Patents Examined by Robert L. Stoll
  • Patent number: 5514364
    Abstract: The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of sublethal doses of total body irradiation, cell type-specific antibodies, especially antibodies directed to bone marrow stromal cell markers, cytotoxic drugs, or a combination thereof. The methods of the invention have a wide range of applications, including, but not limited to, the conditioning of an individual for hematopoietic reconstitution by bone marrow transplantation for the treatment of hematologic malignancies, hematologic disorders, autoimmunity, infectious diseases such as acquired immunodeficiency syndrome, and the engraftment of bone marrow cells to induce tolerance for solid organ, tissue and cellular transplantation.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: May 7, 1996
    Assignee: University of Pittsburgh
    Inventor: Suzanne T. Ildstad
  • Patent number: 5505740
    Abstract: A bleaching product and a method of removing soils from fabrics by contacting the fabrics in an aqueous wash solution with a product comprising a peracid precursor, a source of hydrogen peroxide and a source for delayed release of an acid into the wash solution to initially permit effective in situ formation of peracid, the acid thereafter reducing the pH of the wash solution for enhancing bleach performance of the peracid. The source of the acid may be included in the bleaching product, for example, as an acid of delayed solubility, an acid coated with a low solubility agent or an acid generating species, or independent of the bleaching product. The acid source is selected to be compatible with the peracid or precursor and adjuncts.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: April 9, 1996
    Assignee: The Clorox Company
    Inventors: Stephen B. Kong, Dale S. Steichen, Steven D. Ratcliff
  • Patent number: 5482653
    Abstract: The invention relates to fluoro-chloro-benzene derivatives of the formula I ##STR1## wherein R denotes an alkyl or halogenoalkyl residue of up to 12 C atoms wherein one or two non-adjacent CH.sub.2 groups may also be replaced by -0- and/or -HC=CH-,the radical A is a ring of the formula (1) or (2): ##STR2## Q is a bivalent radical of the formula (1) or (2) or a single bond or--if radical A denotes trans-1,4-cyclohexylene--is also a bivalent radical of the formulae (3), (4) or (5): ##STR3## and, L.sup.1 and L.sup.2 are each independently H or F, with the proviso that at least one of, L.sup.1 and L.sup.2 present in the molecule denotes F.
    Type: Grant
    Filed: June 24, 1992
    Date of Patent: January 9, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: David Coates, Ian C. Sage, Simon Greenfield, Graham Smith, David W. Baxter
  • Patent number: 5451339
    Abstract: The present invention is to provide a liquid crystal monomeric compound where a liquid crystal phase readily appears, which is excellent in alignment control, film-formability, durability, heat-stability and compatibility, and is able to be applied to electro-optical liquid crystal elements and recording elements; and a side-chain liquid crystal polymer compound modified with such a monomeric compound.The liquid crystal monomeric compound is represented by the following formula:CH.sub.2 .dbd.CH--(CH.sub.2).sub.m --R [1]wherein m is an integer of 2 to 20 and R is a group selected from the group consisting of ##STR1## wherein p is 1 or 2, Rf is CF.sub.3 or CF.sub.2 F.sub.5, R.sup.1 is an alkyl group having 3-18 carbon atoms, * means an optically active carbon atom, (A) and (B) each is a group independently selected from the group consisting of ##STR2## which may be substituted with one or more halogen atoms, and X is --O--, --COO--or a direct linkage, and ##STR3## wherein p, Rf, R.sup.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: September 19, 1995
    Assignee: Showa Shell Sekiyu Kabushiki Kaisha
    Inventors: Yoshiichi Suzuki, Yoshio Imai, Masaaki Kakimoto
  • Patent number: 5437817
    Abstract: Liquid crystalline organopolysiloxane is provided having the general formula:R.sub.a (A).sub.b (B).sub.c SiO.sub.(4-a-b-c)/2wherein R is independently selected from the group consisting of a hydrogen atom, hydrocarbon group having i to 4 carbon atoms, and phenyl group, A is a group of the formula: ##STR1## wherein m, n, and x are integers in the range: m.gtoreq.3, n.gtoreq.2, 5.ltoreq.m+nx.ltoreq.15, x=1 or 2, B is an organic chromophore group having an absorption peak in the visible spectrum, a, b, and c are numbers in the range: 1.ltoreq.a<2, 0<b+c.ltoreq.1, 0.45.ltoreq.b(b+c).ltoreq.0.95, and 1<a+b+c.ltoreq.3. This organopolysiloxane as a high molecular weight liquid crystal is combined with a low molecular weight liquid crystal to form a liquid crystal composition.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: August 1, 1995
