Patents Examined by Tara L Martinez
  • Variant serum albumin with improved half-life and other properties
    Patent number: 10711050
    Abstract: The invention provides methods and materials for making and using variant serum albumin amino acid sequences which exhibit improved properties compared to wild type serum albumin sequences. The invention further provides methods and materials for making and using fusion proteins in which the variant serum albumin amino acid sequences are fused to a therapeutic or diagnostic agent, such as a therapeutic protein, or a functional fragment or variant thereof that maintains activity, and exhibits improved properties.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: July 14, 2020
    Assignee: ALBUMEDIX LTD
    Inventors: Michael March Schmidt, Eric Steven Furfine, Amy Jada Andreucci, Thomas M. Barnes
  • Therapeutic vitamin D conjugates
    Patent number: 10702574
    Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.
    Type: Grant
    Filed: February 11, 2017
    Date of Patent: July 7, 2020
    Assignee: Extend Biosciences, Inc.
    Inventors: Tarik Soliman, Laura M. Hales, Daniel B. Hall, Christopher So, Howard P. Sard, Vishnumurthy Hegde
  • Targeting deregulated Wnt signaling in cancer using stabilized alpha-helices of BCL-9
    Patent number: 10703785
    Abstract: The invention provides structurally-constrained peptides by hydrocarbon stapling of a BCL9 HD2 helix for use as a therapeutic agent. The invention further provides methods and kits for use of the structurally-constrained peptide of the instant invention. The invention is based, at least in part, on the results provided herein demonstrating that hydrocarbon stapled helical peptides display excellent proteolytic, acid, and thermal stability, restore the native helical structure of the peptide, possess superior pharmacokinetic properties compared to the corresponding unmodified peptides, and are highly effective in binding to ?-catenin in vitro, in cellulo, and in vivo, disrupting the BCL-9/?-catenin interaction, and thereby interfering with deregulated Wnt/?-catenin signaling for therapeutic benefit in a variety of human diseases including human cancer.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: July 7, 2020
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Loren D. Walensky, Ruben Carrasco, Gregory H. Bird
  • Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
    Patent number: 10695407
    Abstract: The present invention relates to a protective solution for preventing or reducing reperfusion injury of the brain which contains magnesium ions and which has an osmolality of 350 to 600 mOsm/L, a pH value of 6.8 to 7.8 and albumin in an amount of 1 to 20% by weight.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: June 30, 2020
    Assignee: ResuSciTec GmbH
    Inventors: Christoph Benk, Friedhelm Beyersdorf, Georg Trummer
  • Complement factor B analogs and their uses
    Patent number: 10689637
    Abstract: The invention provides polypeptides comprising a complement factor B analog. The invention also provides various complement factor B analogs including complement factor B analogs comprising a mutation of a free cysteine amino acid and related methods, nucleic acids and vectors. These complement factor B analogs and related methods, nucleic acids and vectors can be used to modulate a complement pathway or for the study and/or treatment of various conditions or diseases related to a complement pathway.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: June 23, 2020
    Assignee: Wellstat ImmunoTherapeutics, LLC
    Inventors: ChangHung Chen, Michael Kaleko, Beibei Li, Tianci Luo, Jeffrey Allan Miller, Ruigong Wang
  • Wound spray
    Patent number: 10646613
    Abstract: The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: May 12, 2020
    Assignee: MÖLNLYCKE HEALTH CARE AB
    Inventors: Michael Sander, Harald Potzschke
  • Pediatric nutritional composition with milk peptides for healthy growth and development
    Patent number: 10639334
    Abstract: The present disclosure generally provides pediatric nutritional compositions comprising a protein source comprising an intact milk protein and a partially hydrolyzed milk protein, wherein about 5% to about 25% of total nitrogen content of the composition is non-protein nitrogen. The pediatric nutritional compositions described herein also comprise a fat source and a carbohydrate source. The partially hydrolyzed protein source, in certain embodiments, provides peptides that have similar structure and function to the peptides found in human milk.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: May 5, 2020
    Assignee: MEAD JOHNSON NUTRITION COMPANY
    Inventors: Dattatreya Banavara, Roseanne P. Batema
  • Acceleration of growth
    Patent number: 10633630
    Abstract: The invention is in the field of growth of Mycobacteria. In particular, agents have been identified which enhance the growth of Mycobacterial species, which are naturally slow-growing. Such agents can therefore be used in the identification of Mycobacteria and in the diagnosis of Mycobacterial infections.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: April 28, 2020
    Assignee: ST GEORGE'S HOSPITAL MEDICAL SCHOOL
    Inventors: Timothy John Bull, Kai Hilpert
  • Exercise-regulated adipokines as therapy for diabetes management
    Patent number: 10632175
    Abstract: The present invention is related to methods and compositions effective in regulating glycemic control in subject individuals in need of the regulation of glycemic control. Said individuals may have diabetes or be prediabetic condition receive therapeutically effective amounts of identified secreted proteins in an amount suitable for modulating glycemic control and to thereby treat or prevent diabetes in said subject.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: April 28, 2020
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Laurie J. Goodyear, Kristin I. Stanford
  • Methods and compositions for improved cognition
    Patent number: 10632180
