Patents Examined by Taylor V. Oh
  • Patent number: 10450287
    Abstract: Processes for reducing the amount of a gaseous iodide-containing impurity present in a recycle gas stream used in the production of ethylene oxide, in particular an alkyl iodide impurity, are provided. Processes for producing ethylene oxide, ethylene carbonate and/or ethylene glycol, and associated reaction systems are similarly provided.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: October 22, 2019
    Assignee: SHELL OIL COMPANY
    Inventors: Wayne Errol Evans, Jesse Raymond Black
  • Patent number: 10442780
    Abstract: The present disclosure provides processes for the production of 2-5-furandicarboxylic acid (FDCA) and intermediates thereof by the chemocatalytic conversion of a furanic oxidation substrate. The present disclosure further provides processes for preparing derivatives of FDCA and FDCA-based polymers. In addition, the present disclosure provides crystalline preparations of FDCA, as well as processes for making the same.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 15, 2019
    Assignee: Stora Enso OYJ
    Inventors: Valery Sokolovskii, Vincent J. Murphy, Thomas R. Boussie, Gary M. Diamond, Eric L. Dias, Guang Zhu, James M. Longmire, Stanley Herrmann, Staffan Torssell, Mayya Lavrenko
  • Patent number: 10434504
    Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 8, 2019
    Assignee: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Jürgen Klankermayer, Walter Leitner, Markus Meuresch
  • Patent number: 10428008
    Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: October 1, 2019
    Assignee: Institut Pasteur de Montevideo
    Inventors: Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
  • Patent number: 10428035
    Abstract: In a process for the epoxidation of an olefin by continuously reacting the olefin with hydrogen peroxide in a methanol solvent on a fixed bed epoxidation catalyst comprising a titanium zeolite, the hydrogen peroxide is used as an aqueous hydrogen peroxide solution made by an anthraquinone process, the aqueous hydrogen peroxide solution is mixed with methanol to give a feed mixture and this feed mixture is filtered before being contacted with the fixed bed epoxidation catalyst.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: October 1, 2019
    Assignees: Evonik Degussa GmbH, thyssenkrupp Industrial Solutions AG
    Inventors: Matthias Pascaly, Manfred Bärz, Marc Brendel, Robert Jahn, Jürgen Schemel, Michael Dopfer
  • Patent number: 10428036
    Abstract: In a process for the epoxidation of propene, comprising the steps of reacting propene with hydrogen peroxide, separating propene oxide and a recovered propene stream from the reaction mixture, separating propane from all or a part of the recovered propene stream in a C3 splitter column, and passing the overhead product stream of the C3 splitter column to the epoxidation step, a propane starting material with a propane fraction of from 0.002 to 0.10 is used, the epoxidation is operated to provide a propane fraction in the reaction mixture of from 0.05 to 0.20 and the C3 splitter column is operated to provide an overhead product stream which comprises a propane fraction of at least 0.04 in order to reduce the size and the energy consumption of the C3 splitter column.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: October 1, 2019
    Assignees: Evonik Degussa GmbH, thyssenkrupp Industrial Solutions AG
    Inventors: Willi Hofen, Thomas Haas, Wolfgang Wöll, Bärbel Kolbe, Hans-Christian Dietz, Marc Brendel, Bernd Jaeger, Manfred Bärz, Michael Kleiber
  • Patent number: 10428039
    Abstract: Provided herein is a process for preparing furan-2,5-dicarboxylic acid. The process includes the following steps: (A-1) preparing a starting mixture comprising one, two or more carbohydrate compounds selected from the group consisting of: hexoses, oligosaccharides comprising hexose units, and polysaccharides including hexose units, and as a solvent or as a co-solvent for the carbohydrate compounds an amount of one or more carboxylic acid esters of a formula (II) and (A-2) subjecting the starting mixture to reaction conditions so that at least one of the one, two or more carbohydrate compounds reacts, and a fraction of the amount of one or more carboxylic acid esters of formula (II) is hydrolyzed, resulting in a mixture including 5-(hydroxymethyl)furfural and/or the one or more HMF esters of a formula (I), one or more carboxylic acids of a formula (III) and a remaining fraction of the amount of one or more carboxylic acid esters of formula (II).
