Abstract: Process for the production of a diacyl peroxide involving the reaction of an anhydride with an aldehyde and oxygen, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.

Abstract: Process for the production of a diacyl peroxide involving the reaction of an anhydride with hydrogen peroxide, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.

Abstract: Disclosed are methods of treating seizures in a subject. The methods can include administering to the subject in need thereof an effective amount of uridine source and a ketogenic composition including a ketogenic compound.

Abstract: Provided herein are processes for the separation of acetonitrile from low-purity feedstock streams. The provided processes are particularly useful for isolating acetonitrile at high purity from chemical manufacturing waste streams that include methanol, water, and allyl alcohol.

Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

Abstract: There is provided herein a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X1, X2, Y1 to Y4, Z1 to Z3 and n have meanings provided in the description.

Abstract: Use of a stereoselective transaminase in the asymmetric synthesis of a chiral amine. In particular, provided is use of a polypeptide in the production of a chiral amine or a downstream product using a chiral amine as a precursor. Further provided is a method for producing a chiral amine, comprising culturing a strain expressing the polypeptide so as to obtain a chiral amine. Further provided are novel prochiral compounds, a chiral amine production strain and a method for constructing the chiral amine production strain. The stereoselective transaminase has a broad substrate spectrum and thus has a broad application potential in the preparation of a chiral amine.

Abstract: The application relates to a process for the preparation of a compound of formula (II) by cyclisation of a polyene of formula (I), and to an intermediate of formula (III). The obtained compounds are useful intermediates in the preparation of specific isoprenoids, preferably in the production of vitamin A and derivatives of vitamin A.

Abstract: The disclosure relates to methods of treating multiple sclerosis. Also provided are pharmaceutical products containing ponesimod, instructions for use of ponesimod, methods for selling a drug product containing ponesimod, and methods for reducing clinical management events before or during treatment of multiple sclerosis.

Abstract: The invention relates to methods of hydrodeoxygenation of oxygenated compounds into compounds with unsaturated carbon-carbon bonds, comprising the steps of: a) providing a reaction mixture comprising, an oxygenated compound containing one or more of a hydroxyl, keto or aldehyde group, an ionic liquid, a homogeneous metal catalyst, and carbon monoxide or a carbon monoxide releasing compound, b) reacting said reaction mixture under a H2 atmosphere at acidic conditions at a temperature between 180 and 250° C. and a pressure between 10 and 200 bar.

Abstract: An 5,5?-naphthalene-1,5-diylbis(diazene-2,1-diyl)bis(2-hydroxybenzaldehyde) compound, its synthesis, and its use as an antioxidant agent.

Abstract: Disclosed in the present invention is a polyether polyol refining method, comprising (1) neutralising or diluting crude polyether polyol to obtain a mixed solution; (2) flowing the mixed solution through a hydrophilic medium to aggregate same into a first density phase liquid and a second density phase liquid, the first density phase liquid being an aqueous solution containing alkaline metal ions and/or alkaline earth metal ions, and the second density phase liquid being polyether polyol; and (3) allowing the first density phase liquid to settle and separating same from the second density phase liquid to obtain refined polyether polyol. In the present refining method, using the hydrophilic medium for one-step removal of the alkaline ions and water in the polyether polyol simplifies the treatment steps, increases treatment efficiency, and can prevent polyether polyol loss; the obtained polyether polyol has low alkaline ion content and little odour.

Abstract: Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula A, as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, —CF3, or —CH3, and the other is H; and R7 is H or PG.

Abstract: Provided herein are salt and solid forms of (2E,4E)-3-methyl-5-((1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)penta-2,4-dienoic acid, including a Tris salt form of (2E,4E)-3-methyl-5-((1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)penta-2,4-dienoic acid, and polymorphs thereof, methods of preparing the compounds, and their uses.

Abstract: In a cyclic anthraquinone process for producing hydrogen peroxide, which comprises a distillation unit with vapor compression for concentrating hydrogen peroxide, aqueous condensate from the distillation unit is passed over a bed of a cation exchange resin in its protonated from to provide a purified condensate, and the purified condensate is used as extractant for extracting hydrogen peroxide in the anthraquinone process, as column reflux for the distillation unit or as a diluent for diluting an aqueous hydrogen peroxide solution.

Abstract: A bakuchiol derivative, a pharmaceutically acceptable salt thereof, and a preparation method and use of the same. The bakuchiol derivative has a structure shown in formula (I): The above series of amphiphilic antibacterial compounds based on bakuchiol have comparatively excellent antibacterial activities and can overcome the generation of drug resistance of bacteria in drug resistance research simulated in a laboratory.

Abstract: The disclosure relates to methods for treating brain injuries that include administering to a patient a first dosage of about 100 mg to about 500 mg of cannabidiol (CBD) and administering to the patient, concomitantly with the first dosage, a second dosage of about 1 to about 10 milligrams of Psilocybin.

Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A fabric detergent formulation is provided. The formulation comprises a preservative system that includes one or more sorbates in an amount of from about 0.01 wt. % to about 0.8 wt. % of the fabric detergent formulation; one or more anionic surfactants, wherein the weight ratio of the anionic surfactants to the sorbates is about 10 or more; and a solvent system that includes water in an amount of from about 50 wt. % to 100 wt. % of the fabric detergent formulation. The pH of the fabric detergent formulation is about 6.5 or more.

Abstract: The present disclosure provides methods whereby products can be prepared in a manner that adds value to the products beyond the market value of such products, and the present disclosure further provides methods for optimizing production of products toward processes that yield a positive net result. The methods for preparing a product can utilize a synthesized oxide compound and, depending upon the order of combination, can modify the synthesized oxide compound by combination with both of carbon dioxide and a secondary component.