Patents Examined by Taylor V. Oh
  • Patent number: 11555022
    Abstract: A group of polyfunctional oxetane-based compounds having a structure as represented by general formula (I) or a product obtained by a reaction between a compound of general formula (I) and epichlorohydrin, an ester compound, or an isocyanate compound. When these polyfunctional oxetane-based compounds are used as cation polymerizable monomers in combination with an epoxy compound, the curing speed is high, and the cured product has highly excellent hardness, flexibility, adherence, and heat resistance.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: January 17, 2023
    Inventor: Xiaochun Qian
  • Patent number: 11555021
    Abstract: This disclosure concerns fatty acid derivatives, pharmaceutical compositions comprising the fatty acid derivatives, and methods of using the fatty acid derivatives, for example, to treat inflammation, chronic itch, chronic pain, an autoimmune disorder, atherosclerosis, a skin disorder, arthritis, a neurodegenerative disorder, or a psychiatric disorder in a subject. In some embodiments, the fatty acid derivative is a compound, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, having a structure according to: wherein X is from 1-16 carbons in length, Z is aliphatic from 1-16 carbons in length, or is not present, Y is selected from: R1, R2, and R3 are independently hydrogen or lower alkyl, R4 is lower alkyl, hydroxyl, carboxyl, or amine, R5 is hydrogen, lower alkyl, or halide, R6 is hydroxyl or substituted thiol, and each R7 is independently hydrogen or fluoride or is not present and the adjacent carbons form alkyne.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: January 17, 2023
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Christopher Ramsden, Gregory Keyes
  • Patent number: 11548898
    Abstract: The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: January 10, 2023
    Assignees: President and Fellows of Harvard College, Eisai R&D Management Co., LTD.
    Inventors: Yoshito Kishi, Yanran Ai, Ning Ye, Qiaoyi Wang, Kenzo Yahata, Kentaro Iso, Santhosh Reddy Naini, Shuji Yamashita, Jihoon Lee, Isao Ohashi, Takashi Fukuyama
  • Patent number: 11547985
    Abstract: A catalyst support comprising at least 95% silicon carbide, having surface areas of ?10 m2/g and pore volumes of ?1 cc/g. A method of producing a catalyst support, the method including mixing SiC particles of 0.1-20 microns, SiO2 and carbonaceous materials to form an extrusion, under inert atmospheres, heating the extrusion at temperatures of greater than 1400° C., and removing residual carbon from the heated support under temperatures below 1000° C. A catalyst on a carrier, comprising a carrier support having at least about 95% SiC, with a silver solution impregnated thereon comprising silver oxide, ethylenediamine, oxalic acid, monoethanolamine and cesium hydroxide. A process for oxidation reactions (e.g., for the production of ethylene oxide, or oxidation reactions using propane or methane), or for endothermic reactions (e.g., dehydrogenation of paraffins, of ethyl benzene, or cracking and hydrocracking hydrocarbons).
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: January 10, 2023
    Inventor: Madan Mohan Bhasin
  • Patent number: 11548853
    Abstract: The present invention is directed to novel compounds of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof. Pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, are also described. The invention is also directed to use of the compounds of Formula (I) for treating a condition in a mammal associated with AhR imbalance, such as an inflammatory disease or disorder.
