Patents Examined by Taeyoon Kim
  • Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders
    Patent number: 10124025
    Abstract: Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can include Bacteroides (e.g., B. fragilis, B. thetaiomtaomicron, and/or B. vulgatus), and/or Enterococcus (e.g., E. faecalis, E. faecium, E. hirae, E. avium, E. durans, E. gallinarum, or E. casseliflavus). Upon treatment, one or more ASD-related behaviors can be improved in the subject.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: November 13, 2018
    Assignee: California Institute of Technology
    Inventors: Elaine Hsiao, Sara McBride, Sarkis K. Mazmanian, Paul H. Patterson
  • Method for inducing differentiation of pluripotent stem cells into neural precursor cells
    Patent number: 10119120
    Abstract: The present invention provides a method for inducing differentiation of pluripotent stem cells into neural precursor cells, comprising culturing the pluripotent stem cells in the presence of a small molecule BMP inhibitor, and induced neural precursor cells prepared by this method.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: November 6, 2018
    Assignee: Kyoto University
    Inventors: Jun Takahashi, Asuka Morizane
  • Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same
    Patent number: 10117884
    Abstract: The present invention includes compositions and methods of making and using a dietary supplement manufactured from one or more natural polysaccharides previously incubated with a probiotic bacteria in a bioreactor system, wherein the bacteria process the polysaccharides and the resulting processed polysaccharide are provided in the nutritional supplement.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: November 6, 2018
    Assignee: MANNATECH, INC.
    Inventor: Robert A. Sinnott
  • Specific detection and quantification of cardiolipin and isolated mitochondria by positively charged AIE fluorogens and method of manufacturing thereof
    Patent number: 10113968
    Abstract: The present subject matter relates to a one-step method of detecting and quantifying cardiolipin in a sample using a positively charged AIE luminogen by introducing the AIE luminogen to a solution containing the sample and measuring fluorescence intensity of the solution; a method of quantifying isolated mitochondria using a positively charged AIE luminogen by staining a sample containing isolated mitochondria with the AIE luminogen and measuring the fluorescence intensity; and a method of quantifying isolated mitochondria using a positively charged AIE luminogen by introducing the AIE luminogen to a sample containing isolated mitochondria, wherein the AIE luminogen stains the isolated mitochondria and identifying the stained isolated mitochondria under microscope.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: October 30, 2018
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Yuning Hong, Wai Tung Leung
  • Methods and compositions for delivering interleukin-1 receptor antagonist
    Patent number: 10106587
    Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: October 23, 2018
    Assignee: Biomet Biologics, LLC
    Inventors: Joel C. Higgins, Jennifer E. Woodell-May, Jacy C. Hoeppner
  • Methods and compositions for treatment of bone defects with placental cell populations
    Patent number: 10105399
    Abstract: Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: October 23, 2018
    Assignee: CELULARITY, INC.
    Inventors: James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Kristen S. Labazzo, Marian Pereira, Sascha Dawn Abramson
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 10094821
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: October 9, 2018
    Assignee: Organovo, Inc.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
  • Methods for inducing the differentiation of blood monocytes into functional dendritic cells
    Patent number: 10087418
    Abstract: Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins. The leukocyte concentrate comprising monocytes and plasma containing proteins is pumped through a plastic treatment device, such as a photopheresis device. The resulting treated cells may be incubated for a sufficient period of time to allow the monocytes to form dendritic cells, or the treated cells may be reinfused directly to the subject.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 2, 2018
    Assignee: YALE UNIVERSITY
    Inventor: Richard Leslie Edelson
  • Modeling connections between dopaminergic neurons and the cerebral cortex
    Patent number: 10081791
    Abstract: Disclosed are methods that include separately differentiating stem cells to form cortical neural progenitor cells and differentiating stem cells to form dopaminergic neural progenitor cells. The cortical progenitor cells are transferred to a first compartment of a culture dish and the dopaminergic progenitor cells are transferred to a second compartment of the culture dish, separated by a removable barrier. The cortical progenitor cells and dopaminergic progenitor cells are cultured in medium that promotes differentiation of cortical neurons and dopaminergic neurons, respectively. The barrier is then removed, creating a single chamber containing the cortical progenitor cells and the dopaminergic progenitor cells, separated by a gap.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: September 25, 2018
    Inventors: William J. Freed, Chun-Ting Lee
  • Method for producing ciliary marginal zone-like structure
    Patent number: 10077425
    Abstract: The invention provides a method for producing a cell aggregate containing a ciliary marginal zone-like structure by culturing a cell aggregate containing a retinal tissue in which Chx10 positive cells are present in a proportion of 20% or more of the tissue in a serum-free medium or serum-containing medium, each containing a substance acting on the Wnt signal pathway for only a period before the appearance of a RPE65 gene expressing cell, followed by culturing the “cell aggregate in which a RPE65 gene expressing cell does not appear” thus obtained in a serum-free medium or serum-containing medium, each not containing a substance acting on the Wnt signal pathway and so on.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: September 18, 2018
    Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, RIKEN