    Assignees: Shin-Etsu Chemical Company, Limited, Toyota Jidosha Kabushiki Kaisha
    Inventors: Takashi Kondou, Masaaki Yamaya, Hiroshi Yoshioka, Yasuhiro Ohtsuka, Kazuo Tojima, Yasufumi Shibata, Naomi Ohkuwa, Shinobu Okayama
  • Patent number: 5433891
    Abstract: Methods of using a mixture as a corrosion inhibitor, moisture or formaldehyde scavenger, reactive diluent, rheological modifier, thermoplastic foam inhibitor, antifreezing agent, decolorizing agent, drying agent, agent for reducing bubble formation, and an agent for reducing downglossing. The mixture consists of from 0 to 100 mole percent of an iminoalcohol compound: ##STR1## wherein: R.sub.1 is a methyl or methylol group, an ethyl or ethylol group, a branched or straight chain alkyl or alkanol group, a cycloalkyl group, or an aryl group; R.sub.2 is a hydrogen atom, a methyl or methylol group, an ethyl or ethylol group, a straight chain or branched chain alkyl or alkanol group, a cycloalkyl group, or an aryl group, or R.sub.1 and R.sub.2 are fused together with the attached carbon to form a cycloalkane ring; R.sub.3, R.sub.4 and R.sub.5 are, individually, a hydrogen atom, a methyl or methylol group, an ethyl or ethylol group, or a straight chain or branched chain alkyl or alkanol group; R.sub.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: July 18, 1995
    Assignee: Angus Chemical Company
    Inventors: Chih-Yueh Chou, Pattabbi K. Raman, Robert E. Malocha, Thomas L. Johnson, Vincent Nocito, Marina D. Hoffman, Patrick E. Brutto
  • Patent number: 5427999
    Abstract: Amines which are compounds of the formula I: ##STR1## where R is a C.sub.6-20 hydrocarbon;X is --NR.sub.1 -- or --O--;each R.sub.1 is independently H or --[(CH.sub.2).sub.1-4 ]COOH or a C.sub.6-20 hydrocarbon;n is 1, 2 or 3;and which contains at least one (CH.sub.2).sub.1-4 COOH group; or salt thereof are useful in inhibiting corrosion of metals in a marine or freshwater environment e.g. in oil- and gas-field applications since they show relatively low toxicity to marine organisms.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: June 27, 1995
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Paul J. Clewlow, John A. Haslegrave, Niall Carruthers, Daniel S. Sullivan, III, Brent Bourland
  • Patent number: 5425896
    Abstract: A method of initiating oxygen scavenging by compositions which comprise oxidizable organic compounds and transition metal catalysts is disclosed. The method comprises initiating scavenging by exposing the composition, etc., to radiation. The radiation exposure is preferably electron beam or ultraviolet light and is preferably used on oxygen scavenging compositions which comprise a substituted or unsubstituted ethylenically unsaturated hydrocarbon and a transition metal catalyst. Inclusion of a photoinitiator or antioxidant in the scavenging composition is also preferred to facilitate and/or control the composition's scavenging properties. The method can be used for initiating scavenging in packaging layers or articles for oxygen sensitive products such as food and beverage.
    Type: Grant
    Filed: April 7, 1993
    Date of Patent: June 20, 1995
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Drew V. Speer, William P. Roberts, Charles R. Morgan
  • Patent number: 5424005
    Abstract: A composition of (R)-isomer and (S)-isomer of a liquid crystal compound represented by the formula; ##STR1## wherein X represents --O-- or a direct bond, Z represents a halogen-substituted alkyl group selected from a group consisting of --CF.sub.3, --CHF.sub.2, --CH.sub.2 F, --C.sub.2 F.sub.5, --CClF.sub.2, -CCl.sub.2 F, --CCl.sub.2 CF.sub.3, and --C.sub.3 F.sub.7, m represents an integer of from 1 to 20, n represents an integer of from 1 to 20, and * represents an asymmetric carbon, and the optical purity of said composition is high enough to exhibit optically tristable states in S*(3) phase when electric voltage is applied.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: June 13, 1995
    Assignee: Showa Shell Sekiyu K.K.
