Abstract: A container for use in the treatment and/or prophylaxis of viral infections and/or associated conditions prefilled with a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3.

Abstract: Oral care compositions with an anticaries or anticavity effect. Oral care compositions that have one or more hops beta acids, such as from an extract from a species in the Humulus family, and one or more amino acids. Oral care compositions having one or more amino acids and an extract from Humulus lupulus. Methods of use of the disclosed compositions to disrupt biofilm in the oral cavity of a patient in need of treatment.

Abstract: Described are new biodegradable nanoparticle platforms for encapsulation and sustained release of protein therapeutics through a scalable and reproducible method. Specifically nanoparticles comprising a complex comprising a protein, or peptide, and a counter ion polymer are described.

Abstract: The present invention is directed to embodiments of a method for coloring hair using an oxidative hair coloring composition based upon the primary dye compounds MBB, Aminol and optional secondary precursor and coupler compounds PAP, DPE, MAP, AHT and EOAP, a carbonate and/or bicarbonate source, an alkalizer and one or more amino acids. Additional subsidiary precursors and couplers may be included to broaden the color space delivered by the primary dye compounds. The oxidative hair coloring composition is free of resorcinol and C1-C10 alkyl resorcinol. The L*a*b* color space of embodiments of the oxidative hair coloring composition as measured by L*a*b* techniques is about the same as that delivered by the resorcinol based composition.

Abstract: The present disclosure provides a radiotheranostic agent targeting LRRC15 expressed on cells derived from or associated with mesenchymal stem cells. The LRRC15 targeting agent would significantly improve diagnosis and treatment of a broad range of diseases and malignancies. In one embodiment, the LRRC15 targeting agent is a humanized monoclonal antibody (DUNP19) that has high binding affinity to LRRC15 and is internalized by cells expressing LRRC15.

Abstract: The present invention relates to new uses of seignette salt and can be used in the field of dental and oral care products.

Abstract: Provided are systems, compositions, methods and devices for manufacturing artificial skin substitutes and related products mimicking the morphology and appearance of human skin. Applications of the invention pertain to the fields of regenerative medicine and pharma with products that can support tissue replacement and tissue engineering. The most immediate applications pertain to the field of cosmetics with the development of pigmented compositions that can be incorporated in various skin care and cosmetic foundation products.

Abstract: A chewable stable gel composition having a high oil content, comprising, on the basis of the total weight of the composition, 55-70 wt % oil, 1-15 wt % first gelling agent, 0.1-2 wt % second gelling agent, 0.1-7 wt % stabilizer, optional other additives for medicine, food, and/or a health care product, and the balance of water. Also provided are a preparation method for and an application of the gel composition.

Abstract: Methods and compositions for biofilm removal in industrial applications and systems with prevalent biofilm and/or slime are disclosed. Various industrial processing, such as food and beverage processing, mining pipelines, cooling towers, and energy services applications benefit from the biofilm removal disclosed herein. In particular, the methods and compositions employ alumina nanoparticles alone or in combination with conventional biocides to remove biofilm and/or slime.

Abstract: The present disclosure relates to a water-based cosmetic composition thickened with xanthan gum and sodium carboxymethyl cellulose, having a strongly alkaline pH, to be used as an alkalizing component in a two- or three-part oxidative hair lightening agent.

Abstract: The disclosure provides a mouldable artificial bone composite material and a preparation method thereof. The mouldable artificial bone composite material is characterized in a composition composed of a degradable polymer material and inorganic particles distributed in the polymer material. The average molecular weight of the polymer material is 1,000 Da to 20,000 Da. The inorganic particles are composed of calcium-phosphorus compounds. The artificial bone composite material has a shape of a mouldable plasticine. The disclosure provides an artificial bone composite material that can be freely shaped and injected, and the disclosure further provides a preparation method of the artificial bone composite material.

Abstract: A dental composition is described that includes a homogenous solution having a stabilized zinc complex with amine-containing ligands and a source of fluoride anions. Also described are methods for treating or preventing caries activity at a tooth surface employing the dental composition, and kits re the same.

