Patents Examined by Thomas A. Waltz
  • Process for preparing N-[2-(p-hydroxyphenyl)-ethyl]-p-chlorobenzamide
    Patent number: 4281190
    Abstract: A process for preparing N-[2-(p-hydroxyphenyl)ethyl]-p-chlorobenzamide, a penultimate precursor for bezafibrate, is described.
    Type: Grant
    Filed: August 14, 1980
    Date of Patent: July 28, 1981
    Assignee: Morton-Norwich Products, Inc.
    Inventor: Nicholas Harris
  • Sulfonamide intermediates for adrenergic blocking agents
    Patent number: 4281189
    Abstract: There are disclosed compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n --wherein n is 2 to 20, ##STR2## and ##STR3## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy, and ##STR4## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n --wherein n is 2 to 20, ##STR5## and ##STR6## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof.There are also disclosed processes and intermediates utilized to produce the end products.The end products have utility as agents exhibiting both .alpha. and selective .beta. adrenergic blocking action.
    Type: Grant
    Filed: August 22, 1980
    Date of Patent: July 28, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Jefferson W. Tilley
  • N-(2,5-Dihydroxy-3,4,6-trimethyl-benzyl)-acrylamide and-methacrylamide
    Patent number: 4281192
    Abstract: Unsaturated compounds corresponding to the following formula: ##STR1## in which: R' represents a hydrogen atom or a methyl radical are provided as antioxidant monomers from which antioxidant polymers can be prepared.
    Type: Grant
    Filed: October 16, 1979
    Date of Patent: July 28, 1981
    Assignee: L'Oreal
    Inventors: Bernard Jacquet, Claude Mahieu, Christos Papantoniou
  • Insecticidal N-methyl-N-(benzene sulfonic acid methylamide-N'-sulfenyl)-carbamic acid oxime esters
    Patent number: 4281011
    Abstract: N-methyl-N-(benzene sulfonic acid methylamide-N'-sulfenyl)-carbamic acid esters of the formula ##STR1## in which X is halogen, C.sub.1 -C.sub.6 alkyl or hydrogen, andR is a phenyl, naphthyl, benzodioxolanyl or indanyl radical optionally carrying at least one alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, alkylmercapto, alkenylmercapto, alkynylmercapto, dialkylamino, trihalogenemethyl, halogeno, nitro, nitrile, cycloalkyl, formamidino, dioxanyl or dioxolanyl radical; or an oxime radical of the formula ##STR2## in which R.sup.1 and R.sup.2 each individually is alkyl, alkoxy, alkylthio or alkoxycarbonyl, the alkyl moieties of R.sup.1 and R.sup.2 optionally being linked to one another,which possess insecticidal and acaricidal properties.
    Type: Grant
    Filed: January 27, 1976
    Date of Patent: July 28, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Siegle, Engelbert Kuhle, Ingeborg Hammann, Wolfgang Behrenz
  • 19-Hydroxy-19-methyl-6a-carba-PGI.sub.2 sulfonylamides
    Patent number: 4281150
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-6a-carba-PGI.sub.1 sulfonylamides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: July 28, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • High thermal stability liquid hydrocarbons and methods for producing them
    Patent number: 4280894
    Abstract: Liquid petroleum hydrocarbon blends having improved thermal stability at temperatures of 1000.degree. F. and higher are prepared by removing from the blends dissolved molecular oxygen and maintaining low levels of certain trace impurities in the blends. Trace impurity compounds that are maintained at low levels include: sulfur compounds classed as thiols, sulfides, disulfides and polysulfides; organic oxygen compounds classed as hydroperoxides, peroxides, paraffinic carboxylic acids, and phenols; nitrogen compounds classed as amides and alkyl-pyridines; and reactive olefins. Additional improvements in the blends can be obtained by providing them with a dibenzothiophene or a nitrogen compound classed as a paraffinic amine, carbazole or piperidine. The treated blends of this invention have substantially the same physical properties as similar blends that have not been so treated.
    Type: Grant
    Filed: June 4, 1975
    Date of Patent: July 28, 1981
    Assignee: Exxon Research & Engineering Co.
    Inventor: William F. Taylor
  • Process for the preparation of 2,4-dinitrophenyl urea
    Patent number: 4281187
    Abstract: 2,4-Dinitrophenyl urea is obtained in a technologically simple manner with high yield, if 2,4-dinitro-1-chlorobenzene 1s reacted with cyanamide, advantageously in an excess amount, at a temperature at from about 55.degree. to 75.degree. C. to yield 2,4-dinitrophenyl cyanamide which is subsequently hydrolyzed without intermediate isolation in an aqueous acid medium at a temperature of from about 40.degree. to 75.degree. C. 2,4-Dinitrophenyl urea serves as starting compound for the preparation of 5-amino-benzimidazolones which may be employed, for example, when preparing azo compounds.
    Type: Grant
    Filed: December 20, 1979
    Date of Patent: July 28, 1981
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Theodor Papenfuhs, Kurt Gengnagel
  • Process for the preparation of tris(aminomethyl)phosphine oxide and its ternary salts
    Patent number: 4278811
    Abstract: Tris(aminomethyl)phosphine oxide and its ternary salts, useful as catalysts for the chemical finishing of cotton, are prepared by the hydrolysis of tris(N-carbalkoxylaminomethyl)-phosphine oxides having the formula (RO.sub.2 CNHCH.sub.2).sub.3 PO with an alkali or alkaline earth in the presence of water, followed optionally by acidification.
