Patents Examined by Taylor V. Oh
  • Molten salt system and method and apparatus of transformation for multi-carbon production by using the same
    Patent number: 10941130
    Abstract: This invention relates to a novel molten salt system in chemical transformation of saccharides and a method as well as an apparatus for multi carbon production by the molten salt system. It is found that an eutectic molten salt composition is advantageous for multi-carbon productions through chemical transformation under mild conditions. This invention further provides a method and an apparatus for preparing 5-hydroxymethylfurfural (HMF) and HMF-derived chemicals from saccharides by the said molten salt system.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: March 9, 2021
    Assignee: Academia Sinica
    Inventors: Po-Wen Chung, Prasenjit Bhaumik, Hao-Ju Chou
  • Method for preparing pimavanserin and tartrate thereof by using triphosgene
    Patent number: 10934257
    Abstract: The present disclosure discloses a method for safely preparing pimavanserin and tartrate thereof by using triphosgene. The synthesis route includes: Raw materials used in the method of the present disclosure are safe and inexpensive, thereby effectively reducing the production costs. The method of the present disclosure has mild reaction conditions, and avoids using phosgene, which is highly toxic and difficult to handle is avoided. Thus, the method is readily implemented industrially.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: March 2, 2021
    Assignee: Livzon New North River Pharmaceutical Co., Ltd.
    Inventors: Biao Wang, Qiao Jiang, Bingbing Li, Murong Peng, Weijian Xie
  • Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
    Patent number: 10927114
    Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: February 23, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Liqi He, Sanjeev Gangwar, Shoshana L. Posy, Yam B. Poudel, Prasanna Sivaprakasam
  • Charged ion channel blockers and methods for use
    Patent number: 10925865
    Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: February 23, 2021
    Assignee: Nocion Therapeutics, Inc.
    Inventors: Bridget McCarthy Cole, James Lamond Ellis
  • Continuous carbonylation processes
    Patent number: 10927091
    Abstract: Provided are processes for monitoring and maintaining continuous carbonylation of epoxides or lactones. Processes include measuring parameters affecting the rate of the carbonylation reaction and adding supplemental replacement catalyst replacement components to maintain a constant rate of carbonylation.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: February 23, 2021
    Assignee: Novomer, Inc.
    Inventors: Jay J. Farmer, Peter Galebach, Kyle Sherry, Sadesh H. Sookraj
  • Method for producing 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, and said related substance
    Patent number: 10919872
    Abstract: Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of a 2-alkylcarbonyl[2,3-b]furan-4,9-dione, which comprises reacting a 1-butyne derivative in which a ketone or an alcohol is protected with a 2-hydroxy-1,4-naphthoquinone derivative having a leaving group at position-3 in a solvent in the presence of a metal or a metal compound and a base; and a substance relating to the intermediate.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: February 16, 2021
    Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Kazuhiko Takahashi, Shoji Watanabe, Katsuya Uchiyama, Kento Senami
  • Compounds and methods for detection of enzymes that remove methyl succinyl groups from epsilon-amino lysine moieties
    Patent number: 10920265
    Abstract: Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ?-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ?-amino of a lysine.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: February 16, 2021
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Konrad T. Howitz, Zhongda Zhang, Anne Kisielewski, Elizabeth Dale, Wayne Forrest Patton
  • Method of treatment of aqueous effluent
    Patent number: 10919871
    Abstract: A method of treatment of an aqueous effluent stream obtained during production of furfural is disclosed. The aqueous effluent stream containing organic solvents, furfural, and water is subjected to azeotropic distillation to obtain a distillate stream and a treated effluent stream having lower BOD and COD values which can be further reduced by biomethanation.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: February 16, 2021
    Assignee: BASF SE
    Inventors: Sunil Sadashiv Divekar, Pramod Shankar Kumbhar, Rahul Vasantrao Bagal, ShreekantUttam Satav
  • Nitroalkene non steroidal anti-inflammatory drugs (NA-NSAIDS) and methods of treating inflammation related conditions
    Patent number: 10906864
    Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: February 2, 2021
    Assignees: INSTITUT PASTEUR DE MONTEVIDEO, UNIVERSIDAD DE LA REPUBLICA
    Inventors: Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
  • Polyfunctional oxetane-based compound and production method thereof
    Patent number: 10906882
    Abstract: A group of polyfunctional oxetane-based compounds having a structure as represented by general formula (I) or a product obtained by a reaction between a compound of general formula (I) and epichlorohydrin, an ester compound, or an isocyanate compound. When these polyfunctional oxetane-based compounds are used as cation polymerizable monomers in combination with an epoxy compound, the curing speed is high, and the cured product has highly excellent hardness, flexibility, adherence, and heat resistance.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: February 2, 2021
    Assignee: CHANGZHOU TRONLY ADVANCED ELECTRONIC MATERIALS CO., LTD.
