Patents Examined by Taylor V. Oh
  • Patent number: 10844050
    Abstract: The invention provides efficient cyclization processes of hydroxyalkenoic acids and products produced therefrom. The following reactions are claimed: Formula (I), (II), (V) and (VI).
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: November 24, 2020
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventor: Dmitry Tsvelikhovsky
  • Patent number: 10836733
    Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: November 17, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Alan Kozikowski, Irina Gaisina
  • Patent number: 10829466
    Abstract: A stilbene derivative, which is a compound of the following general formula I or general formula II, or an acceptable salt formed by the compound of the general formula I or the general formula II and an inorganic or organic acid; wherein, in the general formula I or the general formula II, the atom represented by X is a hydrogen atom or a halogen atom; the substituent represented by R is C1-C6 alkyl, 1-6-membered heteroalkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, 3-6-membered heterocycloalkyl, substituted 3-6-membered heterocycloalkyl, 5-18-membered aryl, substituted 5-18-membered aryl, 5-18-membered heteroaryl, or substituted 5-18-membered heteroaryl.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: November 10, 2020
    Assignee: BEIJING INSTITUTE OF TECHNOLOGY
    Inventors: Jianhua Liang, Hong Qing, Si Wu, Sisi Liu, Nuomin Li, Liang Yang
  • Patent number: 10828287
    Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: November 10, 2020
    Assignee: Nocion Therapeutics, Inc.
    Inventors: Bridget McCarthy Cole, James Lamond Ellis
  • Patent number: 10825995
    Abstract: The present invention provides a material for photoelectric conversion elements for use in imaging elements which comprises a compound represented by the following formula (1). The material for photoelectric conversion elements for use in imaging elements, which comprises a compound represented by the following formula (1), is used to produce a photoelectric conversion element which is excellent in terms of hole- or electron-leakage prevention, thermal resistance to processing temperatures, transparency to visible light, etc. In formula (1), R1 and R2 each independently represent a substituted or unsubstituted aromatic group.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: November 3, 2020
    Assignee: NIPPON KAYAKU KABUSHIKI KAISHA
    Inventors: Hidenori Yakushiji, Kazuki Niimi, Ryoutarou Morita, Tatsuya Yamamoto, Toshifumi Inouchi, Masahiro Hamada
  • Patent number: 10815198
    Abstract: A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes: 1) in the process of producing chloro ?-trifluoromethylpyridine compounds by allowing a ?-methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a ?-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chloro ?-trichloromethylpyridine compound to react with hydrogen fluoride in a reaction apparatus, 2) fractionating a liquid mixture containing chloro ?-trifluoromethylpyridine compounds from the reaction apparatus, and 3) separating and purifying 2-chloro-3-trifluoromethylpyridine from the liquid mixture.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: October 27, 2020
    Assignee: ISHIHARA SANGYO KAISHA, LTD.
    Inventor: Takayoshi Ando
  • Patent number: 10815208
    Abstract: Provided is a method for preparing 2-hydroxy-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative represented by formula (I). The method comprises the following steps: (1) preparing 3-aryl-2-substituted toluene derivative 2 by using 3-iodo-2-substituted toluene derivative 1 and aryl boronic acid 5 or aryl boronate as starting materials; (2) preparing a benzyl halide derivative 3 by using 3-aryl-2-substituted toluene derivative 2 as starting materials; and (3) preparing 4-(2, 3-disubstituted benzyloxy)-2-hydroxy-5-substituted benzaldehyde derivative (I) by using benzyl halide derivative 3 and 2,4-dihydroxy-5-substituted benzaldehyde 6.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: October 27, 2020
    Assignees: Institute of Materia Medica, Chinese Academy of Medical Sciences, Tianjin Chase Sun Pharmaceutical Co., LTD
    Inventors: Zhiqiang Feng, Xiaoguang Chen, Yang Yang, Fangfang Lai
  • Patent number: 10807868
    Abstract: Catalysts, catalytic systems and related synthetic methods for in situ production of H2O2 and use thereof in reaction with oxidizable substrates.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: October 20, 2020
    Assignee: Northwestern University
    Inventors: Kimberly A. Gray, Justin M. Notestein, Todd R. Eaton
  • Patent number: 10807979
    Abstract: A 4,5-disubstituted-1H-pyrrolo(2,3-f)quinolin-2,7,9-tricarboxylate compound, or an analog, or derivative thereof, having a structure of Formula I: R1 and R4 are each independently an atom or group selected from hydrogen, a linear or branched C1-8 alkyl group, a deuterated linear or branched C1-8 alkyl group, an aralkyl group, or a substituted aryl group; R2 is independently an atom or group selected from halogens, a linear or branched C1-8 alkoxy group, or a deuterated linear or branched C1-8 alkoxy group; and R3 is independently an atom or group selected from a linear or branched C1-8 alkoxy group, or a deuterated linear or branched C1-8 alkoxy group. The compound is useful as a reaction intermediate for the synthesis of PQQ. A process in which CAN is used as an oxidant in the synthesis of PQQ in existing patents and literatures is replaced. This makes the process cheaper and more efficient.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 20, 2020
    Assignee: SHANGDONG CAMASY BIOTECHNOLOGY CO., LTD.
