Patents Examined by Vera C. Clarke
  • Indanoxyacetic acid derivatives
    Patent number: 4975460
    Abstract: Novel indanoxyacetic acid derivatives of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, a substituted or unsubstituted phenyl group, naphtyl group or a sulfur-containing heterocyclic group, R.sup.2 is hydroxy group or a protected hydroxy group, p is an integer of 2 or 3, and q is an integer of 0 or 1, and a salt thereof are disclosed.Said derivative (I) and a salt thereof are useful as a platelet aggregation-inhibiting agent and an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis, embolism, coronary and cerebral vascular smooth muscl vellication, asthma, and the like.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: December 4, 1990
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Takeo Iwakuma, Harumichi Kohno, Yasuhiko Sasaki, Katsuo Ikezawa, Akio Odawara
  • Thromboxane A.sub.2 antagonists and pharmaceutical compositions thereof
    Patent number: 4973604
    Abstract: This invention relates to several thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids, pharmaceutical compositions employing them and methods of their use.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: November 27, 1990
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Liquid crystal compounds having naphthalene nucleus
    Patent number: 4973738
    Abstract: Novel ferroelectric liquid crystal compounds which may realize a stable molecular orientation which makes it possible to give a definite light-dark contrast in the no electric field state and attain a definite threshold property as well as hysteresis, and for making it possible to attain the dynamic driving as well as the high speed of response, owing to tri-stable phase thereof, of the general formulae (I) and (II) ##STR1## in which R.sub.1 means an alkyl, alkoxy or alkyloxycarbonyl each of 1-20 carbon atoms, R.sub.
    Type: Grant
    Filed: April 28, 1989
    Date of Patent: November 27, 1990
    Assignee: Showa Shell Sekiyu K.K.
    Inventors: Yoshiichi Suzuki, Ichiro Kuwamura, Takashi Hagiwara
  • Process for the production of polybasic acid esters with recovery of boron trifluoride
    Patent number: 4973743
    Abstract: This invention provides a process for preparing an oligomer of at least one polyunsaturated aliphatic C.sub.12-22 monocarboxylic acid ester in the presence of boron trifluoride resulting in a high yield or predominantly trimeric product which, upon hydrolysis, affords a high yield of polybasic, predominantly trimeric, acids. This invention further provides such a process with excellent recovery of the boron trifluoride.
    Type: Grant
    Filed: October 27, 1989
    Date of Patent: November 27, 1990
    Assignee: Henkel Corporation
    Inventors: Stephen W. Turner, Charles W. Blewett
  • Process for the recovery of methyl-branched, saturated C.sub.14 -C.sub.24 - f
    Patent number: 4973431
    Abstract: A process for the isolation and purification of essentially fatty acid mixtures, which in addition to the methyl branched fatty acids contain saturated and unsaturated, respectively straight chain as well as methyl branched, unsaturated fatty acids, in which the industrial fatty acid mixtures are first hydrogenated by catalysis and then the methyl branched saturated fatty acids are separated, and in which before the hydrogenation if necessary, a separation by the hydrophilization process is provided, this process produces the desired products with a high yield and purity.
    Type: Grant
    Filed: March 6, 1989
    Date of Patent: November 27, 1990
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Alfred Struve, Horst Baumann, Karl H. Schmid, Alfred Meffert
  • Continuous hydrogenation of unsaturated oils
    Patent number: 4973430
    Abstract: Improvements in determining and controlling a continuous hydrogenation process comprising the obtaining of viscosity operating curves and opacity operating curves for comparison to known hydrogen unsaturation curves and plasticity characteristics. With improved hydrogenation equipment for carrying out the continuous hydrogenation reaction in combination with deodorization and auto-oxidation prevention stations, the present invention provides an overall process and controls for precision hydrogenation of edible oils.
    Type: Grant
    Filed: September 7, 1989
    Date of Patent: November 27, 1990
    Inventor: Jacob B. Rivers, Jr.
  • Resolution of racemic mixtures
    Patent number: 4968837
    Abstract: Racemic 2-(N-propylamino)-5-methoxytetralin is resolved by treating it with a chiral diaroyltartaric acid in an organic solvent at an elevated temperature to form a salt of the amine and chiral diaroyltartaric acid which is soluble in the solvent at the elevated temperature, cooling to precipitate the salt, isolating it, and converting it to the free amine. The product is useful as an intermediate in the synthesis of optionally-active pharmaceutical, such as N-0437.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: November 6, 1990
    Assignee: Ethyl Corporation
    Inventors: Thanikavelu Manimaran, Fred J. Impastato
  • Deodorization of fatty ester mixtures
    Patent number: 4966734
    Abstract: Undesirable odors are removed from fatty ester mixtures which, in addition to other components, contain the esters of highly unsaturated fatty acids, in particular of highly unsaturated 3-fatty acids, such as eicosapentaenoic acid or docosahexaenoic acid, by a process in which the fatty ester mixture is treated with a complex hydride, in particular with sodium borohydride solution. The process is particularly suitable for removing undesirable odors from fatty ester mixtures obtained from fish oil, for example by transesterification with an alkanol of 1 to 3 carbon atoms.
