Patents Examined by Thor Nielsen
  • Patent number: 10667515
    Abstract: (S)-5-ethynyl-anabasine and derivatives thereof; composition comprising same and a carrier; methods of treating an animal; method of protecting a plant from a pest; and methods of making compound and derivatives.
    Type: Grant
    Filed: July 16, 2017
    Date of Patent: June 2, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Richard J. Martin, Alan P. Robertson, Brett VanVeller, Xiangwei Du, Fudan Zheng
  • Patent number: 10231976
    Abstract: Provided are methods and kits for administering progestogen as a glucocorticoid sensitizer to restore corticosteroid sensitivity or reverse the glucocorticoid insensitivity or enhance glucocorticoid sensitivity, in order to treat one or more glucocorticoid insensitivity related diseases or conditions. For example, these include methods for reversing the glucocorticoid insensitivity in a subject having no history of menstrual cycle-related exacerbation or allergy to self-hormones, particularly progesterone, such as premenstrual or perimenstrual deterioration in the symptoms, e.g., premenstrual worsening of atopic dermatitis or premenstrual exacerbations of asthma, and exhibiting relatively or totally refractory responses to glucocorticoid therapy, e.g., glucocorticoid resistance. The methods and kits provide for the administration of a sex hormone to the subject who is corticosteroid dependent or corticoid resistant or unresponsive or intolerant to corticosteroids.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: March 19, 2019
    Inventor: Tao Tom Du
  • Patent number: 10201795
    Abstract: The application describes an aqueous dispersion of microcapsules, wherein the shell of the microcapsules comprises at least one polyurea and the core comprises one or more lipophilic components with the proviso that the core does not contain a fragrance, and having a percentage of the shell weight with reference to the total weight of the capsules of 5 to 40% and wherein the microcapsules have a volume average diameter of 15 to 90 ?m and the dispersion comprises hydroxyalkylcellulose and the use of such a dispersion.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: February 12, 2019
    Assignee: BASF SE
    Inventors: Ewelina Burakowska-Meise, Wolfgang Denuell, Thomas Soltys, Emmanuel Julien Leon Christian Aussant, Addi Fadel, Ian Harrison
  • Patent number: 10188110
    Abstract: A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: January 29, 2019
    Assignee: Teleflex Medical Incorporated
    Inventors: Nisha Gupta, Elaine Steinke, Joel Rosenblatt
  • Patent number: 10183041
    Abstract: An antibacterial composition that comprises as active compound at least one light isotope of an element selected from the group which consists of 1H, 12C, 16O, 14N, 39K, 24Mg, 64Zn, 85Rb, 28Si, 54Fe, 92Mo, 74Se, 58Ni, 70Ge, 52Cr, 63Cu, 50V, or combinations thereof, wherein the composition is enriched for the at least one light isotope. A method of treating and preventing bacterial diseases in humans and non-human animals by administering the composition. The use of the said composition in human and veterinary medicine for the prevention and treatment of diseases in humans and non-human animals and also as an antiseptic and disinfectant.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: January 22, 2019
    Inventors: Peter Y Novak, Maxim V Temnikov, Oleksandr Balakin
  • Patent number: 10159256
    Abstract: The disclosure describes a composition for use in treating wounds in trees, plants and vines. In addition, the disclosure provides a method of making the compositions and their use in treating fungal infections of pruning wounds.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: December 25, 2018
    Assignee: The Regents of the University of California
    Inventor: Philippe Rolshausen
  • Patent number: 10143707
    Abstract: A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof, which include introducing Na2O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCl, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: December 4, 2018
    Inventors: Gregory J. Pomrink, Jipin Zhong, Zehra Tosun, Roy Layne Howell, Cecilia Cao
  • Patent number: 10143650
    Abstract: A dispersion including a plurality of bodies dispersed in a continuous phase. Each dispersed body including an internal drop formed with an internal phase miscible with the continuous phase, the internal drop (16) receiving an active product. Each dispersed body including, around the internal drop, a membrane formed with an intermediate phase immiscible with the continuous phase and totally surrounding the internal drop. The ratio R1 of the average thickness (e) of the membrane over the average transverse dimension (Dc) of the active volume delimited by the internal drop and the membrane is greater than 0.05, and is advantageously less than 0.5. The ratio R2 of the partition coefficient of the active product between the intermediate phase forming the membrane and the internal phase forming the internal drop over the viscosity of the membrane is less than 1 s?1·Pa?1.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 4, 2018
    Assignee: CAPSUM
    Inventors: Jérôme Bibette, Thomas Delmas, Enric Santanach Carreras, Leslie Rolland
  • Patent number: 10130097
    Abstract: The invention relates to an object having a coating arranged on at least one surface of the object, which comprises at least one antimicrobially active layer having an antimicrobial agent, wherein the agent comprises a copper (I) compound and/or a copper (II) compound.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: November 20, 2018
    Inventors: Pascal Meier, Walter Haag, Andriy Romanyuk
  • Patent number: 10130618
    Abstract: This invention is a novel pharmaceutical composition comprising dabigatran or a pharmaceutically acceptable salt thereof in combination with a proton pump inhibitor for use in the antithrombotic treatment with preventing or reducing the risk of a gastrointestinal disorder.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: November 20, 2018
    Inventors: Ali Türkyilmaz, Mehtap Saydam, Yildiz Gülkok, Nur Kirat Uzunogullari, Sevgi Gökcek
  • Patent number: 10123533
    Abstract: The present invention comprises formulations for agricultural use comprising a surfactant and pesticide. The surfactants comprise nitrogen containing surfactants with N+—CH2COO?, N+—CH2COOCH3, N—CH2COO?M+, N—CH2CH2COO?M+, and/or amine oxide functionalities which enhance the pesticide activity. The pesticides include herbicides, fungicides and insecticides.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: November 13, 2018
    Inventors: Shawn Zhu, Joshua Jurs, Elliot Isaac Band, Michael Walters
  • Patent number: 10123988
    Abstract: The present invention provides topical dermal compositions including microsphere encapsulated isotretinoin. Pharmaceutically acceptable salts, esters, or amides of isotretinoin are also contemplated for use in the practice of the invention. The compositions of the invention are useful for treating a variety of conditions associated with excess sebum production, such as, for example, acne.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 13, 2018
    Assignee: Allergan, Inc.
