Patents Examined by Vera C. Clarke
  • Preparation of isopropylidene bis(phthalic acid)
    Patent number: 5028737
    Abstract: An oxidation process is provided for converting dixylylpropane to isopropylidene bis(phthalic acid) in good yields with minimal by-product production, especially trimellitic acid production. The oxidation process employs an oxidation catalyst that includes zirconium as well as cobalt, manganese, and bromine.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: July 2, 1991
    Assignee: Amoco Corporation
    Inventor: Paul A. Sanchez
  • Process for the preparation of dialkyl malonates
    Patent number: 5026900
    Abstract: A process for the preparation of alkyl malonates by carbonylation of chloroacetate in the presence of a carbonyl source, a carbonylation catalyst, such as chromium carbonyl and an aliphatic alcohol, this reaction being carried out in a two-phase liquid medium.A process for recycling the catalyst also forms part of the invention.
    Type: Grant
    Filed: May 18, 1989
    Date of Patent: June 25, 1991
    Assignee: Rhone-Poulenc
    Inventors: Philippe Coste, Philippe Leconte, Robert Perron, Michel Baudoin
  • Trisubstituted benzoic acid intermediates
    Patent number: 5026896
    Abstract: Novel trisubstituted benzoic acid intermediates which are useful in the preparation of certain herbicidal 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexanediones are described.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: June 25, 1991
    Assignee: ICI Americas Inc.
    Inventor: William J. Michaely
  • Aminophosphonate-containing polymers
    Patent number: 5023368
    Abstract: Aminophosphonate-containing polymers of the formula:--B].sub.m [A].sub.nwhereinA represents repeating units from one or more ethylenically unsaturated comonomers;B is ##STR1## wherein R is hydrogen or methyl,X is hydrogen or an alkali metal,Z is CH.sub.2 --P(O)(OX).sub.2 or C.sub.1 -C.sub.6 alkyl, aryl, cyclohexyl or alkaryl, m/n is 0.01 to 0.5.The novel polymers of the present invention may be used as dispersants for concentrated aqueous particulate slurries, and as corrosion inhibitors and scale inhibitors in water treatment.
    Type: Grant
    Filed: June 8, 1989
    Date of Patent: June 11, 1991
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: John C. Leighton, Carmine P. Iovine
  • 3-phenoxy (or phenylthio)-cyclopentanecarbonylamino acid analogues
    Patent number: 5023268
    Abstract: Compounds related to 3-phenoxy (or phenylthio) cyclopentanecarbonylamino acid, processes for their preparation, and treating agents for cerebral edema containing the compounds as active ingredients are described. The compounds are represented by the following formula: ##STR1## The compounds of the present invention and their non-toxic salts have a potent inhibitory effect on the development of cerebral edema.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: June 11, 1991
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Katsuhiro Imaki, Tadao Okegawa, Yoshinobu Arai
  • Linear, low-molecular-weight polyester-based polyol
    Patent number: 5023367
    Abstract: This invention relates to a linear, low-molecular-weight polyester-based polyol having terminal primary hydroxyl groups, low viscosity, high solids content and having the structural formula: ##STR1## where n is 1 or 2 and at least 70% by weight is n=1, and m=2-10, said polyol being substantially free of cyclohexane dimethanol.
    Type: Grant
    Filed: May 22, 1989
    Date of Patent: June 11, 1991
    Assignee: King Industries, Inc.
    Inventors: Leonard J. Calbo, Jr., Lawrence V. Gallacher
  • Preparation of optically active aliphatic carboxylic acids
    Patent number: 5015764
    Abstract: A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises (i) forming a salt solution comprising said racemic mixture of a C.sub.1 to C.sub.6 linear or branched aliphatic carboxylic acid and an organic or inorganic base (ii) treating said salt solution with one-half molar equivalent of a chiral organic nitrogenous base having a base strength no stronger than said organic or inorganic base (iii) precipitating from the reaction solution formed in step (ii) the less soluble diastereomeric salt and (iv) separating said precipitated diastereomeric salt.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: May 14, 1991
    Assignee: Ethyl Corporation
    Inventors: Thanikavelu Manimaran, Fred J. Impastato
  • Composition for imparting moisture to a substrate
    Patent number: 5015474
    Abstract: Methods and compositions are provided for alleviating the dryness of a dermal or mucosal membrane substrate. The compositions are formulated from eriodictyon fluid which is a Yerba Santa extract and viscous excipients, and may be in the form of an aqueous vaginal douche, a cream or a suppository. The compositions may additionally contain a lubricant compound effective to provide lubrication and relieve frictional irritation on the affected area. Preservatives, topical anesthetics, coloring agents, emulsifiers, and the like may be included in the compositions as well. The Yerba Santa-based compositions of the invention are topically administered to an affected patient to alleviate the symptoms of dryness.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: May 14, 1991
    Assignee: Parnell Pharmaceuticals, Inc.
    Inventor: Francis W. Parnell
  • Process for increasing the direct esterification reaction rate of a diacid with a glycol
    Patent number: 5015759
    Abstract: A process for increasing the direct esterification reaction rate between a diacid and 1,4-butanediol and for directly esterifying greater than 95% of the acid ends of the diacid by mixing in any order the diacid, the 1,4-butanediol and a catalyst compound selected from organo-titanium, organo-tin, and organo-zirconium compounds, to form a reaction mixture wherein the ratio of diol:diacid is at least 2:1 and then reacting the reaction mixture at an average temperature ranging between 190.degree. C. to 200.degree. C. for a period of time no longer than sixty minutes. The same process may be followed substituting ethylene glycol for 1,4-butanediol, provided the catalyst compound is added neat, further provided that the average reaction temperature ranges from 190.degree. C. to 200.degree. C., and also provided that the reaction mixture be reacted for a period of time no longer than seventy minutes.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: May 14, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: David J. Lowe
  • Process for preparation of .alpha.-alkoxy acetic acids and their salts
    Patent number: 5013864
    Abstract: A process for producing an .alpha.-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula R--OH wherein R is alkyl, substituted alkyl, or cycloalkyl, or cycloalkyl alkyl with a base in an aprotic organic solvent to give an alkoxide followed by removal of the organic solvent and reaction of the alkoxide with a salt of a monohaloacetic acid in a polar aprotic solvent such as DMSO to give the corresponding alkoxyacetate salt which then may be recovered or may optionally be converted to the corresponding acid by contacting the alkoxy acetate salt with an acid.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: May 7, 1991
    Assignee: G. D. Searle & Co.
    Inventors: Arthur L. Campbell, Richard A. Mueller, John S. Ng, Richard A. Partis
  • Compositions and methods comprising 2-mercaptomethylglutaric acid derivatives
    Patent number: 5010103
    Abstract: New compounds having utility for enhancing the activity of antifolates are disclosed of the formula: ##STR1## wherein X is selected from hydrogen ##STR2## and R" ; R' is selected from alkyl, alkenyl, alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heterocyclic aryl; R" is selected from ##STR3## and R'S; M is selected from OR and secondary amine; and R is selected from hydrogen, alkyl, acyloxymethyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclic aryl, amino cation and metal cation.
    Type: Grant
    Filed: January 17, 1990
    Date of Patent: April 23, 1991
    Assignee: The Research Foundation of State University of N.Y.
    Inventor: Thomas I. Kalman
  • Process for the preparation of methyl (+)-(2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propio nates
    Patent number: 5008434
    Abstract: A process for the preparation of a methyl (+)-(2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)propionat e of the formula (I): ##STR1## in which X denotes hydrogen or chlorine, which process comprises reacting a 2-aminothiophenol of formula (II): ##STR2## in which X is as defined above, with methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, in a 1,2-dichloroethane solvent.
    Type: Grant
    Filed: April 18, 1989
    Date of Patent: April 16, 1991
    Assignee: Synthelabo
    Inventors: Guy Rossey, Antonio Ugolini, Isaac Chekroun, Abkar Vartanian, Alexander Wick
  • Process for exchanging dispersing medium of terephthalic acid slurry
    Patent number: 5008450
    Abstract: A process for exchanging a dispersing medium of a terephthalic acid slurry by introducing an aliphatic carboxylic acid slurry of terephthalic acid into a multi-stage column at the upper part thereof and introducing water at the lower part thereof to form an upflowing stream of water in the multi-stage column, while a sedimentation of terephthalic acid particles is effected, and withdrawing an aqueous aliphatic carboxylic acid solution from the upper part of the multi-stage column and an aqueous slurry of terephthalic acid from the lower part of the multi-stage column.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: April 16, 1991
    Assignee: Mitsui Petrochemical Industries, Ltd.
    Inventors: Ryoichi Yamamoto, Hiroshi Suzuki
  • Process for the continuous esterification of fatty acids
    Patent number: 5008046
    Abstract: The invention is a process for the continuous liquid-phase esterification of C.sub.2 -C.sub.24 fatty acids with alkanols in countercurrent contact and reaction in a reaction column, the catalysts and fatty acids are introduced at the top plate and the alkanols below the lowest plate, at a head pressure of the reaction column of 200 to 900 hPa. The process reduces dehydration of the alkanols.
    Type: Grant
    Filed: March 21, 1989
    Date of Patent: April 16, 1991
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Norbert Bremus, Bernhard Gutsche, Lutz Jeromin, Eberhard Peukert, Bernard Schleper
  • 2-hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionic acid, 8'-phenylmenthyl ester, especially for diltiazem
    Patent number: 5008433
    Abstract: The titled ester, especially having the (2S,3S)-configuration, which is an intermediate for the production of diltiazem, is provided. Very high yields are obtainable.
    Type: Grant
    Filed: April 6, 1990
    Date of Patent: April 16, 1991
    Assignee: Marion Laboratories, Inc.
    Inventor: James T. Palmer
  • Process for the preparation of nitramine-containing homopolymers and co-polymers
    Patent number: 5008443
    Abstract: Energetic binders, and, more specifically, a class of nitramine-containing homopolymers and co-polymers characterized by favorable viscosity and glass transition temperature are prepared.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: April 16, 1991
    Assignee: Olin Corporation
    Inventors: Roger W. Day, Rahim Hani
  • Esters of 2-arylmethyl-1-naphthol derivatives as 5-lipoxygenase inhibitors
    Patent number: 5006555
    Abstract: There are provided novel esters of 2-arylmethyl-1-naphthol derivatives useful as anti-inflammatory agents. Also provided are pharmaceutical compositions containing these compounds and methods of using the compounds to treat inflammatory diseases in man.
    Type: Grant
    Filed: January 17, 1990
    Date of Patent: April 9, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Douglas G. Batt
  • Process for oxidation of alkyl aromatic compounds
    Patent number: 5004830
    Abstract: A process is disclosed for liquid phase oxidation of alkyl aromatic hydrocarbons to aromatic carboxylic acids in presence of a multivalent catalyst promoted by a source of bromine. The oxidation is conducted in at least two oxidation reactions. Exothermic heat of reaction is controlled by means of a liquid phase heat exchanger to control temperature and pressure. Oxygen partial pressure in each stage is at least 1.5 psia to minimize oxygen starvation and improve selectivity. Low reactor temperature, high reactor pressure and improved selectivity improve product yield and product quality.
    Type: Grant
    Filed: November 29, 1989
    Date of Patent: April 2, 1991
    Assignee: Amoco Corporation
    Inventors: Chang M. Park, Wayne P. Schammel
  • 1,1-dioxopenicillanoyl oxymethyl D-6-(.alpha.-(methyleneamino) phenylacetamido)-penicillanate and a process for the preparation thereof
    Patent number: 5004738
    Abstract: A pharmaceutical compound which comprises reacting the sodium penicillanic acid 1,1-dioxides with chloroiodomethane in the presence of a solvent to produce chloromethylpenicillanate 1,1-dioxides, reacting the chloromethylpenicillanate 1,1-dioxides with a sodium iodide to produce iodomethylpenicillanate 1,1-dioxides, and reacting the iodomethylpenicillanate 1,1-dioxide with sodium methampicillin and is effective in the treatment of bacterial infections in a mammal.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: April 2, 1991
    Inventor: Young Sul Kim
  • Polymerizable organosilane compound
    Patent number: 5000881
    Abstract: A novel organosilane compound having polymerizability is disclosed which is a vinyl .omega.-triorganosilyl n-undecanoate of the formula CH.sub.2 .dbd.CH--O--CO--(--CH.sub.2 --).sub.10 --SiR.sub.3, in which R is an alkyl group having 1 to 4 carbon atoms, alkoxy group having 1 to 4 carbon atoms or trialkyl siloxy group of which the alkyl group has 1 to 4 carbon atoms. This compound can be prepared by the hydrosilylation reaction between a triorganosilane of the formula HSiR.sub.3 and vinyl 10-undecenoate of the formulaCH.sub.2 .dbd.CH--O--CO--(--CH.sub.2 --).sub.8 --CH.dbd.CH.sub.2in the presence of a platinum catalyst. The compound is polymerizable to give not only a homopolymer of the compound alone but also a copolymer with other comonomers such as vinyl chloride, chloro trifluoroethylene, methyl methacrylate and the like.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: March 19, 1991
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Toshinobu Ishihara, Mikio Endo, Tohru Kubota