outputs a control signal to open a deflation valve until the pressure falls to below the safety pressure.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: December 7, 2010
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Jian Cen, Xiaoyu Wu, He Bo
  • Patent number: 7835787
    Abstract: An EEG cap (8) having 64 or 128 electrodes (10) is placed on the head of the subject (11) who is viewing CRT monitor (14). The signals on each channel are amplified by amplifier (17) and sent to an analog-to-digital converter (20). PC (23) captures and records the amplified signals and the signals are processed by signal processing PC (26) performing linear signal processing. The resulting signal is sent back to a feedback/display PC (29) having monitor (14).
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: November 16, 2010
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul Sajda, Lucas Cristobal Parra
  • Patent number: 7835777
    Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: November 16, 2010
    Assignee: DexCom, Inc.
    Inventors: Mark C. Shults, Stuart J. Updike, Rathbun K. Rhodes
  • Patent number: 7833164
    Abstract: An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: November 16, 2010
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Avram Scheiner, Donald L. Hopper, Gerrard M. Carlson
  • Patent number: 7831287
    Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: November 9, 2010
    Assignee: DexCom, Inc.
    Inventors: Mark Brister, James R. Petisce, Peter Simpson
  • Patent number: 7828739
    Abstract: A method and apparatus are described for utilizing a source of vascular pulse waveform data from a patient for the purpose of measuring pulsus paradoxus. The arterial pulse waveform data source described is a pulse oximeter plethysmograph but can be any similar waveform data source, including an intra-arterial transducer, external blood pressure transducer, or plethysmograph. Through incorporation of measurements of values, such as an area under a pulse waveform curve, that are time-domain functions of a change in amplitude of the pulse waveform over a duration of the waveform, embodiments of the present invention represent a significant improvement upon previously described methods of measuring pulsus paradoxus.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: November 9, 2010
    Assignee: Precision Pulsus, Inc.
    Inventor: Donald H. Arnold
  • Patent number: 7824340
    Abstract: The present invention relates to a noninvasive medical pulsimeter sensor using magnetic thin films. By forming a pulse-sensing part array with magnetic sensors such as GMR devices, MTJ devices and the likes, over the skin-contacting part which consists of a magnetic material, the present invention increases the integrity of sensors, minimizes the time for searching the pulse and it is applicable widely to portable pulsimeters and the likes.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: November 2, 2010
    Assignee: Sangji University Industry Academy Cooperation Foundation
    Inventors: Sang Suk Lee, Do Guwn Hwang, Ki Wang Kim, Sun Wook Kim, Hyeon Ho Kim
  • Patent number: 7819804
    Abstract: Systems and methods obtain information that allows detection of whether a patient suffers from congestion by monitoring a response of the patient to a recumbent position of the patient's body. The patient may be monitored to determine a respiration pattern for a non-recumbent position such as standing and a respiration pattern for a recumbent position such as lying down. The two patterns may be compared, either by a processing device or a physician, to determine a difference in the two respiration patterns. Furthermore, the congestion may be inferred from detecting an amount of time that the patient spends in a recumbent position or from detecting the recumbent angle that the patient obtains, either of which is presumed to indicate whether a recumbent position presents discomfort to the patient due to the presence of congestion.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: October 26, 2010
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: John D. Hatlestad, Qingsheng Zhu, Jeffrey E. Stahmann
  • Patent number: 7822454
    Abstract: An assembly is described that combines blood chemical analysis with lancing in a single multiple-test disposable cartridge. The penetrating members can be assembled and sterilized without damaging the analytical chemistry, and the functioning of the present radical disc cartridge mechanism is not substantially modified.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: October 26, 2010
    Assignee: Pelikan Technologies, Inc.
    Inventors: Don Alden, Travis Marsot
  • Patent number: 7819811
    Abstract: A method and apparatus for improving the diagnostic performance of a probe system (30) for detecting a medical condition in a patient by sensing volume changes in a monitored body part due to pulsatile arterial blood flow in the body part, characterized in calibrating the probe system (30) for the respective measurement site according to a predetermined characteristic of the monitored body part of the patient and quantifying the arterial pulsatile volume thereat. Such calibration is described with respect to probes including: (1) a pressure sensor (63), which senses pressure changes in a compressible fluid system to which the patient's body part (e.g.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: October 26, 2010
    Assignee: Itamar Medical Ltd.
