Abstract: The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising at least one pharmaceutical active ingredient, with the exception of opioids, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer or copolymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0. characterized in that the coating layer further contains 110 to 250% by weight, calculated on dry weight of the polymer mixture, of a non-porous inert lubricant and the is present in an amount of at least 60% by weight calculated on the weight of core.
Type:
Grant
Filed:
September 25, 2007
Date of Patent:
January 31, 2017
Assignee:
EVONIK ROEHM GmbH
Inventors:
Hans-Ulrich Petereit, Hema Ravishankar, Ashwini Samel
Abstract: The present invention provides methods of treating a human or other mammal infected with a parasitic microorganism by administering an effective amount in unit dosage form of a C8-C16-alpha, beta-unsaturated aliphatic aldehyde, such as trans-2-dodecenal, to the human or other mammal. The parasitic microorganisms may include trypanosomes, bacteria, fungi and nematodes.
Type:
Grant
Filed:
September 22, 2014
Date of Patent:
January 17, 2017
Assignee:
SLIPPERY ROCK UNIVERSITY FOUNDATION, INC.
Abstract: Novel radiation curable gel-based mammalian nail coating compositions, kits containing these compositions, and methods of their use are disclosed. The novel compositions and/or kits are useful, inter alia, for providing durable, “soak-off” type nail coatings.
Abstract: The present invention relates to infant nutrition, in particular to infant nutrition comprising special lipid globules for improvement of the fatty acid composition in brain membranes.
Type:
Grant
Filed:
March 17, 2011
Date of Patent:
October 25, 2016
Assignee:
N.V. Nutricia
Inventors:
Eline Marleen Van Der Beek, Marieke Abrahamse-Berkeveld, Annemiek Lidewij Schipper, Gelske Speelmans
Abstract: A hair care composition comprising: a crosslinking component comprising an inorganic fluoride; and a conditioning component, wherein the composition has a ratio of crosslinking component to conditioning component in the range of about 10:90 to about 95:5.
Type:
Grant
Filed:
September 16, 2013
Date of Patent:
October 11, 2016
Assignee:
Zotos International, Inc.
Inventors:
Andrew Savaides, Rushi Tasker, Komal Ladd, Mona Vaidya
Abstract: This invention provides an effervescent solid form that dissolves in cold water quickly enough to not disappoint consumers yet not so quickly that the visual interest generated during the effervescent reaction is lost. This performance is achieved by forming effervescent particles that are dense enough to retard dissolution and small enough to not take too long to dissolve. The aim of this invention is to provide a beverage in solid effervescent form that takes between about 30 and about 120 seconds to dissolve in warm water. The granules may carry functional additives such as flavors, vitamins, minerals, sweeteners, colors and drugs. The granules may also be compounded of materials intended to provide relief from skin or topical discomfort, as in the form of a wash or bath additive. The granules may also be formulated to provide cleaning agents, such as ceramic cleaners and denture cleaners.
Type:
Grant
Filed:
August 6, 2009
Date of Patent:
October 4, 2016
Assignee:
Tower Laboratories, Ltd.
Inventors:
Allen Rau, Nicole Quinn, Donald Stadolnik, Eric Sterner
Abstract: The present invention relates to a method for treating muscular dystrophy which comprises administering diethyl-[6-(4-hydroxycarbamoyl-phenyl-carbamoyloxy-methyl)-naphthalen-2-yl-methyl]-ammonium chloride or other pharmaceutically acceptable salts and/or solvates thereof to a patient in need of such a treatment. The invention further relates to a method for treating muscular dystrophy which comprises administering diethyl-[6-(4-hydroxycarbamoyl-phenyl-carbamoyloxy-methyl)-naphthalen-2-yl-methyl]-ammonium chloride or other pharmaceutically acceptable salts and/or solvates thereof in combination with one or more additional anti-inflammatory active agents to a patient in need of such a treatment.
Type:
Grant
Filed:
July 28, 2014
Date of Patent:
August 23, 2016
Assignee:
ITALFARMACO S.P.A.
Inventors:
Valentina Saccone, Silvia Consalvi, Pier Lorenzo Puri, Paolo Mascagni
Abstract: There are provided a metal soap which is useful as a food additive to be added to various foods for the purposes of improving a fluidity, an anti-bridging property, a low moisture absorption property and feel upon eating of foods, and has a less adverse influence on the foods, as well as a process for producing the metal soap. The metal soap for a food additive is constituted of a fatty acid calcium salt or a fatty acid magnesium salt having 6 to 24 carbon atoms which is obtained by a double decomposition method, and a water dispersion containing the metal soap in an amount of 2% by mass exhibits a pH of not less than 6 but less than 7. The process for producing the metal soap for a food additive includes the steps of reacting 1 mol of a fatty acid having 6 to 24 carbon atoms with not less than 0.9 mol but less than 1 mol of a monovalent basic compound to obtain a fatty acid basic compound salt; and reacting the fatty acid basic compound salt with a calcium salt or a magnesium salt in an aqueous medium.
