Abstract: Disclosed is a transdermal composition for delivery of diclofenac comprising the use of a pharmaceutically acceptable acid or salt form in an admixture with a pharmaceutically acceptable adhesive matrix carrier. In a preferred embodiment, diclofenac is present as the free acid and potassium salt form in the adhesive matrix composition together with a dual permeation enhancer. The adhesive matrix composition is applied in a method of substantially increasing drug delivery for 24 or more hours.

Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.

Abstract: Cosmetic powders which contain an N-mono long chain acyl basic amino acid and a particular ?-aminolactam derivative are superior in spreadability on the skin and affinity to the skin upon application, and the lightness and moisture of the skin after application, as well as safety.

Abstract: A high swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring high swell and slow degradation, for example, tissue augmentation, both cosmetic and reconstructive; void filling; tissue bulking, for example treatment of urinary incontinence and acid reflux; and embolization. The high swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.