Patents Examined by Ronald W. Griffin
  • Double-substituted cationic cellulose ethers
    Patent number: 5407919
    Abstract: Double-substituted, water-soluble, cellulose ethers substituted with a cationic substituent and a hydrophobic substituent are disclosed. The levels of substitution for the cationic substituent and the hydrophobic substituent can provide enhanced properties when used in personal care compositions, such as, for example, enhanced substantivity, saline capability and low irritation potential to mucosal linings.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: April 18, 1995
    Inventors: George L. Brode, Russell L. Kreeger, George A. Salensky
  • Pet foods with water-soluble zinc compound coating for controlling malodorous breath
    Patent number: 5405836
    Abstract: Breath freshening, dry pet foods, e.g., pet biscuits are prepared by topically applying a breath freshening amount of a water-soluble zinc salt to a farinaceous-based baked or cooked pet food. The amount of the water-soluble zinc salt is sufficient so that said topically-applied water-soluble zinc salt contains from about 2 mg to about 6 mg of zinc ion per 10 gm of the breath freshening pet food. Consumption of the dry pet food controls the malodorous breath of the animal. Rawhide chew coated in the same manner also provides breath freshening when chewed.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: April 11, 1995
    Assignee: Nabisco, Inc.
    Inventors: Thomas Richar, James B. Taylor, Jan Karwowski, Felice Scaglione, James E. Roe, Michael S. Otterburn, Wayne Steensen, Henry C. Spanier, Richard L. Antrim, Leif Solheim
  • Pranoprofen-containing, suspending medicinal composition
    Patent number: 5405840
    Abstract: A pranoprofen-containing, suspending medicinal composition is formed of the following three ingredients (a) to (c):(a) pranoprofen;(b) a suspending agent comprising microcrystalline cellulose-sodium carboxymethylcellulose, sodium carboxymethylcellulose and hydroxypropyl methylcellulose; and(c) a saccharide solution.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: April 11, 1995
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Toshiaki Kurazumi, Katsumi Imamori, Akira Iwasa
  • Amphiphilic compounds containing two sugar or sugar-derived head groups
    Patent number: 5403922
    Abstract: The subject of the invention is a surface-active composition, comprising a bolaamphiphile or bolaform chemical compound, containing a linear or branched, hydrophobic carbon chain at the two ends of which are arranged two hydrophilic portions or head group groups, corresponding to the following general formula:R A E A Rin which:E represents the carbon chain, containing at least six carbon atoms, optionally interrupted by at least one aromatic, or heterocyclic, or functional groupA is a bonding functional groupR is a residue of a reducing glucide containing a linear or cyclized chain, or of a derivative of the said glucide, bonded directly or indirectly via one of its aldehyde or ketone functional groups, or derived functional group, to the functional group A.The invention also relates to their applications as components of surface-active agents and vesicular agents, and to a process for their preparation.
    Type: Grant
    Filed: June 7, 1994
    Date of Patent: April 4, 1995
    Inventors: Rachel Garelli-Calvet, Florence Brisset, Isabelle Rico, Armand Lattes, Lionel Godefroy
  • Sequential removal of monosaccharides from the reducing end of oligosaccharides and uses thereof
    Patent number: 5403927
    Abstract: Methods are provided for the sequential removal of monosaccharides from the reducing end of oligosaccharides. The present invention also discloses the use of such methods for structural determinations of oligosaccharides and to enable new structures to be generated from pre-existing oligosaccharides. In addition, the methods of the present invention may be automated by the incorporation into systems.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: April 4, 1995
    Assignee: The Biomembrane Institute
    Inventor: Brad K. Bendiak
  • Purification of cyclodextrin complexes
    Patent number: 5403828
    Abstract: A method is provided for purifying crude inclusion complexes of cyclodextrin which is used as a host material, in combination with a guest material, such as light mineral oil. After the crude cyclodextrin complex is formed in an aqueous media, the moisture content of the crude cyclodextrin complex is substantially reduced before it is washed with a wash solvent to substantially eliminate uncomplexed guest molecules.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: April 4, 1995
    Assignee: American Maize-Products Company
    Inventors: Larry N. Lewis, Chris A. Sumpter, Erick V. Sprenne, Allan R. Hedges, Matthew L. Romberger
  • Exercise hydration regimen to enhance exercise endurance and performance
    Patent number: 5403921
    Abstract: An exercise regimen which enhances exercise endurance and performance. The regimen includes pre-exercise hydration with a glycerol solution combined with hydration during exercise with a glycerol based solution to prolong hydration effects. The first pre-exercise glycerol solution regimen begins 2 hours prior to exercise and ends 1/2 hour before exercise begins. The hydration during exercise regimen combines glycerol with a carbohydrate and sodium to prolong fluid retention.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: April 4, 1995
    Assignee: University of New Mexico
    Inventors: Paul Montner, Thomas W. Chick, Dan Stark, Marvin L. Riedesel
  • Process of producing conventional or non-viscous xanthan by action of xanthomonas campestrisCNCM 1-956
    Patent number: 5401644
    Abstract: The present invention relates toa mutant strain of Xanthomonas campestris;a method of preparing xanthan by fermentation of said strain; anda non-viscous xanthan capable of being obtained by said method.