    Inventors: Yoshiichi Suzuki, Hiroyuki Mogamiya, Ichiro Kawamrua
  • Patent number: 5422036
    Abstract: A liquid crystal display device having a pair of electrodes at least one of which is transparent and a composite film which is placed between the pair of electrode and contains a low molecular weight liquid crystal, a side-chain type polymer liquid crystal having a backbone of polyoxetane and a mesogen group in a side chain, and an electrolyte, which composite film has a self-supporting property and prevents formation of a short-circuit between the-electrodes.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: June 6, 1995
    Assignee: Sumitomo Electric Industries, Ltd.
    Inventors: Yuhsuke Kawakami, Kouji Hara, Tohru Kashiwagi, Junichi Ono, Kensaku Takata
  • Patent number: 5413735
    Abstract: A liquid crystal composition comprises at least one type of liquid crystal compound having the following general formula (I) and at least one type of liquid crystal compound having the following general formula (II): ##STR1## wherein R.sub.1 and R.sub.2 each is a straight-chain or branched-chain alkyl group having 1 to 18 carbon atoms. These alkyl groups may have alkoxy groups having 1 to 12 carbon atoms as substituents. Both R.sub.1 and R.sub.2 are optically inactive. Z.sub.1 is a single bond, --O--, ##STR2## wherein R.sub.3 and R.sub.4 each is a straight-chain or branched-chain alkyl group having 1 to 18 carbon atoms. Z.sub.2 and Z.sub.3 each is single bond, ##STR3## A.sub.1 is --A.sub.2 -- or --A.sub.2 --A.sub.3 --, wherein A.sub.2 and A.sub.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: May 9, 1995
    Assignee: Canon Kabushiki Kaisha
    Inventors: Masataka Yamashita, Masahiro Terada, Shousei Mori, Kazuharu Katagiri
  • Patent number: 5413778
    Abstract: A method of imaging a target site in an animal's body in which a labelled CC chemokine or Monocyte Attractant Protein (MCP) material is introduced into the animal's body and allowed to accumulate at a target site which includes MCP receptor molecules. The accumulated, labelled MCP material is then detected so as to image the target site of the body.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: May 9, 1995
    Assignees: The Regents of the University of Michigan, Mallinckrodt Medical, Inc.
    Inventors: Steven L. Kunkel, Leon R. Lyle, Robert M. Strieter
  • Patent number: 5413734
    Abstract: Compounds of the formula ##STR1## wherein ring A is trans-1,4-cyclohexylene, 1,4-phenylene, pyrimidine-2,5-diyl or trans-1,3-dioxane-2,5-diyl; n is either 0 or 1; ring B stands for 1,4-phenylene or trans-1,4-cyclohexylene; and R.sup.1 is 3E-alkenyl or on a saturated ring also 1E-alkenyl, their manufacture, liquid crystalline mixtures which contain these compounds as well as their use for electro-optical purposes.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: May 9, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Buchecker, Martin Schadt
  • Patent number: 5411673
    Abstract: Solid Peroxyacid bleach precursor compositions are provided in which the external surfaces of a particulate peroxyacid precursor material is treated with from 2% to 20% by weight of a solid organic acid compound of Mpt> C. and an aqueous solubility of at least 20 g/100 g water at C. The bleach precursor material, when so treated, perhydrolyses after 3 minutes in a standard test at C., to at least 90% of the extent of the untreated bleach precursor material under the same conditions. Preferred organic acid compounds are monomeric aliphatic hydroxycarboxylic and polycarboxylic acids such as citric, lactic and glycolic acids. Detergent compositions containing the treated peroxyacid bleach precursor particulates are also disclosed.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: May 2, 1995
    Assignee: The Procter & Gamble Company
    Inventors: Joseph T. H. Agar, Douglas G. Fraser
  • Patent number: 5411677
