Patents Examined by T. D. Wessendorf
  • Patent number: 7625570
    Abstract: The present invention provides methods of purifying adeno-associated virus (AAV) from compositions comprising AAV and at least a second, non-AAV; and methods for selectively inactivating a non-adeno-associated virus (non-AAV) in a liquid composition comprising AAV and the non-AAV. The methods generally involve subjecting the composition to hydrostatic pressure such that the non-AAV is selectively inactivated.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: December 1, 2009
    Assignee: The Regents of the University of California
    Inventors: David V. Schaffer, Joshua N. Leonard
  • Patent number: 7598344
    Abstract: The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: October 6, 2009
    Assignee: Board of Regents, The University of Texas System
    Inventors: Angela M. Belcher, Christine J. Schmidt, Kiley P. H. Miller, Archit Sanghvi
  • Patent number: 7576198
    Abstract: A compound of the formula (I): wherein X is hydroxy or the like; Y is —C(?R2)—R3—R4 wherein R2 and R3 is oxygen atom or the like, R4 is hydrogen, optionally substituted alkyl, optionally substituted heteroaryl or the like; Z is hydrogen or the like; Z1 and Z3 each is independently a bond, alkylene or the like; Z2 is a bond, alkylene, —O— or the like; R1 is optionally substituted aryl, optionally substituted heteroaryl or the like; p is 0 to 2 and ring (A) is optionally substituted aromatic heterocycle, a tautomer of itself, a prodrug thereof, a pharmaceutically acceptable salt thereof or a solvate thereof has an integrase-inhibiting activity.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: August 18, 2009
    Assignee: Shionogi & Co., Ltd.
    Inventors: Takashi Kawasuji, Tomokazu Yoshinaga
  • Patent number: 7575928
    Abstract: This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of intestines and colorectal cancer tissue; (2) collecting genes with highly differential gene expression by Suppression Subtractive Hybridization (SSH), and building library; (3) deriving colonies with relatively high signal intensities from cancer tissue; (4) collecting more clinically cancer tissues by Northern Hybridization, real-time Polymerase Chain Reaction (PCR) combined with analysis of bioinformation to affirm variation between differential gene expression; and (5) selecting the most suitable genes from said library, and using the gene sequence as reagent provides the effects of early diagnosis, specificity, highly sensitivity and safety.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: August 18, 2009
    Assignee: Kaohsiung Medical University
    Inventors: Shiu-Ru Lin, Jaw-Yuan Wang
  • Patent number: 7569540
    Abstract: A method for improved administration of nutrient is provide. The method includes co- or separate administration of a source of nutrients, especially carbohydrates, and insulinotropic peptides and derivatives, analogs, fragments and the like. The method provides high carbohydrate nutrition while avoiding hyper- and hypo-glycemia and their attendant deleterious effects.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: August 4, 2009
    Assignee: Amylin Pharmaceuticals, Inc.
    Inventors: Michael A. Nauck, Fred A. Wagner
  • Patent number: 7556929
    Abstract: Methods and kits for identifying novel anti-tumor agents are provided.
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: July 7, 2009
    Assignee: Tufts University
    Inventor: Dean Dawson
  • Patent number: 7541157
    Abstract: The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: June 2, 2009
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Vincent Dive, André Menez, Reto Stocklin, Bertrand Tavitian, Fabrice Beau, Bertrand Czarny, Joël Cotton
  • Patent number: 7488590
    Abstract: Pharmacologically active compounds are prepared by (a) selecting at least one peptide that modulates the activity of AGP-3, (b) preparing a gene construct that comprises at least one said selected sequence, and (c) expressing the pharmacologically active compound in which an Fc domain is covalently linked to the selected peptide. The pharmacologic agent can be expressed in E. coli.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: February 10, 2009
    Assignee: Amgen Inc.
