Patents Examined by Tekchand Saidha
  • Steviol glycoside transport
    Patent number: 11297862
    Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: April 12, 2022
    Assignee: DSM IP ASSETS B.V.
    Inventors: Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
  • Steviol glycoside transport
    Patent number: 11293043
    Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 35 or SEQ ID NO: 38 or an amino acid sequence having at least about 50% sequence identity to either thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 35 or SEQ ID NO: 38 or an amino acid sequence having at least about 50% sequence identity to either thereto.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: April 5, 2022
    Assignee: DSM IP ASSETS B.V.
    Inventors: Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
  • Oligosaccharide production
    Patent number: 11293042
    Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: April 5, 2022
    Assignee: GLYCOM A/S
    Inventors: Margit Pedersen, Manos Papadakis, Peter Becker, Eric Samain, Pauline Peltier-Pain, Katrine Bych, Ted Johanson, Elise Champion, Gyula Dekany
  • Mutant Cas9 proteins
    Patent number: 11286470
    Abstract: Methods of making mutant Cas9 proteins are described.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: March 29, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Alejandro Chavez, Frank J. Poelwijk, George M. Church
  • Processes for preparing ACC inhibitors and solid forms thereof
    Patent number: 11279710
    Abstract: The present disclosure provides solid forms, including a salt or co-crystal, of Compound I: which exhibits Acetyl-CoA carboxylase (“ACC”) inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: March 22, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Michael Geier, Luke Humphreys, Mark E. Scott
  • Method of producing lipid
    Patent number: 11279958
    Abstract: A method of producing lipids, containing the steps of: culturing a transformant into which a gene encoding at least one of the proteins selected from the group consisting of the following proteins (A) to (C) is introduced; and producing fatty acids or lipids containing the same as components: (A) A protein consisting of the amino acid sequence of the 23rd to 146th amino acids set forth in SEQ ID NO: 1; (B) A protein consisting of an amino acid sequence having 70% or more identity with the amino acid sequence of the protein (A), and having acyl carrier protein activity; and (C) A protein containing the amino acid sequence of the protein (A) or (B), and having acyl carrier protein activity.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: March 22, 2022
    Assignee: Kao Corporation
    Inventor: Tatsuro Ozaki
  • Method for producing polyester
    Patent number: 11279957
    Abstract: To provide a method for producing a polyester comprising at least a 3-hydroxybutyrate unit as a polymerization unit and having a high molecular weight and a narrow molecular weight distribution (that is, small Mw/Mn). A method for producing a polyester comprising culturing a microorganism in a culture solution containing a carbon source and a nitrogen source, the polyester having a weight average molecular weight of 1,000,000 or greater and comprising at least a 3-hydroxybutyrate unit as a polymerization unit. The culture conditions include maintenance of an osmotic pressure of the culture solution from 200 mOsm to 900 mOsm during culture period, and maintenance of a nitrogen atom concentration of the culture solution at 0.30 g/L or greater during culture period.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: March 22, 2022
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventor: Akira Maehara
  • Method for the enzymatic conversion of a phenol substrate into a corresponding catechol product
    Patent number: 11274283
    Abstract: A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: March 15, 2022
    Assignee: University College Dublin, National University of Ireland, Dublin
    Inventors: Kevin O'Connor, Susan Molloy, Reeta Davis, Wesley Shaw
  • Recombinant cell, method for producing recombinant cell, and method for producing isoprene or terpene
    Patent number: 11261450
    Abstract: Provided is a recombinant cell that produces isoprene or terpene, wherein the recombinant cell includes an ability to synthesize isopentenyl diphosphate through a mevalonate pathway (MVA pathway), wherein the recombinant cell lacks an ability to synthesize isopentenyl diphosphate through an endogenous non-mevalonate pathway (MEP pathway), wherein the recombinant cell includes an isoprene synthase gene or a terpene synthase gene as a foreign gene, and wherein the recombinant cell produces, with the expression of the foreign gene, isoprene or terpene having 10, 15, 20, 30, or 40 carbon atoms. The mevalonate pathway is preferably an exogenous mevalonate pathway.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: March 1, 2022
    Assignee: SEKISUI CHEMICAL CO., LTD.
    Inventors: Kana Matsushima, Masahiro Furutani, Kazufumi Kawabata
  • Species of genus
    Patent number: 11261218
    Abstract: The present invention relates to a species of genus Pseudomonas identified as Pseudomonas BR11571, termed Candidatus Pseudomonas metallosolvens, having Accession Deposit Number DSM 32538.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 1, 2022
    Assignee: BRAIN AG
    Inventors: Esther Gabor, Renate Schulze, Arnulf Kletzin
  • Glycosylation modification of bioactive compounds and drugs by plant glycosyltransferases (UGTs)
    Patent number: 11261477
    Abstract: In alternative embodiments, provided are methods for the glycosylation modification of bioactive compounds and drugs using isolated, recombinant or genetically modified uridine diphosphate glycosyl-transferases (UGTs). In alternative embodiments, provided are methods for modifying UGTs to generate recombinant UGTs with altered donor and/or acceptor specificities. In alternative embodiments, provided are methods for screening for recombinantly engineered UGTs with new or altered properties, for example, for new or altered donor and/or acceptor specificities, where in alternative embodiments the screening comprise use of bacterial, yeast or baculovirus expression system.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: March 1, 2022
    Assignee: UNIVERSITY OF NORTH TEXAS
    Inventor: Xiaoqiang Wang
  • Alpha-synuclein substrates and methods for making and using the same
    Patent number: 11254718
    Abstract: An expression vector is provided for production of human alpha-synuclein (?S) protein or a conservative variant thereof that exhibits a decreased tendency to self-aggregate in an ?S seed amplification assay (SAA). The expression vector comprises a nucleic acid sequence coding for human ?S protein or a conservative variant, the nucleic acid sequence comprising codons that have been optimized to produce human ?S protein or a conservative variant when expressed by a host cell such as E. coli. The codons have been optimized to avoid amino acid misincorporation in the expressed protein. Methods for purification of the expressed protein are also provided.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: February 22, 2022
    Assignee: Amprion, Inc.
