Patents Examined by Tara L Martinez
  • Antimicrobial peptides
    Patent number: 10538559
    Abstract: The invention provides a peptide comprising: a core amino acid sequence, which is identical or similar to the amino acid sequence of a member of the Cecropin family. The invention further provides a nucleic acid sequence encoding the peptide and a vector comprising said nucleic acid. The invention further provides a pharmaceutical composition comprising said peptide or said nucleic acid. The invention further provides methods of treating an infection, overcoming inherent or acquired resistance of a microorganism to an antibiotic agent or disinfecting a wound, the methods comprises administering the peptide to a subject in need thereof.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: January 21, 2020
    Assignee: OMNIX MEDICAL LTD.
    Inventors: Niv Bachnoff, Moshe Cohen-Kutner
  • Uses of peptides to treat brain injury and disease
    Patent number: 10501494
    Abstract: A method of treating loss of brain function in a patient comprising the steps of preparing a composition comprising a D peptide and a pharmaceutically acceptable carrier. The D peptide has the general structure: A-B-C-D-E-F-G-H in which A is Ala, or absent, B is Ser, Thr or absent, C is Ser, Thr or absent, D is Ser, Thr, Asn, Glu, Arg, Ile, Leu, E is Ser, Thr, Asp, Asn, F is Thr, Ser, Asn, Arg, Gln, Lys, Trp, G is Tyr, and H is Thr, Ser, Arg, Gly. All amino acids in the D peptide are the D stereoisomeric configuration. The peptide composition is administered in a therapeutically effective dose.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: December 10, 2019
    Assignee: Creative Bio-Peptides
    Inventor: Michael Ruff
  • Conotoxin peptide ?-CPTx-BTL01, preparation method therefor, and uses thereof
    Patent number: 10501498
    Abstract: Provided is a new conotoxin peptide ?-CPTx-bt101. The conotoxin peptide ?-CPTx-bt101 has derivative polypeptide that has an amino acid sequence indicated by SEQ ID NO:1, or has derivative polypeptide that has an amino acid sequence indicated by SEQ ID NO:1 and that is formed after substitution, addition or deletion of one or more amino acids are performed and has original functions. Also provided is polynucleotide for coding the peptide, comprising a constructed body of the polynucleotide, an expression carrier and transformed cells. A peptide preparation method and uses in the treatment of diseases related to a calcium ion channel.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: December 10, 2019
    Assignee: BGI SHENZHEN
    Inventors: Jie Liu, Zhilong Lin, Bo Wen, Ting Tong, Fen Mo, Chao Peng, Qiong Shi
  • Peptides that stimulate subcutaneous adipogenesis
    Patent number: 10494402
    Abstract: Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis in mammals and uses thereof are provided.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: December 3, 2019
    Assignee: The Regents of the University of California
    Inventors: Eva A. Turley, Seyed Bahram Bahrami, Mina J. Bissell
  • Oxyntomodulin analogue
    Patent number: 10479819
    Abstract: Provided is an oxyntomodulin analogue. The analogue comprises GCGR and GLP-1R dual agonist activity, improved enzymolysis stability and biological activity, and no adverse reactions. The analogue can be used to prepare medication for treating hyperphagia, obesity and diabetes.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: November 19, 2019
    Assignee: JIANG, XIANXING
    Inventor: Xianxing Jiang
  • Wound spray
    Patent number: 10471175
    Abstract: A method for preparing a composition for external treatment of wounds includes charging at least 90% of the oxygen binding sites of hemoglobin with carbon monoxide during or after isolation from its natural environment. The method further includes adding at least one further ingredient selected from the group consisting of electrolyte(s), preservative(s), stabilizer(s), anti-flocculant(s), anticoagulant(s), pH buffering agent(s), solvent(s), antioxidant(s), film-forming agent(s) and crosslinking agent(s). The method can further include packaging the composition, such as in an aerosol can.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: November 12, 2019
    Assignee: MÖLNLYCKE HEALTH CARE AB
    Inventors: Michael Sander, Harald Potzschke
  • Methods for treating neurological disorders
    Patent number: 10471029
    Abstract: Disclosed herein are methods and compositions for treating, ameliorating, and/or preventing Alzheimer's disease in ApoE4-postitive patients using particular compounds and compositions thereof.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: November 12, 2019
    Assignee: Alzheon, Inc.
    Inventors: Martin Tolar, John A. Hey, Petr Kocis, Jeremy Yu
  • Dosage of a gluten peptide composition
    Patent number: 10449228
    Abstract: Provided herein are methods and compositions for treating subjects with Celiac disease.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: October 22, 2019
    Assignee: ImmusanT, Inc.