    Type: Grant
    Filed: January 28, 2022
    Date of Patent: January 10, 2023
    Inventors: Channa K. Jayawickreme, Susan H. Smith, Cunyu Zhang, William Zuercher
  • Patent number: 11541004
    Abstract: A method for treating or mitigating Parkinson's disease (PD) symptoms or progression, including administering an effective amount of nicotine to a subject in need thereof, via inhalation using a nicotine inhaler or via nasal spray using a nicotine nasal spray. Significant dose-dependent improvement of all symptoms by nicotine inhaler or nicotine nasal spray is expected. A novel treatment in PD is thus provided.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: January 3, 2023
    Inventors: Yousef Tizabi, Robert L. Copeland
  • Patent number: 11511260
    Abstract: The present invention relates to a preparation method for an olefin epoxidation catalyst, comprising: (1) preparing a titanium-silicon gel; (2) performing pore-enlarging treatment to the titanium-silicon gel by using organic amine or liquid ammonia, and drying, calcinating to obtain a titanium-silicon composite oxide; (3) optionally performing alcohol solution of organic alkali metal salt treatment; and (4) optionally performing gas-phase silanization treatment. The catalyst prepared by the method of the present invention has adjustable variability for pore size, so that the activity thereof for epoxidation reactions of the olefin molecules with different dynamic diameters is higher; the surface acidity of the catalyst can be reduced effectively through two-step modification to the catalyst, so that the catalyst has higher selectivity for epoxidation product.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: November 29, 2022
    Inventors: Tongji Wang, Fei Ye, Lei Wang, Naibo Chu, Lichao Yang, Kang Sun, Yuan Li, Weiqi Hua
  • Patent number: 11504349
    Abstract: The present invention relates to: a 4-benzopyranone derivative and a pharmaceutically acceptable salt, solvate, racemate, or stereoisomer thereof; a composition for preventing, alleviating or treating TNF-related diseases, containing the same as an active ingredient; and a method for treating TNF-related diseases, a reagent composition for inhibiting TNF, and a method for inhibiting TNF, all of which use the same. The compositions can be orally administered so as not to cause injection side effects, do not cause immunological tolerance, and can effectively inhibit a TNF activity by being directly bound to TNF while facilitating co-administering with a conventional oral preparation and dosage control.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: November 22, 2022
    Assignee: ILAB
    Inventors: Tae-Hwe Heo, Kye Jung Shin
  • Patent number: 11504362
    Abstract: This invention relates to a liquid pharmaceutical composition comprising cabozantinib to treat locally advanced or metastatic solid tumors, particularly advanced urothelial cancer or renal cell carcinoma in patients in need thereof.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: November 22, 2022
    Assignee: Exelixis, Inc.
    Inventors: Khalid Shah, Gisela Schwab, Steven Lacy
  • Patent number: 11505534
    Abstract: A diastereoselective method of preparing benzofuran-based 4,5-spirocycles via metal catalyzed alkenylation is described. The method can be used to provide compounds containing the benzofuranone-4,5-spirocyclic motif of the phainanoids, a class a natural products having immunosuppressive activity. Synthetic analogs of phainanoids, e.g., compounds that mimic the structure of the “western” part of the structure of the phainanoids and that contain the benzofuranone-4,5-spirocycle are described, as well as their synthetic intermediates, and their methods of synthesis.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: November 22, 2022
    Assignee: The University of Chicago
    Inventors: Jiaxin Xie, Guangbin Dong
  • Patent number: 11498892
    Abstract: Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated (“Fe/Cu-mediated”) coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: November 15, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Yoshito Kishi, Kenzo Yahata, Vemula Praveen Kumar, Sudheer Babu Vaddela
  • Patent number: 11491134
    Abstract: A composition for inhibiting skin cell proliferation and/or anti-inflammation is provided. The composition for inhibiting skin cell proliferation and/or anti-inflammation includes: apigenin and luteolin, wherein a weight ratio of the apigenin to the luteolin is about 1.5-25:1, or a mole ratio of the apigenin to the luteolin is about 1.5-25:1. Moreover, the apigenin and the luteolin have a synergistic effect on inhibiting skin cell proliferation and/or anti-inflammation.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: November 8, 2022
    Inventors: I-Hong Pan, Ming-Han Li, Kai-An Chuang, Shu-Fang Wen
  • Patent number: 11492336
