Patents Examined by Taeyoon Kim
  • Histological specimen treatment
    Patent number: 10641688
    Abstract: A single dissolving compound forms plural azeotropes, which can be azeotropically vaporized off at various stages of the treatment process, thus maintaining predictable concentrations of the chemicals present. The treatment process can be performed in the absence of formalin or related compounds which can interfere with the preservation of genetic material. A process for preserving a specimen includes using a dissolving compound that can form a plural number of azeotropes, at least one azeotrope being formed between one or more components of the dissolving compound and specimen-supplied water, and at least one azeotrope being formed between different components of the dissolving compound; successively and azeotropically vaporizing off formed azeotropes; and impregnating the specimen with a support medium.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: May 5, 2020
    Inventor: Steven Wheeler
  • Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
    Patent number: 10632155
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: April 28, 2020
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • In-vitro embryonic culture medium comprising an inhibitor of cathepsin L and the use of the same in embryo cryopreservation
    Patent number: 10624336
    Abstract: The present invention belongs to the technical field of embryo cryopreservation. In particular, the present invention relates to an in-vitro embryonic culture medium for improving the thawed recovery rate of an embryo, comprising an inhibitor of Cathepsin L inhibitor, for example, E-64d. The present invention also relates to a method for improving the freezing resistance and the thawing recovery rate of an embryo and a method for freezing an embryo. With the present invention, the freezing resistance and the thawing recovery rate of an embryo are significantly improved.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: April 21, 2020
    Assignee: BEIJING UNIVERSITY OF AGRICULTURE
    Inventors: Yong Guo, Hemin Ni, Yu Chen, Di Liu, Xiangguo Wang, Xiaolong Qi
  • Deparaffinization of tissue by electric field generation and ionization
    Patent number: 10613005
    Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: April 7, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Victor Lim, Carol T. Schembri, Adrienne Mccampbell, Nazumi Alice Yama-Dang
  • Low gluten yeast hydrolysates
    Patent number: 10604780
    Abstract: The present invention relates to a process for preparing a yeast hydrolysate comprising less than 100 ppm gluten and at least 1 ppm gluten based on salt-free yeast dry matter.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: March 31, 2020
    Assignee: DSM IP ASSETS B.V.
    Inventor: Petrus Norbertus Van Beelen
  • Enrichment and selective culture of mycobacteria
    Patent number: 10597693
    Abstract: A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4?-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibiting Pseudomonas aeruginosa bacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: March 24, 2020
    Assignee: BIOMERIEUX
    Inventors: Sylvain Orenga, Audrey Perry, John Perry, Clair Preece
  • Nutritional supplements including cardiovascular support components
    Patent number: 10583168
    Abstract: A composition for use in cardiovascular support includes transfer factor. The transfer factor may be nonmammalian transfer factor, such as that derived from eggs, or mammalian transfer factor, such as that derived from colostrum. The composition may also include one or more of the following: an LDL receptor-binding element; a blood flow-enhancing element; a cholesterol reducing element; a fat oxidation prevention element, and an antioxidant. Treatment methods include enlisting the immune system of a subject receiving therapy to attack pathogens that cause inflammation of blood vessels or to otherwise reduce inflammation of blood vessels.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: March 10, 2020
    Assignee: 4Life Patents, LLC
    Inventor: William J. Hennen
  • Photodynamic process and product obtained therefrom
    Patent number: 10577584
    Abstract: The present invention relates to a method for ex vivo photodynamic treatment of cells. A cell preparation is incubated in a first medium having 5 ?M or less of a photosensitive compound. A population of cells in the cell preparation retains the photosensitive compound, for example, a salt of 2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid methyl ester. The first medium is then replaced with an extrusion medium to remove the photosensitive compound. The cell preparation is then illuminated in the extrusion medium to selectively kill the population of cells retaining the photosensitive compound, thereby creating an illuminated cell preparation.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: March 3, 2020
    Assignee: KIADIS PHARMA INTELLECTUAL PROPERTY BV
    Inventors: Jurjen Velthuis, Liesbeth De Jong, Manfred Rudiger
  • Blood analyzer, blood analyzing method, and non-transitory storage medium
    Patent number: 10578603
    Abstract: A blood analyzer comprises a sample preparing part, a light source, a light receiving part, and a processing part configured to discriminate and count reactive B lymphocytes based on at least one of fluorescent light signals and forward scattered light signals.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 3, 2020
    Assignee: Sysmex Corporation
    Inventors: Konobu Kimura, Kinya Uchihashi, Jo Linssen, Jarob Saker
  • Methods for localized modification of tissue products
    Patent number: 10568988
    Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a cross-linking agent and/or a proteolytic enzyme to produce a tissue matrix with variable mechanical and/or biological properties.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: February 25, 2020
    Assignee: LifeCell Corporation
    Inventors: Gary Monteiro, Christopher T. Wagner, Neil L. Rodriguez, Aubrey Irene Delossantos
  • Pharmaceutical composition comprising botulinum, a non ionic surfactant, sodium chloride and sucrose
    Patent number: 10561604
    Abstract: Solid and liquid pharmaceutical compositions comprising botulinum neurotoxin complex or high purity botulinum neurotoxin and a surfactant. The composition may comprise a crystalline agent.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: February 18, 2020
    Assignee: IPSEN BIOPHARM LIMITED
    Inventors: Paul Webb, Mary White, Julie Partington
  • Treatment of lung and pulmonary diseases and disorders
    Patent number: 10557116
    Abstract: Compositions and methods of using cells derived from umbilical cord tissue to stimulate and support lung tissue angiogenesis, to improve blood flow to lung tissue, to regenerate, repair, and improve lung tissue damaged by lung disease, disorder and/or injury, and to protect lung tissue from damage caused by lung disease, disorder and/or injury in a patient.