    Inventor: Robert P. Anderson
  • Matrix scaffold with antimicrobial activity
    Patent number: 10449271
    Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: October 22, 2019
    Assignee: Worcester Polytechnic Institute
    Inventors: Marsha Rolle, Fioleda Prifti, Christopher Malcuit, Terri Anne Camesano, Tanja Dominko, Denis Kole
  • Bacteriocidal peptides and uses thereof
    Patent number: 10435447
    Abstract: Peptide compositions having bacteriocidal peptides are described. Also described is a method of bacterial infections using compositions comprising bacteriocidal peptides or modified peptides with structural relationships to cathelicidins.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: October 8, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: C. Cheng Kao, Xiaoyan Lin
  • Methods and pharmaceutical compositions for the treatment of respiratory tract infections
    Patent number: 10426816
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of respiratory tract infections. More particularly, the present invention relates to a TLR5 agonist for use in a method for treating a respiratory tract infection.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: October 1, 2019
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Institut Pasteur de Lille
    Inventors: Jean-Claude Sirard, Jose A. Chabalgoity
  • Peptide
    Patent number: 10428110
    Abstract: Provided are a novel peptide, a polynucleotide encoding the peptide, an expression vector including the polynucleotide, and a pharmaceutical composition including the peptide, a quasi-drug composition including the peptide, and a health functional food composition including the peptide.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: October 1, 2019
    Assignee: HysensBio Co., Ltd.
    Inventors: Joohwang Park, Jihyun Lee
  • Compositions and methods for the treatment of carboxyhemoglobinemia
    Patent number: 10421800
    Abstract: Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: September 24, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Mark T. Gladwin, Jesus Tejero Bravo
  • Hybrid polymers, pharmaceutical compositions and methods of synthesizing the same
    Patent number: 10421954
    Abstract: Novel hybrid polymers are disclosed that have a structure represented by the following formula I: wherein Abiotic oligomer, Polypeptide, X, Y, and R1 are as described herein. The methods to prepare the hybrid polymers via novel oxazolidinyl compounds are also described.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: September 24, 2019
    Assignee: NEW YORK UNIVERSITY
    Inventors: Kent Kirshenbaum, Paul Levine, Timothy Craven
  • Insulin vitamin D conjugates
    Patent number: 10420819
    Abstract: The invention provides non-hormonal vitamin D conjugated to insulin peptides that result in the peptides having increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. The vitamin D targeting groups are coupled to the insulin peptides via the third carbon on the vitamin D backbone.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: September 24, 2019
    Assignee: Extend Biosciences, Inc.
    Inventors: Tarik Soliman, Laura M. Hales, Daniel B. Hall, Howard Sard, Vishnumurthy Hegde
  • Complement factor B analogs and their uses
    Patent number: 10415026
    Abstract: The invention provides polypeptides comprising a complement factor B analog. The invention also provides various complement factor B analogs including complement factor B analogs comprising a mutation of a free cysteine amino acid and related methods, nucleic acids and vectors. These complement factor B analogs and related methods, nucleic acids and vectors can be used to modulate a complement pathway or for the study and/or treatment of various conditions or diseases related to a complement pathway.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 17, 2019
    Assignee: Wellstat ImmunoTherapeutics, LLC
    Inventors: ChangHung Chen, Michael Kaleko, Beibei Li, Tianci Luo, Jeffrey Allan Miller, Ruigong Wang
  • Therapeutic vitamin D conjugates
    Patent number: 10406202
    Abstract: The invention provides non-hormonal vitamin D conjugated via the third carbon on the vitamin D backbone to parathyroid hormone (PTH) proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: September 10, 2019
    Assignee: Extend Biosciences, Inc.
    Inventors: Tarik Soliman, Laura M. Hales, Daniel B. Hall, Christopher So, Howard P. Sard, Vishnumurthy Hegde
  • Murine anti-NY-ESO-1 T cell receptors
    Patent number: 10407485
    Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: September 10, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Maria R. Parkhurst, Richard A. Morgan, Steven A. Rosenberg, Shannon Faith Rosati
  • Methods and compositions related to inhibition of viral entry
    Patent number: 10406229
    Abstract: Disclosed herein are compositions and methods for inhibiting viral entry.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: September 10, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: J. Nicholas Francis, Joseph S. Redman, Michael S. Kay
  • Method and compositions for improving selective catabolysis in cells of keratin surfaces
    Patent number: 10383815
    Abstract: A skin care composition for stimulating selective catabolysis in cells of keratin surfaces comprising at least one autophagy activator and at least one proteasome activator, and a method for improving selective catabolysis in cells of keratin surfaces by treating with the composition.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 20, 2019
    Assignee: ELC MANAGEMENT LLC
    Inventors: Nadine A. Pernodet, Kelly Dong, Edward Pelle, Daniel B. Yarosh