    Inventor: Xiaochun Qian
  • Biosynthetic pathways and products
    Patent number: 10907181
    Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: February 2, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Kechun Zhang, Mingyong Xiong
  • Method for producing bicyclic compound
    Patent number: 10899729
    Abstract: A method for producing a compound, such as 2-propanyl 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-buten-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepin-3-yl}butanoate, and a novel intermediate suitable for the method, whereby the compound can be stably supplied with a high total reaction yield, by changing the starting material and improving the metathesis reaction, asymmetric reduction reaction and the like.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 26, 2021
    Assignee: ONO PHARMACEUTICAL CO.. LTD.
    Inventors: Hideki Moriguchi, Yusuke Tanaka, Tatsunori Ino, Tohru Kambe, Taihei Nishiyama, Shinichiro Tsujiyama, Yohei Ueda
  • Selective solid catalyst for tail end of olefin-epoxidation flow reactor
    Patent number: 10898887
    Abstract: In one example, a method for converting a first compound into a second compound is provided. The method includes providing the first compound in an entrance of a flow through reactor, wherein the entrance comprises a first catalyst and an oxidant, converting the first compound and the oxidant into the second compound as the first compound and the oxidant contact the first catalyst in the entrance of the flow through reactor while moving towards a tail end of the flow through reactor, and converting the first compound and the oxidant into the second compound via a solid catalyst comprising a white crystalline solid with a titanium content of about 0.5 to about 1.5 weight percent (wt %) in the tail end of the flow through reactor.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: January 26, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alexander Okrut, Alexander Katz
  • Total synthesis of trioxacarcin DC-45-A2 and preparation of trioxacarcin analogs
    Patent number: 10899773
    Abstract: In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 26, 2021
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C Nicolaou, Quan Cai
  • Method for the preparation of a monothiocarbonate compound
    Patent number: 10889559
    Abstract: Process for the preparation of a compound with at least one monothiocarbonate group by reacting:—a compound with at least one mercaptoalcohol group and—a dialkylcarbonate, in the presence of a catalyst wherein the catalyst is a salt of a metal selected from group IIIb or IVb of the periodic system.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 12, 2021
    Assignee: BASF SE
    Inventors: Peter Rudolf, Jan-Dirk Arndt, Nicole Holub, Verena Mormul, Indre Thiel
  • Process for preparing 2-exo-(2-methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane
    Patent number: 10875873
    Abstract: This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-iso-propyl-7-oxabicyclo[2.2.1]heptane of the formula (I), (I) any one of its individual enantiomers or any non-racemic mixture thereof comprising the steps of (a) deprotonating (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: December 29, 2020
    Assignee: BASF AGRO B.V.
    Inventors: Stefan Benson, Michael Rack, Roland Goetz, Bernd Wolf, Joachim Gebhardt, Helmut Kraus
  • Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome
    Patent number: 10874676
    Abstract: Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: December 29, 2020
    Assignee: ESSENTIALS, INC.
    Inventor: Neil M. Cowen
  • Method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione
    Patent number: 10875835
    Abstract: The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 29, 2020
    Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Toshikazu Yagi, Satoshi Suzuki, Hiroto Tatamidani, Kazuki Hashimoto
  • Process for the epoxidation of propene
    Patent number: 10870631
    Abstract: In a process for the epoxidation of propene, comprising continuously reacting a propene feed with hydrogen peroxide in the presence of an epoxidation catalyst in a reaction step, using propene in excess to hydrogen peroxide, to provide a liquid reaction mixture comprising non-reacted propene, extra safety measures caused by the presence of oxygen during work-up of the liquid reaction mixture of the epoxidation reaction can be avoided by stripping liquid reaction mixture from step a) with an inert gas to provide an oxygen depleted stripped liquid reaction mixture and a strip gas stream, selecting the amount of inert gas to provide an oxygen concentration in the strip gas stream in the range of from 0.1 to 10% by weight, separating non-reacted propene from the strip gas stream and recycling it to the reaction step, and separating propene oxide from the stripped liquid reaction mixture.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: December 22, 2020
    Assignees: EVONIK OPERATIONS GMBH, THYSSENKRUPP INDUSTRIAL SOLUTIONS AG
    Inventors: Willi Hofen, Thomas Haas, Wolfgang Wöll, Jürgen Schemel, Hans-Christian Dietz, Marc Brendel
  • Processes for preparing 2,5-furandicarboxylic acid and esters thereof
    Patent number: 10865190
    Abstract: A process for producing furan dicarboxylic acid or an ester thereof from a feedstock comprising hydroxymethyl furfural (HMF) and humins is disclosed. Humins are a byproduct from reactions forming HMF from sugars and are typically removed from the HMF prior to any further processing. A humins-containing HMF feedstock is utilized to produce furan dicarboxylic acids and ester substantially free from humins.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: December 15, 2020
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Pranit S Metkar, Ronnie Ozer, Bhuma Rajagopalan