    Inventor: Robert P. Schnall
  • Patent number: 7815569
    Abstract: Continuous Glucose Error-Grid Analysis (CG-EGA) method, system or computer program product designed for evaluation of continuous glucose sensors providing frequent BG readings. The CG-EGA estimates the precision of such sensors/devices in terms of both BG values and temporal characteristics of BG fluctuation. The CG-EPA may account for, among other things, specifics of process characterization (location, speed and direction), and for biological limitations of the observed processes (time lags associated with interstitial sensors).
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: October 19, 2010
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Linda Gonder-Frederick, Daniel J. Cox, William L. Clarke
  • Patent number: 7815576
    Abstract: A method for determining haemodynamic parameters from patient pressure signals includes receiving patient pressure signals from a measurement receiver to which vessel pressures measured in the body of a patient are supplied, selecting and determining a patient pressure signal as reference pressure signal from the patient pressure signals sent from the measurement receiver, dividing the patient pressure signals and reference pressure signal into segments, and examining these segments for artifacts with methods in the time range by using the first derivative with respect to time of the pressure signals wherein artifact afflicted segments are discarded. The method further includes determining the start and end of a heart beat by the reference pressure signal and using the non-discarded segments of the patient pressure signals for calculating haemodynamic parameters.
    Type: Grant
    Filed: February 16, 2005
    Date of Patent: October 19, 2010
    Assignee: Deutsches Herzzentrum Berlin
    Inventor: Ernst Wellnhofer
  • Patent number: 7813780
    Abstract: Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: October 12, 2010
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Rajiv Shah, Gopikrishnan Soundararajan, Rebecca K. Gottlieb, Udo Hoss, Eric A. Grovender, Shaun M. Pendo
  • Patent number: 7813793
    Abstract: A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in an electrographic signal received from a patient's brain. The features and window-based characteristics are combinable in various ways according to the invention to detect and predict neurological events in real time, enabling responsive action by the implantable device.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: October 12, 2010
    Assignee: NeuroPace, Inc.
    Inventors: Benjamin D. Pless, Stephen T. Archer, Craig M. Baysinger, Barbara Gibb, Suresh Gurunathan, Bruce Kirkpatrick, Thomas K. Tcheng
  • Patent number: 7809432
    Abstract: Apparatus for measuring neural network activity with a textured semiconductor substrate. Sensor elements have a respective detection electrode on the substrate surface for detecting neural network signals, and the detected neural signals are a basis for outputting electrical sensor output signals via respective sensor element outputs. Each amplifier element has an input and an output. Each of the sensor elements has associated therewith one of the amplifier elements whose input is connected to the sensor output of the respective sensor element. The amplified sensor output signal is output the amplifier output as an amplifier output signal. An activity evaluator has an input, which is connected to at least one of the amplifier outputs, and an output. The activity evaluation device produces an activity signal, which is a measure of activity of the neural network, based on the amplifier output signal, and outputs the amplifier output signal via the evaluation output.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: October 5, 2010
    Assignee: Infineon Technologies AG
    Inventors: Bjorn-Oliver Eversmann, Martin Jenkner, Christian Paulus, Roland Thewes
  • Patent number: 7809434
    Abstract: The invention provides a method of estimating cerebral sources of electrical activity from a small subset of EEG channels utilizing existing methods to provide a 3-dimensional, discrete, distributed, linear solution to the inverse problem using inputs consisting of a small number of EEG channels (e.g., 4 channels) augmented with synthetic EEG data for the other channels. The resultant image of cerebral electrical activity in the region of the EEG channels from which data is recorded is of comparable spatial resolution in the corresponding region to images of cerebral electrical activity obtained using a complete set of EEG channels (e.g., using 24 channels).
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: October 5, 2010
    Assignee: Nellcor Puritan Bennett LLC
    Inventors: Tim Kofol, Scott D. Greenwald, Philip H. Devlin
  • Patent number: 7803117
    Abstract: The invention relates to a method, device, and computer program product for monitoring the physiological state of a person. In the method, the heartbeat of the person is detected in order to obtain a pulse signal, and at least one parameter depicting the respiration of the person is determined in the time domain with the aid of time stamps made of the basis of the pulse signal. With the aid of the method, it is possible to calculate an estimate of the person's energy consumption during exercise, without complicated calculations or preliminary data based on measurements.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: September 28, 2010
    Assignee: Suunto Oy
    Inventors: Mikko Martikka, Erik Lindman