Patents Examined by Taylor V. Oh
  • Patent number: 10544179
    Abstract: A process for the hydrogenation of a substrate comprising a carbon heteroatom double bond in the presence of a transition metal complex comprising a tridentate or bisdentate-ligand containing a nitrogen, sulphur and phosphorus atom, of which at least the N- and P- and optionally also the S-atom coordinates with the transition metal.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: January 28, 2020
    Assignee: GIVAUDAN S.A.
    Inventors: Roger Wilhelm Geisser, Jürg Daniel Oetiker, Fridtjof Schröder
  • Patent number: 10543181
    Abstract: The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: January 28, 2020
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: Todd Brady, Scott Young, William A. Kinney, Kenneth J. Mandell
  • Patent number: 10544116
    Abstract: Disclosed herein is a process for purifying propylene oxide, including the steps of: (i) providing a stream S0 containing propylene oxide, acetonitrile, water, and an organic compound containing a carbonyl group —C(?O)—; and (ii) separating propylene oxide from the stream S0 by subjecting the stream S0 to distillation conditions in a distillation column to obtain a gaseous top stream S1c which is enriched in propylene oxide compared to the stream S0, a liquid bottoms stream S1a which is enriched in acetonitrile and water compared to the stream S0, and a side stream S1b containing propylene oxide which is enriched in the carbonyl compound compared to the stream S0.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: January 28, 2020
    Assignee: BASF SE
    Inventors: Joaquim Henrique Teles, Marvin Kramp, Christian Mueller, Nicolai Tonio Woerz, Bernd Metzen, Tobias Keller, Dominic Riedel, Markus Weber, Daniel Urbanczyk, Andrei-Nicolae Parvulescu, Ulrike Wegerle, Ulrich Mueller
  • Patent number: 10543167
    Abstract: Disclosed herein are compositions for topical application that effectively deliver antioxidants across the epidermis, dermis, or a combination thereof into cells and/or the bloodstream while concurrently maintaining chemical activity of the antioxidants. In certain aspects, these formulations include emulsions and balms each having a lipophilic carrier and a lipophilic antioxidant solubilized by the lipophilic carrier. Also disclosed herein are methods for making these compositions for topical application.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: January 28, 2020
    Assignee: ALPS SOUTH EUROPE S.R.O.
    Inventors: Aldo Laghi, Nathaniel Vint
  • Patent number: 10544118
    Abstract: Disclosed herein is a very efficient method to make 5-(alkoxycarbonyl)furan-2-carboxylic acids (ACFC) from feedstocks comprised of furoates. When a feedstock comprised of methyl 5-methylfuran-2-carboxylate (MMFC) is used a product comprised of (5-(methoxycarbonyl)furan-2-carboxylic acid (MCFC) is obtained in high yield.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: January 28, 2020
    Assignee: Eastman Chemical Company
    Inventor: Mesfin Ejerssa Janka
  • Patent number: 10544101
    Abstract: The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I),
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: January 28, 2020
    Assignee: Hikal Limited
    Inventors: Rahul Bhalerao, R. Sridharan, Shivaji Sadashiv Kandre, Ganesh Suryakant Deore, Kishorkumar Shivajirao Kadam, Dharnidhar Mundhe
  • Patent number: 10544115
    Abstract: A continuous process for the preparation of propylene oxide, comprising a start-up stage and normal run stage, wherein the normal run stage comprises (i) continuously providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, a formate salt, water and optionally propane, wherein in the liquid feed stream, the molar amount of the formate salt relative to the molar amount of hydrogen peroxide at a given point of time during the normal run stage is aN(Fo/H2O2); (ii) continuously passing the liquid feed stream provided in (i) into an epoxidation zone comprising a catalyst comprising a titanium zeolite having framework type MWW, and subjecting the liquid feed stream to epoxidation reaction conditions in the epoxidation zone, obtaining a reaction mixture comprising propylene oxide, acetonitrile, water, the formate salt, optionally propene, and optionally propane; (iii) continuously removing an effluent stream from the epoxidation zone, the effluent stream comprising propylene oxide, acetoni