    Type: Grant
    Filed: December 19, 2009
    Date of Patent: February 11, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: David C. Colter, Anthony J. Kihm, Christine K. Ward, Anna Gosiewska
  • Systems and methods for monitoring tissue sample processing
    Patent number: 10539487
    Abstract: A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 21, 2020
    Assignee: VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Jefferson Curtis Taft, David Chafin, Michael Otter, Benjamin Stevens
  • Graft scaffold for cartilage repair and process for making same
    Patent number: 10532126
    Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: January 14, 2020
    Assignee: ETH ZURICH
    Inventors: Matti Kesti, Marcy Zenobi-Wong, Michael Muller
  • Cultured cell sheet, production method thereof, and application method thereof
    Patent number: 10533158
    Abstract: The problem to be solved by the present invention is to provide a cultured cell sheet that expresses phenotypes of the chondroid tissue. The problems can be solved by producing the cultured cell sheet in which cells are cultured on a surface of a cell cultureware that is coated with a temperature responsive polymer having an upper or lower critical solution temperature ranging from 0° C. to 80° C. in water, including steps of: adjusting the temperature of the culture medium to a temperature below the lower critical solution temperature or above the upper critical solution temperature; bringing the cultured cell sheet in close contact with the carrier; and detaching the cultured cell sheet together with the carrier.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: January 14, 2020
    Assignees: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, CELLSEED, INC.
    Inventors: Masato Sato, Hideaki Sakai
  • Cartilage-damage treatment agent and method for producing same
    Patent number: 10507266
    Abstract: A method according to the present invention for producing a cartilage-damage treatment agent, includes the steps of: (i) proliferating mesenchymal stem cells in a serum-free medium A containing an FGF, a PDGF, a TGF-?, an HGF, an EGF, at least one phospholipid and at least one fatty acid; and (ii) mixing the mesenchymal stem cells thus proliferated in the step (i), an isotonic preserving agent, and a cytoprotective agent. This method provides a cartilage-damage treatment agent which favorably regenerates a cartilage tissue.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 17, 2019
    Assignee: TWO CELLS Co., Ltd.
    Inventors: Koichiro Tsuji, Minoru Morikawa, Satoshi Maeda, Yui Kitayama, Aki Ohmori, Jin Chang Shao, Shinichi Hasegawa, Yukio Kato, Takashi Matsushita, Masato Takao, Shinya Miki, Ken Innami, Yasufumi Takahashi
  • Methods for isolating human cardiac ventricular progenitor cells
    Patent number: 10508263
    Abstract: The present invention provides methods for isolating human cardiac ventricular progenitor cells (HVPs), wherein cultures of day 5-7 cardiac progenitor cells are negatively selected for one or more first markers expressed on human pluripotent stem cells, such as TRA-1-60, to thereby isolate HVPs. The methods can further include positive selection for expression of a second marker selected from the group consisting of JAG1, FZD4, LIFR, FGFR3 and TNFSF9. Large populations, including clonal populations, of isolated HVPs that are first marker negative/second marker positive are also provided. Methods of in vivo use of the HVPs for cardiac repair or to improve cardiac function are also provided. Methods of using the HVPs for cardiac toxicity screening of test compounds are also provided.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: December 17, 2019
    Assignee: Procella Therapeutics AB
    Inventors: Kenneth R. Chien, Jonathan Clarke, Miia Lehtinen, Kylie Foo, Chuen Yan Leung
  • Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
    Patent number: 10500234
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 10, 2019
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Sanjay Mistry, Anthony J. Kihm, Ian R. Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Nitrate- and nitrite-reducing probiotic feed additive
    Patent number: 10494683
    Abstract: The present invention concerns novel probiotic compositions that increase nitrate- and nitrite-reduction in animals such as ruminants. The present invention thus provides compositions and methods for reducing nitrate/nitrite toxicity in such animals, or prophylactically protecting such animals from the effects of toxicity, such as methemoglobinemia. A novel strain of an unspeciated bacterial strain related to Paenibacillus species with nitrate- and nitrite-reducing capabilities is described. In conjunction with nitrate-supplemented diets, the probiotics of the present invention can also be utilized to reduce methanogenesis in livestock. Furthermore, the probiotic compositions of the present invention can be used to reduce the number and kind of food-borne pathogens, such as Escherichia coli and Campylobacter jejuni.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 3, 2019
    Assignees: The Secretary of Agriculture, The Texas A&M University System
    Inventors: Robin C. Anderson, Elizabeth A. Latham, William E. Pinchak
  • Osteochondroreticular stem cells for bone and cartilage regeneration
    Patent number: 10479977
    Abstract: The invention is directed to osteochondroreticular stem cells and methods of using osteochondroreticular stem cells. In another aspect the invention is directed to a method of treating osteoarthritis or skeletal fractures using osteochondroreticular stem cells.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: November 19, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Timothy Wang, Daniel Worthley, Siddhartha Mukherjee