    Inventors: Jinglin Wang, Song Qin, Zhenqiang Mu, Yang Li
  • Patent number: 10807961
    Abstract: A method for producing propylene oxide involves an oxidation step, a distillation step, an epoxidation step, and a separation step. The distillation step involves distilling the reaction mixture containing cumene hydroperoxide to separate it into a concentrate containing cumene hydroperoxide and a distillate. The reaction mixture is continuously distilled so that the ratio of the flow rate of the distillate to the flow rate of the reaction mixture to be distilled is 0.037 to 0.13. The epoxidation step involves obtaining a reaction mixture containing propylene oxide and cumyl alcohol by contacting the concentrate with propylene in the presence of a catalyst in one or more reactors to cause a reaction between propylene and cumene hydroperoxide in the concentrate, in which the outlet temperature of the final reactor is adjusted to 115° C. or more and less than 140° C.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: October 20, 2020
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Hirofumi Koike, Tomonori Kawabata, Takuo Takemoto, Motoshi Nakamura, Satoru Takemoto
  • Patent number: 10793537
    Abstract: Disclosed herein are a method of acid saccharification of biomass and a method of polymerization of furan compounds. The method of acid saccharification of biomass comprises recovering pentose-derived furan compounds produced during the acid saccharification process of biomass. The method of acid saccharification of biomass comprises introducing furan compounds into the acid saccharification process of biomass, to produce and recover furan polymers.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: October 6, 2020
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jeong-Myeong Ha, Hyemin Yang, Ye Seul Jeong, Jae Wook Choi, Dong Jin Suh, Young Hyun Yoon, Gi Seok Yang, Ung Lee
  • Patent number: 10793515
    Abstract: A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: October 6, 2020
    Assignee: AURIMMED PHARMA, INC.
    Inventors: Amir Pesyan, Manuel F. Balandrin
  • Patent number: 10787418
    Abstract: The present invention relates to a Palladium (II)-catalyzed C(sp3)-H alkynylation of amines using picolinamide as directing group. The developed alkynylation strategy is simple, efficient, and tolerant of various ring size including five to eight member cyclic, quaternary amines, and N-heterocyclic motifs.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: September 29, 2020
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ekambaram Balaraman, Vinod Gokulkrishna Landge, Akash Mondal
  • Patent number: 10781146
    Abstract: The object of the present invention is to provide a process for preparing a 5-alken-1-yne compound efficiently at low costs and a process for preparing (2E,6Z)-2,6-nonadienal by making use of the aforesaid process for preparing the 5-alken-1-yne compound. There is provided a process for preparing a 5-alken-1-yne compound of the following formula (4): Y—Z—CR1?CR2—(CH2)2—C?CH (4) in which Y in formula (4) represents a hydrogen atom or a hydroxyl group, the process comprising at least steps of: subjecting (i) an alkenylmagnesium halide compound prepared from a haloalkene compound of the following formula (1): Y—Z—CR1?CR2—(CH2)2—X1 (1) and (ii) an alkyne compound of the following formula (2): X2—C?C—Si(R3)(R4)(R5) (2) to a coupling reaction to form a silane compound of the following formula (3): Y—Z—CR1?CR2—(CH2)2—C?C—Si(R3)(R4)(R5) (3); and subjecting the silane compound (3) to a desilylation reaction to form the 5-alken-1-yne compound (4).
