Patents Examined by Vera C. Clarke
  • Patent number: 5149859
    Abstract: A naphthalene derivative having the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or a non-toxic salt moiety; R.sup.2 and R.sup.3 independently represent a hydrogen atom or --OR.sup.4 where R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group;A represents a group: ##STR2## [where X.sup.1 and X.sup.2 represents an oxygen atom or N--OR.sup.5 (where R.sup.5 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group)], a group: ##STR3## [where Y.sup.1 and Y.sup.2 independently an oxygen atom or a group N--OR.sup.6 (where R.sup.6 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group)], or a group: ##STR4## (where n is 0 or 1); and B represents --(CH.sub.2).sub.m --wherein m is an integer of 1, to 8,--(CH.sub.2).sub.m.sbsb.1 --O--(CH.sub.2).sub.m.sbsb.2 --wherein m.sub.1 and m.sub.2 are independently 1 or 2, or ##STR5## wherein m.sub.3 is 0 or 1.
    Type: Grant
    Filed: September 14, 1990
    Date of Patent: September 22, 1992
    Assignee: Teijin Limited
    Inventors: Atsuo Hazato, Takumi Takeyasu, Koji Tomimori, Yoshinori Kato
  • Patent number: 5145992
    Abstract: A process for producing an .alpha.-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 can be hydrogen, alkyl, alkoxy, halo, phenyl, substituted phenyl, or hydroxy; A can be S, O or --CH.sub.2 --; and Alk is straight or branched chain alkylene, with a base in an aprotic solvent, then reacting the resulting alkoxide with a monohaloacetic acid ester to give an alkoxyacetate followed by reaction of the alkoxyacetate with a hydrogen halide, organic acid or Lewis acid in nitromethane to give the corresponding .alpha.-alkoxyacetic acid which then may be recovered or may optionally be converted to the corresponding salt by contracting the .alpha.-alkoxyacetic acid with a base.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: September 8, 1992
    Assignee: G. D. Searle & Co.
    Inventors: Richard A. Mueller, Richard A. Partis
  • Patent number: 5145867
    Abstract: Naphthylalkylamino-substituted sulfamoylbenzoic acid derivatives, processes for the preparation thereof and the use thereof as medicines.Compounds I ##STR1## R(1) hydrogen, (C.sub.1 -C.sub.4)-alkyl and Na, K, NH.sub.4, Ca, Mg, R(2) and R(3) hydrogen, alkyl groups which can also be linked together in a ring,X oxygen, sulfur, SO, SO.sub.2, NR(6) [with R(6)=hydrogen-alkyl], CH.sub.2, CO, or a bond,R(4) phenyl, thienyl, which are unsubstituted or substitutedR(5) hydrogen, (C.sub.1 -C.sub.4)-alkyl,n 1, 2, 3 or 4,where the naphthyl system is unsubstituted or substituted like the phenyl radical of R(4),and where X and R(4) together can also be Cl are medicaments for treating sickle-cell anemia.
    Type: Grant
    Filed: April 6, 1990
    Date of Patent: September 8, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: John C. Ellory, Heinrich C. Englert, Hans-Jochen Lang, Dieter Mania, Wulf Merkel
  • Patent number: 5145869
    Abstract: The present invention provides a novel class of phenylsulfonylalkanoic acid compounds such as a structure corresponding to the formula: ##STR1## or a pharmaceutically acceptable salt thereof. A present invention phenylsulfonylalkanoic acid compound is useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.
