Abstract: The techniques of this disclosure generally relate to a modular stent device that is deployed via supra aortic access through the brachiocephalic artery. The modular stent device is a base or anchor component to which additional modular stent devices can be attached to exclude diseased areas of the aorta while at the same time allowing perfusion of the left common carotid artery and the left subclavian artery.

Abstract: Some embodiments described herein include a heart valve replacement system that may be delivered to the targeted heart valve site via a delivery catheter. In some embodiments, the heart valve replacement system can assemble a valve device after the valve device is delivered to the heart. In some embodiments, heart valve replacement system includes two anterior flaps that are separate but overlap each other.

Abstract: An implantable prosthesis designed to transition from a contracted state to an expanded state, including a continuous tubular helical winding and a plurality of bridges. The helical winding includes a plurality of circumferential sections spaced apart along a helical axis, each of the plurality of circumferential sections forming a non-orthogonal helical angle relative to the helical axis. The plurality of bridges connect adjacent circumferential sections, each having a length extending from a first end to a second end on a plane orthogonal to the helical axis, the length being equal to a circumferential offset between the adjacent circumferential sections in both the contracted state and the expanded state. The implantable prosthesis also includes a first annular ring orthogonal to the helical axis, and a first marker having a first end connected to the first annular ring, and a second end coupled to the first end of the helical winding.

Abstract: A component of an artificial joint according to an exemplary aspect of the present disclosure includes, inter alia, a base plate and a post selectively removable from the base plate. Further, an outer surface of the post includes a layer of the bone ingrowth material along substantially the entire length of the post.

Abstract: A lubricated tubular graft is implanted in the inferior vena cava and the superior vena cava in order to control the inflow of blood to the right atrium. A bifurcated leg with a non-collapsing stent extends across the tricuspid valve. A bioprosthetic valve is positioned proximal of the stent in the bifurcated leg in order to regulate flow through the tricuspid valve and to eliminate tricuspid regurgitation.

Abstract: An implantable prosthetic valve can comprise an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration, the frame defining an axial direction extending from the inflow end to the outflow end, a leaflet structure positioned within the frame and secured thereto, and an annular outer skirt positioned around an outer surface of the frame, wherein the outer skirt comprises an inflow edge secured to the frame at a first location, an outflow edge comprising a plurality of alternating projections and notches, wherein the projections are secured to the frame at a second location, and the notches are not directly secured to the frame, an intermediate portion between the inflow edge and the outflow edge that comprises a plurality of openings.

Abstract: The present disclosure provides devices and methods for treating breasts. The devices can include an acellular tissue matrix having a predefined shape that allows for complete or enhanced coverage of an anterior portion of a breast implant or tissue expander or to support an implant and/or surrounding tissues.

Abstract: The present disclosure relates to drug eluting stents, methods of making, using, and verifying long-term stability of the drug eluting stents, and methods for predicting long term stent efficacy and patient safety after implantation of a drug eluting stent. In one embodiment, a drug eluting stent may include a stent framework; a drug-containing layer; a drug embedded in the drug-containing layer; and a biocompatible base layer disposed over the stent framework and supporting the drug-containing layer. The drug-containing layer may have an uneven coating thickness. In addition or in alternative, the drug-containing layer may be configured to significantly dissolve/dissipate/disappear between 45 days and 60 days after stent implantation. Stents of the present disclosure may reduce, minimize, or eliminate patient risks associated with the implantation of a stent, including, for example, restenosis, thrombosis, and/or MACE.

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 120 ?m. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.

Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.

Abstract: A textured fabric for an implantable bioprosthesis is provided. The textured fabric can include a woven base layer and a plurality of loops projecting from the woven base layer. The plurality of loops are formed from a composite core-sheath yarn. The core can be made of a material that is different from the sheath. The core material can be selected to impart strength and resiliency to bending and the sheath material can be selected to impart a larger surface area or texture that facilitates cellular or tissue in-growth.

Abstract: Luminal grafts and methods of making and using the same. An exemplary luminal graft of the present disclosure is configured as a generally tubular element configured for nerve cells to grow therethrough and comprises at least one sheet of biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof; and a plurality of microchannels formed on a surface of the at least one sheet of biological tissue, each of the microchannels extending longitudinally between a first end and a second end of the at least one sheet of biological tissue and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough.

