Abstract: Benzalkonium chloride and benzethorium chloride are each useful in radiopharmaceutical preparations (optionally in the presence of a polymyxin or a polymyxin derivative) as bacteriostatic agents which are compatible with anti-oxidants.
Abstract: A mixture of C.sub.16 -C.sub.28 alkyl glucosides (A) and C.sub.16 -C.sub.28 fatty alcohols (B) in a weight ratio (A):(B) of between 20:1 and 1:9 possesses foam inhibiting properties even when highly diluted. The mixture is suitable for use in the food industry, and is preferably employed in a chemically inert liquid carrier oil that is immiscible with water.
Type:
Grant
Filed:
January 3, 1992
Date of Patent:
April 26, 1994
Assignee:
Henkel Kommanditgesellschaft auf Aktien
Inventors:
Karlheinz Hill, Adolf Asbeck, Karl Heinz Schmid
Abstract: A composition useful as an imaging agent comprises a beta adrenergic receptor antagonist compound, preferably iodopindolol, to which is covalently attached an iodine radioisotope such as .sup.123 I or .sup.124 I. This composition is used in a method for radioimaging beta adrenergic receptors in a tissue, preferably brain. In particular, the method is useful with the radioimaging technique of single photon emission computed tomography (SPECT) or positron emission tomography (PET). The above composition, as well as a kit comprising a set of one or more standard radiographic images of beta adrenergic receptors, are also useful in methods for (1) diagnosing an alteration in beta adrenergic receptors in a tissue, particularly brain; (2) diagnosing suicidal depression in a subject; and (3) detecting the therapeutic normalization of beta adrenergic receptor expression in a subject.
Abstract: A monodispersed glycol suspension having excellent dispersion stability at a pH within a wide range, comprising a monodispersed suspension in a glycol of spherical fine particles of an amorphous inorganic oxide having an average particle diameter of 0.15 to 5 micrometers and a relative particle size standard deviation of 1.0 to 1.5 and containing glycol bonded to its surface. This monodispersed suspension is useful as a raw material for the production of a polyester film having improved slipperiness.
Abstract: The fire fighting and hot surface cooling methods of this invention use a composition formed by combining a nonionic surfactant possessing a specific photoexcitable functional group with an arylphosphate, also of photoexcitable nature, in a solvent medium of composition and content that allows for a convenient workable viscosity and is resistant to effects of freezing. The ultimate water solution used for spraying to extinguish a fire or cool a surface contains from 2000 ppm of the surfactant nonylphenolethoxylate and 94 ppm of the arylphosphate, poly(oxy-1,2-ethanediyl), .alpha.-phenol-.omega.-hydroxy-(2)-phosphate to 3000 ppm surfactant and 141 ppm arylphosphate. The spray solution is applied to the fire until the desired result occurs.
Abstract: Microspheres for radiation therapy of a mammal which have a non-radioactive isotope which emits beta or gamma radiation of therapeutic intensity upon being irradiated. The microspheres also contain elements which do not become radioactive upon irradiation. The chemical durability of the microspheres is such that they do not release a significant amount of radiation emitting radioisotope into the mammal's system upon administration. Microspheres containing phosphorus or yttrium; and carbon, nitrogen, fluorine, sodium, magnesium, aluminum, silicon, potassium, vanadium, manganese, gallium, niobium, iodine and/or lead.
Type:
Grant
Filed:
August 29, 1991
Date of Patent:
April 12, 1994
Assignee:
The Curators of the University of Missouri
Abstract: The corrosion of steam and condenser systems and piping therefor is minimized by the addition of anti-corrosion amounts of Vitamin A or Vitamin E.
Abstract: The invention relates to compounds having the general formula I ##STR1## where A if required can contain a functional and/or activated group C for coupling to selectively concentrating compounds or can contain a selectively concentrating compound coupled via the group C. B and B' are functional groups for coordinate bonding of groups carrying metal ions. The novel compounds are for forming complexes with radioactive metal ions, more particularly rhenium and technetium isotopes, and are used in medical diagnosis and therapy.
Type:
Grant
Filed:
August 22, 1990
Date of Patent:
April 12, 1994
Assignee:
Institut fur Diagnostikforschung GmbH
Inventors:
Reinhard Neumeier, Wolfgang Kramp, Helmut R. Macke
Abstract: Compounds of the formula ##STR1## wherein X.sup.1 denotes fluorine or chlorine and X.sup.2 denotes hydrogen, fluorine or chlorine; R.sup.1 is 3E-alkenyl, 4-alkenyl, 2E-alkenyloxy or 3-alkenyloxy; n stands for the number 0 or 1; one of the groups Y.sup.1 and Y.sup.2 is a single covalent bond, --COO--, --OOC--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O-- or --OCH.sub.2 -- and the other of the groups Y.sup.1 and Y.sup.2 is a single covalent bond; and rings A.sup.1 and A.sup.2 each individually are substituted or unsubstituted trans-1,4-cyclohexylene, in which optionally 2 non-adjacent CH.sub.2 groups are replaced by oxygen, or substituted or unsubstituted 1,4-phenylene, in which optionally 1 CH group or 2 CH groups is/are replaced by nitrogen; with the proviso that X.sup.2 denotes fluorine or chlorine and/or Y.sup.1 or Y.sup.2 denotes --CH.sub.2 O-- or --OCH.sub.2 -- when simultaneously X.sup.1 is fluorine and R.sup.1 is 3E-alkenyl,and their use for liquid crystalline mixtures and electro-optical purposes.