    Type: Grant
    Filed: April 11, 1991
    Date of Patent: September 8, 1992
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Makio Kitazawa, Masuo Akahane, Yasushi Nakano, Atsushi Tsubaki, Kazuaki Sato, Masaaki Ban, Michihiro Kobayashi
  • Patent number: 5144066
    Abstract: A method of producing naphthalenedicarboxylic acids by the oxidation of dialkyl-substituted naphthalene with a gas containing molecular oxygen under liquid phase conditions in an organic solvent and in the presence of a catalyst comprising copper and bromine, or a catalyst comprising copper, bromine and at least one kind of element/compound selected from the group of consisting of amine compounds and heavy metallic elements which are vanadium, manganese, iron, cobalt, nickel, palladium and cerium. And a method of producing diaryldicarboxylic acids by the oxidation of dialkyl-substituted diaryl compounds with a gas containing molecular oxygen in an organic solvent and in the presence of the same catalyst. These methods permit high yields of naphthalenedicarboxylic acids of high purity and of diaryldicarboxylic acids of high purity with the use of small amounts of catalyst.
    Type: Grant
    Filed: June 25, 1991
    Date of Patent: September 1, 1992
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Noboru Saitou, Koichi Hirota, Ren Hasebe, Norimasa Okuda, Ikuyo Katsumi
  • Patent number: 5141959
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is CH.dbd.CY--C(CH.sub.3).dbd.CHX wherein X and Y are different and each is of the formula ##STR2## wherein R' and R" independently are H or alkyl of C.sub.1-6 and R.sub.1 includes all possible geometric isomers are demonstrated effective in treating inflammation, both topically and internally. The mechanism appears to be the inhibition of phospholipase A.sub.2 enzymes.
    Type: Grant
    Filed: September 21, 1990
    Date of Patent: August 25, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: F. Ivy Carroll, Anita Lewin, Kenneth Tramposch, Stephen A. Steiner
  • Patent number: 5142088
    Abstract: Ester polyphenols such as the tris(bisphenol A) ester of trimellitic acid are prepared by the reaction of the corresponding aromatic poly(acyl halide) with a dihydroxyaromatic compound such as bisphenol A. They may be employed in the preparation of branched polycarbonates via chloroformate oligomer compositions.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: August 25, 1992
    Assignee: General Electric Company
    Inventors: Peter D. Phelps, Eugene P. Boden, Paul W. Buckley
  • Patent number: 5142097
    Abstract: Acetic acid is recovered from the mother liquor used to oxidize para-xylene to terephthalic acid by adding at least one organic compound having a melting point below 140.degree. C. and an atmospheric boiling point above 230.degree. C.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: August 25, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert E. Michel, Roger G. Rudolph
  • Patent number: 5142098
    Abstract: The invention relates to novel monoesters and diesters of 9,10-endoethano-9,10-dihydroanthracene-11,11-dicarboxylic acid.These novel monoesters and diesters correspond to the following structural chemical formula (II): ##STR1## in which R.sup.1 and R.sup.2 are identical or different and can represent H, an alkali metal or alkaline earth metal atom, a linear or branched alkyl group having from 1 to 6 carbon atoms, an alicyclic group having form 3 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, defined in their cis or trans variety, or an alkynyl group having from 2 to 6 carbon atoms, the said groups optionally being substituted by one or more functional groups such as ether, epoxide, halogeno, cyano, ester, aldehyde, ketone, aryl etc., where R.sup.1 and R.sup.2 cannot be H or ethyl simultaneously. These addition products constitute valuable intermediates for the preparation of methylidenemalonates in high yields and with a high purity.
    Type: Grant
    Filed: March 23, 1990
    Date of Patent: August 25, 1992
    Assignee: Laboratoires UPSA
    Inventors: Nicole Bru-Magniez, Christian De Cock, Jacques Poupaert, Jean-Luc De Keyser, Pierre Dumont
  • Patent number: 5138071
    Abstract: A process for preparing dipeptides with N-terminal non-proteinogenous amino acids of the formula ##STR1## in which R.sup.1 to R.sup.6 have the meaning stated in the description, from compounds of the formula ##STR2## is described.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: August 11, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Schoellkopf, Ulrich Groth, Meinolf Lange
  • Patent number: 5136083
    Abstract: The present invention relates to a process for the purification of 4-acetoxystyrene from a crude product mixture comprising 4-acetoxystyrene and typically 5 or more contaminants in substantial amount.The crude product mixture is purified by melt crystallization by cooling the mixture to a temperature ranging from about +8.degree. C. to about -50.degree. C., whereby at least a first portion of the mixture is crystallized; removing the liquid remaining from contact with the crystallized first portion of the mixture; and, subsequently slowly heating the crystallized first portion, while simultaneously removing liquid which forms due to the heating, whereby impurities contained in the liquid which forms are removed from the crystallized first portion.Surprisingly, despite the large number of contaminants present, and use of the process to purify crude product mixtures containing as little as 50% by weight 4-acetoxystyrene, purities as high as 99.
    Type: Grant
    Filed: August 30, 1990
    Date of Patent: August 4, 1992
    Assignee: Hoechst Celanese Corporation
    Inventors: Jack Chosnek, George E. Beck, Donna L. Keene, Siegbert Rittner, Volker Hautzel
  • Patent number: 5136087
    Abstract: Disclosed herein is an improved process for the preparation of polymethylene polyphenyl polyisocyanate by reacting phosgene with a corresponding polyamine, followed by removing residual phosgene from the reaction mixture, the improvement comprising removing the residual phosgene by contacting the reaction mixture which is maintained at 150 degrees Centigrade or lower, with an inert solvent vapor stream at a temperature which is sufficient to effect a substantially complete removal of the residual phosgene.
    Type: Grant
    Filed: May 15, 1991
    Date of Patent: August 4, 1992
    Assignee: Miles Inc.
    Inventors: Irvin Van Horn, Ralph W. Hodges, Jr., Susan M. Strausser
  • Patent number: 5136084
    Abstract: A novel process for the acetylation of a mono-substituted phenol or a mono-substituted naphthol is disclosed which comprises reacting the said mono-substituted phenol or the said mono-substituted naphthol respectively with vinyl acetate at a temperature of not more than 160.degree. C.
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: August 4, 1992
    Assignee: San Fu Chemical Co., Ltd.
    Inventors: Shu-Chung Lin, Min-Hon Rei
  • Patent number: 5132450
    Abstract: A process for producing isophthalic acid by oxidation of m-xylene with an oxygen-containing gas in a hydrous acetic acid solvent in the presence of a cobalt/manganese/bromine system catalyst, the process being capable of industrially advantageously producing high-purity isophthalic acid having excellent whiteness, the process comprising (1) a step of carrying out an oxidation reaction in a main oxidation reactor under specified ranges of a catalyst concentration, a reaction temperature and an oxygen concentration in a discharge gas such that the concentration of 3-carboxybenzaldehyde becomes 500 to 10,000 ppm, (2) a step of further carrying out an oxidation reaction in a post oxidation reactor such that the concentration of 3-carboxybenzaldehyde becomes 100 to 800 ppm, separating crude isophthalic acid, evaporating remaining mother liquor and recovering acetic acid, and (3) mixing the crude isophthalic acid with purified acetic acid, stirring the resultant mixture at 100.degree. C.
    Type: Grant
    Filed: June 25, 1991
    Date of Patent: July 21, 1992
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Kazuo Tanaka, Terumasa Yoshida, Fumio Okoshi, Ichihei Motoyama, Tazuo Ohta, Toshiaki Abe
  • Patent number: 5130335
    Abstract: Retinoid-like activity is exhibited by compounds of the formula ##STR1## where the R groups are independently hydrogen, or lower alkyl; A is --C(O)O--, --OC(O)--, --C(O)S--, or --SC(O)--; n is 0-5; and Z is H, --COB where B is --OH or a pharmaceutically acceptable salt, or B is --OR.sub.1 where R.sub.1 is an ester-forming group, or B is --N(R).sub.2 where R is hydrogen or lower alkyl, or Z is --OE where E is hydrogen or an ether-forming group or --COR.sub.2 where R.sub.2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is --CHO or an acetal derivative thereof, or Z is --COR.sub.3 where R.sub.3 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4 and the sum of n and m does not exceed 4.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: July 14, 1992
    Assignee: Allergan, Inc.