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: January 28, 2020
    Assignee: BASF SE
    Inventors: Dominic Riedel, Joaquim Henrique Teles, Heiner Schelling, Ulrike Wegerle, Ulrich Mueller, Andrei-Nicolae Parvulescu, Jochen Mannweiler, Timo Henn, Thomas Luederitz, Nicolai Tonio Woerz, Christian Mueller, Markus Weber, Daniel Urbanczyk
  • Patent number: 10538499
    Abstract: An integrated process is described for producing 2,5-furandicarboxylic acid and/or a derivative thereof from a six carbon sugar-containing feed, comprising: a) dehydrating a feed comprising a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed comprised of at least one of 5-hydroxymethylfurfural and/or a derivative or derivatives of 5-hydroxymethylfurfural in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture comprising 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof, the solvent, and a residual catalyst; c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: January 21, 2020
    Assignees: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC, ARCHER DANIELS MIDLAND COMPANY
    Inventors: Stephen J. Howard, Kristina A. Kreutzer, Bhuma Rajagopalan, Eric R. Sacia, Alexandra Sanborn, Brennan Smith
  • Patent number: 10538512
    Abstract: 2-Acylindazole compounds of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: January 21, 2020
    Assignee: The Rockefeller University
    Inventors: Manish P. Ponda, Jan L. Breslow, Harold Selnick, Melissa Egbertson
  • Patent number: 10538503
    Abstract: To provide a method for producing 3-methyl-2-thiophenecarboxylic acid. A method for producing 3-methyl-2-thiophenecarboxylic acid, which comprises reacting 3-methylthiophene with chlorosulfonyl isocyanate, and hydrolyzing the obtained reaction product.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: January 21, 2020
    Assignee: ISHIHARA SANGYO KAISHA, LTD.
    Inventor: Tatsunori Yoshida
  • Patent number: 10538470
    Abstract: The present invention relates to a process for the preparation of limonene-4-ol by an epoxide ring opening isomerization of terpinolene epoxide.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: January 21, 2020
    Assignee: BASF Agro B.V.
    Inventors: Bernd Wolf, Michael Rack, Stefan Benson, Helmut Kraus, Roland Goetz, Sukunath Narayanan, Chidambaram Rishinaradamangalam
  • Patent number: 10538507
    Abstract: Provided is a purifying method for dabigatran etexilate free base, comprising subjecting a dabigatran etexilate free base crude product to water slurrying to obtain a crude product B; then conducting recrystallization on the crude product B with acetone and water to obtain a crude product C; and subsequently, purifying the crude product C with a mixed solvent of tetrahydrofuran and ethyl acetate, filtering and drying to obtain a dabigatran etexilate free base finished product. The purifying method of the present invention can effectively remove various impurities and is suitable for workshop production. Salts and water-soluble organic impurities are removed by purified water slurrying, impurities with a high polarity are removed by purifying with an acetone-water solution, and impurities with a low polarity are removed by purifying with a mixed solvent of tetrahydrofuran and ethyl acetate.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: January 21, 2020
    Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO., LTD.
    Inventors: Lingjie Chen, Wenling Zhang, Peng Wang
  • Patent number: 10533017
    Abstract: A method for producing 1,4:3,6-dianhydrohexitols, including the steps of: a) supplying at least one hexitol, b) dehydrating the hexitol, and c) distillating the dehydration product produced in step b), wherein: the hexitol is supplied in the form of an aqueous solution in step a); and the distillation is carried out by means of a thin-film evaporator in step c).