    Type: Grant
    Filed: December 27, 1991
    Date of Patent: March 28, 1995
    Assignees: Sanofi, Societe Nationale Elf Aquitaine
    Inventor: Marc Salome
  • Process of preparing N-substituted aldonamides having improved color and color stability
    Patent number: 5401839
    Abstract: A process of preparing N-substituted aldonamides, the process including the steps of mixing and reacting an aldonolactone and an amine in an organic polar solvent, in the presence of an antioxidant and a reducing agent. The aldonamides have improved color; the discoloration or browning of the aldonamides upon storage or elevated temperature processing is eliminated or substantially minimized.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: March 28, 1995
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Van Au, Bijan Harirchian
  • Enteral formulations for treatment of inflammation and infection
    Patent number: 5397778
    Abstract: The present invention features saponin containing enteral formulations for treatment of infection and inflammation. These saponin containing formulations are particularly useful in conjunction with oils rich in .omega.3 polyunsaturated fatty acids such as fish oils and flax oil but also show benefits with .omega.6 rich oils such as borage oil, black currant seed oil, canola oil and rapeseed oil. These formulations may also contain a lignan from the sesamin family.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: March 14, 1995
    Assignee: New England Deaconess Hospital Corporation
    Inventors: R. Armour Forse, Sambasiva Chavali
  • Preparation for treating renal disease
    Patent number: 5393742
    Abstract: A preparation is useful for treating renal disease, such as nephritis and especially nephrosis (nephrotic syndrome), which comprises an effective amount of N-acetylneuraminic acid shown by the formula ##STR1## wherein, when n is 1, Z represents hydrogens, lithium, potassium, sodium, ammonium or organic ammonium, and when n is 2, Z represents calcium, barium or magnesium, and a pharmacologically acceptable carrier.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: February 28, 1995
    Assignee: MECT Corporation
    Inventors: Takayuki Ishii, Makiko Kasano, Tae Yasunaga, Mariko Ishii, Mamoru Sugimoto, Kenkichi Tomita, Takeshi Miyata, Makoto Tanaka
  • Process for producing maltooligosaccharide derivatives
    Patent number: 5393876
    Abstract: A polyacyl maltooligosaccharide derivative which is a precursor of a maltooligosaccharide derivative having modified groups at the 6-position or 4- and 6-positions of non-reducing end glucose unit and being effectively used as a substrate for measuring .alpha.-amylase activity, can be produced under mild conditions by crosslinking OH groups in the non-reducing end glucose unit of oligosaccharide with a benzylidene group having an alkoxy group, followed by acylation and treatment with a dilute acid.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: February 28, 1995
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Atsunori Sano, Satoshi Hashizume, Hiroyuki Tsurumoto
  • Acetal derivatives of aromatic aldehydes
    Patent number: 5393741
    Abstract: New compounds having the general formula I ##STR1## wherein Y may be H or D; and A is H, D, alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkyl groups have 1-4 C atoms or OR wherein R is H or alkyl of 1-4 C-atoms;X.sub.1 and X.sub.2 may together with the carbon atom to which they are bound form a cyclic acetal, thioacetal, dithiane, aminal, oxazolidine or thiazolidine;or pharmaceutically acceptable salts thereof.The compounds are useful as anti-carcinoma agents.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: February 28, 1995
    Assignee: Norsk Hydro a.s.
    Inventors: Erik O. Pettersen, Rolf O. Larsen, Bernt Borretzen, John M. Dornish, Reidar Oftebro
  • Amino acid derivatives having renin inhibiting activity
    Patent number: 5393875
    Abstract: The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the significance given in claim 1,in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharamaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured according to various methods which are known per se.