    Inventors: Roshantha A. S. Chandraratna, Robert J. Weinkam
  • Patent number: 5129944
    Abstract: A herbicidal aryloxynaphthalene derivatives of the formula ##STR1## in which R.sup.1 is selected from the group consisting of hydrogen, halogen, cyano and trifluoromethyl,R.sup.2 is hydrogen or halogen,R.sup.3 is selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio and trifluoromethylsulphonyl,R.sup.4 is hydrogen or halogen,R.sup.5 is alkoxy or alkylthio,Y is selected from the group consisting of --A--, --O--A-- and --S--A,whereA is an optionally halogen-substituted alkanediyl, andZ is selected from the group consisting of hydroxyl, alkoxy, alkenyloxy, alkynyloxy, halogenoalkoxy, alkoxyalkoxy, aralkoxyalkoxy, alkoxycarbonylalkoxy, arylalkoxy, amino, alkylamino, alkenylamino, alkynylamino, dialkylamino, dialkenylamino, dialkynylamino, alkoxyalkylamino and alkoxycarbonylalkylamino.
    Type: Grant
    Filed: August 17, 1990
    Date of Patent: July 14, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Roland Andree, Michael Haug, Klaus Lurssen, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 5130470
    Abstract: A process for polymerizing tetrahydrofuran using a fluorinated resin containing sulfonic acid groups a trifluoromethane sulfonic acid as catalyst and a mixture of maleic acid and maleic anhydride as weight control agent. The product has the formula ##STR1## which can be hydrogenated to produce polytetramethylene ether glycol. The preferred molecular weight range of the polytetramethylene ether glycol is 600 to 4,000.
    Type: Grant
    Filed: March 27, 1991
    Date of Patent: July 14, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Suriyanarayan Dorai, Willard L. Quon, Kirk M. Schall, Gary A. Hida
  • Patent number: 5126108
    Abstract: Aminophosphonate-containing polymers of the formula:--B].sub.m [A].sub.nwhereinA represents repeating units from one or more ethylenically unsaturated comonomers;B is ##STR1## wherein R is hydrogen or methyl.X is hydrogen or an alkali metal,Z is CH.sub.2 --P(O)(OX).sub.2 or C.sub.1 -C.sub.6 alkyl, aryl, cyclohexyl or alkaryl,m/n is 0.1 to .5.The novel polymers of the present invention may be used as dispersants for concentrated aqueous particulate slurries, and as corrosion inhibitors and scale inhibitors in water treatment.
    Type: Grant
    Filed: February 27, 1991
    Date of Patent: June 30, 1992
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: John C. Leighton, Carmine P. Iovine
  • Patent number: 5126462
    Abstract: Aromatic tetracarboxylic acids or derivatives thereof of the general formula I ##STR1## in which R denotes a divalent radical of the formula II ##STR2## Ar denotes tri- or tetravalent aromatic radicals or mixtures thereof, X, if Ar is trivalent, denotes an amide radical, and if Ar is tetravalent denotes an imide radical, and Y and Z either together denote the anhydride radical --CO--O--CO-- or by themselves and independently of one another denote the radicals --COOH, --COCL or --COOR.sub.1, and a process for their preparation.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: June 30, 1992
    Assignee: Chemie Linz Gesellschaft m.b.H.
    Inventors: Gerd Greber, Heinrich Gruber, Marcel Sychra
  • Patent number: 5126482
    Abstract: Novel fluorine-containing compounds and processes for producing the same are disclosed, the compounds being represented by the general formula (I): ##STR1## wherein R.sup.1 represents an alkyl group or an alkylvinyl group; R.sup.2 represents a fluoroalkyl group; and Y represents a carboxyl group, a chloroformyl group, an alkoxyalkoxycarbonyl group or a hydroxymethyl group.
    Type: Grant
    Filed: January 3, 1991
    Date of Patent: June 30, 1992
    Assignee: Nippon Mining Co., Ltd.
    Inventors: Takeshi Nakai, Osamu Takahashi