    Abstract: A corrosion inhibitor composition and a method for employing the same to prevent corrosion of copper and copper containing metals in contact are disclosed. Protection is afforded thereto by contacting the metal surface with the medium containing sufficient amount of benzotriazole/its derivatives and halogen, preferentially iodide or bromide ions. The inhibitor has particular utility in protecting metal surfaces which are subject to corrosion in aggressive aqueous systems.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: May 2, 1995
    Assignee: The Penn State Research Foundation
    Inventors: Howard W. Pickering, Yongchun Wu
  • Patent number: 5412147
    Abstract: C.sub.1 -C.sub.6 -Alkyl nitrites can be prepared by reacting nitrogen dioxide with C.sub.1 -C.sub.6 -alcohols, by, in a counterflow-operated column, feeding the alcohol or an alcohol/water mixture into the upper part of the column and the nitrogen dioxide or a nitrogen dioxide/inert gas mixture into the lower part of the column. The resulting alkyl nitrite is removed from the column as the top product and the co-formed nitric acid is removed from the column as the bottom product.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: May 2, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Landscheidt, Paul Wagner, Alexander Klausener
  • Patent number: 5409632
    Abstract: An aqueous cleaning and bleaching composition with a pH of from about 0.5 to about 6, which contains amidoperoxyacid, hydrogen peroxide, and acylated citrate ester which has been emulsified in two or more ethoxylated alcohols is described.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: April 25, 1995
    Assignee: The Procter & Gamble Company
    Inventors: Michael S. Showell, Philip G. Sliva, Stefano Scialla, Anna M. Vercillo-Martino, Elisabetta L. Russo
  • Patent number: 5409631
    Abstract: The present invention discloses high viscosity sustained release dental compositions, such as tooth bleaching or fluoride compositions, for treating tooth surfaces. For maximum results, an improved dental tray having reservoirs for holding the dental composition adjacent the desired tooth surfaces is preferably used in combination with the sustained release dental composition. The sustained release dental compositions include a high carboxypolymethylene concentration which results in very high viscosity. The high level of carboxypolymethylene makes dilution of the dental compositions from saliva difficult and time consuming so that the compositions stay within the tray reservoirs, thereby providing sustained release. The concentrated carboxypolymethylene adds a unique tackiness to the dental composition which helps retain and seal the soft tray material against the patient's teeth.
    Type: Grant
    Filed: November 22, 1991
    Date of Patent: April 25, 1995
    Assignee: Ultradent Products
    Inventor: Dan E. Fischer
  • Patent number: H1510
    Abstract: A continuous process for forming spheroidal high bulk density nitroguanid crystals from an aqueous solution of nitroguanidine which contains methylcellulose and partially hydrolyzed poly(vinyl alcohol) as crystal habit modifiers. A saturated aqueous solution of nitroguanidine is formed at a temperature T.sub.1 where C..ltoreq.T.sub.1 C. and crystallization occurs at a lower temperature T.sub.2 where C..ltoreq.T.sub.1 -T.sub.2 C.
    Type: Grant
    Filed: June 23, 1988
    Date of Patent: December 5, 1995
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Steven L. Collignon, Kerry L. Wagaman
  • Patent number: H1695
    Abstract: A one-step method of manufacturing soluble phthalocyanines and metallophthalocyanines, like zinc phthalocyanine, by converting a phthalocyanine or a metallophthalocyanine to a trialkylsilyl-substituted derivative is disclosed. The phthalocyanine or metallophthalocyanine is converted to a soluble trialkylsilyl-substituted derivative by interacting the phthalocyanine or metallophthalocyanine with an active metal amide, like lithium 2,2,6,6-tetramethylpiperidide, and a halotrialkylsilane, like chlorotrimethylsilane, to provide a phthalocyanine compound, like phthalocyanine monomers, dimers or polymers, metalated or unmetalated, that are soluble in organic media.
    Type: Grant
    Filed: June 1, 1990
    Date of Patent: November 4, 1997
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Jerome W. Rathke, Michael J. Chen, Carol M. Fendrick