Patents Examined by Tara L Martinez
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Patent number: 10040836Abstract: An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4 X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is a hydrophobic amino acid, X3 is a hydrophobic amino acid, X4 is an acidic amino acid and X5 is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.Type: GrantFiled: January 12, 2017Date of Patent: August 7, 2018Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Daniel Offen, Israel Aharony
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Patent number: 10040822Abstract: A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines (SEQ ID NO: 1), and further comprising 1 or more terminal cysteines. The composition is administered in therapeutically effective dosages prophylactically or as soon as possible post-injury in treating neuronal injury.Type: GrantFiled: December 29, 2016Date of Patent: August 7, 2018Assignee: National Institutes of Health, U.S. Dept. of Health and Human Services, NIH Division of Extramural Inventions and Technology ResourcesInventors: Dennis J. Goebel, John Marshall
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Patent number: 10004779Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.Type: GrantFiled: December 8, 2015Date of Patent: June 26, 2018Assignees: Human Matrix Services, LLC, The Hospital for Sick ChildrenInventors: Thomas Mitts, Felipe Jimenez, Aleksander Hinek
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Patent number: 9974801Abstract: Disclosed is a method of treating or preventing a disease or disorder of the central nervous system (CNS) in a patient comprising administering transcranially, for example, directly to the skull, an effective amount of an anti-inflammatory agent to the patient. Examples of the anti-inflammatory agent include glutathione and inhibitors of purinergic receptors such as P2X4, P2X7, P2Y6, and P2Y12 receptors. Examples of disease or disorder of the CNS include brain injury, particularly traumatic brain injury, inflammation, infection, degeneration of brain cells, stroke, brain edema, tumor, Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Also disclosed is a kit comprising at least one anti-inflammatory agent and printed materials containing instructions for transcranially administering the anti-inflammatory agent to the patient having a disease or disorder of the CNS.Type: GrantFiled: April 11, 2016Date of Patent: May 22, 2018Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Dorian B. McGavern, Theodore Roth
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Patent number: 9963805Abstract: Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.Type: GrantFiled: August 22, 2016Date of Patent: May 8, 2018Assignees: University of South Florida, University of Central Florida Research Foundation, Inc.Inventors: Donald T. Haynie, Lei Zhai
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Patent number: 9951348Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: June 9, 2016Date of Patent: April 24, 2018Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Ruth Cong, Jingtong Hou, Zhenglin Hou, Phillip Patten, Takashi Yamamoto
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Patent number: 9951104Abstract: We describe peptides and their uses for the treatment of autoimmune, inflammatory and metabolic diseases.Type: GrantFiled: January 7, 2013Date of Patent: April 24, 2018Assignee: Serpin Pharma, LLCInventors: Soren Mogelsvang, Cohava Gelber
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Patent number: 9943564Abstract: The present disclosure teaches the protection of plants and human and non-human subjects from pathogens. The present disclosure enables a multivalent approach to inhibiting pathogen infection in plant and human and non-human animal subjects and to ameliorate damage to susceptible subjects.Type: GrantFiled: November 22, 2013Date of Patent: April 17, 2018Assignee: Hexima LimitedInventors: Nicole Van Der Weerden, Marilyn Anne Anderson
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Patent number: 9931437Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.Type: GrantFiled: February 4, 2015Date of Patent: April 3, 2018Assignee: WORCESTER POLYTECHNIC INSTITUTEInventors: Marsha Rolle, Fioleda Prifti, Christopher Malcuit, Terri Anne Camesano, Tanja Dominko, Denis Kole