    Inventors: Tokushige Nakano, Satoshi Ando, Yoshiki Sasai, Mototsugu Eiraku
  • Methods of producing RPE cells and compositions of RPE cells
    Patent number: 10077424
    Abstract: The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: September 18, 2018
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Christopher Malcuit, Linda Lemieux, William Holmes, Pedro Huertas, Lucy Vilner
  • Process for separating and determining the viral load in a pancreatin sample
    Patent number: 10072256
    Abstract: Processes for separating an infectious viral load from a pancreatin sample and for quantitatively determining the viral load in a pancreatin sample are described herein.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: September 11, 2018
    Assignee: ABBOTT PRODUCTS GMBH
    Inventors: Frauke Busse, Martin Frink, Dietmar Becher, Leopold Doehner
  • Cell sorting method
    Patent number: 10072242
    Abstract: The invention provides a method of removing or reducing undifferentiated cells from a differentiated cell population contaminated or having a risk of contamination with undifferentiated cells by contacting a pigment epithelium-derived factor with the differentiated cell population to induce apoptosis of the undifferentiated cells. The invention also provides an agent for cell transplantation therapy, containing a differentiated cell population substantially free of an undifferentiated cell, which is obtained by the method, as well as an agent for inducing apoptosis of an undifferentiated cell, containing a pigment epithelium-derived factor, and combined use of the aforementioned agent for cell transplantation therapy and the aforementioned agent for inducing apoptosis.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: September 11, 2018
    Assignee: Foundation for Biomedical Research and Innovation at Kobe
    Inventors: Hoshimi Kanemura, Masahiro Go, Shin Kawamata, Naoki Nishishita
  • Hematopoietic cell phenotyping using circulating cell-free markers
    Patent number: 10067133
    Abstract: The present invention provides methods of classifying cluster of differentiation (CD) marker phenotype for hematopoietic cancer cells using multiple circulating cell-free CD markers in bodily fluid. In other aspects, treatment and disease progression of particular hematopoietic cancers can be monitored by measuring the levels of CD and other markers in bodily fluids of a patient.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: September 4, 2018
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Maher Albitar
  • Cosmetic compositions
    Patent number: 10064813
    Abstract: Disclosed are compositions and methods for their use that can be used in cosmetic applications. The composition can include an effective amount of a Centella asiatica stem cells to reduce the activity of hyaluronidase in skin, an effective amount of tetradecyl aminobutyroylvalylamino butyric urea trifluoroacetate or Alpinia galanga leaf extract to promote the production of hyaluronic acid in skin, an effective amount of tripeptide-1 to promote the production of fibronectin and laminin in skin, and a dermatologically acceptable vehicle.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 4, 2018
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan
  • Systems and methods for characterizing kidney diseases
    Patent number: 10060930
    Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: August 28, 2018
    Assignee: Renovar Incorporated
    Inventors: Huaizhong Hu, Stuart Knechtle
  • Method for differentiating pluripotent stem cell induced from mesenchymal stem cell into osteoblast
    Patent number: 10053669
    Abstract: The present invention relates to a medium composition containing an Ecklonia cava extract for dedifferentiation an induced pluripotent stem cell. Also, the present invention relates to a method for differentiating an induced pluripotent stem cell produced by using the medium composition into osteoblasts. When using the medium composition according to the present invention, induced pluripotent stem cells using mesenchymal stem cells can be produced efficiently, and the pluripotent stem cells which have been produced can be useful as a cell treatment agent by being capable of being differentiated into osteoblasts.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: August 21, 2018
    Assignee: BBHC Co., Ltd.
    Inventors: Sang Yeon Lee, Won Ju Jung, Ho Bin Kim, Min Sun Oh, Kye Ho Lee
  • Mesenchymal stem cells for the treatment of CNS diseases
    Patent number: 10052363
    Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
    Type: Grant
    Filed: September 11, 2016
    Date of Patent: August 21, 2018
    Assignees: Ramot at Tel-Aviv University Ltd., Brainstorm Cell Therapeutics Ltd.
    Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
  • Method for increasing ethanol yield from grain
    Patent number: 10053710
    Abstract: A process for increasing ethanol yield from grain that includes mixing grain, water and cavitated enzymes to form a grain-based liquid medium wherein the cavitated enzymes have increased activity and promote increased ethanol yield form the grain. The enzymes are passed individually through a cavitation apparatus at a velocity and pressure capable of generating a cavitation activation energy of at least 0.4 kJ per kilogram of liquid medium to enhance enzyme activity and increase ethanol yield.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: August 21, 2018
    Assignee: ARISDYNE SYSTEMS, INC.
    Inventor: Oleg Kozyuk
  • Method for recovering selenium
    Patent number: 10047378
    Abstract: An object of the present invention is to provide a method for efficiently recovering solid selenium or gaseous selenium from wastewater/waste using a microorganism. The present invention provides a method for recovering selenium, comprising reducing a water-soluble selenium compound so as to produce elemental selenium or gaseous selenium by allowing a sample containing a water-soluble selenium compound to come into contact at a temperature which is more than 35° C. and is 40° C. or less at pH 7.0 to 9.4 with a microorganism capable of producing elemental selenium or gaseous selenium through reduction of a water-soluble selenium compound.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: August 14, 2018
    Assignee: SHIBAURA INSTITUTE OF TECHNOLOGY
    Inventor: Mitsuo Yamashita