Abstract: A novel therapy for Pseudomonas aeruginosa infections, in particular in cystic fibrosis patients, is described. Macrophages provide the first line of defence in protecting the lung against bacterial infections. Nonetheless, Pseudomonas aeruginosa infections continue to be problematic in cystic fibrosis patients and are the leading cause of death in these patients. Previously, little was known regarding the factors which regulate the capacity of macrophages to mediate phagocytosis of Pseudomonas aeruginosa. The inventors have now shown that phagocytosis of nonopsonized Pseudomonas aeruginosa by macrophages is dependent upon the presence of glucose. They have also shown that the action of glucose is on the macrophage rather than the bacteria. Glucose therapy can therefore be used to prevent or combat Pseudomonas aeruginosa infections.
Type:
Grant
Filed:
May 26, 1992
Date of Patent:
August 15, 1995
Assignee:
University of British Columbia
Inventors:
David Speert, Sameer Barghouthi, Siamon Gordon
Abstract: The invention relates to highly water soluble substituted .alpha.-, .beta.- or .gamma.-cyclodextrin sulfates associated with a physiologically acceptable cation. Pathological or otherwise undesirable cell or tissue growth in mammals, including humans, is inhibited by administering thereto (1) a water-soluble substituted cyclodextrin sulfate salt, together with (2) a growth-inhibiting organic compound. The growth-inhibiting compound (2) may be asteroid having no inhibiting effect in the absence of (1), or an organic compound which may be an active growth inhibitor, the action of which is potentiated by (1). The invention provides a method for inhibiting angiogenesis and controlling the growth of tumors as well as treating other diseases and pathological conditions associated with undesired cell or tissue growth, including angiogenesis.
Type:
Grant
Filed:
September 18, 1992
Date of Patent:
August 15, 1995
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Paul B. Weisz, William R. Ewing, Madeleine M. Joullie
Abstract: The invention provides an agent against HIV-1 and related viruses, the agent being or including dextrin sulphate containing at most two sulphate groups per glucose unit. The invention also provides a composition containing such an agent, and the use of the agent or composition against HIV-1 and related viruses. By restricting the degree of substitution of the dextrin sulphate to a maximum of 2, the invention makes it possible to produce a dextrin sulphate having adequate anti-HIV activity while maintaining toxicity within acceptable limits.
Abstract: Disclosed is a pharmaceutical composition comprising a dextrin derivative in which a proportion of the hydroxyl groups of dextrin are replaced by basic groups. Such compositions are useful for the treatment of acidic conditions.
Abstract: The present invention relates to a method for the treatment and prevention of diarrhea comprising administering to humans a sugar selected from the group consisting of a caramel composition comprising a high content of fructose oligosaccharides, termed sucrose thermal oligosaccharides (STO), a composition comprising sucrose thermal kestoses, and fructoglucan polymers. The sugars are a natural product and greatly speed recovery from diarrhea and reduce the recurrence of diarrhea.
Type:
Grant
Filed:
May 26, 1993
Date of Patent:
August 8, 1995
Assignee:
University of Montana
Inventors:
Geoffrey N. Richards, Carolyn E. Campbell
Abstract: This invention involves the use of amorphous calcium compounds such as: amorphous calcium phosphate (ACP), amorphous calcium phosphate fluoride (ACPF) and amorphous calcium carbonate phosphate (ACCP) for use in remineralizing teeth. These amorphous compounds or solutions which form the amorphous compounds, when applied either onto or into dental tissue prevent and/or repair dental weaknesses such as dental caries, exposed roots and dentin sensitivity. The compounds have the highest solubilities, fastest formation rates and fastest conversion rates (to apatite) among all the calcium phosphorate under physiological conditions. Moreover, in the presence to fluoride the amorphous compound convert rapidly to fluoride containing apatite.
Type:
Grant
Filed:
August 9, 1993
Date of Patent:
August 1, 1995
Assignee:
American Dental Association Health Foundation
Abstract: Salts of medetomidine and optically active enantiomers, thereof, particularly the d-enantiomer are disclosed. These salts may be used to regulate the rate of the transdermal administration of active drugs. The transdermal delivery system comprises a drug impermeable backing layer and an adhesive layer wherein the medetomidine is dispersed throughout the adhesive layer.
Abstract: Glassy coatings are made by curing in situ a coating of a sol gel of tetraethoxysilicon, water, alcohol, and the alkoxides of: Al, Ti and Na; or of Na and Zr.The coating may be applied to teeth as a dental fissure sealant or varnish to protect restorations, or (if filled) as an inherently coloured cosmetic coating, or as a prophylactic coating.
Abstract: The use of galacturonic acid and derivatives thereof for preparing a medicament for the treatment of hyperlipidaemia and/or atherosclerosis is described.
Abstract: Glassy coatings are made by curing in situ a coating of a sol gel of tetraethoxysilicon, water and alcohol, filled with kaolinite or with flat plates (1-2 .mu.m.times.10-50 .mu.m) of mica, which may be colored by Fe.sub.2 O.sub.3 /TiO.sub.2 coatings.The coating may be applied to teeth as a dental fissure sealant or varnish to protect restorations, or as an inherently colored cosmetic coating, or as a prophylactic coating.