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: October 1, 2019
    Assignee: BASF SE
    Inventors: Alvaro Gordillo, Martin Alexander Bohn, Stephan A. Schunk, Ivana Jevtovikj, Rene Backes, Holger Werhan, Svenia Duefert, Richard Dehn, Markus Piepenbrink
  • Patent number: 10420778
    Abstract: The present invention relates generally to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to methods for the use of calmodulin inhibitors and calcium channel blockers for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA).
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: September 24, 2019
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Leonard I. Zon, Alison M. Taylor
  • Patent number: 10421734
    Abstract: Disclosed is simple, novel, scalable and environment friendly process for the preparation of enantiopure 3-amino tetrahydrofuran and its salts.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: September 24, 2019
    Assignee: SAMI LABS LIMITED
    Inventors: Muhammed Majeed, Kalyanam Nagabhushanam, Savita Ganjihal, Rajendran Ramanujam
  • Patent number: 10421736
    Abstract: Disclosed is a process to produce a purified vapor comprising dialkyl-furan-2,5-dicarboxylate (DAFD). Furan-2,5-dicarboxylic acid (FDCA) and an alcohol in an esterification zone to generate a crude diester stream containing dialkyl furan dicarboxylate (DAFD), unreacted alcohol, 5-(alkoxycarbonyl)furan-2-carboxylic acid (ACFC), and alkyl furan-2-carboxylate (AFC). The esterification zone comprises at least one reactor that has been previously used in an DMT process.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: September 24, 2019
    Assignee: Eastman Chemical Company
    Inventors: Kevin John Fontenot, Mesfin Ejerssa Janka, Kenny Randolph Parker, Ashfaq Shahanawaz Shaikh
  • Patent number: 10421735
    Abstract: The invention relates to a novel process for the conversion of a feedstock comprising at least one sugar to 5-hydroxymethylfurfural, in which said feedstock is contacted with one or more catalysts of the family of the homogeneous sulphonic acids in the presence of at least one aprotic polar solvent, used alone or in a mixture, at a temperature comprised between 30° C. and 200° C., and at a pressure comprised between 0.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: September 24, 2019
    Assignee: IFP Energies nouvelles
    Inventors: Myriam Souleymanou, Marc Jacquin, Damien Delcroix
  • Patent number: 10420761
    Abstract: The current invention is directed to a class of compounds that inhibit the function of Thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells. Thymidylate synthase inhibition is, thus, useful for treatment of various types of cancers, including but not limited to, acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: September 24, 2019
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Maria Zajac-Kaye, Lidia Kulemina
  • Patent number: 10413549
    Abstract: The present invention relates to a compositions for and methods for cancer treatment, for example, hematopoietic cancers (e.g. B-cell Lymphoma). In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more of the disclosed compounds and, for example, 26S proteasome inhibitors, such as, for example, Bortezomib. In another aspect the present invention relates to autoimmune treatment with the disclosed compounds. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: September 17, 2019
    Assignee: Eutropics Pharmaceuticals, Inc.
    Inventors: David Richard, Michael H. Cardone
  • Patent number: 10399942
    Abstract: The present invention provides an improved process for the preparation of Apremilast using novel intermediates. The present invention also relates to the novel crystalline polymorphic form of Apremilast.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: September 3, 2019
    Assignee: Alembic Pharmaceuticals Limited
    Inventors: Mahender Rao Siripragada, Dinesh Panchasara, Ilesh Patel, Bhavesh Prajapati, Ankit Shah, Ananda Babu Thirunavakarasu, Pinky Parikh
  • Patent number: 10392358
    Abstract: Provided herein are methods of producing halomethylfuroic and acyloxymethylfuroic acid and ester compounds from furfural starting compounds. For example, 5-chloromethyl-2-furoic acid may be produced from 5-chloromethylfurfural, in the presence of various oxidants. Salts of the furoic acids may also be produced.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 27, 2019
    Assignee: Micromidas, Inc.