    Inventors: Luis Concha, Carly Farris, Bret Holguin, Yihua Ma
  • Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
    Patent number: 11248220
    Abstract: The present disclosure relates to a novel acetohydroxy acid synthase, a microorganism comprising the same, or a method for producing an L-branched-chain amino acid using the same.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: February 15, 2022
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Ae Ji Jeon, Byeong Cheol Song, Ji Hye Lee, Jong Hyun Kim, Hye Won Kim
  • Cleaning compositions comprising enzymes
    Patent number: 11248194
    Abstract: Cleaning compositions comprising endo-?-1,3-glucanase enzyme and cleaning adjunct. Methods of treating surfaces including fabrics by contacting the surface with an aqueous was liquor having the cleaning composition therein. The compositions and methods are particularly for cleaning cotton fabrics. The compositions and methods are particularly for removal of soils containing callose, curdlan, pachyman, scleroglucan or schizophyllan. The compositions and methods are particularly for improving whiteness of a fabric, improved soil removal from a fabric, for malodour removal from a fabric, for anti-wrinkle benefits and/or for improved drying of a fabric.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: February 15, 2022
    Assignee: The Procter & Gamble Company
    Inventors: Neil Joseph Lant, Katherine Esther Latimer
  • Lipid production
    Patent number: 11236372
    Abstract: The present invention relates to at least one cell for producing at least one lipid with general formula II from at least one carbon substrate, wherein R1 and R2 independently of one another comprises identical or different organic radicals each with 5 to 13 carbon atoms, wherein the cell is a non-pathogenic cell that is genetically modified to increase the heterologous expression relative to the wild type cell of: an enzyme (E2) capable of converting 3-hydroxyalkanoyl-3-hydroxyalkanoyl-CoA/ACP or 3-(3-hydroxyalkanoyloxy)alkanoic acid (HAA) and NDP-glucose into ?-D-glucopyranosyl-3-hydroxyalkanoyl-3-hydroxyalkanoate.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: February 1, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Mirja Wessel, Steffen Schaffer, Anne Jeremias, Martin Schilling, Hans Henning Wenk
  • Fatty acid decarboxylase and its uses
    Patent number: 11236367
    Abstract: The present invention relates to the identification of a new class of fatty acid decarboxylases and its uses, in particular for producing alkanes/alkenes from fatty acids.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: February 1, 2022
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Frederic Beisson, Damien Sorigue, Bertrand Legeret, Stephan Cuine, Stephanie Blangy, Gilles Peltier
  • Aqueous fermentation feedstock and a method for the production thereof
    Patent number: 11229226
    Abstract: Provided are dry-milling methods for producing an aqueous fermentation feedstock ingredient. The methods include providing a corn-processing filtration feed; filtering at least a fraction of said filtration feed on a microfiltration membrane, whereby an aqueous filtration permeate and a filtration retentate are formed; separating said filtration permeate from said filtration retentate, to form separated permeate and separated retentate; forming a fermentation feedstock comprising said separated permeate, and saccharifying and/or washing said separated retentate.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: January 25, 2022
    Assignees: SUPERBREWED FOOD, INC., ADVANCEBIO, LLC.
    Inventors: Bryan P. Tracy, Dale A. Monceaux
  • Genetically modified isopropylmalate isomerase enzyme complexes and processes to prepare elongated 2-ketoacids and C-Ccompounds therewith
    Patent number: 11230705
    Abstract: Genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD? enzyme complexes), microbial organisms including genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD?), and processes for preparing C7-C11 2-ketoacids with genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD?). The genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD? enzyme complexes), microbial organisms, and processes for preparing C7-C11 2-ketoacids can be used to produce C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: January 25, 2022
    Assignee: Dow Global Technologies LLC
    Inventors: Paresh Sanghani, Eric C. Shiue, Scott A. Greenwalt
  • Mutant ?-glucosidase
    Patent number: 11225679
    Abstract: Provision of a mutant ?-glucosidase having high protease resistance. A mutant ?-glucosidase consists of an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1, wherein the amino acid sequence comprises Gln and Thr respectively at positions corresponding to positions 649 and 655 of SEQ ID NO: 1 or Tyr-Glu-Pro-Ala-Ser-Gly in a region corresponding to the region from position 653 to position 658 of SEQ ID NO: 1, and has ?-glucosidase activity.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: January 18, 2022
    Assignee: Kao Corporation
    Inventors: Junichi Sumitani, Yutaro Baba, Shuji Tani, Takashi Kawaguchi
  • Compositions and methods for enhancing efficiencies of microbial-derived biosurfactants
    Patent number: 11220699
    Abstract: Disclosed herein are compositions comprising a sophorolipid surfactant and a bio-synergist and the methods of using the same.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: January 11, 2022
    Assignee: Advanced BioCatalytics Corporation
    Inventor: Carl W. Podella