Patents Examined by Sin J. Lee
  • Patent number: 11026891
    Abstract: The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: June 8, 2021
    Assignee: Eth Zurich
    Inventors: Jean-Christophe Leroux, Simon Matoori, Aaron Christoph Schmidt
  • Patent number: 11007501
    Abstract: Disclosed is a composition including controlled release particles, wherein each of the controlled release particles includes: (a) a core including at least one hydrophobic active ingredient; and (b) a wall at least partially surrounding the core and including: (i) an outer layer including a copolymer of polyacrylamide and polyacrylate; (ii) an intermediate layer under the outer layer and including a polyurea; (iii) an inner layer under the intermediate layer and including an acrylate copolymer; and optionally (iv) an optional outer layer above the outer layer and including a quaternary amine containing moiety, wherein the inner layer is a mesh and the controlled release particles are effective to retain the at least one hydrophobic active ingredient upon exposure to water and effective to release the at least one hydrophobic active ingredient in response to friction. A method for preparing the composition is also disclosed.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: May 18, 2021
    Assignee: Trucapsol LLC
    Inventor: Praveen Bachawala
  • Patent number: 11000462
    Abstract: The present invention relate to liquid cleansing compositions comprising 12-HSA which are both processable and stable. Applicants have defined a specific composition window (defined by specific types and ratios of fatty acid and/or fatty acid soaps, as well as critical ceiling for 12-HSA and floor levels of polyol) where these objectives can be met.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 11, 2021
    Assignee: Conopco, Inc.
    Inventors: Leonora Yokubinas, Jessica Ann Krisiak, Kevin David Hermanson
  • Patent number: 10966912
    Abstract: The present invention belongs to the fields of pharmaceuticals and cosmetics, and concerns on the one hand a medicament for the inhibition of and refers also on the cosmetic, non-therapeutic use for the treatment of hyperpigmentation, particularly induced by sun light radiation, preferably induced by visible light radiation.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: April 6, 2021
    Assignee: Symrise AG
    Inventors: Marielle Le Maire, Imke Meyer, William Johncock
  • Patent number: 10966921
    Abstract: The invention relates to the use of an oral bolus for drying-off cattle, preferably daily cattle, as well as methods of improving/facilitating the drying-off of cattle, reducing the milk production in pregnant and/or lactating cattle, decreasing milk accumulation in the udder of cattle, increasing the daily lying time of cattle, inducing a mild and temporary metabolic acidosis in cattle, reducing the dry matter intake (DMI) in cattle and/or reducing urine pH in cattle, preferably dairy cattle, comprising administering to such cattle at least one oral bolus, preferably on the last milking day and/or before dry-off.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: April 6, 2021
    Inventors: Daniel Zaspel, Juergen Bubeck, Holger Enderle, Laurent Goby, Leif Hoejvang-Nielsen
  • Patent number: 10961245
    Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, the compounds of Formula I: in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of central nervous system (CNS) diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 30, 2021
    Inventors: Peng Li, Robert Davis
  • Patent number: 10953023
    Abstract: The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: March 23, 2021
    Assignee: Applaud Medical, Inc.
    Inventors: Daniel J. Laser, Alice Luong, Robert G. Miotke
  • Patent number: 10933019
    Abstract: The present invention relates to liquid pharmaceutical compositions comprising daptomycin, methods of providing such compositions and the use thereof. Provided herein are formulations comprising daptomycin, one or more polar protic solvents, and mixtures thereof. Formulations according to the present invention can further comprise polar aprotic solvent and/or source of calcium.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: March 2, 2021
    Inventors: Tina Gjoni, Dubravka Strazic
  • Patent number: 10932998
    Abstract: The present invention relates to a fluid/creamy pigmented hydrogen peroxide-based oxidising composition, to be used in combination with persulfates-based hair bleaches or with dyes, lightening, super-lightening products. The composition of the semi-finished product includes hydrogen peroxide in various titles in proportions from 1% to 12% by weight, plus other substances in addition to a first dye which provides the semi-finished product with a yellow/green colour at an acid pH. By combining the oxidising composition (first product) with bleaching products of various nature/lightening dyes (second product) in an emulsion, the pH of the emulsion becomes strongly alkaline, from the initial 2-3 it may increase up to 11.5. In this pH transition from acid to alkaline, the oxidising emulsion changes its colour from yellow/green to blue.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: March 2, 2021
    Inventor: Mara Dall'Oglio
  • Patent number: 10925816
    Abstract: The present invention relates to: a composition for transdermal delivery, comprising 1) a nanoemulsion comprising an active ingredient, saturated lecithin, phytosteryl/behenyl/octyldodecyl lauroyl glutamate, a polyol, and water, and 2) a modified layered double hydroxide; and a preparation method therefor.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: February 23, 2021
    Assignee: H&A PHARMACHEM CO., LTD.