    Type: Grant
    Filed: March 10, 1980
    Date of Patent: July 14, 1981
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Arlen W. Frank, Donald J. Daigle, Russell M. H. Kullman
  • 19-Keto-PG amides
    Patent number: 4278815
    Abstract: The present invention provides novel 19-keto-PG amides, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: July 14, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19,20-Didehydro-13,14-dihydro-PG.sub.2, sulfonyl amides
    Patent number: 4278813
    Abstract: The present invention provides novel 19,20-didehydro-13,14-dihydro-PG.sub.2, sulfonyl amides, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: July 14, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Bis(sulfonamide) stabilizers for synthetic polymers
    Patent number: 4278577
    Abstract: Bis(sulfonamides) containing one or more hindered phenol groups are disclosed, as is their use as thermal stabilizers for polymers. Further stabilization results from combinations thereof with a thiodipropionate ester and a divalent metal salt of a carboxylic acid.
    Type: Grant
    Filed: July 23, 1980
    Date of Patent: July 14, 1981
    Assignee: American Cyanamid Company
    Inventor: John Song
  • 19,20-Didehydro-PG.sub.2 sulfonyl amides
    Patent number: 4278812
    Abstract: The present invention provides novel 19,20-didehydro-PG.sub.2 sulfonyl amides, methods for their preparation, and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: July 14, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Combating insects with N-(substituted-phenyl)-N-(2-chloro-6-fluoro-benzoyl)-ureas
    Patent number: 4277499
    Abstract: N-(Substituted-phenyl)-N'-(2-chloro-6-fluoro-benzoyl)- ureas of the formula ##STR1## in which R represents halogenoalkyl with 1-4 carbon atoms,R.sup.1 represents hydrogen, halogen or halogenoalkyl with 1-4 carbon atoms,X represents oxygen or sulphur, andn represents the number 1 or 2which possess insecticidal properties.
    Type: Grant
    Filed: February 1, 1980
    Date of Patent: July 7, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Sirrenberg, Erich Klauke, Albrecht Marhold, Ingeborg Hammann, Wilhelm Stendel, Ingomar Krehan
  • 19,20-Didehydro-PG.sub.1, sulfonyl amides
    Patent number: 4276435
    Abstract: The present invention provides novel 19,20-didehydro-PG.sub.1, sulfonyl amides methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Acylurea insecticides
    Patent number: 4276309
    Abstract: Acylurea insecticides and methods of preparation thereof are disclosed. The acylureas have compositions of the general formula ##STR1## wherein R.sub.1 is halogen, alkyl with from 1 to 6 carbon atoms or alkoxy with from 1 to 6 carbon atoms; R.sub.2 is hydrogen or halogen; R.sub.3 is hydrogen or alkyl with from 1 to 6 carbon atoms; R.sub.4 is hydrogen, alkyl with from 1 to 6 carbon atoms, aryl with from 6 to 12 carbon atoms, halogen substituted aryl with from 6 to 12 carbon atoms or alkaryl with from 7 to 12 carbon atoms; R.sub.5 is halogen; R.sub.6 is hydrogen or halogen; X is halogen or alkyl with from 1 to 6 carbon atoms; and n is 0, 1 or 2.
    Type: Grant
    Filed: July 10, 1980
    Date of Patent: June 30, 1981
    Assignee: Schering AG
    Inventors: Heinrich Franke, Hartmut Joppien
  • 19-Keto-PG sulfonylamides
    Patent number: 4276436
    Abstract: The present invention provides novel 19-keto-PG sulfonylamides, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Combating pests with N-(4-substituted-phenyl)-N'-(2-substituted-benzoyl)-thioureas
    Patent number: 4276310
    Abstract: N-(4-Substituted-phenyl)-N'-(2-substituted-benzoyl)-thioureas of the formula ##STR1## in which R.sup.1 represents halogen,R.sup.2 represents hydrogen or halogen,R.sup.3 represents hydrogen, halogen or halogenoalkyl,R.sup.4 represents halogen, halogenoalkyl, halogenoalkoxy, halogenoalkylthio or halogenoalkylsulphonyl, with the proviso that R.sup.3 represents halogenoalkyl if R.sup.4 represents halogen, andR.sup.5 represents hydrogen or halogen,which possess arthropodicidal, fungicidal and bactericidal properties.
    Type: Grant
    Filed: August 16, 1979
    Date of Patent: June 30, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Sirrenberg, Erich Klauke, Ingeborg Hammann, Ingomar Krehan, Peter Kraus, Wilhelm Stendel
  • 19,20-Didehydro-13,14-dihydro-PG.sub.1, sulfonyl amides
    Patent number: 4276434
    Abstract: The present invention provides novel 19,20-didehydro-13,14-dihydro-PG.sub.1, sulfonyl amides, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Fungicidal N-alkynylanilides
    Patent number: 4275079
    Abstract: N-alkynylanilides, a process for their preparation, fungicidal compositions containing the N-alkynylanilides as the active ingredient and methods for the use of such compounds or compositions for combatting plant fungi are disclosed.
    Type: Grant
    Filed: May 7, 1980
    Date of Patent: June 23, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Franz Dorn
  • .beta.-Adrenergic blocking alkanolamine derivatives
    Patent number: 4275058
    Abstract: 1-Indanyloxy- or tetrahydronaphthyloxy-3-amino-2-butanol derivatives, especially erythro-1-(7-methylindan-4-yloxy)-3-isopropylaminobutan-2-ol, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess peripherally-selective .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: June 23, 1981
    Assignee: Imperial Chemical Industries Limited
    Inventor: Howard Tucker