Patents Examined by Ronald W. Griffin
  • Crystalline mixture solid containing maltitol and a process for preparing it
    Patent number: 5354856
    Abstract: The crystalline mixture solid containing maltitol of the present invention has a crushed and relatively tight crystal structure which can be observed at 1,000 magnifications by a scanning electron microscope, an apparent specific gravity in the range of 0.650-0.750, an oil absorptivity of the powdered crystalline mixture solid containing maltitol having a particle size from 50 mesh to 20 mesh in the range of 7.0%-17%, in other words, is relatively heavy in apparent specific gravity and low in oil absorptivity, and the crystalline mixture solid containing maltitol is prepared by continuously supplying an aqueous solution of maltitol to an extruder provided with elongated cooling and kneading zones, cooling and kneading it in the presence of seed crystals to form a maltitol magma, and continuously extruded from a nozzle.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: October 11, 1994
    Assignee: Towa Chemical Industry Co., Ltd.
    Inventors: Shigeru Kawashima, Mitsuo Magara, Yoshibumi Ishii, Kazuaki Kato
  • Shelf-stable product and process for isolating RNA, DNA and proteins
    Patent number: 5346994
    Abstract: Shelf-stable solvent solutions and methods for simultaneously isolating RNA, DNA and proteins from biological samples are disclosed. The solvent solutions include phenol and a guanidinium compound, preferably at a concentration below about 2M, which is effective in isolating substantially pure and undegraded RNA, substantially pure and undegraded DNA, and proteins from the same biological sample.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: September 13, 1994
    Inventor: Piotr Chomczynski
  • Absorbable dusting powder derived from reduced-protein modified starch
    Patent number: 5346892
    Abstract: Absorbable dusting powders suitable for medical, consumer and industrial applications such as lubricating gloves and medical apparatus are prepared by treating starch with a hypochlorite to remove protein and oxidize some of the hydroxyl groups. The modified starch dusting powders are free flowing and are characterized by a protein content of less than about 0.15% by weight and hydroxyl groups oxidized to a level of from about 0.03 to about 0.5% by weight. Protein content can be reduced further by washing with water.
    Type: Grant
    Filed: April 3, 1992
    Date of Patent: September 13, 1994
    Assignee: CPC International Inc.
    Inventors: Larry E. Fitt, Harry T. McNary
  • Method for reducing insulin secretion
    Patent number: 5344824
    Abstract: A food composite for saving insulin secretion comprising a refined product of pyrodextrin obtained as an active ingredient through a process of decomposing starch or starch hydrolyzate by heating in the presence of an acid or without acid.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: September 6, 1994
    Assignee: Matsutani Chemical Industries Co., Ltd.
    Inventors: Kazuhiro Ohkuma, Shigeru Wakabayashi, Yoshimi Mochizuki, Mitsuko Satouchi
  • Glycosylated steroid derivatives for transport across biological membranes and process for making same
    Patent number: 5338837
    Abstract: Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is also provided.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: August 16, 1994
    Assignee: The Trustees of Princeton University
    Inventor: Daniel E. Kahne
  • Esters of alginic acid
    Patent number: 5336668
    Abstract: Total and partial esters of alginic acid which possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: August 9, 1994
    Assignee: Fidia, S.p.A.
    Inventors: Francesco della Valle, Aurelio Romeo
  • Method for producing capsular polysaccharides
    Patent number: 5330903
    Abstract: Structurally altered capsular polysaccharides are produced by mutant bacteria. These polysaccharides are isolated by selecting a wild type bacterial strain and a phage producing degradative enzymes that have substrate specificity for the capsular polysaccharides produced by the wild type bacteria. Phage-resistant mutants producing capsular polysaccharides are selected and the structurally altered capsular polysaccharide is isolated therefrom.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: July 19, 1994
    Assignee: California Institute of Technology
    Inventors: Roger G. Kern, Gene R. Petersen, Gil F. Richards
  • Antitumor antibiotic BMY-41219
    Patent number: 5326754
    Abstract: An antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: July 5, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Kin S. Lam, Leonard A. McDonald, Jacqueline Mattei, Salvatore Forenza, James A. Matson
  • Compositions and methods for drug delivery and chromatography
    Patent number: 5324750
    Abstract: Cyclodextrin derivatives and inclusion complexes having increased solubility and stability are provided. Cyclodextrin derivatives include amino and other modified cyclodextrins, and linked cyclodextrins. Inclusion complexes comprising the foregoing cyclodextrins, and processes for making the cyclodextrin derivatives are disclosed. Also disclosed are cyclodextrin derivatives comprising otherwise substituted or unsubstituted cyclodextrins covalently bonded to agents such as pharmaceuticals. The covalent bond, when broken, yields the agent in active form. Pharmaceutical compositions and methods of treating an animal host are also described, as well as chromatographic compositions and a method for separating racemic mixtures.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: June 28, 1994
    Assignee: Australia Commercial Research & Development Limited
    Inventors: Stephen F. Lincoln, John H. Coates, Christopher J. Easton, Stephen J. Van Eyk, Bruce L. May, Paramjit Singh, Michael L. Williams, Martyn A. Stile
  • Therapeutical composition comprising hydrolyzed carboxylalkyl cellulose
    Patent number: 5324717
    Abstract: A therapeutical composition comprising hydrolyzed carboxyalkyl cellulose, wherein alkyl is methyl, ethyl or propyl, optionally in salt form, which hydrolyzed carboxyalkyl cellulose has a mass average molecular mass from about 200 to about 10,000. A method for providing a laxative effect comprises the administration of such a composition.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: June 28, 1994
    Inventors: Thomas Berglindh, Anthony de Belder
  • Cyclodextrin/drug complexation
    Patent number: 5324718
    Abstract: The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-libile drug, comprising combining from about 0.1 to about 70% (weight/volume) of a cyclodextrin and from about 0.01 to about 5% (weight/volume) of a pharmaceutically acceptable, pharmacologically inactive, water-soluble polymer in an aqueous medium with a lipophilic and/or water-labile drug to form a drug complex, optionally followed by removal of water. Related methods, co-complexes of drug/cyclodextrin/polymer, pharmaceutical compositions and cyclodextrin/polymer complexing agents are also provided.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: June 28, 1994
    Inventor: Thorsteinn Loftsson
  • Cryoprotectant sorbitol crystal spherules
    Patent number: 5324751
    Abstract: Free-flowing formations of spherules of loose knit microcrystals of the polymorphs of sorbitol and mannitol are useful in fast-frozen food products as cryoprotectants due to their improved rate of solubility and dispersion. The free-flowing formations are also helpful in formulating confectionary and pharmaceutical products by improving processing efficiencies and texture and are useful in selected industrial applications as a result of their improved rate of solution and free-flowing characteristics.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: June 28, 1994
    Assignee: ICI Americas Inc.
    Inventor: James W. DuRoss
  • Alkyl-substituted aryl-saccharides, surface-active agents which contain such saccharides and their use in diagnostic tests
    Patent number: 5321129
    Abstract: Novel compounds having the general formulaS--Ar--Xin whichS denotes a saccharide residueAr denotes an aryl residue andX denotes a straight-chained or branched alkyl residue with 2 to 20 carbon atoms,provided that the aryl residue may not be a 4-ethylphenyl, 4-isopropylphenyl, 4-sec.-butyl or 4-dodecylphenyl residue if the saccharide is a galactopyranoside residue, are interesting surface-active agents and are particularly suitable in diagnostic tests in order to clear serum.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: June 14, 1994
    Assignee: Boehringer Mannheim GmbH
    Inventors: Peter Sluka, Hans-Georg Batz, Bernd Vogt
  • Sulphated polysaccharides, anticoagulant agent and anticomplementary agent obtained from brown algae fucuses and method of obtaining same
    Patent number: 5321133
    Abstract: The invention relates to sulphated polysaccharides obtained from fucuses extracted from pheophyceae. The molecular weight of these polysaccharides is greater than 5 and less than 40 Kda; their sulphur content is greater than that of the original fucus and they contain less than 0.15% of contaminant proteins. Applications as anticoagulant and anticomplementary agents.