    Inventors: Jong Hyeon Lee, Se Hee Cho, Young Rong Woo, Young Ah Park, Hong Geun Ji
  • Patent number: 10894023
    Abstract: Disclosed herein is an oral dosage formulation suitable for treating a neurodegenerative disorder. The oral dosage formulation contains both sustained-release and immediate-release drugs. The sustained-release drug in the oral dosage formulation is memantine, and the immediate-release drug in the oral dosage formulation is donepezil and/or memantine, and the formulation is characterized in having a pH-independent dissolution profile of memantine at a pH range from about 1.0 to about 7.0.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: January 19, 2021
    Inventors: Meng-Ju Lee, Shu-Hsien Chang, Chih-Chiang Yang, Yuan-Chih Le, Tse-Ching Lin, Ko-Chiang Chen, Lai-Cheng Chin, Tai-Yin Ke, Pei-Ying Liao
  • Patent number: 10888552
    Abstract: Compositions and methods for stimulating erogenous zones of female and male subjects are disclosed. More particularly, the present disclosure relates to compositions for topical application to the female and male genitalia that increase cell membrane excitability and to methods of using the compositions for treating sexual dysfunction and enhancing sexual arousal and facilitating orgasm.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 12, 2021
    Inventor: Steven Rothman
  • Patent number: 10888513
    Abstract: The invention provides a personal cleansing composition comprising: (i) an aqueous continuous phase including cleansing surfactant; (ii) one or more oily liquid conditioning agents for skin and/or hair wherein the agent is solubilized in wormlike micelles in the aqueous continuous phase via the incorporation of at least one inorganic electrolyte and at least one linker molecule; (iii) one or more cationic deposition polymers which are selected from cationic polygalactomannans having a mean charge density at pH7 from 0.2 to 2 meq per 10 gram; and (iv) a hair substantive cationic conditioning polymer which is a homopolymer of (3-acrylamidopropyl) trimethyl ammonium chloride.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: January 12, 2021
    Assignee: Conopeo, Inc.
