Patents Examined by Taylor V. Oh
  • Method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione
    Patent number: 10875835
    Abstract: The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 29, 2020
    Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Toshikazu Yagi, Satoshi Suzuki, Hiroto Tatamidani, Kazuki Hashimoto
  • Process for the epoxidation of propene
    Patent number: 10870631
    Abstract: In a process for the epoxidation of propene, comprising continuously reacting a propene feed with hydrogen peroxide in the presence of an epoxidation catalyst in a reaction step, using propene in excess to hydrogen peroxide, to provide a liquid reaction mixture comprising non-reacted propene, extra safety measures caused by the presence of oxygen during work-up of the liquid reaction mixture of the epoxidation reaction can be avoided by stripping liquid reaction mixture from step a) with an inert gas to provide an oxygen depleted stripped liquid reaction mixture and a strip gas stream, selecting the amount of inert gas to provide an oxygen concentration in the strip gas stream in the range of from 0.1 to 10% by weight, separating non-reacted propene from the strip gas stream and recycling it to the reaction step, and separating propene oxide from the stripped liquid reaction mixture.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: December 22, 2020
    Assignees: EVONIK OPERATIONS GMBH, THYSSENKRUPP INDUSTRIAL SOLUTIONS AG
    Inventors: Willi Hofen, Thomas Haas, Wolfgang Wöll, Jürgen Schemel, Hans-Christian Dietz, Marc Brendel
  • Processes for preparing 2,5-furandicarboxylic acid and esters thereof
    Patent number: 10865190
    Abstract: A process for producing furan dicarboxylic acid or an ester thereof from a feedstock comprising hydroxymethyl furfural (HMF) and humins is disclosed. Humins are a byproduct from reactions forming HMF from sugars and are typically removed from the HMF prior to any further processing. A humins-containing HMF feedstock is utilized to produce furan dicarboxylic acids and ester substantially free from humins.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: December 15, 2020
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Pranit S Metkar, Ronnie Ozer, Bhuma Rajagopalan
  • Process for preparing mixtures of epoxidized fatty acid esters
    Patent number: 10858611
    Abstract: The present invention relates to a process for preparing two mixtures of epoxidized fatty acid esters, comprising in the order given a transesterification of an epoxidized vegetable oil, followed by a reduction of the volatile saturated non-epoxidized fraction by short path distillation of the transesterified epoxidized vegetable oil, followed by a selection on the one hand of the non-vaporized fraction (residue) of the previous process step as the first mixture of epoxidized fatty acid esters and a selection on the other hand of the vaporized fraction (distillate) as the second mixture of epoxidized fatty acid esters. The first mixture is in particular suitable as plasticizer in halogenated polymers, the second mixture being particularly suitable as plasticizer in non-halogenated polymers.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: December 8, 2020
    Assignee: Proviron Holding N.V.
    Inventors: Arnaud Verraes, Jelle Cornelus
  • Method and an apparatus for separating furfural
    Patent number: 10858330
    Abstract: In a method and an apparatus furfural is separated from a material stream (3) which is formed in a treatment of a pretreated wood based material (1). The material stream (3) which comprises at least furfural is introduced to a separation column (5). A top vapor condensate (6) is introduced from a top end of the separation column (5) to a decanter (10) in which two liquid phases (9,11) are separated from each other. An organic phase (9) which comprises at least furfural is recovered, and an aqueous phase (11) is supplied as a reflux to the separation column (5). Further, the invention relates to a furfural based product and chemical product and a use of the organic phase.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: December 8, 2020
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Juha Tamper, Hans Hasse, Nadia Galeotti, Fabian Jirasek, Jakob Burger
  • Processes for the preparation of 2,5-furandicarboxylic acid and intermediates and derivatives thereof
    Patent number: 10851074
    Abstract: The present disclosure provides processes for the production of 2-5-furandicarboxylic acid (FDCA) and intermediates thereof by the chemocatalytic conversion of a furanic oxidation substrate. The present disclosure further provides processes for preparing derivatives of FDCA and FDCA-based polymers. In addition, the present disclosure provides crystalline preparations of FDCA, as well as processes for making the same.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: December 1, 2020
    Assignee: Stora Enso Oyj
    Inventors: Valery Sokolovskii, Vincent J. Murphy, Thomas R. Boussie, Gary M. Diamond, Eric L. Dias, Guang Zhu, James M. Longmire, Stanley Herrmann, Staffan Torssell, Mayya Lavrenko
  • Arf6 inhibitors and methods of synthesis and use thereof
    Patent number: 10849901
    Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: December 1, 2020
    Assignees: Navigen, Inc., The University of Utah Research Foundation
    Inventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
  • Cyclization processes of hydroxyalkenoic acids and products thereof
    Patent number: 10844050
    Abstract: The invention provides efficient cyclization processes of hydroxyalkenoic acids and products produced therefrom. The following reactions are claimed: Formula (I), (II), (V) and (VI).