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: September 22, 2020
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Tomohiro Watanabe, Takeshi Kinsho, Yuki Miyake
  • Patent number: 10781193
    Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: September 22, 2020
    Assignee: KANEKA CORPORATION
    Inventors: Hiroaki Yasukouchi, Masaru Mitsuda, Akira Nishiyama, Makoto Funabashi
  • Patent number: 10780431
    Abstract: A method of using biopolymer to synthesize titanium-containing silicon oxide material and applications thereof are disclosed. The method comprises steps: mixing a titanium source, a silicon source, an acid source, a base source, a biopolymer and a solvent to form an aqueous solution, and letting the aqueous solution react to form a semi-product; performing aging, solid-liquid separation and drying of the semi-product to obtain a dried solid; and performing calcination or extraction of the dried solid to obtain a titanium-containing silicon oxide material with a high specific surface area. The present invention adopts a biopolymer as the templating agent, which makes the fabrication process of titanium-containing silicon oxide material more environment-friendly. After calcination or extraction, the product still has superior catalytic activity, able to catalyze epoxidation of olefins and favorable for the production of epoxide.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: September 22, 2020
    Assignee: ORIENTAL UNION CHEMICAL CORP.
    Inventors: Yu-Chuan Hsu, Pin-Hsuan Huang, Chien-Chang Chiang, Ying-Shih Chang, Hsi-Chin Tsai, Hong-Ping Lin
  • Patent number: 10774088
    Abstract: The present invention relates to an improved process for preparing [(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](2-methyl-propyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester—which compound is also known under its INN as darunavir—by reacting carbonic acid 2,5-dioxo-1-pyrrolidinyl[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]ester with 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-benzenesulfonamide in ethanol as solvent. Furthermore said process allows for darunavir to be isolated immediately in its ethanolate form, i.e. darunavir monoethanolate, which is the marketed form of darunavir under the tradename Prezista™.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: September 15, 2020
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Alfred Elisabeth Stappers, Yolande Lydia Lang, Shane Barry Robinson
  • Patent number: 10773184
    Abstract: The disclosure provides embodiments processing and extracting compounds from cannabis. In one embodiment, the method includes providing a composition comprising the cannabis; inserting the composition into a treatment zone; applying a pulsed electric field to the composition within the treatment zone, wherein a portion of the cell membranes of the cannabis are lysed by electroporation to provide a product comprising a lysate; and separating at least a portion of a compound within the lysate from a remainder of the product.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: September 15, 2020
    Assignee: X TRAXION, LLC
    Inventors: Jeffery S. Held, Konstantin Stanis
  • Patent number: 10766021
    Abstract: Disclosed is a propylene direct oxidation reaction catalyst capable of preparing a propylene oxide from propylene and oxygen at a higher yield than catalysts prepared by conventional methods, by applying a specific transition metal oxide promoter in preparation of a catalyst containing silver, a transition metal oxide promoter and a carrier through a slurry process. The present invention provides a propylene direct oxidation reaction catalyst, which is a supported silver catalyst used for preparing a propylene oxide from the propylene direct oxidation reaction, the catalyst including a molybdenum oxide and a tungsten oxide as a catalyst promoter.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: September 8, 2020
    Assignees: Lotte Chemical Corporation, Seoul National University R&DB Foundation
    Inventors: Joong Won Lee, Hyung Ki Min, Young Jong Seo, In Kyu Song, Eo Jin Lee, Jong Heop Yi
  • Patent number: 10766871
    Abstract: A continuous process for the preparation of propylene oxide, comprising providing a liquid feed stream comprising propene, hydrogen peroxide, methanol, water, at least one dissolved potassium salt of hydroxyethylidenediphosphonic acid, and optionally propane; passing the liquid feed stream provided in (i) into an epoxidation reactor comprising a catalyst comprising a titanium zeolite of structure type MFI, and subjecting the liquid feed stream to epoxidation reaction conditions in the epoxidation reactor, obtaining a reaction mixture comprising propylene oxide, methanol, water, and the at least one dissolved potassium salt of hydroxyethylidenediphosphonic acid, and optionally propane; removing an effluent stream from the epoxidation reactor, the effluent stream comprising propylene oxide, methanol, water, at least a portion of the at least one potassium salt of hydroxyethylidenediphosphonic acid, and optionally propane.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: September 8, 2020
    Assignees: BASF SE, Dow Global Technologies LLC
    Inventors: Edward O. Madenjian, Kenric A. Marshall