Patents Examined by Robert L. Stoll
  • Patent number: 5306482
    Abstract: Benzalkonium chloride and benzethorium chloride are each useful in radiopharmaceutical preparations (optionally in the presence of a polymyxin or a polymyxin derivative) as bacteriostatic agents which are compatible with anti-oxidants.
    Type: Grant
    Filed: March 3, 1992
    Date of Patent: April 26, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Daniel Tartaglia, Richard J. Flanagan
  • Patent number: 5306442
    Abstract: A mixture of C.sub.16 -C.sub.28 alkyl glucosides (A) and C.sub.16 -C.sub.28 fatty alcohols (B) in a weight ratio (A):(B) of between 20:1 and 1:9 possesses foam inhibiting properties even when highly diluted. The mixture is suitable for use in the food industry, and is preferably employed in a chemically inert liquid carrier oil that is immiscible with water.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: April 26, 1994
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Karlheinz Hill, Adolf Asbeck, Karl Heinz Schmid
  • Patent number: 5304367
    Abstract: A composition useful as an imaging agent comprises a beta adrenergic receptor antagonist compound, preferably iodopindolol, to which is covalently attached an iodine radioisotope such as .sup.123 I or .sup.124 I. This composition is used in a method for radioimaging beta adrenergic receptors in a tissue, preferably brain. In particular, the method is useful with the radioimaging technique of single photon emission computed tomography (SPECT) or positron emission tomography (PET). The above composition, as well as a kit comprising a set of one or more standard radiographic images of beta adrenergic receptors, are also useful in methods for (1) diagnosing an alteration in beta adrenergic receptors in a tissue, particularly brain; (2) diagnosing suicidal depression in a subject; and (3) detecting the therapeutic normalization of beta adrenergic receptor expression in a subject.
    Type: Grant
    Filed: November 16, 1990
    Date of Patent: April 19, 1994
    Assignee: New York University
    Inventor: Anat Biegon
  • Patent number: 5304324
    Abstract: A monodispersed glycol suspension having excellent dispersion stability at a pH within a wide range, comprising a monodispersed suspension in a glycol of spherical fine particles of an amorphous inorganic oxide having an average particle diameter of 0.15 to 5 micrometers and a relative particle size standard deviation of 1.0 to 1.5 and containing glycol bonded to its surface. This monodispersed suspension is useful as a raw material for the production of a polyester film having improved slipperiness.
    Type: Grant
    Filed: August 10, 1992
    Date of Patent: April 19, 1994
    Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.
    Inventors: Tadahiro Yoneda, Saburo Nakahara, Mitsuo Takeda, Midori Kamo
  • Patent number: 5304313
    Abstract: The fire fighting and hot surface cooling methods of this invention use a composition formed by combining a nonionic surfactant possessing a specific photoexcitable functional group with an arylphosphate, also of photoexcitable nature, in a solvent medium of composition and content that allows for a convenient workable viscosity and is resistant to effects of freezing. The ultimate water solution used for spraying to extinguish a fire or cool a surface contains from 2000 ppm of the surfactant nonylphenolethoxylate and 94 ppm of the arylphosphate, poly(oxy-1,2-ethanediyl), .alpha.-phenol-.omega.-hydroxy-(2)-phosphate to 3000 ppm surfactant and 141 ppm arylphosphate. The spray solution is applied to the fire until the desired result occurs.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: April 19, 1994
    Assignee: Metro Fire & Rescue, Inc.
    Inventor: Paul H. Berger
  • Patent number: 5302369
    Abstract: Microspheres for radiation therapy of a mammal which have a non-radioactive isotope which emits beta or gamma radiation of therapeutic intensity upon being irradiated. The microspheres also contain elements which do not become radioactive upon irradiation. The chemical durability of the microspheres is such that they do not release a significant amount of radiation emitting radioisotope into the mammal's system upon administration. Microspheres containing phosphorus or yttrium; and carbon, nitrogen, fluorine, sodium, magnesium, aluminum, silicon, potassium, vanadium, manganese, gallium, niobium, iodine and/or lead.