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: November 24, 2020
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventor: Dmitry Tsvelikhovsky
  • Process and crystalline forms of lumacaftor
    Patent number: 10844048
    Abstract: The present invention generally relates to crystalline forms of Lumacaftor, processes for its preparation and pharmaceutical compositions thereof. The present invention also relates to an improved process for preparation of Lumacaftor.
    Type: Grant
    Filed: January 6, 2018
    Date of Patent: November 24, 2020
    Assignee: Laurus Labs Limited
    Inventors: Ravindra Babu Bollu, Prasanta Kumar Dalasingh, Sushmita Dwarampudi, Chandrahasa Reddy Annem, Uma Maheswer Rao Vasireddi
  • Solid form of (?)-Ambrox formed by a bioconversion of homofarnesol in the presence of a biocatalyst
    Patent number: 10844412
    Abstract: A solid form of (?)-Ambrox formed by a bioconversion process.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: November 24, 2020
    Assignee: Givaudan S. A.
    Inventors: Ghislain Sanhaji, Alix Rousseaux, Sandrine Noel, Eric Eichhorn
  • HDAC inhibitors and therapeutic methods using the same
    Patent number: 10836733
    Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: November 17, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Alan Kozikowski, Irina Gaisina
  • Stilbene derivative and preparation method thereof
    Patent number: 10829466
    Abstract: A stilbene derivative, which is a compound of the following general formula I or general formula II, or an acceptable salt formed by the compound of the general formula I or the general formula II and an inorganic or organic acid; wherein, in the general formula I or the general formula II, the atom represented by X is a hydrogen atom or a halogen atom; the substituent represented by R is C1-C6 alkyl, 1-6-membered heteroalkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, 3-6-membered heterocycloalkyl, substituted 3-6-membered heterocycloalkyl, 5-18-membered aryl, substituted 5-18-membered aryl, 5-18-membered heteroaryl, or substituted 5-18-membered heteroaryl.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: November 10, 2020
    Assignee: BEIJING INSTITUTE OF TECHNOLOGY
    Inventors: Jianhua Liang, Hong Qing, Si Wu, Sisi Liu, Nuomin Li, Liang Yang
  • Charged ion channel blockers and methods for use
    Patent number: 10828287
    Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: November 10, 2020
    Assignee: Nocion Therapeutics, Inc.
    Inventors: Bridget McCarthy Cole, James Lamond Ellis
  • Material for photoelectric conversion element for an imaging element, and photoelectric conversion element including same
    Patent number: 10825995
    Abstract: The present invention provides a material for photoelectric conversion elements for use in imaging elements which comprises a compound represented by the following formula (1). The material for photoelectric conversion elements for use in imaging elements, which comprises a compound represented by the following formula (1), is used to produce a photoelectric conversion element which is excellent in terms of hole- or electron-leakage prevention, thermal resistance to processing temperatures, transparency to visible light, etc. In formula (1), R1 and R2 each independently represent a substituted or unsubstituted aromatic group.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: November 3, 2020
    Assignee: NIPPON KAYAKU KABUSHIKI KAISHA
    Inventors: Hidenori Yakushiji, Kazuki Niimi, Ryoutarou Morita, Tatsuya Yamamoto, Toshifumi Inouchi, Masahiro Hamada
  • Method for separating and purifying 2-chloro-3-trifluoromethylpyridine
    Patent number: 10815198
    Abstract: A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes: 1) in the process of producing chloro ?-trifluoromethylpyridine compounds by allowing a ?-methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a ?-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chloro ?-trichloromethylpyridine compound to react with hydrogen fluoride in a reaction apparatus, 2) fractionating a liquid mixture containing chloro ?-trifluoromethylpyridine compounds from the reaction apparatus, and 3) separating and purifying 2-chloro-3-trifluoromethylpyridine from the liquid mixture.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: October 27, 2020
    Assignee: ISHIHARA SANGYO KAISHA, LTD.