    Abstract: Provided herein are klotho polypeptide compositions and methods for improving cognitive function in an individual comprising treatment of with klotho polypeptides.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: April 28, 2020
    Assignee: The Regents of the University of California
    Inventor: Dena Dubal
  • Peptide derivatives and uses thereof
    Patent number: 10626144
    Abstract: The invention provides for novel peptide derivatives and compositions comprising the same. The invention further provides methods of treatment comprising administering novel peptide derivatives and/or compositions comprising the same.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: April 21, 2020
    Assignee: Nosopharm
    Inventors: Philippe Villain-Guillot, Maxime Gualtieri, Emilie Racine
  • Bactericidal peptides and uses thereof
    Patent number: 10624947
    Abstract: Antimicrobial compositions having bactericidal activity are described. Also described is a method of treating bacterial infections using compositions comprising antimicrobial peptides or variants thereof.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 21, 2020
    Assignee: Indiana University Research and Technology Corporation
    Inventors: C. Cheng Kao, Dean Rowe-Magnus, Antonio Cembellin Prieto
  • Skin whitening peptide agents
    Patent number: 10603265
    Abstract: The present invention provides new peptides useful as skin whitening agents and their uses in cosmetic or therapeutic applications.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: March 31, 2020
    Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Graca Raposo, Cecile Campagne, Cedric Delevoye
  • Use of pertussis toxin as a therapeutic agent
    Patent number: 10596233
    Abstract: The present application relates to the use of pertussis toxin, and its derivatives, analogs, salts and pharmaceutical equivalents. In one embodiment, the invention provides a method of treating or preventing a neurological disease or injury by administering pertussis toxin to the individual.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: March 24, 2020
    Assignee: Dignity Health
    Inventor: Jiong Shi
  • Combination therapy with peptide epoxyketones
    Patent number: 10596222
    Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered agents are administered with peptide epoxyketones or a pharmaceutically acceptable salt thereof. Another aspect of the invention relates to treating cancer with a peptide epoxyketone administered in combination with another therapeutic agent.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: March 24, 2020
    Assignee: ONYX THERAPEUTICS, INC.
    Inventors: Christopher J. Kirk, Susan D. Demo, Mark K. Bennett
  • Method and carrier complexes for delivering molecules to cells
    Patent number: 10584182
    Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 10, 2020
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Hazel H. Szeto, Kesheng Zhao, Hugh Robertson, Alex V. Birk
  • Ganirelix precursor and method for preparing ganirelix acetate by using the same
    Patent number: 10577394
    Abstract: Disclosed is a method for preparing ganirelix acetate. The method includes the following steps: respectively replacing Fmoc-HArg(Et)2-OH and Fmoc-D-HArg(Et)2-OH by employing Fmoc-Lys(Boc)-OH and Fmoc-D-Lys(Boc)-OH or Fmoc-Lys(Alloc)-OH and Fmoc-D-Lys(Alloc)-OH; synthesizing a ganirelix precursor I or ganirelix precursor II-peptide resin in advance; and then respectively performing modifications and treatments on side chain amino groups of Lys and D-Lys in the precursor I or the precursor II-peptide resin to obtain ganirelix acetate. The ganirelix acetate synthesized therefrom is high in purity, has few impurities and a relatively low cost, and is suitable for large-scale production.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: March 3, 2020
    Assignee: HYBIO PHARMACEUTICAL CO., LTD.
    Inventors: Youjin Chen, Jian Liu, Yaping Ma, Jiancheng Yuan
  • Synthetic artificial peptides with antimicrobial effect
    Patent number: 10556926
    Abstract: The present invention relates to antimicrobial peptides of the general formula AxByCz with x, z?1, y?3 and x+y+z?50, where A and C, in each case independently of one another, have at least 65% basic amino acids and B has at least 65% hydrophobic and/or nonpolar amino acids and comprises a direct sequence of at least three hydrophobic amino acids. Moreover, a medical use of the peptides, a conjugate and an antimicrobial composition are indicated.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: February 11, 2020
    Assignee: Fraunhofer-Gesellschaft
    Inventors: Karsten Rapsch, Markus v. Nickisch-Rosenegk
  • Compositions and methods for treating central nervous system (CNS) disorders and mood disorders
    Patent number: 10550157
    Abstract: Compositions and methods of treating a central nervous system (CNS) disorder or mood disorder in a subject in need of such treatment are described. A therapeutically effective amount of a composition comprising a melanocortin 5 receptor (MC5R) peptide ligand in a pharmaceutically acceptable carrier is administered to the subject. The MCSR peptide ligand is a selective MCSR antagonist, in which administration thereof to the subject can treat the CNS disorder or mood disorder with clinical improvement observed in a relatively short time.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: February 4, 2020
    Assignee: ARIZONA BOARD OF REGENT ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Victor J. Hruby, Minying Cai, Horst Kessler
  • Method or improving selective catabolysis in cells of keratin surfaces
    Patent number: 10537517
    Abstract: A skin care composition for stimulating selective catabolysis in cells of keratin surfaces comprising at least one autophagy activator and at least one proteasome activator, and a method for improving selective catabolysis in cells of keratin surfaces by treating with the composition.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: January 21, 2020
    Assignee: ELC Management LLC
    Inventors: Nadine A. Pernodet, Kelly Dong, Edward Pelle, Daniel B. Yarosh