    Type: Grant
    Filed: August 3, 1993
    Date of Patent: February 28, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Quirico Branca, Marie-Paule Heitz, Werner Neidhart, Heinz Stadler, Eric Vieira, Wolfgang Wostl
  • Cytotoxic drug conjugates for treatment of neoplastic diseases
    Patent number: 5393737
    Abstract: A novel composition of matter comprising a ligand-carbohydrate-cytotoxic drug conjugate is produced by the steps of (1) reacting a carbohydrate with a ligand, (2) reacting the product of step (1) with a cytotoxic drug, and (3) stabilizing the product of step (2) by reduction. The composition is used for treating a neoplastic disease by a process of administering a non-toxic, effective amount of a ligand-carbohydrate-cytotoxic drug conjugate to a human being or animal in need of such a treatment.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: February 28, 1995
    Assignee: Health Research, Inc.
    Inventors: George L. Mayers, Jafar Razeq, Mahmoud M. Abu-Hadid
  • Aqueous film forming foam concentrates for hydrophilic combustible liquids and method for modifying viscosity of same
    Patent number: 5391721
    Abstract: Aqueous film-forming foam (AFFF) concentrates for fighting polar and non-polar fuel and solvent fires, comprising hydrocarbon solvents, hydrocarbon surfactants, fluorosurfactants, high molecular weight polysaccharides, alginates, salts of aryl or alkylaryl sulfonates and water, and method for modifying the viscosity of the AFFF concentrates.
    Type: Grant
    Filed: February 4, 1993
    Date of Patent: February 21, 1995
    Assignee: Wormald U.S., Inc.
    Inventors: Steven W. Hanen, Debbie L. Wagner
  • Combating of undesired organisms
    Patent number: 5391545
    Abstract: Undesired organisms, including insects, mites and fungi, may be combated by application of a liquid composition which comprises starch dextrin or an analogous derivative of amylopectin as an active ingredient. The aforementioned active ingredients may be used as the sole active ingredient or in combination with other active ingredients. Examples of undesired organisms which have been found to be affected are whiteflies, thrips, red spider mites, broadmites, cucumber powdery mildew and oat powdery mildew.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: February 21, 1995
    Assignees: Aquaspersions Limited, Humber Growers Marketing Organisation Limited
    Inventor: Robert J. J. Pickford
  • Compositions of matter and methods for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
    Patent number: 5391550
    Abstract: Disclosed are methods and compositions of matter for increasing the intracellular synthesis of ATP. The compositions comprise amino acids, metabolites, electrolyte and/or a pentose sugar. When applied to wounds, the invention increases the rate of wound repair and has a antimicrobial effect. When administered orally, the invention increases ATP blood levels and physical performance levels.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: February 21, 1995
    Assignee: Raymond A. Roncari
    Inventors: Francis J. Carniglia, Alan J. Kenyon
  • Modified hydrophobic cationic thickening compositions
    Patent number: 5387675
    Abstract: Water soluble quaternary ammonium ethers of polysaccharides or polyols wherein the quaternary ammonium ether substituents correspond to the formula ##STR1## wherein R.sub.1 is a monohydroxylated or polyhydroxylated alkyl group containing between about one and about six carbon atoms; R.sub.2 and R.sub.3 are independently, alkyl groups containing between about one and about six carbon atoms; R.sub.4 is an alkyl group containing between about six and about 24 carbon atoms; and X is a halide, wherein the degree of substitution of said ethers ranges from about 0.001 to about 0.5. is provided. The composition have multiple uses as thickeners and are particularly suited for use in personal care products.
    Type: Grant
    Filed: March 10, 1993
    Date of Patent: February 7, 1995
    Assignee: Rhone-Poulenc Specialty Chemicals Co.
    Inventor: Michael H. Yeh
  • Polysulfate of .beta.-cyclodextrin derivative and process for preparing the same
    Patent number: 5385891
    Abstract: Disclosed is a polysulfate of a .beta.-cyclodextrin in which at least one of 7 D-glucose units constituting the .beta.-cyclodextrin is a unit represented by the formula (I-a): ##STR1## wherein R.sup.1 is an alkyl group having 1 to 8 carbon atoms, a lower alkyl group having a substituent(s) or a lower alkenyl group, or a salt thereof, which has excellent antiretrovirus activity and is useful as an antiretrovirus agent.
    Type: Grant
    Filed: August 12, 1992
    Date of Patent: January 31, 1995
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Tamon Moriya, Hironori Kurita, Toru Otake, Haruyo Mori, Motoko Morimoto