Patents Examined by Satyendra K. Singh
  • Patent number: 11518978
    Abstract: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: December 6, 2022
    Assignee: The Curators of the University of Missouri
    Inventors: Gabor Forgacs, Francoise Suzanne Marga, Cyrille Norotte
  • Patent number: 11517605
    Abstract: The invention relates to methods of evaluating the quality of a batch of an herbal composition, the method comprising subjecting a test batch of the herbal composition to one or more biological analysis methods and comparing the results derived from the test batch to the results of a known batch of herbal composition which has a known in vivo effect.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: December 6, 2022
    Inventor: YungChi Cheng
  • Patent number: 11512276
    Abstract: The present disclosure provides methods for controlling oxygen concentration during aerobic biosynthesis, e.g., fermentation. The method may comprise feeding an oxygen-containing gas into a vessel including a fermentation feedstock and reacting the fermentation feedstock with the oxygen-containing gas to form a broth including a gaseous phase dispersed within the broth. The gaseous phase may comprise any unreacted oxygen from the oxygen-containing gas. The method further includes reducing the concentration of the unreacted oxygen in the dispersed gaseous phase to less than the limiting oxygen concentration (“LOC”) for flammability before separating the gaseous phase from the fermentation broth. The concentration of the unreacted oxygen in the gaseous phase is reduced by employing oxygen removal schemes or oxygen dilution schemes.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: November 29, 2022
    Inventors: Gary J. Smith, Paul S. Pearlman, Gregory S. Kirby
  • Patent number: 11512291
    Abstract: Disclosed herein are methods for generating satellite cells and compositions including satellite cells.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: November 29, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Feodor D. Price
  • Patent number: 11503823
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: November 22, 2022
    Assignees: The Curators of the University of Missouri, The Trustees of Columbia University
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Patent number: 11491196
    Abstract: The disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: November 8, 2022
    Assignees: Universiteit Gent, Microbial Resource Management Health NV MRM Health
    Inventors: Sam Possemiers, Massimo Marzorati, Tom Van de Wiele, Ilse Scheirlinck, Pieter Van den Abeele, Selin Bolca, Davide Gottardi
  • Patent number: 11478000
    Abstract: Disclosed herein is a composition that includes Lactobacillus plantarum LP28 deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 3346, and Streptococcus thermophilus ST30 deposited at Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH under an accession number DSM 32788. Also disclosed herein are an animal feed comprising the composition, and a method for improving pork quality, which comprises administering to a pig the composition.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: October 25, 2022
    Assignee: SYNBIO TECH INC.
    Inventors: Ting-Yu Lee, Jin-Seng Lin
  • Patent number: 11472894
    Abstract: Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: October 18, 2022
    Assignee: Carnegie Mellon University
    Inventors: Krzysztof Matyjaszewski, Alan Enciso Barros, Liye Fu, Alan J. Russell
  • Patent number: 11421261
    Abstract: A method is provided. The method includes providing an article, the article including a nonwoven substrate having a copolymer grafted thereto, the copolymer including interpolymerized monomer units of a quaternary ammonium-containing ligand monomers; an amide monomer; an oxy monomer; and a coating on the nonwoven substrate, the coating including a plurality of test microorganisms, an enzyme or a second substrate; and contacting the article with a detection medium for a period of time.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: August 23, 2022
    Assignee: 3M Innovative Properties Company
    Inventors: Kelvin J. Witcher, Francois Ahimou, Naiyong Jing, Tonya D. Bonilla, Joshua D. Erickson, Hsi-Chou Liu, Andrew W. Vail
  • Patent number: 11396671
    Abstract: The present invention relates to a method for producing a vitamin- and protein-rich product, to a food product containing the vitamin- and protein-rich product, and to a nutrient medium appropriate for said method on the basis of agricultural tributaries or food tributaries.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: July 26, 2022
    Inventor: Martin Frettlöh
  • Patent number: 11377652
    Abstract: Systems and methods are provided for transfecting cells, such as mammalian cells and nonmammalian cells, using an electroporation apparatus having an electroporation chamber including an upper micromesh electrode, a lower micromesh electrode and a path defined in the electroporation chamber. The electroporation apparatus includes a first input allowing passage of cells into the electroporation chamber and a first output allowing passage of electroporated cells from the electroporation chamber. The first input and the first output are separated by an offset distance.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: July 5, 2022
    Assignee: NANOCAV, LLC
    Inventor: Chih-Wei Chang
  • Patent number: 11351262
    Abstract: A method of treatment is disclosed, comprising administering a composition of Cyclodextrin and reduced, nanonized L-Glutathione to a patient in need of treatment, wherein the L-Glutathione molecule is non-acetylated, non-Esterified, and non-fatty acid attached.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: June 7, 2022