    Inventors: Ningning Li, Arash Mohajer Moghadam, Joseph Muscat, Cheryl Anne Taylor
  • Patent number: 10881595
    Abstract: The present disclosure relates to an antiperspirant composition for a roll-on application comprising a) at least one antiperspirant active substance including an inorganic or organic salt of aluminum, zirconium or a mixture thereof, b) a rice starch and c) a hydrophobically modified clay mineral. Furthermore, the present disclosure relates to a roll-on applicator including a composition as contemplated herein, and a non-therapeutic use of a composition as contemplated herein.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: January 5, 2021
    Assignee: Henkel AG & Co. KGaA
    Inventor: Thomas Doering
  • Patent number: 10869816
    Abstract: A powder additive for a keratin fiber coloring or bleaching agent or developer is provided. The powder additive includes a dicarboxylic acid containing from about 2 to about 10 carbon atoms, selected from the group of malic acid, D-tartaric acid, L-tartaric acid, meso-tartaric acid, racemic acid, alpha-ketoglutaric acid, beta-ketoglutaric acid, oxaloacetic acid, maleic acid, fumaric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, azelaic acid, sorbic acid, a salt of these dicarboxylic acids, and mixtures thereof. The powder additive also includes an amino acid or a salt of an amino acid and an alkalisilicate. The powder additive has no greater than about 10% by weight water, based on the weight of the powder additive. In addition, the powder additive includes particles and at least about 80% of the particles have an average particle size of less than 200 ?m.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: December 22, 2020
    Inventors: Hartmut Manneck, Thomas Hippe, Marc Stucky, Stephanie Smith, Robert Schaeffler
  • Patent number: 10849845
    Abstract: Disclosed is a composition including (per 100% weight): a) 90 wt.-% to 99.0 wt.-% water including, in dissolved form, 0.002 mol/L to 0.1 mol/L of at least one salt of ammonium cation or of a monovalent or multivalent metal cation with an organic or inorganic anion; b) 0.5 wt.-% to 5 wt.-% of a crosslinked anionic polyelectrolyte; and c) 0.5 wt.-% to 5 wt.-% of a compound having formula (II): R1—(O—CH2—CH2)p—OH (II), where the weight ratio of the crosslinked anionic polyelectrolyte to the compound of formula (II) is greater than or equal to 0.2 and less than or equal to 2.0, and the molar ratio of the compound of formula (II) to the salt greater than or equal to 0.05 and less than or equal to 1. Also disclosed is a composition in cosmetics and a method for lightening the thickened salt-rich composition.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: December 1, 2020
    Inventors: Benoît Verdu, Cindy Sourdon, Alicia Roso
  • Patent number: 10836872
    Abstract: A visible light-curable chitosan derivative, a hydrogel thereof, and a preparation method therefor are disclosed. The visible light-curable glycol chitosan derivative is curable by light in the visible light range and has a wound healing activity. A hydrogel obtained by cross-linkage of the visible light-curable glycol chitosan derivative using visible light has a wound healing effect per se, and further, a hydrogel obtained by cross-linkage in a combination of one or more growth factors has an excellent wound healing effect. In addition, a glycol chitosan hydrogel that can prevent the denaturation of contained drugs and growth factors due to the cross-linkage by visible light and is optimized for application to a wet dressing dosage form can be prepared.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: November 17, 2020
    Inventors: Dae Hyeok Yang, Heung-Jae Chun, Dong In Seo
  • Patent number: 10828241
    Abstract: Compositions and methods for effecting skin lightening and/or even toning involving the use of select aryl alkanones.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: November 10, 2020
    Inventor: Ratan K. Chaudhuri
  • Patent number: 10813362
    Abstract: The present disclosure relates to a composition that includes lemongrass, castor oil, cedarwood oil, geraniol, sodium laurel sulfate, and corn oil for repelling and killing mosquitos. In one aspect of the inventive compositions comprise Guatemalan lemongrass, Juniperus virginiana and cedarwood oil. Some compositions further comprise mint oil, e.g., and Montana mint oil. Compositions according to the inventive subject matter kill insects at multiple stages in their life cycle including adult insects, larvae, and disrupt the egg cycle. In another aspect, the inventive compositions repel insects and retain repellency and insecticidal potency over a longer period of time than other natural insect repellents.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: October 27, 2020
    Assignee: Operation Organic LLC
    Inventors: Neil B. Teevan, Lanny Weaver
  • Patent number: 10811166
    Abstract: Embodiments of the present disclosure pertain to methods of making conductive films by associating an inorganic composition with an insulating substrate, and forming a porous inorganic layer from the inorganic composition on the insulating substrate. The inorganic layer may include a nanoporous metal layer, such as nickel fluoride. The methods of the present disclosure may also include a step of incorporating the conductive films into an electronic device. The methods of the present disclosure may also include a step of associating the conductive films with a solid electrolyte prior to its incorporation into an electronic device. The methods of the present disclosure may also include a step of separating the inorganic layer from the conductive film to form a freestanding inorganic layer. Further embodiments of the present disclosure pertain to the conductive films and freestanding inorganic layers.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: October 20, 2020
    Inventors: James M. Tour, Yang Yang, Gedeng Ruan