    Inventors: John E. Donello, Rong Yang
  • Patent number: 10125099
    Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: November 13, 2018
    Assignee: University of Southern California
    Inventors: Jean C. Shih, Florence M. Hoffman, Thomas C. Chen
  • Patent number: 10123531
    Abstract: A plant or algae control composition is disclosed. The composition contains a herbicide and/or algaecide adsorbed onto a solid carrier. The composition may comprise a free-flowing granular product. The solid carrier contains a mixture of different clay materials. Two different clay materials are combined that synergistically mix together to allow for greater amounts of the herbicide or algaecide to be adsorbed onto the particles. The composition is particularly well suited for treating aquatic environments.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: November 13, 2018
    Assignee: Arch Chemicals, Inc.
    Inventors: James Charles Schmidt, John Weber, Ryan M. Wersal
  • Patent number: 10123535
    Abstract: The present invention relates to methods for modifying an agricultural crop comprising treating the agricultural crop with a composition comprising a xyloglucan endotransglycosylase and (a) a polymeric xyloglucan and a functionalized xyloglucan oligomer comprising a chemical group; (b) a polymeric xyloglucan functionalized with a chemical group and a functionalized xyloglucan oligomer comprising a chemical group; (c) a polymeric xyloglucan functionalized with a chemical group and a xyloglucan oligomer; (d) a polymeric xyloglucan, and a xyloglucan oligomer; (e) a polymeric xyloglucan functionalized with a chemical group; (f) a polymeric xyloglucan; (g) a functionalized xyloglucan oligomer comprising a chemical group; or (h) a xyloglucan oligomer, or (a-h) without a xyloglucan endotransglycosylase, in a medium under conditions leading to a modified agricultural crop possessing an improved property compared to the unmodified agricultural crop.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: November 13, 2018
    Assignee: Novozymes A/S
    Inventors: Alex Berlin, Jason Quinlan, Romil Benyamino
  • Patent number: 9999222
    Abstract: The present invention relates to herbicidal combinations comprising at least one compound of formula (I) (component a) and at least one further compound selected from herbicidally active compounds (component b) and/or safeners (component c) wherein Ra, Rb, Rc, Rd are inter alia H, halogen, CN, NO2, C1-C6-alkyl, C1-C6-haloalkyl, OH, C1-C6-alkoxy, C1-C6-alkylthio, etc.; R1 is inter alia H, OH, S(O)2NH2, CN, C1-C6-alkyl, etc.; R2 is inter alia H, halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C6-alkynyl, etc.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: June 19, 2018
    Assignee: BASF SE
    Inventors: Julia Major, Florian Vogt, Frederick Calo, Thomas Seitz, Doreen Schachtschabel, Trevor William Newton, Kristin Hanzlik, Johannes Hutzler, Klaus Kreuz, Stefan Tresch
  • Patent number: 9999223
    Abstract: The present invention relates to a herbicidal composition which comprises: a) at least one herbicide A selected from glyphosate, glufosinate and their salts, and b) a herbicide B which is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole [common name: pyroxasulfone]. The present invention relates in particular to a herbicidal composition comprising: a) at least one herbicide A selected from glyphosate, glufosinate and their salts, b) a herbicide B which is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole [common name: pyroxasulfone], and c) at least one further herbicide C, which is selected from the herbicide groups C.1 to C.8: C.1 herbicides of the group of acetolactate synthase inhibitors (ALS inhibitors), C.2 herbicides of the group of protoporphyrinogen oxidase inhibitors (PPO inhibitors), C.3 herbicides of the group of auxines, C.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 19, 2018
    Assignee: BASF SE
    Inventors: Bernd Sievernich, William Karl Moberg, Anja Simon, Helmut Walter, Richard R. Evans
  • Patent number: 9987232
    Abstract: A pharmaceutical composition comprising a mixture of: (c) an active macromolecular principle; (d) an aromatic alcohol absorption enhancer chosen from propyl gallate, butylated hydroxy toluene (BHT), butylated hydroxy anisole (BHA) and analogs and derivatives thereof, or mixtures thereof; and (d) a biguanide or a pharmaceutically acceptable salt thereof, capable of increasing the solubility of the aromatic alcohol absorption enhancer in an aqueous medium, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active principle.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: June 5, 2018
    Assignee: Axcess Limited
    Inventor: Roger R. C. New
  • Patent number: 9987306
    Abstract: The present invention pertains to the use of the calcium-sensing receptor (CaSR)-activating nutrients (designated as “CaSR-based nutrients”) for the prevention and/or treatment of diarrheal diseases and inflammation in the gastrointestinal tract. In one embodiment, the current invention is formulated for oral administration. The anti-diarrheal composition of the present invention is useful for treating diarrheal and gastrointestinal inflammatory conditions in infants and young children.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: June 5, 2018
    Inventor: Sam Xianjun Cheng
  • Patent number: 9974859
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: May 22, 2018
    Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of TechnoIogy
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer