Abstract: The present invention relates to novel aminoalkyl substituted nitrosourea derivatives as well as their acid addition salts with pharmaceutically acceptable acids showing pronounced antineoplastic effectiveness in animal experiments.The novel compounds of the present invention may be represented by the following formula: ##STR1## wherein X and Y are the same or different, and are selected from the group consisting of a phenyl group and a cyclohexyl group, said phenyl and cyclohexyl groups being optionally substituted with one or two substituents selected from a halogen atom, a lower alkyl group having from one to four carbon atoms inclusive, a trifluore methyl group, a cyano group, a phenyl group, a cyclohexyl group and a lower alkyloxy group having from one to four carbon atoms inclusive."Alkylene" is an alkylene group, branched or unbranched, having from one to four carbon atoms inclusive, and R.sup.1 and R.sup.
Abstract: A process for producing tolylthiourea having high purity comprises reacting toluidine with a thiocyanate and a mineral acid in the presence of an organic solvent and water.
Abstract: Reaction of monohydroxy-fatty acids of the formulaCH.sub.3 --(CH.sub.2).sub.m --CHOH--(CH.sub.2).sub.n --COOHwhere m is an integer from 4 to 9 and n is an integer from 6 to 11, with from 12 to 20 moles of ethylene oxide, the products thus obtained, and their use as solubilizers.
Type:
Grant
Filed:
August 12, 1981
Date of Patent:
December 28, 1982
Assignee:
BASF Aktiengesellschaft
Inventors:
Knut Oppenlaender, Heinz Krapf, Siegfried Lang
Abstract: Completely biodegradable, toxicologically innocuous, oxidation-resistant, flavorless and odorless, light-colored, homogeneous liquid ester mixtures with low turbidity points, low evaporation losses at elevated temperatures, and viscosities and densities adjustable as desired, comprising the products of esterification of 1 mol of glycerin with from 1.4 to 2.8 mols of a saturated aliphatic monocarboxylic acid having from 6 to 10 carbon atoms, or mixtures thereof, and from 0.1 to 0.8 mol of a saturated aliphatic dicarboxylic acid, or mixtures or anhydrides thereof, said ester mixtures having hydroxyl numbers ranging from 5 to 20 and an acid number of less than 5.
Abstract: This invention provides an improved process for synthesizing carboxamides which involves reacting 3-p-menthyl halide with magnesium to form 3-p-menthylmagnesium halide Grignard reagent, and reacting the Grignard reagent with hydrocarbyl isocyanate at a temperature below about -20.degree. C. to form N-hydrocarbyl-p-menthane-3-carboxamide product.The product comprises a mixture of geometric isomers in which the 3-p-menthyl:3-p-neomenthyl weight ratio is at least 4:1 and can be as high as 9:1 under optimal conditions.This invention also provides a novel process for producing acylurea compounds such as N-(3-p-menthylcarbonyl)-N-t-butyl-N'-t-butylurea.
Abstract: In a process for producing acrylamide by hydrating acrylonitrile in the presence of a copper-based catalyst, the reaction is carried out in the presence of 30 to 10,000 ppm of acetone in the reaction solution. According to this process, the activity of the copper-based catalyst is maintained and the economic advantage of acrylamide production is enhanced.
Abstract: New triiodinated isophthalic acid diamides of the formula ##STR1## wherein the amide residues --CO--N.R.sub.1 R.sub.2 and --CO--N.R.sub.3 R.sub.4 are different from each other andR.sub.1 is hydrogen or C.sub.1-6 alkyl,R.sub.2 is mono- or polyhydroxyalkyl,R.sub.3 is hydrogen or C.sub.1-6 alkyl,R.sub.4 is mono- or polyhydroxylalkyl,R.sub.5 is C.sub.1-6 alkyl or mono- or polyhydroxy-C.sub.1-6 -alkyl or C.sub.1-3 -alkoxy-C.sub.1-3 -alkyl, andR.sub.6 is hydrogen, C.sub.1-6 alkyl or mono- or polyhydroxyalkyl provide superior nonionic X-ray contrast media.
Type:
Grant
Filed:
March 6, 1980
Date of Patent:
December 21, 1982
Assignee:
Schering, Aktiengesellschaft
Inventors:
Ulrich Speck, Peter Blaszkiewicz, Dieter Seidelmann, Erich Klieger
Abstract: 4(5)-acetyl-9,9-dimethyltricyclo-[4,4,0,1.sup.8,10 ]-undec-1-ene having the formula ##STR1## its synthesis, its use as a perfumery agent and as an olfactant component in perfumery compositions and as an odorant for technical products.