    Inventors: Nayan Patel, Chinh Tran
  • Patent number: 11339373
    Abstract: Novel adult liver progenitor cells (called H2Stem Cells) have been have been characterized on the basis of a series of biological activities and markers. Methods for producing H2Stem Cells allow providing such cells in the form of adherent cells and three-dimensional cell clusters in suspension that can be differentiated into cells having strong liver-specific activities and/or that can be used for treating liver diseases or for evaluating the efficacy, the metabolism, and/or toxicity of a compound.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: May 24, 2022
    Assignee: Promethera Therapeutics SA
    Inventors: Etienne Sokal, Sarah Snykers, Tuba Baran, Kris Gellynck, Luca Falciola
  • Patent number: 11327079
    Abstract: The present invention relates to a method of directly detecting, using a mass-spectrometry method, whether a microorganism contained in a sample is resistant to antibiotics, and a kit for detection used therewith. More particularly, the present invention relates to a method and kit for directly detecting an antibiotic hydrolase secreted by a microorganism resistant to antibiotics, thereby directly determining whether the microorganism is resistant to antibiotics. According to the present invention, it is possible to very simply and immediately confirm whether a specific strain is resistant to antibiotics in the field. In particular, a complicated pretreatment process such as proteolysis is not performed, and a complicated identification process of calibrating and then combining the obtained results is not performed.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: May 10, 2022
    Inventors: Kye Shin Park, Joon Sang Park, Eun Hee Lee, Dong Hwi Hwang, In Jung Ji, Jae Woo Roh, Jin Sung Ahn, Eun-Jeong Yoon, Ji Hye Ko
  • Patent number: 11317633
    Abstract: Microbial compositions for application to plants, plant parts and plant seeds are provided for improvement of plant yield and/or other beneficial plant traits. Methods of making and applying microbial compositions or formulations to plants, plant parts or plant seeds or to growth media are further provided to increase or improve plant yield and/or other beneficial plant traits.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: May 3, 2022
    Inventors: Kenneth L. Ferreira, Linda L. Lutfiyya, Ryan T. McCann, Scott R. Schaecher
  • Patent number: 11311043
    Abstract: The present invention discloses a glucan-based shell-core structure carrier material and preparation and application thereof, and belongs to the technical field of modern food processing. Spherical hyperbranched water-soluble amylum grains are used as the raw material, and an enzymatic grafting and chain extending process is adopted for treatment to modify the surfaces of water-soluble glucan molecules into a firm shell structure with densely cumulated crystal structures, and form the glucan-based carrying material with the shell-core structure of which an inner core cavity has an amorphous state and an outer shell layer has a crystalline state.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: April 26, 2022
    Inventors: Ming Miao, Bo Jiang, Yang Qi, Zhengyu Jin, Chen Chen, Tao Zhang
  • Patent number: 11310968
    Abstract: A system for growing fungi, the system comprising a nutritive vehicle, a porous material, an administrable space, fungal tissue comprising fungal hyphae having a growth pattern, the fungal tissue connecting said nutritive vehicle to said porous material to said administrable space, wherein the fungal tissue within said space defines at least one successive fungal material layer; and a chemically or physically altered separated portion of fungal material, the separated portion separated from said fungal tissue.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: April 26, 2022
    Assignee: MycoWorks, Inc.
    Inventors: Philip Ross, Nicholas Wenner, Caitlin Moorleghen
  • Patent number: 11298389
    Abstract: The present invention provides a method for preparing non-toxic lacquer by detoxifying stems or sprouts of lacquer trees using a malt juice and a fermented rice bran, and a method for manufacturing a fermented rice bran enzyme with improved preservability or a powdered grain nutrient food with improved preservability and dietary property by using the non-toxic lacquer prepared thereby.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: April 12, 2022
    Inventor: Hunam Yoon
  • Patent number: 11286456
    Abstract: The subject invention provides method of producing Trichoderma fungi on an industrial scale. In specific embodiments, the subject invention provides methods of producing both a liquid Trichoderma-based product and a solid-state Trichoderma-based product from the same starting seed culture and inoculant.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: March 29, 2022
    Inventors: Sean Farmer, Ken Alibek, Sharmistha Mazumder
  • Patent number: 11279965
    Abstract: The subject invention provides microbe-based products and efficient methods of producing them. In specific embodiments, methods are provided for symbiotic cultivation of Acinetobacter venetianus RAG1 and Bacillus subtilis B1, as well as growth by-products thereof. Methods are also provided for using the subject microbe-based products, for example, in microbially enhanced oil recovery (MEOR).
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: March 22, 2022
    Inventors: Sean Farmer, Ken Alibek, Yajie Chen