    Type: Grant
    Filed: August 29, 1991
    Date of Patent: April 12, 1994
    Assignee: The Curators of the University of Missouri
    Inventors: Delbert E. Day, Gary J. Ehrhardt
  • Patent number: 5302321
    Abstract: The corrosion of steam and condenser systems and piping therefor is minimized by the addition of anti-corrosion amounts of Vitamin A or Vitamin E.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: April 12, 1994
    Assignee: Aquas Corporation
    Inventors: Shunichi Akama, Takanobu Sasa, Tokuko Yanagisawa
  • Patent number: 5302370
    Abstract: The invention relates to compounds having the general formula I ##STR1## where A if required can contain a functional and/or activated group C for coupling to selectively concentrating compounds or can contain a selectively concentrating compound coupled via the group C. B and B' are functional groups for coordinate bonding of groups carrying metal ions. The novel compounds are for forming complexes with radioactive metal ions, more particularly rhenium and technetium isotopes, and are used in medical diagnosis and therapy.
    Type: Grant
    Filed: August 22, 1990
    Date of Patent: April 12, 1994
    Assignee: Institut fur Diagnostikforschung GmbH
    Inventors: Reinhard Neumeier, Wolfgang Kramp, Helmut R. Macke
  • Patent number: 5302317
    Abstract: Compounds of the formula ##STR1## wherein X.sup.1 denotes fluorine or chlorine and X.sup.2 denotes hydrogen, fluorine or chlorine; R.sup.1 is 3E-alkenyl, 4-alkenyl, 2E-alkenyloxy or 3-alkenyloxy; n stands for the number 0 or 1; one of the groups Y.sup.1 and Y.sup.2 is a single covalent bond, --COO--, --OOC--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O-- or --OCH.sub.2 -- and the other of the groups Y.sup.1 and Y.sup.2 is a single covalent bond; and rings A.sup.1 and A.sup.2 each individually are substituted or unsubstituted trans-1,4-cyclohexylene, in which optionally 2 non-adjacent CH.sub.2 groups are replaced by oxygen, or substituted or unsubstituted 1,4-phenylene, in which optionally 1 CH group or 2 CH groups is/are replaced by nitrogen; with the proviso that X.sup.2 denotes fluorine or chlorine and/or Y.sup.1 or Y.sup.2 denotes --CH.sub.2 O-- or --OCH.sub.2 -- when simultaneously X.sup.1 is fluorine and R.sup.1 is 3E-alkenyl,and their use for liquid crystalline mixtures and electro-optical purposes.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: April 12, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur Boller, Richard Buchecker, Martin Schadt, Alois Villiger
  • Patent number: 5302768
    Abstract: This invention relates to a process for preparing a white or at least near white product which is predominant in decabromodiphenylalkane, and which contains a minor amount of dodecabromodiphenylalkane.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: April 12, 1994
    Assignee: Ethyl Corporation
    Inventor: Saadat Hussain
  • Patent number: 5300280
    Abstract: The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: April 5, 1994
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mark A. DeRosch, Edward A. Deutsch, Mary M. Dyszlewski, Dennis L. Nosco
  • Patent number: 5300253
    Abstract: A composition composed of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether and at least one surface-active substance and the use of such a composition for removing water from surfaces of objects of diverse material and type are described.
    Type: Grant
    Filed: July 31, 1992
    Date of Patent: April 5, 1994
    Assignee: Solvay Fluor und Derivate GmbH
    Inventors: Hans Buchwald, Joachim Hellmann, Boleslaus Raszkowski, Pierre Barthelemy, Mireille Paulus
  • Patent number: 5300255
    Abstract: A surfactant comprising a carboxylic acid ester or amide carrying a terminal strong acid group selected from carboxymethyl, sulphate, sulphonate, phosphate and phosphonate, suitable for stabilising dispersions of solids in organic liquids and oil/water emulsions, processes for the preparation of the surfactant and dispersions and emulsions containing the surfactant. A preferred species of the surfactant is a poly(hydroxyalkanecarboxylic acid) having the strong acid group attached, either directly or through a linking group, to a terminal hydroxy or carboxylic acid group.
    Type: Grant
    Filed: July 6, 1987
    Date of Patent: April 5, 1994
    Assignee: Imperial Chemical Industries, PLC.