    Abstract: The present invention provides: a method for producing an epoxyalkane capable of obtaining an epoxide in a high yield while attaining a high olefin conversion rate and a high selectivity for epoxides even when an olefin includes a long carbon chain, and a solid oxidation catalyst. The method for producing an epoxyalkane of the present invention comprises reacting an olefin with an oxidant in the presence of a solid oxidation catalyst, wherein the solid oxidation catalyst comprises a transition metal and a carrier that supports the transition metal, and the carrier is a composite of a metal oxide with a phosphonic acid.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: November 8, 2022
    Inventors: Mee Lin Yap, Shingo Takada
  • Patent number: 11485717
    Abstract: The invention provides a method for producing an epoxy compound by hydrogen peroxide using an organic compound having a carbon-carbon double bond as a raw material, wherein a by-product is suppressed from being generated and the epoxy compound is produced in a high yield. In particular, the invention provides a method for producing an epoxy compound involving oxidizing a carbon-carbon double bond in an organic compound with hydrogen peroxide in the presence of a catalyst, wherein the catalyst comprises a tungsten compound; a phosphoric acid, a phosphonic acid or salts thereof; and an onium salt having an alkyl sulfate ion represented by formula (I) as an anion: wherein R1 is a linear or branched aliphatic hydrocarbon group having 1 to 18 carbons, which may be substituted with 1 to 3 phenyl groups.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: November 1, 2022
    Inventors: Shohei Takata, Kenta Ue, Takeshi Koike, Atsushi Kameyama
  • Patent number: 11485711
    Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: November 1, 2022
    Inventors: Sung Youn Chang, Hyuk Lee, Ki Young Kim, Bum Tae Kim, Sung Soo Kim, Seong Hwan Kim, Hwan Jung Lim, Jung Nyoung Heo, Sang Joon Shin, Sang Youn Park
  • Patent number: 11479568
    Abstract: Large ring silacrown ethers having at least fourteen ring atoms with at least one lipophilic or hydrophobic substituent on the ring and/or on the silicon atom are provided. Pharmaceutical compositions containing these silacrown ethers and the use of these materials as therapeutic agents are also described.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: October 25, 2022
    Inventors: Barry C. Arkles, Jeffrey S. Arkles
  • Patent number: 11479528
    Abstract: This disclosure is related to aromatic compounds of formula (I), and methods of their use in treating medical conditions associated with Heat Shock Protein-90 (HSP90), e.g., cancer. Compounds of formula (I) have the following structure: Also disclosed are pharmaceutical compositions comprising compounds of formula (I).
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: October 25, 2022
    Inventors: Jing-ping Liou, Che-ming Teng, Shiow-lin Pan
  • Patent number: 11471868
    Abstract: This disclosure relates to synthetic coupling methods using catalytic molecules. In certain embodiments, the catalytic molecules comprise heterocyclic thiolamide, S-acylthiosalicylamide, disulfide, selenium containing heterocycle, diselenide compound, ditelluride compound or tellurium containing heterocycle.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: October 18, 2022
    Assignee: Emory University
    Inventors: Lanny Steven Liebeskind, Pavan Kumar Reddy Gangireddy
  • Patent number: 11472801
    Abstract: The present disclosure relates to solid forms of N-{[2?-(2,6-difluoro-3,5-dimethoxyphenyl)-3?-oxo-2?,3?-dihydro-1?H-spiro[cyclopropane-1,4?-[2,7]naphthyridin]-6?-yl]methyl}acrylamide, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the FGFR-associated or mediated diseases such as cancer.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: October 18, 2022
    Assignee: Incyte Corporation
    Inventors: Yongchun Pan, Chongsheng Eric Shi, Ming Tao, Wayne Han, Michael Xia, Dengjin Wang, Zhongjiang Jia, Jiacheng Zhou, Qun Li
  • Patent number: 11453653
    Abstract: Systems and methods for producing ethylene oxide (EO) are disclosed. Ethylene oxide is produced by direct oxidizing ethylene with oxygen in a reactor. The effluent from the reactor is processed to produce (a) a product stream comprising water and ethylene oxide, (b) a reabsorber overhead stream comprising ethylene, methane, argon, and carbon dioxide, and (c) a carbonate flash gas stream comprising carbon dioxide, ethylene, methane, and water. The reabsorber overhead stream and the carbonate flash gas stream are combined to form a reclaim gas stream. The reclaimed gas stream is separated in a membrane separation unit to remove carbon dioxide and argon, forming a recycle stream comprising primarily ethylene and methane, collectively.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: September 27, 2022
    Inventor: Jintang Duan