Abstract: The invention relates to a composition, especially a cosmetic composition, comprising at least one silicon resin comprising at least one T unit and at least one tackifying agent, as well as to methods of using such compositions.
Type:
Grant
Filed:
December 28, 2012
Date of Patent:
May 24, 2016
Assignee:
L'OREAL
Inventors:
Hy Si Bui, Ramakrishnan Hariharan, Yoriko Bukawa, Nishith Patel
Abstract: The invention provides compositions and methods for achieving storage stable aceclidine. The compositions preferably comprise aceclidine, a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. The invention further provides methods for treating refractive errors of the eye with a storage stable aceclidine composition.
Abstract: The adhesive composition for soft tissues, the adhesive composition for wound dressing or the wound dressing agent composition of the present invention is an adhesive composition for soft tissues, an adhesive composition for wound dressing or a wound dressing agent composition, comprising a monomer (A), a polymer (B) and a polymerization initiator composition (C) containing an organoboron compound, and is characterized by having a viscosity of 0.4 to 75,000 cp within 30 seconds after mixing of the components (A), (B) and (C). The composition of the present invention not only has low toxicity, low harmfulness and high adhesive strength but also is excellent in workability during application and is capable of forming films of excellent properties.
Abstract: The invention provides compositions and methods for the improvement of distance vision. The invention further provides compositions and methods for the treatment of refractive errors of the eye. The invention further provides compositions that preferably comprise aceclidine lyophilized with a cryoprecipitate separate or together with a diluent comprising a cycloplegic agent, a surfactant, and optionally a viscosity enhancer.
Abstract: The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.
Type:
Grant
Filed:
May 21, 2014
Date of Patent:
April 5, 2016
Assignees:
Northwestern University, University of Maryland, Baltimore, Ann & Robert H. Lurie Children's Hospital of Chicago
Inventors:
Dean Ho, Erik M. Robinson, Sunjay Kaushal, Patrick M. McCarthy
Abstract: A hair care composition containing inorganic fluoride for straightening, smoothing, and/or relaxing hair, and a method for using the hair care composition a hair care composition containing an inorganic fluoride for straightening, smoothing, defrizzing, curling and/or relaxing of hair, and its method of use in a variety of hair care products, e.g., straightener solution, shampoo, conditioner, color binding treatment, volumizing treatment, a combination thereof, etc. The hair care composition is formaldehyde-free, even when heated.
Type:
Grant
Filed:
July 26, 2013
Date of Patent:
March 15, 2016
Assignee:
Zotos International, Inc.
Inventors:
Andrew Savaides, Rushi Tasker, Komal Mann, Mona Vaidya
Abstract: A hair care composition containing inorganic fluoride for straightening, smoothing, and/or relaxing hair, and a method for using the hair care composition a hair care composition containing an inorganic fluoride for straightening, smoothing, defrizzing, curling and/or relaxing of hair, and its method of use in a variety of hair care products, e.g., straightener solution, shampoo, conditioner, color binding treatment, volumizing treatment, a combination thereof, etc. The hair care composition is formaldehyde-free, even when heated.
Type:
Grant
Filed:
October 19, 2012
Date of Patent:
March 15, 2016
Assignee:
Zotos International, Inc.
Inventors:
Andrew Savaides, Rushi Tasker, Komal Mann, Mona Vaidya
Abstract: The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.
Type:
Grant
Filed:
February 15, 2013
Date of Patent:
March 15, 2016
Assignee:
TEVA PHARMACEUTICAL INDUSTRIES, LTD.
Inventors:
Vladimir Ioffe, Konstantin Ulanenko, Avital Laxer, Muhammad Safadi, Danit Licht, Ioana Lovinger, Ulf Tomas Fristedt
Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.
Type:
Grant
Filed:
May 3, 2013
Date of Patent:
January 26, 2016
Assignee:
The Regents of the University of California
Inventors:
William R. Freeman, Michael J. Sailor, Lingyun Cheng
Abstract: The invention relates to a composition, especially a cosmetic composition, comprising at least one ester of polyol(s) and of fatty diacid dimer or an ester thereof, at least one acrylic film forming agent and at least one tackifier, as well as to methods of using such compositions.
Type:
Grant
Filed:
December 30, 2011
Date of Patent:
January 5, 2016
Assignee:
L'OREAL
Inventors:
Yoriko Bukawa, Hy Si Bui, Momoko Shimizu
Abstract: The present invention concerns a cosmetic composition comprising the following fluorinated analog of prostaglandin F2?: The cosmetic composition may further comprise a complexing agent and/or a humectant. The present invention further relates to a cosmetic kit, comprising the cosmetic composition and an applicator for application thereof.
Type:
Grant
Filed:
March 21, 2013
Date of Patent:
December 29, 2015
Assignee:
S & V Technologies AG
Inventors:
SooWhan Choi, Said Hilton, Maricica Munteanu