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Patent number: 9925398Abstract: The present application discloses angiogenic peptides that cause intracellular calcium release in target cells and thereby induce proliferation, migration, and capillary-like tube formation in primary cultured endothelial cells. The angiogenic peptides can be used for preventing and/or treating angiognesis-related conditions, especially wound healing, treating foot and leg ulcers in a subject, etc. In addition, the angiogenic peptides can be used for cosmetics a constituent of cosmetics for aged skin, for examples, anti-wrinkle and skin whitening.Type: GrantFiled: April 23, 2009Date of Patent: March 27, 2018Assignee: NOVACELL TECHNOLOGY INC.Inventor: Taehoon Lee
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Patent number: 9919029Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.Type: GrantFiled: July 25, 2014Date of Patent: March 20, 2018Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite de Droit et de la Sante de Lille 2, Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Lille, Universite de Lille 1 Sciences et Technologies, ETH Zurich, Universidad de la RepublicaInventors: Wolf-Dietrich Hardt, Patrick Kaiser, Jean-Claude Sirard, Christophe Carnoy, Delphine Fougeron, Jose Alejandro Chabalgoity, Natalia Munoz
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Patent number: 9920099Abstract: The present invention relates to a composition for preventing or treating cancer comprising Wnt decoy receptor. The composition of the present invention or the expression product thereof inhibits cancer generation, growth, proliferation and metastasis, and induces apoptosis of cancer cells, by binding to Wnt ligand and blocking ligand-receptor interactions, therefore may be effectively used as an anti-cancer agent.Type: GrantFiled: April 21, 2017Date of Patent: March 20, 2018Assignee: GENEMEDICINE CO., LTD.Inventors: Chae Ok Yun, Jung-Sun Lee
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Patent number: 9907837Abstract: The present invention relates to composition for preventing or treating cachexia, and more specifically, to a composition for preventing or treating cachexia containing a peptide derived from a telomerase. The composition for preventing or treating cachexia, according to present invention, has the advantages of improving symptoms of cachexia, such as weight loss, anemia, edema, and loss of appetite, and has few side effects.Type: GrantFiled: May 10, 2013Date of Patent: March 6, 2018Assignee: GemVax & KAEL Co., Ltd.Inventor: Sang Jae Kim
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Patent number: 9896491Abstract: Novel oligopeptides, combinations thereof and fusion proteins composed of the above-mentioned oligopeptides are disclosed. Oligopeptides are homologous in amino acid sequence to the selected parts of the amino acid sequence of human myelin basic protein (MBP) and are capable to ameliorate the progression of multiple sclerosis by means of binding to and inactivation of epitope-specific anti MBP catalytic auto antibodies (ESAMBPCAA) involved into binding and catalytic degradation of MBP in course of progression of Multiple Sclerosis.Type: GrantFiled: April 11, 2012Date of Patent: February 20, 2018Assignee: LIFEBIO LABORATORIES LLCInventors: Aleksey Anatolievich Belogurov, Alexandr Gabibovich Gabibov, Natalya Alexandrovna Ponomarenko
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Patent number: 9884091Abstract: Methods treat neurological disorders, for example neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke. Particularly although not exclusively, GIP/GLP-1 co-agonist peptide is used in the treatment of such neurological disorders. Pharmaceutical compositions include a GIP/GLP-1 co-agonist peptide for use in treatment of such disorders.Type: GrantFiled: July 14, 2015Date of Patent: February 6, 2018Assignee: Lancaster University Business Enterprises LimitedInventor: Christian Holscher
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Patent number: 9869038Abstract: Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.Type: GrantFiled: August 22, 2016Date of Patent: January 16, 2018Assignees: UNIVERSITY OF SOUTH FLORIDA, UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Donald T. Haynie, Lei Zhai
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Patent number: 9814663Abstract: An isolated peptide for inhibiting melanogenesis in a mammal subject is provided. The isolated peptide consisting of an amino acid sequence of SSASTTED (SEQ ID NO: 1). Also provided are methods and compositions for inhibiting melanogenesis in a mammal subject.Type: GrantFiled: April 6, 2017Date of Patent: November 14, 2017Assignee: RENORIGIN INNOVATION INSTITUTE CO., LTD.Inventors: Hsiu-Chin Huang, Hsuan Lin