Abstract: The present invention relates to a hydroxyapatite-supporting porous silica particle, in which hydroxyapatite is supported on a surface a spherical porous silica particle and inner surfaces of pores of the spherical porous silica particle, and in which the hydroxyapatite-supporting porous silica particle has a circularity of 0.760 or larger, a method for producing the hydroxyapatite-supporting porous silica particles, and a composition containing the hydroxyapatite-supporting porous silica particle.

Abstract: The present disclosure relates to a tooth brightening composition comprising polyurethane, at least one white food colours and at least one blue food colours and optionally other orally acceptable carriers and/or excipients. The present disclosure also provides a tooth brightening kit and a tooth brightening method with the tooth brightening composition.

Abstract: Methods and kits for removing calculus from a tooth, wherein the method can include applying a component A to the tooth, wherein component A comprises: a metal ion selected from the group of lithium ion, magnesium ion, calcium ion, a precursor thereto, and a combination thereof; and an aprotic base having a pKb in water of greater than 15.4, or a precursor thereto; applying a component B to the tooth, wherein component B comprises a bicarbonate ion or a precursor thereto; wherein components A and B are applied simultaneously or sequentially to the tooth, thereby generating a gas to soften and/or loosen at least part of the calculus on the tooth; and removing at least a part of the calculus from the tooth.

Abstract: A phosphorous compound such as STMP is used as a cross-linking agent while making a starch nanoparticle in an emulsion process. Negative charge of the nanoparticle is reduced or reversed by adding cations and/or cationizing the starch optionally while forming the nanoparticles. Anionic active agents, such as fluoride or fluorescein, are optionally incorporated into the nanoparticle during the formation process. For example, a fluoride salt can also be used, which promotes the crosslinking reaction while also providing fluoride in the nanoparticle. The retention of both calcium and fluoride in the nanoparticle is improved when both salts are used. Alternatively, the nanoparticle may be used without added calcium and/or fluoride. The nanoparticles may be useful for tooth remineralization, the treatment of dentinal hypersensitivity, to treat caries, or as a diagnostic agent to locate carious lesions.

Abstract: A photocurable resin composition for nails or artificial nails, contains the following components (A) to (D): a component (A): a urethane (meth)acrylate oligomer, a component (B): a monomer selected from the group consisting of a (meth)acrylate monomer, a (meth)acrylamide monomer, and (meth)acrylic acid (excluding the component (A)), a component (C): polyglycerol having no (meth)acryloyl group and/or a compound having a polyglyceryl ether skeleton having no (meth)acryloyl group, a component (D): a photoinitiator. A molecular weight of the component (C) is 200 or more.

Abstract: Embodiments of the present disclosure relate to a composition that comprises a recombinant plasmid (RP) with a sequence of nucleic acids. The sequence comprise a start region, an end region and an insert positioned between the start region and the end region. The insert encodes for a sequence of micro interfering ribonucleic acid (miRNA) that may be complementary to a sequence of target messenger RNA (mRNA) that encodes for translation of a target biomolecule. The miRNA can cause the target mRNA to be degraded or inactivated, thereby causing a decrease in bioavailability of the target biomolecule because it is degraded or inactivated by the miRNA, thereby decreasing the bioavailability of the target biomolecule. In some embodiments of the present disclosure, the target biomolecule is an immune checkpoint protein.

Abstract: Therapeutic compositions, primarily for topical application, and methods of making and using the composition. Pharmaceutical compositions formulated for specific forms of administration are also provided.

Abstract: This application provides, among other things, novel aqueous biphasic compositions comprising two distinct aqueous phases, useful for combining and delivering poorly compatible ingredients, for example to deliver effective levels of cationic antibacterial agents in combination with anionic polymers, e.g. that protect against erosion and staining, by addition of a stabilizing amount of a polyamine, e.g. lysine, and methods for making and using the same.