Patents Examined by Stephen Chong
  • Patent number: 8530205
    Abstract: The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: September 10, 2013
    Assignee: IL Dong Pharm Co., Ltd.
    Inventors: Dae-Jung Kang, Jong-Hyuk Im, Hyun-Jung Jung, Jae-Hoon Kang
  • Patent number: 8512976
    Abstract: Disclosed is a method of selectively inhibiting for growth of non-target cells in a mixed population of target and non-target cells, the method comprising the steps of: (a) contacting the mixed population with a selective agent which comprises a carrier moiety linked by a scissile linkage to a toxic moiety; wherein the selective agent is able to enter non-target cells in which the scissile linkage is cleaved, releasing the toxic moiety to exert a toxic effect on the non-target cells causing inhibition of the growth of the non-target cells, whereas the selective agent is unable to enter target cells and/or the scissile linkage is not cleaved in target cells and/or toxic moiety, if released from the selective agent, does not exert a toxic effect on the target cell; and (b) culturing the cells in conditions which allow for growth of non-inhibited cells.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 20, 2013
    Assignee: Oxoid Limited
    Inventor: Patrick Druggan
  • Patent number: 8486669
    Abstract: A process for preparing glucose from a cellulose material, in which a cellulose-comprising starting material is provided and treated with a liquid treatment medium comprising an ionic liquid whose anions are selected from among polyatomic anions and the cellulose-comprising material which has been treated with the ionic liquid is subjected to an enzymatic hydrolysis, is described.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: July 16, 2013
    Assignee: BASF SE
    Inventors: Tim Balensiefer, Julia Brodersen, Giovanni D'Andola, Klemens Massonne, Stephan Freyer, Veit Stegmann
  • Patent number: 8460652
    Abstract: A topical anti-aging skin care formulation comprising an effective amount of a benzoquinone, such as CoQ10, plus a synergistic pair of stabilizers and a synergistic pair of whiteners. The stabilizers are octyl salicylate and octyl methoxycinnamate. The whiteners are titanium dioxide and zinc oxide. When proper amounts of these ingredients are used in an aqueous based emulsion formulation, the product will be initially white, and will remain white for an extended period of time.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: June 11, 2013
    Inventor: Louise Holyfield