    Type: Grant
    Filed: January 16, 1992
    Date of Patent: June 14, 1994
    Assignee: Institut Francais de Recherche pour l'Exploitation de la Mer-IFREMER
    Inventors: Sylvia Colliec, Jacqueline Bretaudiere, Patrick Durand, Anne-Marie Fischer, Jacqueline Jozefonvicz, Bernard Kloareg, Catherine Vidal
  • Molecular encapsulation and delivery of alkenes alkynes and long chain alkanes, to living mammalian cells
    Patent number: 5321014
    Abstract: A complex of a cyclodextrin and an alkane, alkene, alkyne, aromatic compound, etc. can be prepared according to the method of the present invention. These complexes can be delivered to prokaryotic and eukaryotic cells, tissues, and organs in vitro and in vivo. In this manner, the toxic, genotoxic, and mitogenic effects of these compounds can be determined. Ternary complexes further including one or more biologically active molecules in addition to an alkane, etc. can be employed to determine the modulatory effects of such biologically active molecules on these alkanes, etc.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: June 14, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Siegfried Janz, Emily Shacter
  • Method and element for assay of catechol and catechol generating substances
    Patent number: 5320946
    Abstract: A method and multilayer analytical element for the determination of catechol and catechol generating substances such as salicylate is described. A series of enzymatic conversions involving tyrosinase is used to convert catechol to o-quinone and the latter to convert a leuco dye to a colored dye.
    Type: Grant
    Filed: July 5, 1990
    Date of Patent: June 14, 1994
    Assignee: Eastman Kodak Company
    Inventors: Daniel S. Daniel, James R. Schaeffer
  • .alpha.-amylase assay using modified oligosaccharide and process for producing said modified oligosaccharide
    Patent number: 5319078
    Abstract: .alpha.-Amylase activity can be determined rapidly and precisely by using as a substrate a modified oligo-saccharide wherein a benzylozymethyl group or a halo-methyl group is bonded to the C.sub.6 position of non-reducing-end glucose residue and the reducing-end glucose residue is bonded to a group which exhibits an optically measurable change upon cleavage. Processes for producing such a compound are also disclosed.
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: June 7, 1994
    Assignee: Wako Pure Chemical Industries, Inc.
    Inventors: Tokuji Ikenaka, Kaoru Omichi, Shinji Satomura, Yuko Nagamine
  • Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
    Patent number: 5314811
    Abstract: A process for converting lipid-containing bacterial capsular polysaccharide, such as lipo-polyribosyl ribitol phosphate, lipo-PRP, into lipid-free, endotoxin-free polysaccharide, such as polyribosyl ribitol phosphate, PRP, by solubilizing polysaccharide-containing powder derived from culture media of bacteria, such as Haemophilus influenzae type b, cleaving covalently bound fatty acids from the polysaccharide, and removing the lipids, and endotoxin.
    Type: Grant
    Filed: July 13, 1992
    Date of Patent: May 24, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Ann L. Lee, Mark S. Rienstra, Walter E. Manger, Robert D. Sitrin
  • Water-soluble pentacyclic triterpene composition and method for producing the same
    Patent number: 5314877
    Abstract: Disclosed is water-soluble composition made by subjecting pentacyclic triterpene compound belonging to amylin group such as oleanolic acid, ursolic acid and hederagenin to inclusion in cyclodextrins. Though the aforementioned pentacyclic triterpene compound has various pharmacological functions, it has suffered a disadvantage such that it is insoluble in water. However, by subjecting the compound to inclusion in cyclodextrins, the water-soluble composition can be made with maintaining the pharmacological functions, and applied for foods, drinks, toothpaste, gargle and chewing gum, exhibiting the effect of cariostatic.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: May 24, 1994
    Assignee: Hokkaido Sugar Co., Ltd.
    Inventors: Hiroshi Suzuki, Sigeru Watano, Tadashi Sasazuka, Taira Tsutsumi
  • Composition for removing or inactivating harmful components in blood or other extracellular body fluids
    Patent number: 5314878
    Abstract: A composition for removing or inactivating harmful components including virus from blood or other extracellular liquids comprises a crownether compound substituted on a polysaccharide, preferably dextrane. The composition may be soluble in water, preferably for intraveneous application, or insoluble for extracorporeal application.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: May 24, 1994
    Assignee: A/S af 18. juni 1990
    Inventors: Henry M. Christensen, Hans B. Andreasen