Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: A device comprises a head mounting arrangement sized and shaped to be worn on a user's head and a plurality of electrodes disposed on the arrangement so that, when the arrangement is worn on the user's head, the electrodes contact target portions of a scalp to detect electrical activity of a brain of the user in combination with an image capture device disposed on the arrangement so that, when the arrangement is worn on the user's head, a field of view of the image capture device includes a portion of an anatomy of the user and a processing unit generating EEG data from the electrical activity, wherein, when the EEG data is indicative of an epileptic event, the processing unit activates the image capture device to capture video data of the user and may store the EEG and/or the video data with transmission of warning signals to one or more remote displaying and/or computing arrangements.

Abstract: The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present invention further provides methods of increasing arterial compliance in individuals who have Type 1 or Type 2 diabetes. The present invention further provides methods of increasing arterial compliance in perimenopausal, menopausal, and post-menopausal women. The present invention further provides methods of increasing arterial compliance in individuals who have or who are at risk of developing age-associated arterial stiffness.

Abstract: This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.

Abstract: A system and method for a biological interface system that processes multicellular signals of a patient and controls one or more devices is disclosed. The system includes a sensor that detects the multicellular signals and a processing unit for producing the control signal based on the multicellular signals. The system further includes an automated configuration routine that is used to set or modify the value of one or more system configuration parameters.

Abstract: Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15? cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided.

Abstract: Method for treating a medical condition in a human patient comprising choosing a psychological strategy for treating the medical condition, encoding electronic instructions for an interactive video game in such a way that the interactive video game implements the psychological strategy, loading the electronic instructions into a microprocessor-based unit equipped with a display for displaying the interactive video game and with an patient input device for receiving responses to the interactive video game from the human patient, and instructing the human patient how and when to use the microprocessor-based unit to play the interactive video game. The interactive video game contains instructions for a scoring procedure for quantitatively analyzing the medical condition of the human patient, and/or counseling instructions or self-care instructions. The video game can be used in conjunction with a physical parameter measuring device connected to the microprocessor-based unit.

Abstract: An interface device in accordance with the present claimed invention is an interface device 4 that intervenes between a measuring means 2 that measures brain activities of a subject H and an object 31 to be controlled, and that comprises a reference signal storing part D1 that stores a brain activity signal measured at a time when the subject H conducts predetermined thinking different from direct thinking in order to control the object 31 to be controlled in a desired mode as a reference signal, a discriminating part 41 that compares the brain activity signal measured by the measuring means 2 with the reference signal and discriminates whether or not the thinking of the subject H is the predetermined thinking, and a controlling part 42 that controls the object 31 to be controlled in the desired mode when the discriminating part 41 discriminates that the thinking of the subject H is the predetermined thinking.

Abstract: Method for treating a medical condition in a human patient comprising choosing a psychological strategy for treating the medical condition, encoding electronic instructions for an interactive video game in such a way that the interactive video game implements the psychological strategy, loading the electronic instructions into a microprocessor-based unit equipped with a display for displaying the interactive video game and with an patient input device for receiving responses to the interactive video game from the human patient, and instructing the human patient how and when to use the microprocessor-based unit to play the interactive video game. The interactive video game contains instructions for a scoring procedure for quantitatively analyzing the medical condition of the human patient, and/or counseling instructions or self-care instructions. The video game can be used in conjunction with a physical parameter measuring device connected to the microprocessor-based unit.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: Methods of determining gastro-intestinal conditions by performing a succession of breath tests or others tests, particularly for determining the gastric emptying or gastric accomodation condition of a subject. Methods of performing successive gastric emptying tests with different test meals are also presented, enabling the gastric accommodation to be determined. The effects of different test means on the results is presented. Novel substrates for use in such tests are suggested, including the use of micro-encapsulation. Breath tests for the detection of bacterial overgrowth, lactose intolerance and combinations thereof are presented.

Abstract: A method of diabetes management, comprising (a) providing a remote communications unit in communication with a portable microprocessor-based unit; (b) transmitting blood glucose level data into the portable microprocessor-based unit or the remote unit, or both; (c) running a program of instructions on the portable microprocessor-based unit or on the remote unit, or both, using data corresponding to the blood glucose level data; and (d) providing a signal including instructions to inject insulin when the blood glucose level data indicates.

Abstract: A diabetes management system, comprising a glucose meter measuring blood glucose level data and a portable microprocessor-based unit in communication with the blood glucose meter such as to be capable of accessing the blood glucose level data. Input data corresponding to the blood glucose level data is used in a program of instructions running on the portable microprocessor-based unit or the glucose meter, or both. The program of instructions includes instructions to communicate a signal to inject insulin based upon the blood glucose level data.

Abstract: A system and method for determining a left ventricular end-diastolic pressure of blood within a left ventricle of a patient includes non-invasively measuring a plurality of cardiac parameters of the patient. The cardiac parameters may include a mitral valve area, and at least one of a stroke volume of the left ventricle, a left ventricular diastolic filling time, and a maximum velocity of blood entering the left ventricle. The systems and methods further include a step of calculating the left ventricular end-diastolic pressure using the measured cardiac parameters.

Abstract: An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.

Abstract: Lumen-traveling devices and associated methods and systems are described. Lumen-traveling devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, as well as additional components such as a sensor, an active portion, and/or control circuitry. In some embodiments, a sensor may be used to detect a local condition, and an action may be performed within the body lumen. Actions that may be performed include, but are not limited to, transmitting information, releasing a material within the lumen, performing a surgical step, or collecting a sample, among others.

Abstract: From the global end-diastolic volume GEDV and the global ejection fraction GEF the patient monitor (4) determines a corrected global end-diastolic volume cGEDV according to cGEDV=GEDV/ƒ(GEF) which is used as a novel parameter for volume responsiveness of the patient (3). In the above formula, f(GEF) is a correction function depending on global ejection fraction GEF. Further, from the right ventricular end-diastolic volume RVEDV and the right ventricular ejection fraction RVEF the patient monitor (4) determines a corrected right ventricular end-diastolic volume cRVEDV according to cRVEDV=RVEDV1f(RVEF) which is used as another novel parameter for volume responsiveness of the patient (3). In the above formula, f(RVEF) is a correction function depending on right ventricular ejection fraction RVEF.

Abstract: The present invention discloses a non-invasive blood pressure measurement apparatus and a safety protection method. In addition to a main pressure measurement circuit and a main microprocessor circuit, the measurement apparatus also includes an independently disposed assist pressure measurement circuit and an independently disposed assist microprocessor circuit. In normal measurement, the assist microprocessor circuit periodically samples a cuff pressure via the assist pressure measurement circuit, and compares the measured cuff pressure with a specified overpressure protection value, and if the cuff pressure exceeds the specified overpressure protection value, the assist microprocessor circuit outputs a control signal to open a deflation valve until the pressure falls to below the safety pressure.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.