    Inventors: Frederick Campbell, John D. Schofield, Alan S. Baker
  • Patent number: 5300281
    Abstract: Radioactive compositions containing a calcific matrix and methods for using the compositions for therapeutic radiation treatment including rheumatoid arthritis are disclosed.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: April 5, 1994
    Assignee: The Dow Chemical Company
    Inventors: Kenneth McMillan, Jaime Simon
  • Patent number: 5300278
    Abstract: The invention relates to the preparation of complexes of 99m-technetium, 186-rhenium or 188-rhenium usable as radiopharmaceutical products.For this preparation, an oxidized compound of .sup.99m Tc, .sup.186 Re or .sup.188 Re, e.g. an alkali metal or ammonium perrhenate or pertechnetate, is reacted with a first ligand chosen from the group of substituted or unsubstituted, aliphatic and aromatic phosphenes and polyphosphenes and a second nitrogenous ligand constituted by an ammonium nitride or a pharmaceutically acceptable metal or by a nitrogenous compound having a >N--N< unit, such as hydrazine, a hydrazine derivative, dithiocarbazic acid and dithiocarbazic acid derivatives.The product obtained can be used as it is as a radiopharmaceutical product or can serve as an intermediate for the preparation of other radiopharmaceutical products by exchange reaction with a third ligand, a monoclonal antibody or an antibody fragment.
    Type: Grant
    Filed: September 7, 1990
    Date of Patent: April 5, 1994
    Assignee: Cis Bio International
    Inventors: Roberto Pasqualini, Luciano Magon, Andre Bardy, Adriano Duatti, Andrea Marchi
  • Patent number: 5300235
    Abstract: Amine derivatives which are compounds of the formula (I): ##STR1## in which R is a C.sub.6-20 hydrocarbon; Y is --CO--NH-- and n is an integer of 1 to 6; or ##STR2## in which X is an alkylene group of 2 to 6 carbon atoms and n is an integer of 0 to 6;each R.sub.1 is independently H, --(CH.sub.2).sub.1-4 COOH, a C.sub.6-20 hydrocarbon or C.sub.6-20 hydrocarbon-carbonyl;R.sub.2 is H, (CH.sub.2).sub.1-4 COOH or C.sub.6-20 hydrocarboncarbonyl;the compound containing at least one (CH.sub.2).sub.1-4 COOH group; or a salt thereof are useful in inhibiting corrosion of metals in oil- and gas-field applications, and also show low toxicity to marine organisms.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: April 5, 1994
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Paul J. Clewlow, John A. Haselgrave, Niall Carruthers, Terence M. O'Brien
  • Patent number: 5300279
    Abstract: Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors or the relief of bone pain in animals.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: April 5, 1994
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, Joseph R. Garlich, William F. Goeckeler, Davis A. Wilson, Wynn A. Volkert, David E. Troutner
  • Patent number: H1297
    Abstract: A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.
    Type: Grant
    Filed: April 4, 1990
    Date of Patent: April 5, 1994
    Assignee: The United States of America as represented by the Department of Energy
    Inventors: Judy K. Partin, Alan E. Grey
  • Patent number: H1300
    Abstract: There is disclosed a silver halide light-sensitive color photographic material having a high sensitivity and excellent granularity. The photographic material contains in at least one of the emulsion layers the core/shell type tabular silver halide grains comprising:a. a numerical ratio of monodispersed grains to all grains of 70% or more;b. an average aspect value of not less than 1 and less than 5; andc. a portion having a silver iodide content of 15.3 mol % or more in the core.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: April 5, 1994
    Assignee: Konica Corporation
    Inventors: Toshiya Kondou, Toshihiko Yagi, Hiroyuki Hoshino, Katsuhiko Heki
  • Patent number: H1304
    Abstract: 5,7-Diamino-4,6-dinitrobenzofuroxan is synthesized in high yield by aminan of 7-amino-4,6-dinitrobenzofuroxan with hydroxylamine in the presence of strong base such as potassium hydroxide. Acidification of the potassium salt produces a fine powder. Recrystallization of the powder by an extraction process under vacuum in solvents such as dimethylformamide results in large, cube-like crystals which can be pressed to high density explosive formulations. These explosive formulations show high performance as explosives.
    Type: Grant
    Filed: May 11, 1992
    Date of Patent: April 5, 1994
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: William P. Norris, David J. Vanderah, Michael P. Kramer