Abstract: Described herein are oral care compositions comprising vitamin D, or a derivative thereof; an alkanoic acid of formula R—COOH or an alkali metal salt thereof, wherein R is a C1 to C13 hydrocarbyl group; and an orally acceptable carrier. Methods of making and using same are also described.

Abstract: A cosmetic kit is disclosed having a container and a shaving cap. The container comprises interior chamber containing a solidified gel of a micellar solution and a dispensing opening that exposes an outer surface of the solidified gel. The exposed surface of the solidified gel to a surface, like skin, and can be cleaned with the shaving cap, which removes at least a portion of the exposed surface of the solidified gel. The shaving cap comprises a planer surface and one or more openings or slits through the planar surface having shaving edges that shave the exposed surface of the solidified gel when applied against the exposed surface, for example, by rotating the shaving cap relative to the container with sufficient force to overcome shearing resistance of the solidified gel. The cosmetic kit is particularly useful for hygienically cleansing the skin.

Abstract: A staurosporine-emamectin benzoate suspending agent and a preparation method and application thereof. The suspending agent contains staurosporine and emamectin benzoate. Among them, the mass ratio of staurosporine to emamectin benzoate is 1-9:9-1. The suspending agent in the present invention can be prepared by adding an appropriate amount of wetting agent, dispersing agent, wetting & dispersing agent, thickener, stabilizer, antifreeze, pH adjuster and defoaming agent into staurosporine and emamectin benzoate. The preparation is highly efficient, low-toxic and pollution-free. After being sprayed, it is distributed on the surface of crops as fine particles, which is more conducive to the direct control of pests, can reduce the dosage of emamectin benzoate, enhance the effect of pest control, and effectively delay the resistance.

Abstract: An object of the present invention is to provide a lipid particle that can be produced without using a PEG-modified lipid, or that exhibits higher drug effects, safety, or stability than those of a lipid particle produced using a PEG-modified lipid; or that has immunokinetics different from those of a lipid particle produced using a PEG-modified lipid. A lipid particle comprising an ionized lipid, a phospholipid, and a sterol as lipid components of the lipid particle, and a modified polysaccharide containing a hydrophobic group.

Abstract: The present invention provides new dental care products comprising self-assembling peptides that are capable of undergoing self-assembly at a certain pH that are useful in dental care, in particular, useful for reducing or preventing demineralisation of teeth of a subject, in particular, for reducing or preventing further demineralisation of teeth of a subject. The dental care products comprises self-assembling peptides, in particular, comprise self-assembling peptides comprising the sequence of SEQ ID NO: 21, that are capable of undergoing self-assembly at a pH below 7.5, wherein the self-assembling peptides are essentially present in the dental care product in assembled form, and a pharmaceutically acceptable basis. The dental care product is an essentially solid product selected from the group consisting of chewing gum, soft chew, toffee, gelatin gum, chewy candy, chew toy, lozenge. Preferably, it is a chewy product. The dental care product is not abrasive.

Abstract: Provided are fermentation extracts, cosmetic composition, and manufacturing method of fermentation extracts. For this, the present invention discloses a fermentation extract consisting of a glutathione liquid dispersion liposomized using a liquid collagen extract as a solvent and a Lactobacillus fermentation filtrate obtained by stirring and extracting the same at a preset low temperature.

Abstract: The present disclosure provides methods of treating immune evasive cancers using surface functionalized particles alone or in combination with cancer therapeutics.

Abstract: A pharmaceutical composition to be applied to the pulmonary epithelium for the treatment of pulmonary diseases, comprising ibuprofen, arginine, solubilized in a hypertonic alkaline aqueous solution.

Abstract: The present invention relates to the use of sweet steviol glycoside compounds, particularly rebaudioside B, in sweetening compositions. Sweetening compositions comprising selected amounts of rebaudioside B have been shown to possess favorable flavor profiles when compared to other high intensity sweetener compounds and are useful in the preparation of consumables.

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.

Abstract: Described are: a multi-layer oral thin film, comprising at least two layers arranged one on top of the other, which each comprise at least one water-soluble polymer, these at least two layers being connected to one another by at least one sealing, characterised in that the at least one sealing is not provided over the entire surface; a method for producing same; and use thereof as a medicament.

Abstract: A container for use in the treatment and/or prophylaxis of viral infections and/or associated conditions prefilled with a thixotropic gel characterized by a density selected from about 1.02 g/cm3 to about 1.05 g/cm3.

Abstract: Oral care compositions with an anticaries or anticavity effect. Oral care compositions that have one or more hops beta acids, such as from an extract from a species in the Humulus family, and one or more amino acids. Oral care compositions having one or more amino acids and an extract from Humulus lupulus. Methods of use of the disclosed compositions to disrupt biofilm in the oral cavity of a patient in need of treatment.

Abstract: Described are new biodegradable nanoparticle platforms for encapsulation and sustained release of protein therapeutics through a scalable and reproducible method. Specifically nanoparticles comprising a complex comprising a protein, or peptide, and a counter ion polymer are described.

Abstract: The present invention is directed to embodiments of a method for coloring hair using an oxidative hair coloring composition based upon the primary dye compounds MBB, Aminol and optional secondary precursor and coupler compounds PAP, DPE, MAP, AHT and EOAP, a carbonate and/or bicarbonate source, an alkalizer and one or more amino acids. Additional subsidiary precursors and couplers may be included to broaden the color space delivered by the primary dye compounds. The oxidative hair coloring composition is free of resorcinol and C1-C10 alkyl resorcinol. The L*a*b* color space of embodiments of the oxidative hair coloring composition as measured by L*a*b* techniques is about the same as that delivered by the resorcinol based composition.

Abstract: The present disclosure provides a radiotheranostic agent targeting LRRC15 expressed on cells derived from or associated with mesenchymal stem cells. The LRRC15 targeting agent would significantly improve diagnosis and treatment of a broad range of diseases and malignancies. In one embodiment, the LRRC15 targeting agent is a humanized monoclonal antibody (DUNP19) that has high binding affinity to LRRC15 and is internalized by cells expressing LRRC15.

Abstract: The present invention relates to new uses of seignette salt and can be used in the field of dental and oral care products.

Abstract: Provided are systems, compositions, methods and devices for manufacturing artificial skin substitutes and related products mimicking the morphology and appearance of human skin. Applications of the invention pertain to the fields of regenerative medicine and pharma with products that can support tissue replacement and tissue engineering. The most immediate applications pertain to the field of cosmetics with the development of pigmented compositions that can be incorporated in various skin care and cosmetic foundation products.

Abstract: A chewable stable gel composition having a high oil content, comprising, on the basis of the total weight of the composition, 55-70 wt % oil, 1-15 wt % first gelling agent, 0.1-2 wt % second gelling agent, 0.1-7 wt % stabilizer, optional other additives for medicine, food, and/or a health care product, and the balance of water. Also provided are a preparation method for and an application of the gel composition.

Abstract: Methods and compositions for biofilm removal in industrial applications and systems with prevalent biofilm and/or slime are disclosed. Various industrial processing, such as food and beverage processing, mining pipelines, cooling towers, and energy services applications benefit from the biofilm removal disclosed herein. In particular, the methods and compositions employ alumina nanoparticles alone or in combination with conventional biocides to remove biofilm and/or slime.