Abstract: A prosthetic implant transfer device is provided that may be used to insert a prosthetic implant through a surgical opening. In some embodiments, the device may comprise a flexible sheet of material that may be formed into an elongated hollow structure. The flexible sheet of material includes a plurality of fasteners that may be selected and engaged to define a desired size distal opening.

Abstract: A valve device includes a valve, a scaffold connected coaxially to an external surface of the valve, a luminal prosthesis that is adapted to be implanted into a lumen of a patient, with the scaffold and the valve removably attachable inside of the luminal prosthesis.

Abstract: A deficient native mitral valve is treated by implanting a prosthetic mitral valve assembly valve in a patient's heart. The prosthetic mitral valve assembly includes a stent having a flared upper portion, an intermediate portion, and a lower portion. The diameter at the inflow end of the stent is larger than at the outflow end. The prosthetic mitral valve assembly also includes a valve portion formed with pericardial tissue leaflets. A tether has a first end attached to the stent and a second end attached to an anchor. The tether extends through a wall of the left ventricle and the tissue anchor is placed outside the left ventricle. After implantation, the flared upper portion resists movement in the downstream direction and the tether resists movement in the upstream direction for securing the prosthetic mitral valve assembly in the native mitral valve.

Abstract: This prosthesis (1), comprises an expandable tubular frame (2) with a mesh structure and a prosthetic valve (3) mounted on this frame; the ventricular portion (2v) of the frame (2) has a large indentation (6) on one side, extending lengthwise from the end of this ventricular portion (2v) that is opposite said annular portion (2i) to the part of this ventricular portion (2v) close to the annular portion (2i), this indentation (6) extending over a sector of the circumference of the prosthesis (1) of about 90 to 140°; said atrial portion (2a) flares toward the outside of the prosthesis, from said annular portion (2i) toward the end of this atrial portion opposite this annular portion, and comprises anchoring spikes (5a) on the side of said annular portion (2i); and said ventricular portion (2v) has a substantially spherical or ovoid shape and comprises anchoring spikes (5v) on the side of said annular portion (2i).

Abstract: A cover device may include a body with an inner surface and an outer surface, each of the inner surface and the outer surface extending from a first end face of the body to a second end face of the body. The inner surface may define a channel extending through the body from the first end face to the second end face. The outer surface may define a plurality of grooves extending from the first end face to the second end face. Each of the body, the inner surface, and the outer surface may be configured to elastically deform relative to at least an axis of the channel.

Abstract: A biological construct for the repair and replacement of damaged connective tissue is provided. Methods of repairing or otherwise replacing connective tissue are also provided.

Abstract: The present invention relates to a prosthetic mitral valve device for implanting at the native mitral valve region of a heart. The prosthetic mitral valve coaptation enhancement device comprises a main body consisting of a stentframe and a valve element attached thereto, wherein the main body has a sealing section and a valve-bearing section, the valve-bearing section; the shape of the sealing section of the main body, in the compressed state, has a form that is adapted to the coaptation zone of the native mitral valve during systole, and the sealing section of the main body, the radial rigidity of the stentframe is lower than the radial rigidity of the valve-bearing section; the prosthetic mitral valve coaptation enhancement device further comprises at least one anchoring element, which anchoring element is coupled to the main body and is capable to anchor the main body within the native mitral valve region of a heart.

Abstract: Apparatus, systems, and methods for inserting prosthesis implants into surgically-created implant pockets in a subject and for preventing capsular contracture resulting from surgical insertion of prosthesis implants. The apparatus includes a base having an upper surface and a lower surface and having an aperture formed therein which extends through the upper surface and the lower surface of the base. The apparatus also includes a tubular member that is coupled to the base. The inner bore of the tubular member is operable to receive the implant and has a substantially uniform cross-sectional width over the predetermined length. The apparatus is capable of shielding the implant from microbial contamination, including contamination by the endogenous flora of the subject, during insertion of the implant into the surgically-created implant pocket.