    Inventor: Takayoshi Ando
  • Method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative
    Patent number: 10815208
    Abstract: Provided is a method for preparing 2-hydroxy-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative represented by formula (I). The method comprises the following steps: (1) preparing 3-aryl-2-substituted toluene derivative 2 by using 3-iodo-2-substituted toluene derivative 1 and aryl boronic acid 5 or aryl boronate as starting materials; (2) preparing a benzyl halide derivative 3 by using 3-aryl-2-substituted toluene derivative 2 as starting materials; and (3) preparing 4-(2, 3-disubstituted benzyloxy)-2-hydroxy-5-substituted benzaldehyde derivative (I) by using benzyl halide derivative 3 and 2,4-dihydroxy-5-substituted benzaldehyde 6.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: October 27, 2020
    Assignees: Institute of Materia Medica, Chinese Academy of Medical Sciences, Tianjin Chase Sun Pharmaceutical Co., LTD
    Inventors: Zhiqiang Feng, Xiaoguang Chen, Yang Yang, Fangfang Lai
  • Method for producing propylene oxide
    Patent number: 10807961
    Abstract: A method for producing propylene oxide involves an oxidation step, a distillation step, an epoxidation step, and a separation step. The distillation step involves distilling the reaction mixture containing cumene hydroperoxide to separate it into a concentrate containing cumene hydroperoxide and a distillate. The reaction mixture is continuously distilled so that the ratio of the flow rate of the distillate to the flow rate of the reaction mixture to be distilled is 0.037 to 0.13. The epoxidation step involves obtaining a reaction mixture containing propylene oxide and cumyl alcohol by contacting the concentrate with propylene in the presence of a catalyst in one or more reactors to cause a reaction between propylene and cumene hydroperoxide in the concentrate, in which the outlet temperature of the final reactor is adjusted to 115° C. or more and less than 140° C.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: October 20, 2020
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Hirofumi Koike, Tomonori Kawabata, Takuo Takemoto, Motoshi Nakamura, Satoru Takemoto
  • Catalysts and related methods for photocatalytic production of HOand thermocatalytic reactant oxidation
    Patent number: 10807868
    Abstract: Catalysts, catalytic systems and related synthetic methods for in situ production of H2O2 and use thereof in reaction with oxidizable substrates.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: October 20, 2020
    Assignee: Northwestern University
    Inventors: Kimberly A. Gray, Justin M. Notestein, Todd R. Eaton
  • 4,5-disubstituted-1H-pyrrolo(2,3-f)quinolin-2,7,9-tricarboxylate compound and use thereof
    Patent number: 10807979
    Abstract: A 4,5-disubstituted-1H-pyrrolo(2,3-f)quinolin-2,7,9-tricarboxylate compound, or an analog, or derivative thereof, having a structure of Formula I: R1 and R4 are each independently an atom or group selected from hydrogen, a linear or branched C1-8 alkyl group, a deuterated linear or branched C1-8 alkyl group, an aralkyl group, or a substituted aryl group; R2 is independently an atom or group selected from halogens, a linear or branched C1-8 alkoxy group, or a deuterated linear or branched C1-8 alkoxy group; and R3 is independently an atom or group selected from a linear or branched C1-8 alkoxy group, or a deuterated linear or branched C1-8 alkoxy group. The compound is useful as a reaction intermediate for the synthesis of PQQ. A process in which CAN is used as an oxidant in the synthesis of PQQ in existing patents and literatures is replaced. This makes the process cheaper and more efficient.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 20, 2020
    Assignee: SHANGDONG CAMASY BIOTECHNOLOGY CO., LTD.
    Inventors: Jinglin Wang, Song Qin, Zhenqiang Mu, Yang Li
  • Compounds advantageous in the treatment of central nervous system diseases and disorders
    Patent number: 10793515
    Abstract: A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: October 6, 2020
    Assignee: AURIMMED PHARMA, INC.
    Inventors: Amir Pesyan, Manuel F. Balandrin