Type:
Grant
Filed:
March 29, 1993
Date of Patent:
April 12, 1994
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Arthur Boller, Richard Buchecker, Martin Schadt, Alois Villiger
Abstract: This invention relates to a process for preparing a white or at least near white product which is predominant in decabromodiphenylalkane, and which contains a minor amount of dodecabromodiphenylalkane.
Abstract: The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.
Type:
Grant
Filed:
February 14, 1992
Date of Patent:
April 5, 1994
Assignee:
Mallinckrodt Medical, Inc.
Inventors:
Mark A. DeRosch, Edward A. Deutsch, Mary M. Dyszlewski, Dennis L. Nosco
Abstract: A composition composed of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether and at least one surface-active substance and the use of such a composition for removing water from surfaces of objects of diverse material and type are described.
Type:
Grant
Filed:
July 31, 1992
Date of Patent:
April 5, 1994
Assignee:
Solvay Fluor und Derivate GmbH
Inventors:
Hans Buchwald, Joachim Hellmann, Boleslaus Raszkowski, Pierre Barthelemy, Mireille Paulus
Abstract: A surfactant comprising a carboxylic acid ester or amide carrying a terminal strong acid group selected from carboxymethyl, sulphate, sulphonate, phosphate and phosphonate, suitable for stabilising dispersions of solids in organic liquids and oil/water emulsions, processes for the preparation of the surfactant and dispersions and emulsions containing the surfactant. A preferred species of the surfactant is a poly(hydroxyalkanecarboxylic acid) having the strong acid group attached, either directly or through a linking group, to a terminal hydroxy or carboxylic acid group.
Type:
Grant
Filed:
July 6, 1987
Date of Patent:
April 5, 1994
Assignee:
Imperial Chemical Industries, PLC.
Inventors:
Frederick Campbell, John D. Schofield, Alan S. Baker
Abstract: Radioactive compositions containing a calcific matrix and methods for using the compositions for therapeutic radiation treatment including rheumatoid arthritis are disclosed.
Abstract: The invention relates to the preparation of complexes of 99m-technetium, 186-rhenium or 188-rhenium usable as radiopharmaceutical products.For this preparation, an oxidized compound of .sup.99m Tc, .sup.186 Re or .sup.188 Re, e.g. an alkali metal or ammonium perrhenate or pertechnetate, is reacted with a first ligand chosen from the group of substituted or unsubstituted, aliphatic and aromatic phosphenes and polyphosphenes and a second nitrogenous ligand constituted by an ammonium nitride or a pharmaceutically acceptable metal or by a nitrogenous compound having a >N--N< unit, such as hydrazine, a hydrazine derivative, dithiocarbazic acid and dithiocarbazic acid derivatives.The product obtained can be used as it is as a radiopharmaceutical product or can serve as an intermediate for the preparation of other radiopharmaceutical products by exchange reaction with a third ligand, a monoclonal antibody or an antibody fragment.
Type:
Grant
Filed:
September 7, 1990
Date of Patent:
April 5, 1994
Assignee:
Cis Bio International
Inventors:
Roberto Pasqualini, Luciano Magon, Andre Bardy, Adriano Duatti, Andrea Marchi
Abstract: Amine derivatives which are compounds of the formula (I): ##STR1## in which R is a C.sub.6-20 hydrocarbon; Y is --CO--NH-- and n is an integer of 1 to 6; or ##STR2## in which X is an alkylene group of 2 to 6 carbon atoms and n is an integer of 0 to 6;each R.sub.1 is independently H, --(CH.sub.2).sub.1-4 COOH, a C.sub.6-20 hydrocarbon or C.sub.6-20 hydrocarbon-carbonyl;R.sub.2 is H, (CH.sub.2).sub.1-4 COOH or C.sub.6-20 hydrocarboncarbonyl;the compound containing at least one (CH.sub.2).sub.1-4 COOH group; or a salt thereof are useful in inhibiting corrosion of metals in oil- and gas-field applications, and also show low toxicity to marine organisms.
Type:
Grant
Filed:
May 14, 1992
Date of Patent:
April 5, 1994
Assignee:
Exxon Chemical Patents Inc.
Inventors:
Paul J. Clewlow, John A. Haselgrave, Niall Carruthers, Terence M. O'Brien
Abstract: Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors or the relief of bone pain in animals.
Type:
Grant
Filed:
December 19, 1990
Date of Patent:
April 5, 1994
Assignee:
The Dow Chemical Company
Inventors:
Jaime Simon, Joseph R. Garlich, William F. Goeckeler, Davis A. Wilson, Wynn A. Volkert, David E. Troutner
Abstract: A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.
Type:
Grant
Filed:
April 4, 1990
Date of Patent:
April 5, 1994
Assignee:
The United States of America as represented by the Department of Energy
Abstract: There is disclosed a silver halide light-sensitive color photographic material having a high sensitivity and excellent granularity. The photographic material contains in at least one of the emulsion layers the core/shell type tabular silver halide grains comprising:a. a numerical ratio of monodispersed grains to all grains of 70% or more;b. an average aspect value of not less than 1 and less than 5; andc. a portion having a silver iodide content of 15.3 mol % or more in the core.
Abstract: 5,7-Diamino-4,6-dinitrobenzofuroxan is synthesized in high yield by aminan of 7-amino-4,6-dinitrobenzofuroxan with hydroxylamine in the presence of strong base such as potassium hydroxide. Acidification of the potassium salt produces a fine powder. Recrystallization of the powder by an extraction process under vacuum in solvents such as dimethylformamide results in large, cube-like crystals which can be pressed to high density explosive formulations. These explosive formulations show high performance as explosives.
Type:
Grant
Filed:
May 11, 1992
Date of Patent:
April 5, 1994
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
William P. Norris, David J. Vanderah, Michael P. Kramer