    Inventors: Ulrich Feige, Chuan-Fa Liu, Janet C. Cheetham, Thomas Charles Boone, Jean Marie Gudas
  • Patent number: 7452675
    Abstract: The invention relates, in part, to methods useful in identifying molecules, that bind TRPM4b, which modulate TRPM4b ion channel activity, and/or which alter expression of TRPM4b within cells. The TRPM4b channels as described herein contain TRPM4b polypeptides, which are in turn encoded by TRPM4b nucleic acids. The ion channels described herein are preferably formed in HEK-293 cells from one or more novel TRPM4b polypeptides, which exhibit one or more of the unique TRPM4b properties described herein.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: November 18, 2008
    Assignee: The Queen's Medical Center
    Inventors: Reinhold Penner, Andrea Fleig
  • Patent number: 7432063
    Abstract: This invention provides methods of obtaining a binding molecule, e.g., an antibody, that has enhanced affinity for a binding partner relative to a reference binding molecule.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: October 7, 2008
    Assignee: KaloBios Pharmaceuticals, Inc.
    Inventors: Robert F. Balint, Jeng-Horng Her
  • Patent number: 7425608
    Abstract: Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at least one orthogonal sulfur-protecting group, in which the peptide, peptidomimetic or construct is conformationally fixed on deprotection of the sulfur and complexation of the metal ion-binding region with a metal ion while the peptide, peptidomimetic or construct is cleavably bound to solid phase.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: September 16, 2008
    Assignee: Palatin Technologies, Inc.
    Inventors: Shubh D. Sharma, Yi-Qun Shi
  • Patent number: 7422861
    Abstract: Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can be screened efficiently in a high-throughput format, and selected peptoids are identified post-screening.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: September 9, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Ronald N. Zuckermann, Christoph J. Reinhard, Anne B Jefferson, Eric Beausoleil
  • Patent number: 7416847
    Abstract: The present invention relates to methods of producing peptide or protein expression libraries. In such a library, a population of nucleotide sequences is expressed. The resulting peptides or proteins encoded by those nucleotide sequences are then screened to identify those peptides or proteins having a desired property such as the ability to bind a selected ligand. In the construction and screening of such libraries, it is desired to ensure that the nucleotide encoding a particular protein remains connected in some way with that protein so that once a desired protein having a selected property has been isolated, its encoding nucleotide sequence may be specifically recovered for subsequent manipulation for example using PCR or sequencing. The present invention makes use of a property not previously described in constructing an expression library namely the use of proteins which covalently bind DNA.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: August 26, 2008
    Assignee: Isogenica Limited
    Inventors: Bjorn H. Lindqvist, David Andrews, Elizabeth Haggard-Ljungquist, Morten Isaksen
  • Patent number: 7402392
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: July 22, 2008
    Assignee: Vanderbilt University
    Inventors: Dennis E. Hallahan, Shimian Qu
  • Patent number: 7390619
    Abstract: This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 24, 2008
    Assignee: Maxygen, Inc.
    Inventors: Juha Punnonen, Willem P. C. Stemmer, Robert Gerald Whalen, Russell J. Howard
  • Patent number: 7374893
    Abstract: The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: May 20, 2008
    Assignee: Board of Regents, University of Texas System-
    Inventors: Angela M. Belcher, Brian D. Reiss, Chuanbin Mao, Daniel J. Solis
  • Patent number: 7351540
    Abstract: Novel methods for the identification and/or sequencing of proteins are provided. These methods are particularly suited to screening antibody libraries and in preferred embodiments make use of mass spectrometry techniques for direct or indirect sequencing.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: April 1, 2008
    Assignee: Merck Patent GmbH
    Inventor: Francis J. Carr
  • Patent number: 7338762
    Abstract: The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: March 4, 2008
    Assignee: Board of Regents, The University of Texas System
    Inventors: David G. Gorenstein, Xianbin Yang, Bruce A. Luxon, Norbert Herzog
  • Patent number: 7294472
    Abstract: This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these methods also are disclosed.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: November 13, 2007
    Assignee: Caden Biosciences
    Inventors: Annette Gilchrist, Heidi M. Hamm
  • Patent number: RE39887
    Abstract: Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: October 16, 2007
    Assignee: Pharma Mar, S.A.
    Inventors: Kenneth L. Rinehart, Anna M. Lithgow-Bertelloni