Patents Examined by Sharon Kennedy
  • Patent number: 7887505
    Abstract: A device for delivering fluid to a patient including an exit port assembly adapted to connect to a transcutaneous patient access tool, a flow path extending from the exit port assembly, and a flow condition sensor assembly including a resilient diaphragm having opposing first and second surfaces. The first surface of the diaphragm is positioned against the flow path, and a chamber wall is positioned adjacent the second surface of the diaphragm and defines a sensor chamber against the second surface of the diaphragm. At least one sensor is arranged to provide a threshold signal when the second surface of the diaphragm expands into the chamber in response to at least one predetermined fluid flow condition occurring in the flow path.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 15, 2011
    Assignee: Insulet Corporation
    Inventor: J. Christopher Flaherty
  • Patent number: 7570992
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: August 4, 2009
    Assignee: Genetronics, Inc.
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Patent number: 7455853
    Abstract: A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I).
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: November 25, 2008
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Karl W. Mollison, Angela M. LeCaptain, Sandra E. Burke, Keith R. Cromack, Peter J. Tarcha, Yen-Chih J. Chen, John L. Toner
  • Patent number: 7419678
    Abstract: A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: September 2, 2008
    Assignees: Cordis Corporation, Wyeth
    Inventor: Robert Falotico
  • Patent number: 7412284
    Abstract: A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and effect introduction of selected molecules into cells of the sample.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: August 12, 2008
    Assignee: Genetronics, Inc.
    Inventor: Gunter A. Hofmann
  • Patent number: 7384411
    Abstract: Tis invention is new apparatuses and methods for treatments to be used from inside conduits or biological pathways. Examples of the biological pathways in which these new apparatuses and methods may be used include arteries, veins, and respiratory ways. Multi-purpose catheters (10) and catheter systems using structures including wires (2108), balloons (2150), and cords (2204) are described as well as methods to use such catheters and catheter systems. One of the embodiments is a configurable wire system which carries or transports radioactive sources. The wire is used in conjunction with a closed-end channel catheter.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: June 10, 2008
    Assignee: Condado Medical Devices Corporation
    Inventor: Jose Antonio R. Condado
  • Patent number: 7361367
    Abstract: A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate a healing process in the patient's vasculature when the microcoil is introduced into the patient's vasculature.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: April 22, 2008
    Assignee: Micrus Endovascular Corporation
    Inventors: Michael Henson, Robert A. Stern
  • Patent number: 7361368
    Abstract: A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: April 22, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Charles D. Claude, Paul J. Kawula, Syed Faiyaz Ahmed Hossainy, Kimchi Tran
  • Patent number: 7351423
    Abstract: This invention relates to an implant for a musculoskeletal defect having a bioactive agent having a concentration gradient.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: April 1, 2008
    Assignee: Depuy Spine, Inc.
    Inventors: Sudhakar Kadiyala, Francois Binette, Cynthia Marie Coleman, Theresa Adams Kapur
  • Patent number: 7348021
    Abstract: The present invention discloses an immunostimulating agent that may be applied to various surgical devices to promote rapid healing and the ready acceptance and integration of the surgical devices with the body tissues at the surgical site.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: March 25, 2008
    Assignee: Brennen Medical, LLC
    Inventor: Barbara K. Klein
  • Patent number: 7348024
    Abstract: Economical and improved pull apart fragrance sampling device constructed of a film to film laminate. The mechanism for release of fragrance is accomplished by providing a microcapsule layer between a top ply and a bottom ply, which upon drying holds the overlying plies together, the microcapsules rupture upon peeling the top ply from the bottom ply, the fragrance is thereby released. A sampler produced as disclosed provides greater stability and shelf life than a paper sampler product while dramatically reducing manufacturing and raw material costs due to it's construction. The sampler provides the maximum flexibility in use and manufacture at a minimum cost.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: March 25, 2008
    Inventor: Christopher Tararuj
  • Patent number: 7332179
    Abstract: The present invention discloses tissue products comprising a cleansing composition. The cleansing composition removes soil and contaminants from the skin's surface and comprises a thermoplastic polymer and a water soluble neutral oligosaccharide. In one embodiment, the cleansing composition comprises polymethylmethacrylate and a water soluble starch.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: February 19, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Annastacia Kistler, David M. Koenig, Duane G. Krzysik, Corey Cunningham
  • Patent number: 7332183
    Abstract: The present invention is directed to multilayer pharmaceutical tablets in which an NSAID and a triptan are present in separate and distinct layers. The layers are in a side-by-side configuration, which allows the dissolution of triptan and NSAID to occur independently and immediately.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: February 19, 2008
    Assignee: Pozen Inc.
    Inventors: John R. Plachetka, Venkata Markandeya Kothapalli, Donna L. Gilbert
  • Patent number: 7328064
    Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: February 5, 2008
    Assignee: Inovio AS
    Inventors: Iacob Mathiesen, Torunn Tjelle, Knut Arvid Sørensen Rekdahl, Bjøm David-Andersen
  • Patent number: 7320801
    Abstract: A patch, or bandage for treating skin infections has a backing with pressure-sensitive adhesive for securing on a user's skin in the area of the boil. A liquid absorbent member is positioned in the center of the patch, while a carrier with a medicinal formulation, comprising a menthol solution, surrounds the absorbent member. The medicinal substance is covered with one or more concentric removable covers, which are peeled off depending on the size of the boil. The menthol solution forms a barrier preventing bacteria from expanding the boil. Once the boil drains, the exudates is absorbed by the absorbent member.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: January 22, 2008
    Inventor: Jack Perez Kelly
  • Patent number: 7315758
    Abstract: A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: January 1, 2008
    Assignee: Lynntech, Inc.
    Inventors: Krzysztof C. Kwiatkowski, Ryan T. Hayes, James W. Magnuson, Anthony Giletto
  • Patent number: 7252834
    Abstract: A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: August 7, 2007
    Assignee: Clemson University Research Foundation (CURF)
    Inventors: Narendra R. Vyavahare, Jason C. Isenburg, Dan T. Simionescu
  • Patent number: 7238363
    Abstract: The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: July 3, 2007
    Assignee: Baylor College of Medicine
    Inventors: Mohammad D. Mansouri, Rabih O. Darouiche
  • Patent number: 7226613
    Abstract: Spherical capsule having a liquid core and a seamless solid shell surrounding the core, in which: the diameter of the capsule is in the range of 4-8 mm; the thickness of the shell is in the range of 20-200 ?m; the shell thickness to capsule diameter ratio is in the range of 0.004-0.04; the shell contains 70-90% (m/m) gelatin and 10-30% (m/m) plasticizer, based on the solids content of the shell; and the core has a flavoring content in the range of 1-100% (m/m), based on the total mass of the core.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: June 5, 2007
    Assignee: Symrise GmbH & Co. KG
    Inventors: Birgit Schleifenbaum, Ines Voigt, Frank Aickele
  • Patent number: RE39668
    Abstract: An intravascular catheter such as a dilatation catheter for angioplasty procedures having a removable distal shaft section. The catheter construction allows the original distal shaft section of the catheter to be removed and a replacement distal shaft section to be secured to the proximal section which is useful with angioplasty catheters when the dimensions of the balloon on the original distal shaft section are inappropriate for dilating a particular stenotic region. Such catheter construction is also useful when there is a need to implant a stent into a dilated stenotic region to maintain its patency.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: May 29, 2007
    Inventors: Celso S. J. Bagaoisan, John P. Shanahan, Ketan P. Muni, Elizabeth N. Hammack, Robert M. Abrams, James C. Peacock, III, William S. Tremulis