Abstract: Compounds having the formula ##STR1## in which X and Y are halogen; R is cyano, halogen, thio-C.sub.1 -C.sub.4 alkyl, phenyl, pyridyl, hydroxy, or OR.sub.1 ; R.sub.1 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 mono- or di-alkylcarbamyl, C.sub.2 -C.sub.6 alkoxyalkyl, phenylcarbamyl, C.sub.1 -C.sub.6 alkanoyl or C.sub.1 -C.sub.6 haloalkanoyl; and n is: (a) 1 or 2 if R is thioalkyl, cyano or phenyl; and (b) 2 if R is otherwise as defined, are herbicides.
Abstract: Liquid salts such as quaternary phosphonium and ammonium salts of halides, acids, or more complex anions can be utilized to extract aromatics from mixed aliphatic/aromatic hydrocarbon feeds such as isomerization process feed streams, cat naphthas, lube stocks, and the like. Such salts show the required solubilities in various solvents to exhibit a distinct selectivity advantage over more commonly used extraction solvents such as sulfolane in the extraction of benzene and other aromatics from heptane and other aliphatic feedstreams.
Type:
Grant
Filed:
August 3, 1981
Date of Patent:
November 16, 1982
Assignee:
Exxon Research and Engineering Co.
Inventors:
Kent A. Howard, Howard L. Mitchell, Robert H. Waghorne
Abstract: 2-Phenylsemicarbazides are prepared by a multi-step process involving:(a) treating a phenylhydrazine, or salt thereof, with a chloroformate;(b) adding phosgene;(c) treating the resulting product with an amine; and(d) hydrolyzing the resulting acylated semicarbazide. The reaction can proceed through a .DELTA..sup.2 -1,3,4-oxadiazolin-5-one intermediate formed with heating in step (b). Certain of the products are novel compounds.
Abstract: There are provided novel urea derivatives of the general formula ##STR1## wherein X, n, A and R are defined in the description; processes for preparing the derivatives and herbicidal composition containing as active ingredient the derivative. The derivatives have highly selective herbicidal activities.
Abstract: New nonadienylamines, nonatrienylamines and nonylamines are described, as well as a new process for their manufacture by reacting a 1,3-diolefine with a Schiff's base in the presence of certain nickel catalysts. The new compounds are suitable for combating micro-organisms, for example in the protection of materials.
Type:
Grant
Filed:
November 22, 1978
Date of Patent:
November 2, 1982
Assignee:
Ciba Geigy Corporation, N.Y.
Inventors:
Dieter Reinchr, Bernard Hugelin, Eduard Troxler
Abstract: Novel trifluoropropyl-substituted aryl- or aralkylbenzenes of the formula: ##STR1## wherein R is a not-substituted or ring-substituted phenyl-, benzyl-, phenethyl- or alpha-methylbenzyl group by one 3,3,3-trifluoropropyl group, and n is an integer of 1,2 or 3, provided that the total number of 3,3,3-trifluoropropyl group of the above-mentioned trifluoropropyl-substituted aryl- or aralkylbenzene is at most 3, and a process for the production thereof are disclosed.
Abstract: A series of novel derivatives of phenoxyalkanolamine of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen, alkyl of 1 to 2 carbon atoms, methoxy, halogen, nitro, amino or acylamino residues, and the salts thereof, are described, as are methods for their synthesis. The compounds are highly active .beta..sub.1 -specific sympathicomimetics with a partially antagonistic component.
Type:
Grant
Filed:
March 24, 1980
Date of Patent:
October 26, 1982
Assignee:
Veb Arzneimittelwerk Dresden
Inventors:
Dieter Lehmann, Klaus Femmer, Gottfried Faust
Abstract: The invention relates to a process for the preparation of acyl ureas of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same of different and each is halogen atom, preferably fluorine or chlorine atom, andR.sub.3 is a substituted aryl group.The compounds of the invention can be prepared by reacting an urea of formula (II):R.sub.3 NHCONH.sub.2 (II)wherein R.sub.3 is as defined above, with an acid chloride of formula (III): ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, in an inert organic solvent at a temperature of from 20.degree. C. to 100.degree. C.
Type:
Grant
Filed:
October 17, 1980
Date of Patent:
October 19, 1982
Assignee:
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
Abstract: Dyestuffs of the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the meaning indicated in the description,and their use for dyeing and printing materials containing hydroxyl groups or amide groups, such as textile fibres, filaments and fabrics of wool, silk or synthetic polyamide or polyurethane fibres, and for dyeing and printing natural or regenerated cellulose with dyeings and prints which are fast to washing.
Type:
Grant
Filed:
November 20, 1979
Date of Patent:
October 19, 1982
Assignee:
Bayer Aktiengesellschaft
Inventors:
Klaus von Oertzen, Wolfgang Harms, Klaus Wunderlich
Abstract: This invention is concerned with certain 3-(thiazolidin-2'-yl)-substituted phenyl sulfonamides which find utility as intermediates in the preparation of photographic image dye-providing materials.