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: January 14, 2020
    Assignee: ROQUETTE FRERES
    Inventors: Hervé Wyart, Mathias Ibert
  • Patent number: 10526340
    Abstract: A process for manufacturing crystals of 1,4:3,6-dianhydrohexitols, by manufacturing a solution of an internal dehydration product of at least one hexitol, distilling the solution, crystallizing, and wherein the crystallization mother liquors undergo a step of evaporative crystallization. Unlike the prior art processes that seek to recycle the crystallization mother liquors, evaporative crystallization economically and efficiently replaces the succession of steps consisting of at least one concentration, then at least one step of purification by distillation, chromatography, or crystallization.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: January 7, 2020
    Assignee: ROQUETTE FRERES
    Inventors: Hervé Wyart, Thomas Lesur, Mathias Ibert
  • Patent number: 10526300
    Abstract: Processes for reducing the amount of a gaseous iodide-containing impurity present in a recycle gas stream used in the production of ethylene oxide, in particular alkyl iodide and vinyl iodide impurities, are provided. Processes for producing ethylene oxide, ethylene carbonate and/or ethylene glycol, and associated reaction systems are similarly provided.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: January 7, 2020
    Assignee: SHELL OIL COMPANY
    Inventors: Wayne Errol Evans, Jesse Raymond Black, Michael Francis Lemanski
  • Patent number: 10526306
    Abstract: A method for purifying crystals in a glass or metal container. A hydrocarbon is introduced into feed material containing tetrahydrocannabinol (THC). The feed material and hydrocarbon is placed in a glass or metal container. The hydrocarbon is then removed within a few minutes after introduction, leaving at least some hydrocarbon in the feed material. Pressure is allowed to build within the container in an oven or in a jacketed vessel for 2-3 weeks. During this time, THC acid crystals precipitate out and fall to the bottom of the container. The contents of the container are poured into a Buchner funnel and a vacuum is applied thereto in order to pull terpenes into a beaker. The terpenes are placed into an oven in order to purge off any remaining solvent. The funnel is then scraped to acquire THC acid crystals.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: January 7, 2020
    Inventors: Pratt Bethers, David Goodman, III
  • Patent number: 10526302
    Abstract: The invention relates to a process for the production of 5-hydroxymethylfurfural from a feedstock comprising at least one sugar using a combination of at least one catalyst selected from the homogeneous Lewis acids, the heterogeneous Lewis acids and the heterogeneous bases and at least one homogeneous Brønsted acid catalyst selected from the families of the thioureas, the sulphonic acids and the phosphorus-containing organic compounds, alone or in a mixture, in the presence of at least one aprotic polar solvent, at a temperature comprised between 30° C. and 300° C., and at a pressure comprised between 0.1 MPa and 10 MPa.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: January 7, 2020
    Assignee: IFP Energies Nouvelles
    Inventors: Myriam Souleymanou, Marc Jacquin, Damien Delcroix
  • Patent number: 10513527
    Abstract: The present invention relates to medical chemistry technique field, particularly relates to a preparation method for amorphous darunavir crystal, The present invention provides a preparation method for preparing amorphous form of darunavir using an anti-solvent method. It can be a different method compared to the evaporation and concentration process disclosed in WO2011048604. Although the same with WO2013114382, anti-solvent are used, the target crystal form are truly different. The crystal form of WO2013114382 is solvent-free darunavir crystal, while an amorphous form of darunavir in the present application.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: December 24, 2019
    Inventors: Jiankang Xu, Hao Wu, Meiqi Ye, Kai Ye, Linbing Zhu
  • Patent number: 10508032
    Abstract: Catalysts, catalytic systems and related synthetic methods for in situ production of H2O2 and use thereof in reaction with oxidizable substrates.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 17, 2019
    Assignee: Northwestern University
    Inventors: Kimberly A. Gray, Justin M. Notestein, Todd R. Eaton
  • Patent number: 10507189
    Abstract: The present invention provides compositions useful in reducing or preventing pain in a subject in need thereof. In one embodiment, the compositions comprise a halogenated volatile compound. The present invention further includes a method of reducing or preventing pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition of the invention. Dosing regimens contemplated within the invention include one-time administration, continuous administration or periodic administration.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: December 17, 2019
    Assignee: Vapogenix, Inc.
    Inventors: Danguole Spakevicius, Heather Giles, Terry Farmer