Abstract: A process for the production of semisolid preparations containing micronized active ingredients is described which is characterized in that a mixture of one or two nonionic surfactants with an HLB of 9 to 18 with 2.3 to 100 times the amount by weight of a fatty acid ester of general formulaR.sub.1 --COO--R.sub.2in which R.sub.1 and R.sub.2 each represent alkyl groups or alkenyl groups with 12 to 32 carbon atoms, or a mixture of these fatty acid esters is heated until it melts, the melt with stirring is put into 10 to 200 times the amount by weight of a semisolid preparation, which is heated approximately to the same temperature, the mixture is allowed to cool with stirring and mixed with the micronized active ingredient or active ingredient mixture as well as optionally with scents.
Type:
Grant
Filed:
May 17, 1993
Date of Patent:
July 11, 1995
Assignee:
Schering Aktiengesellschaft
Inventors:
Wolfgang Stindl, Erich Leitner, Johannes Tack, Erwin Dargel
Abstract: Structurally altered capsular polysaccharides are produced by mutant bacteria. These polysaccharides are isolated by selecting a wild type bacterial strain and a phage producing degradative enzymes that have substrate specificity for the capsular polysaccharides produced by the wild type bacteria. Phage-resistant mutants producing capsular polysaccharides are selected and the structurally altered capsular polysaccharide is isolated therefrom.
Type:
Grant
Filed:
June 10, 1994
Date of Patent:
July 11, 1995
Assignee:
California Institute of Technology, Jet Propulsion Laboratory
Inventors:
Roger G. Kern, Gene R. Petersen, Gil F. Richards
Abstract: Methods of reducing post-prandial fluctuations in plasma levels of large, neutral amino acids (LNAA), as well as compositions useful in that method. The foods and compositions comprise a carbohydrate to protein ratio of from about 3:1 to about 8:1 and, in a specific embodiment, a ratio of 7:1, which results in minimizing the variability in responses individuals exhibit to drugs which are LNAA.
Abstract: A continuous method of bleaching an alkylpolyglycoside, substantially free of alcohol, with peroxy compounds, preferably hydrogen peroxide, which is highly efficient to provide an unexpected high degree of color reduction from a dark brown to a light, which product, from an extinction coefficient color respectively of about 10 to about 15 to about 0.025 to about 0.15. The bleaching is carried out at controlled pH and temperature, under pressure preferably in the presence of Mg. The use of a prebleached heel or feed prior to introduction of the unbleached material to be bleached results in a faster approach to equilibrium, steady state, bleaching conditions which results in minimum chemical usage and more rapid production of low color.
Type:
Grant
Filed:
February 25, 1994
Date of Patent:
July 11, 1995
Assignee:
Henkel Corporation
Inventors:
Patrick M. McCurry, Jr., James D. Beaulieu
Abstract: There are provided novel 1,4 Diamine 2,3 Dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.
Type:
Grant
Filed:
December 17, 1993
Date of Patent:
July 4, 1995
Assignee:
The Du Pont Merck Pharmaceutical Company
Inventors:
Prabhakar K. Jadhav, Lawrence R. McGee, Ashok Shenvi, Carl N. Hodge
Abstract: A novel therapeutical use of L-carnitine, acyl L-carnitines and the pharmacologically acceptable salts thereof is disclosed for the treatment of non-insulin-dependent patients with a view to enhancing their peripheral glucose utilization.
Abstract: A pharmaceutical preparation including a drug incorporated into hydrophobic particles comprised of long chain carboxylic acid or ester thereof or long chain alcohol, wherein the particles are incorporated into a unit dosage form and are individually coated with an enteric coating and/or the unit dosage form includes an enteric protective material.
Type:
Grant
Filed:
March 18, 1994
Date of Patent:
July 4, 1995
Assignee:
Pharmavene, Inc.
Inventors:
Edward M. Rudnic, John A. McCarty, George W. Belenduik
Abstract: This invention involves methods and compositions for preparation of unstable carbonated calcium phosphate solutions, which are supersaturated with respect to calcium phosphate solids and carbon dioxide and the use of such solutions for the treatment of dental tissue and hyposalivation. Specifically the methods include mixing a stable alkaline carbonated solution containing carbonate with a stable acidic calcium solution, either or both solutions also containing phosphate to create an unstable carbonated solution with respect to calcium phosphate and carbon dioxide. Also, the methods include adding aqueous solution to the solids containing calcium salts, phosphate salts and carbonate salts to create an unstable carbonated solution supersaturated with respect to calcium phosphate solids and carbon dioxide. The methods further include using alkaline solutions to remove the acidic residue from dental tissue and maintain cariostatic conditions.
Type:
Grant
Filed:
June 23, 1993
Date of Patent:
June 27, 1995
Assignee:
American Dental Association Health Foundation
Abstract: A process for producing a triglyceride mix free from components hampering further processing from a vegetable oil as a starting material, which is cooled and then separated into a predominantly solid and a predominantly liquid phase. The vegetable oil used as starting material is one in which a predetermined reactive fatty acid predominates in the fatty acid pattern with a content of at least about 80%. The cooling temperature of the cooling step is so adjusted that the particularly hard to solidify or readily soluble triglycerides in the starting material remain at least substantially liquid or in solution. In one embodiment, the solid phase obtained after the first separation step is then dissolved and cooled in a second cooling step to a temperature different from an initial temperature step at which the easier to solidify or less soluble triglycerides bearing less reactive groups separate out.
Abstract: Polysaccharides, including hydroxyethyl cellulose, having complex hydrophobic group substitution, provide latex compositions, such as paints, with improved rheology and stability. Improved processes for producing such polysaccharides are also provided.
Type:
Grant
Filed:
May 29, 1992
Date of Patent:
June 20, 1995
Assignee:
Union Carbide Chemical & Plastics Technology Corporation
Inventors:
Richard D. Jenkins, David R. Bassett, Gregory D. Shay