    Inventors: Daniel R. Henton, Makoto Nathanael Masuno, Ryan L. Smith, Alex B. Wood, Dimitri A. Hirsch-Weil, Christian T. Goralski, Robert Joseph Araiza
  • Patent number: 10392362
    Abstract: The present invention relates to a method for the catalytic synthesis of lactide from lactic acid. The method relates to the synthesis of lactide from lactic acid under the catalysis of a zinc oxide nanoparticle aqueous dispersion as a catalyst. The present invention has four technical characteristics: I. the zinc oxide nanoparticle aqueous dispersion catalyst has a sufficient surface area, and the size of nanoparticles is merely 30-40 nm, providing a sufficient contact area between the substrate (lactic acid) and the catalyst; II. the new catalyst has a milder catalytic effect on polymerization, allowing the molecular weight distribution of a prepolymer within a range of 400-1500 g/mol, which is advantageous for depolymerization to proceed; III. the new catalyst is stable, thus avoiding oxidation or carbonization in a high temperature reaction; and IV. the new catalyst has a low toxicity and a small threat to human health.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: August 27, 2019
    Assignee: The Hong Kong Research Institute of Textiles and Apparel Limited
    Inventors: Yunzi Hu, Carol Sze Ki Lin, Walid Daoud
  • Patent number: 10385033
    Abstract: A process for preparing furan-2,5-dicarboxylic acid is disclosed. The process includes the following steps: preparing or providing a starting mixture including 5-(hydroxy-methyl)furfural (HMF), 5,5?-[oxy-bis(methylene)]bis-2-furfural (di-HMF), and water; subjecting said starting mixture to oxidation conditions in the presence of an oxygen-containing gas and a catalytically effective amount of a heterogeneous catalyst including one or more noble metals on a support so that both HMF and di-HMF react to give furane-2,5-dicarboxylic acid in a product mixture also including water and oxidation by-products. The use of a catalyst is also disclosed, the catalyst including one or more noble metals on a support as an heterogeneous oxidation catalyst for catalyzing in an aqueous starting mixture the reaction of both HMF and di-HMF to furane-2,5-dicarboxylic acid.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: August 20, 2019
    Assignee: BASF SE
    Inventors: Alvaro Gordillo, Holger Werhan, Richard Dehn, Benoit Blank, Joaquim Henrique Teles, Stephan A Schunk, Markus Piepenbrink, Rene Backes, Lei Zhang
  • Patent number: 10385032
    Abstract: The invention provides a one pot method for generating propylene oxide, the method having the steps of contacting propane with catalyst clusters no greater than 30 atoms in the presence of oxygen for a time sufficient to directly convert the propane to the propylene oxide. The invented method eliminates the generation of intermediate compounds or intermediate reaction steps.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 20, 2019
    Assignee: UCHICAGO ARGONNE, LLC
    Inventors: Stefan Vajda, Avik Halder, Larry A. Curtiss
  • Patent number: 10381440
    Abstract: Aspects described herein relate to food and beverage compositions infused with lipophilic active agents and methods of use for the treatment of a variety of disorders. More particularly, aspects described herein relate to food and beverage compositions infused with lipophilic active agents such as cannabinoids, nicotine, nonsteroidal anti-inflammatories (NSAIDs), and vitamins, that provide enhanced bioavailability of the lipophilic active agents in a subject, and that mask unpleasant tastes of lipophilic active agents.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: August 13, 2019
    Inventors: Michelle Reillo, Marian E. Washington
  • Patent number: 10376464
    Abstract: Cocrystal compositions of metoprolol and dabigatran bases with enantiomers of theanine.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: August 13, 2019
    Assignee: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice