Patents Examined by Shafiqul Haq
  • Patent number: 11327074
    Abstract: Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: May 10, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Kayla Cortese, Saji Cherian, Paul D'Agostino, Gabriel Hammarquist, Aili Han, Kuldeep Jaggi, Maral Poladian, Niver Sahakian, Seema Sinha, Prakash Tewari, Haekyung Lee
  • Patent number: 11320430
    Abstract: The present invention relates to a magnetic particle dispersion, and the magnetic particle dispersion includes a magnetic particle, an isothiazoline compound, and an aqueous medium.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: May 3, 2022
    Inventors: Hirokazu Kai, Kousuke Hiroki, Yuuichi Ueya
  • Patent number: 11307206
    Abstract: Beads for use as a control, calibration and/or quantification probe in a mass cytometry assay, wherein the beads are labeled with a heavy metal selected from the group comprising osmium or ruthenium. Also disclosed are beads labeled with a heavy metal exhibiting a surface functionalization that allows for the binding of an affinity reagent, such as a metal-conjugated antibody. Methods are described for the labeling of the beads and usage of the beads for quantification of cell surface receptors or for a compensation of channel crosstalk in mass cytometry assays.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: April 19, 2022
    Inventors: Henrik Mei, Axel Ronald Schulz, Lisa Budzinski
  • Patent number: 11293927
    Abstract: The present disclosure is related to methods of identifying Poly(ADP-ribose) polymerases (PARP) inhibitors, and the methods of using PARP probes.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: April 5, 2022
    Assignee: Ribon Therapeutics, Inc.
    Inventors: Timothy J. N. Wigle, Danielle J. Blackwell, Kevin Wayne Kuntz, Melissa Marie Vasbinder, Laurie B. Schenkel, Kerren Kalai Swinger
  • Patent number: 11285166
    Abstract: The present disclosure discloses simple and efficient glycan- or carbohydrate-based processes or methods for the rapid identification of biological markers and therapeutic targets especially glycan-related targets of infectious diseases, cancers, autoimmune diseases, allergies, inflammation, toxicity, obesity and/or other disorders of humans, animals, plants and other organisms. Therefore, novel methods and products for the diagnosis, prevention, and treatment of such diseases obtainable based on these therapeutic targets can be developed.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: March 29, 2022
    Inventor: Huiru Wang
  • Patent number: 11280789
    Abstract: A cell-capturing substrate, methods of using the cell-capturing substrate that allow for label-free cell separation, and kits that incorporate the cell-capturing substrate.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: March 22, 2022
    Inventors: Wei Shen, Mengen Zhang, Bin Xu
  • Patent number: 11268968
    Abstract: A buffer solution includes methanol and the at least one fluoroalkyl surfactant selected from perfluorocarboxylic acids, perfluorosulfonic acids and their salts. A method for detecting and quantifying, in vitro, vitamin D and/or at least one vitamin D metabolite in a biological sample includes treating the sample by incorporating at least one fluoroalkyl surfactant and methanol so as to dissociate the vitamin D and/or its metabolite(s) to be detected from vitamin D binding protein; and detecting and quantifying vitamin D and/or at least one of its metabolites, in particular by immunoassay. A kit for detecting and quantifying vitamin D and/or at least one vitamin D metabolite by immunoassay and including the solution is provided.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: March 8, 2022
    Assignee: BIOMERIEUX
    Inventors: Valerie Meunier, Emmanuel Moreau
  • Patent number: 11262349
    Abstract: A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: March 1, 2022
    Assignee: Cleveland State University
    Inventors: Moo-Yeal Lee, Xue-Long Sun
  • Patent number: 11255848
    Abstract: A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 22, 2022
    Inventors: Michael S. Strano, Jingqing Zhang, Paul Walter Barone, Daniel A. Heller, Jong-Ho Kim
  • Patent number: 11249078
    Abstract: The invention relates to a method for detecting various analytes, characterized by the following steps: a) providing separation particles containing, on their surface, firstly means of binding the analyte to be identified and secondly means of separating the analyte bound to the particles; b) providing identification particles firstly having, on their surface, means for binding the analyte to be identified and secondly containing on their surface or enclosed therein, means which are capable, after they have been detached or released from the particles, by virtue of their labeling, of generating a signal which serves for identification of the analyte; c) combining analyte, separation particles and identification particles; d) removing and washing the identification particles bound via the analyte by means of the separation particles; e) releasing the means which serve to identify the analyte, characterized in that the means which serve to identify the analyte are coupled reversibly to the identification partic
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: February 15, 2022
    Assignee: IST Innuscreen GmbH
    Inventors: Elmara Graser, Timo Hillebrand
  • Patent number: 11249085
    Abstract: Applicants have developed an amplification system and methodology for IHC and ISH staining that utilizes “click chemistry” to covalently bind reporter molecules to tissue.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: February 15, 2022
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Brian D. Kelly, Nathan W. Polaske
  • Patent number: 11237170
    Abstract: Styryl compounds useful for preparing biological detections probes, and the use of the Styryl compounds for the detection, discrimination and quantification of biological targets.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: February 1, 2022
    Assignee: AAT BIOQUEST, INC.
    Inventors: Zhenjun Diwu, Zhen Luo, Jixiang Liu, Pengfei Dong
  • Patent number: 11226337
    Abstract: Chemoproteomic methods for detecting and profiling electrophilic post-translational modifications (PTMs) and oxidative PTMs in proteins are described. The methods including contacting a proteomic mixture with a probe having hydrazine and alkyne moieties or oxyamine and alkyne moieties to form a covalent linkage between the hydrazine or oxyamine moiety of the probe and the electrophilic PTM or oxidative PTM of the protein. The resulting alkyne-derivatized proteins are labelled with an azide modified tag via a click chemistry reaction. The labelled proteins can then be detected or profiled using techniques such as, for example, fluorescence imaging or mass spectrometry. Also described are protein conjugates having a covalent linkage formed by reaction of a hydrazine or oxyamine moiety of a probe with an electrophilic or oxidative PTM of a protein.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: January 18, 2022
    Assignee: ZENAGEM, LLC
    Inventor: Megan L. Matthews
  • Patent number: 11225527
    Abstract: Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, risperidone and paliperidone in a single lateral flow assay device.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: January 18, 2022
    Inventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
  • Patent number: 11215619
    Abstract: Described are fluorescent merocyanine dyes useful as labels for the detection of target molecules. The dyes may be conjugated to a binding agent, such as an aptamer, or used in label-free assays. An exemplary merocyanine dye termed 4QI based on its 4-methylquinoline and indole heterocycle components is also described as well as phosphoramidite compounds and methods for the detection of targets.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: January 4, 2022
    Assignee: University of Guelph
    Inventors: Richard Manderville, Micaela Gray, Prashant Deore, Andrew Chung, Abigail Van Riesen
  • Patent number: 11209438
    Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: December 28, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, ChengJun Sun, Russell A. Baldocchi
  • Patent number: 11204349
    Abstract: A composition is described comprising superparamagnetic particles. Optionally, the particles comprise microbeads. Optionally, the particles comprise nanobeads. Optionally, the particles are non-spherical particles. Optionally, the particles are non-spherical particles suitable for RNA or DNA extraction. A method is described for forming microparticles. Optionally, the method comprises using citrate precipitation. Optionally, a kit comprising one or more of the particles is described. Optionally, a kit for sample preparation for nucleic acid extraction is described comprising non-spherical microparticles or nanoparticles.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: December 21, 2021
    Assignee: Labrador Diagnostics LLC
    Inventor: Alex Ho Fai Lee
  • Patent number: 11192857
    Abstract: The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: December 7, 2021
    Assignee: ALERE SAN DIEGO, INC.
    Inventors: Fei Huang, Dongpei Wu, Lupe Mejorado, Mariusz Banaszczyk
  • Patent number: 11193057
    Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: December 7, 2021
    Assignee: Life Technologies Corporation
    Inventors: Adam York, Eric Welch, Kyle Gee, Xin Wang, Robert Aggeler, Yi-Zhen Hu
  • Patent number: 11181521
    Abstract: The present invention relates to a method for capturing a molecular target present in the aqueous phase of a water-in-oil emulsion, said method being based on the use of a binding system comprising (a) a surfactant bearing a functional moiety on its hydrophilic head group and (b) a chemoprobe that acts as a molecular staple between the functionalized surfactant and the molecular target and comprises at least two distinct domains namely (i) at least one capture moiety which is able to specifically bind the molecular target and (ii) at least one binding domain which is able to interact with the functional group of the surfactant through covalent or non-covalent interactions, directly or through a binding intermediary.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: November 23, 2021
    Inventors: Alain Wagner, Sylvain Ursuegui, Michael Ryckelynck, Ketty Pernod, Andrew David Griffiths