    Type: Grant
    Filed: March 16, 1989
    Date of Patent: October 30, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Hoercher, Peter Lechtken
  • Process for preparing sulfonyl acids
    Patent number: 4966731
    Abstract: There is disclosed a process for preparing sulfonyl acids from mercaptans in a single reactor. The mercaptan is converted to mercaptide and reacted with a lactone or lactam in an organic solvent which is removed after formation of a thioether containing acid. Water is provided as a solvent for the oxidation of the thioether to the sulfone. Mild conditions and readily available starting materials render the method capable of preparing such acids in large scale amounts.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: October 30, 1990
    Assignee: Monsanto Company
    Inventor: Yueting Chou
  • Process for preparation of 3-hydroxy-3-methyl-glutaric acid
    Patent number: 4966993
    Abstract: For the preparation of 3-hydroxy-3-methyl-glutaric acid a process is disclosed based on the direct oxidation with nitric acid of 3-methyl-1,3,5-pentanetriol.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: October 30, 1990
    Assignee: Laboratori Guidotti SpA
    Inventors: Luigi Turbanti, Giorgio Garzelli
  • Preparation of 3,5-disubstituted-4-acetoxystyrene
    Patent number: 4965400
    Abstract: 3-substituted-4-hydroxy- and 4-acetoxystyrene compounds, especially 3,5-di(methyl, bromo or chloro)-4-acetoxystyrene as well as a process for its preparation. 2,6-dimethylphenol is acylated with acetic anhydride and HF catalyzed to produce 3,5-dimethyl-4-hydroxy-acetophenone. After subsequent esterification with acetic anhydride and catalyzed hydrogenation to form 1-(3',5'-dimethyl-4'-acetoxyphenyl)ethanol, this intermediate is then dehydrated with an acid and a polymerization inhibitor to produce 3,5-dimethyl-4-acetoxystyrene.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: October 23, 1990
    Inventors: Richard Vicari, Mohammad Aslam, Wilson B. Ray, Kenneth G. Davenport, Ralph Dammel, Juergen Lingnau, Karl-Friedrich Doessel
  • Glycine derivative and pharmaceutical preparation thereof
    Patent number: 4963587
    Abstract: There are disclosed are glycine derivative of the formula: ##STR1## (wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a carboxyl group which may be protected, Q represents a lower alkylene group and m represents 0 or 1) or a pharmacologically acceptable salt thereof and a process for preparing the same.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: October 16, 1990
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Takeo Iwakuma, Yasuo Sekine, Yasuhiko Sasaki, Katsuo Ikezawa, Akio Odawara
  • Fractionation of fat blends
    Patent number: 4960544
    Abstract: A process for producing a hard fat, which involves fractionating a fat blend in a diluting liquid oil to obtain a stearin fraction rich in triglycerides from two long chain fatty acids and one medium chain fatty acid.Use of the stearin fraction for the production of diet margarines.
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: October 2, 1990
    Assignee: Lever Brothers Company
    Inventors: Karel P. Van Putte, Johannes J. Muller
  • Alkyl monoperoxysuccinic acid precursors and method of synthesis
    Patent number: 4960925
    Abstract: A number of novel peracid precursors each have the general structure: ##STR1## wherein: Z is a leaving group, the conjugate acid of the leaving group being in the range of from about 4 to 15; R is a substituted or unsubstituted alkyl or alkenyl group having from about 1 to 18 carbon atoms; and M is hydrogen or an alkali or alkaline earth metal. A method is also disclosed for synthesizing a product as represented above wherein succinic anhydride, including an R constituent as defined above is dissolved in a water-miscible, non-nucleophilic solvent and an acid including a Z constituent as defined above is neutralized and deprotonated to form a nucleophile, the substituted anhydride and the nucleophile being combined to form the product. The product is a component in a dry bleach product, optionally including other adjuncts.
    Type: Grant
    Filed: October 24, 1988
    Date of Patent: October 2, 1990
    Assignee: The Clorox Company
    Inventors: Dale S. Steichen, Hao Ku, Sheldon N. Lewis
  • Glycolate ester peracid precursors
    Patent number: 4959187
    Abstract: The invention provides novel bleaching compositions comprising peracid precursors with the general structure ##STR1## with R, R', R" and L as defined in the specification. Novel peracids and precursors are also herein disclosed. These peracid precursors provide new, proficient and cost-effective compounds for fabric bleaching.
    Type: Grant
    Filed: October 14, 1988
    Date of Patent: September 25, 1990
    Assignee: The Clorox Company
    Inventors: Ronald A. Fong, Sheldon N. Lewis, Richard J. Wiersema, Alfred G. Zielske
  • Polyfunctional hexasubstituted benzene derivatives
    Patent number: 4959488
    Abstract: Polyfunctional hexasubstituted benzene derivatives wherein at least three of the substituents are saturated carbon chains having from 1 to 21 carbon atoms and functional groups containing hetero functionalities at the ends of the carbon chains and the remainder of the 6 substituents are either saturated carbon chains containing from 1 to 21 carbon atoms or saturated carbon chains containing from 1 to 21 carbon atoms having a functional group including a hetero functional group containing N, O, S, P, or Si at the end of the chains. These derivatives are made by reacting a disubstituted alkyne wherein one or both of the substituents are saturated carbon chains having 1 to 21 carbon atoms to which hetero functional groups are attached with a palladium catalyst and isolating the resulting hexasubstituted benzene derivative.
    Type: Grant
    Filed: May 17, 1989
    Date of Patent: September 25, 1990
    Assignee: Henkel Research Corporation
    Inventors: James M. Renga, Alan G. Olivero, Mark Bosse
  • Hydroxypropafenone glycerides
    Patent number: 4958046
    Abstract: Hydroxypropafenone glycerides of the formula I ##STR1## where R is n-propyl or 1,1-dimethylpropyl,x is 2 or 3,y is 12, 14, 16, 18 or 20, anda and b differ from one another and are 0 or 1,as well as the stereoisomers thereof and the preparation thereof are described. The compounds are suitable as active substances for antiarrhythmics.
    Type: Grant
    Filed: September 19, 1989
    Date of Patent: September 18, 1990
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Juergen Heberger, Hans-Heinrich Gruenhagen, Egon Brode, Gerda von Philipsborn
  • Dialkyl fumarate - vinyl acetate copolymers useful as dewaxing aids
    Patent number: 4956492
    Abstract: Copolymers of dialkyl fumarate and vinyl acetate having Specific Viscosities of at least 2.5 at 2% polymer concentration in xylene at 40.degree. C., and wherein at least 50 wt. % of said alkyl groups are C.sub.20 to C.sub.24, are useful as dewaxing aids, particularly in propane dewaxing.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: September 11, 1990
    Assignee: Exxon Research and Engineering Co.
    Inventors: Abraham R. Dekraker, David J. Martella
  • Method for extracting fats and oils
    Patent number: 4956125
    Abstract: Edible fats and oils are extracted from oil-bearing materials by loading the raw materials onto an inlet end of a flat and fixed conveying surface having elongate slits therein. The materials are conveyed from the inlet end to the outlet end of the conveying surface by scrapers moved by endless chains. Oil extracting solvent is sprayed onto the material on the conveying surface, to produce miscella, which flows through the slits in the surface and into hoppers beneath the surface. The miscella is circulated back to additional sprayers located upstream of the solvent sprayers for spraying the miscella onto the upstream end of the conveying surface. The resulting concentrated miscella is collected in hoppers beneath the surface and delivered to a further use.
    Type: Grant
    Filed: May 2, 1989
    Date of Patent: September 11, 1990
    Assignee: Showa Sangyo Co., Ltd.
    Inventors: Yoshio Kawamata, Kiyoshi Iwai
  • Method for producing citrates
    Patent number: 4954649
    Abstract: Citrate esters are formed utilizing organic titanates as a catalyst allowing excess alcohol to be removed. Four citrate esters have been found which provide advantageous plasticizing properties to PVC compositions which include superior toxicity test results and superior soapy water extraction test results. The four citrate esters are: acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate, and acetyltri-n-(octyl/decyl) citrate. Articles formed from the PVC plasticized mixtures are extremely useful in the medical or health care field as they demonstrate a low order of toxicity.
    Type: Grant
    Filed: June 21, 1989
    Date of Patent: September 4, 1990
    Assignee: Morflex Chemical Company, Inc.
    Inventors: Ezekiel H. Hull, Edward P. Frappier