Abstract: A system and method provides closed-loop sedation, anesthesia, or analgesia by monitoring EEG and automatically adjusting the delivery of sedative, anesthetic, and/or analgesic drugs to maintain that desired level of cortical activity for transportation or evacuation of the injured, and for closed-loop anesthesia during surgical care, and at all echelons of care.

Abstract: The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) extending in an axial direction (1, 2) to operably engage with a piston (14) of a cartridge (12), —a drive sleeve (90) rotatably supported in the housing (20), at least partially enclosing the piston rod (120), the drive sleeve (90) is operably releasable from the piston rod (120) for setting of a dose and the drive sleeve (90) is operably engageable with the piston rod (120) for dispensing of the dose, —a dose limiting member (130) threadedly engaged with the drive sleeve (90), rotatably locked to the housing (20) and being displaceable in axial direction (1, 2) in response to a rotation of the drive sleeve (90) relative to the piston rod (120), —at least one stop member (124) provided on the piston rod (120) to engage with the dose limiting member (130) for impeding a further displacement of the drive sleeve (90) relative to the

Abstract: A male luer connector includes a body having a first end configured to be connected to a fluid line, a second end opposed to the first end, and a body longitudinal axis. The second end is configured to be inserted into and form a luer slip connection with a female luer connector. The male luer connector also includes a locking collar that is connected to the body in a manner such that the locking collar rotates about the longitudinal axis. In some cases, the body second end does not protrude beyond a plane that is transverse to the longitudinal axis and that includes an end face of the locking collar, and/or when male and female connectors are engaged, the locking collar engages an outer surface of the female fluid line connector and is deformed by the engagement.

Abstract: Embodiments of a tamper-proof adapter can be configured to provide interconnection of medical tubing or other devices with varying fitting or coupling types. In one embodiment, the adapter can permanently couple a first male Luer fitting to a second male ISO 80639-6 compliant fitting.

Abstract: Some embodiments of an infusion pump system may be configured to wirelessly communicate with other devices using near field communication (NFC). In particular embodiments, by incorporating near field communication capabilities into the infusion pump system, user communications with the infusion pump system can be enhanced and simplified.

Abstract: The present disclosure is directed to a catheter insertion device, which has a catheter hub at the proximal end of a catheter, a tubular needle hub, at which a hollow needle is fixed and extends through the catheter hub and the catheter in a ready position such that the needle tip projects over the distal end of the catheter, a protective barrel which is received in the tubular needle hub in the ready position and is releasably connected to the catheter hub, and a pressure spring arranged between the needle hub and the protective barrel and which displaces the needle hub and the protective barrel apart from each other in an axial direction, wherein a manually operable holding member is provided between the needle hub and the protective barrel, and holds the needle hub in the ready position at the protective barrel against the bias of the pressure spring, so that after the holding member is released, the pressure spring moves the needle hub into a protective position in relation to the protective barrel, in wh

Abstract: The present invention relates to a supplementary device for a manually operable injection device. The device has a body and a mating unit configured to releasably mount the body to the injection device in a specific position relative to an outside surface of the injection device.

Abstract: A valve (10) for permitting mixing of at least two components within a barrel (12) is provided including a stopper (20) configured for slidable liquid-tight engagement with an inner surface (13) of the barrel. The stopper is moveable between a first position and a second position and includes a proximal end (22), a distal end (24), and a channel (26) extending therebetween. The valve further includes a stationary body (30) comprising a base (32) and a stem (34), the stem being disposed within the channel of the stopper when the stopper is in the second position. When the stopper is in the first position, there is a liquid-tight seal in the channel, such that fluid flow through the channel is prevented. Movement of the stopper to the second position terminates the liquid-tight seal, thereby establishing fluid communication through the channel. A drug containing device and assembly for delivering a reconstituted drug are also provided herein.

Abstract: The present invention relates to an apparatus and a system for controlling an amount of medicine or fluid injection through falling due to potential energy of the fluid. For example, the present invention can automatically adjust an injection rate of a medicine injected into a patient by controlling an opening/closing degree of a medicine hose by using a driving element driven by electric power according to a comparison of the number of drops with a predetermined value. An apparatus for realizing the method includes an accommodating case for accommodating a connecting portion for connecting a fluid, a detection unit for detecting the number of drops, a control unit for comparing the information detected by the detection unit, and a driving element for opening and closing a passage of the medicine hose based on the contents analyzed by a control unit.

Abstract: Systems, methods and devices for creating an effect using microwave energy to specified tissue are disclosed herein. A system for the application of microwave energy to a tissue can include, in some embodiments, a signal generator adapted to generate a microwave signal having predetermined characteristics, an applicator connected to the generator and adapted to apply microwave energy to tissue, the applicator comprising one or more microwave antennas and a tissue interface, a vacuum source connected to the tissue interface, a cooling source connected to said tissue interface, and a controller adapted to control the signal generator, the vacuum source, and the coolant source. The tissue may include a first layer and a second layer, the second layer below the first layer, and the controller is configured such that the system delivers energy such that a peak power loss density profile is created in the second layer.

Abstract: A system and method provides closed-loop sedation, anesthesia, or analgesia by monitoring EEG and automatically adjusting the delivery of sedative, anesthetic, and/or analgesic drugs to maintain that desired or predetermined level of cortical at all echelons of care. The system and method further monitor the subject's cortical activity to detect occurrence of burst suppression which can be indicative of unsafe depth of anesthesia or sedation. Further, the system and methods provide for alteration or cessation of the administration of anesthesia or sedation based on the occurrence of burst suppression to mitigate harm to the subject.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal shaft having a first outer diameter. A distal sheath may be attached to the proximal shaft and may have a second outer diameter greater than the first outer diameter. A trackable tip member may be attached to the distal sheath and extending distally therefrom. The trackable tip member may define a guidewire lumen therein.

Abstract: Guide extension catheters and methods of manufacturing and using guide extension catheters are disclosed. An example guide extension catheter may include a distal sheath having a proximal opening, a distal opening, and a central lumen extending therebetween. The guide extension catheter may also include a proximal shaft having an outer diameter smaller than an outer diameter of the distal sheath, the proximal shaft including a distal opening. The guide extension catheter may also include a coupling member for securing the distal sheath to the proximal shaft. The coupling member may include a distal portion attached to the distal sheath and a proximal portion disposed within the distal opening of the proximal shaft.

Abstract: A method that includes pumping medical fluid out of or drawing medical fluid into a chamber of a medical fluid cassette, calculating a theoretical volume of fluid pumped out of or drawn into the chamber, and multiplying the theoretical volume of fluid pumped out of or drawn into the chamber by a correction factor to determine a corrected volume of fluid pumped out of or drawn into the chamber.

Abstract: A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.

Abstract: A fluid delivery catheter that uses micro-needles for fluid delivery though a vessel wall. The catheter may provide fluid delivery therapy for various procedures, such as, for example, delivery of tumescent fluid or renal denervation. The catheter includes an elongate member with deployable and retractable needles disposed about a distal end of the elongate member. The needles may be disposed radially about the distal end and/or along a length of the distal end.

Abstract: The invention relates to a catheter apparatus comprising: a catheter; a catheter hub having a distal section and a proximal section, wherein the distal section is joined to the catheter and the proximal section defines a chamber; a needle extending through the catheter hub and the catheter and defining an axial direction, wherein the needle has opposite proximal and distal ends, the distal end forming a needle tip; a needle hub attached to the proximal end of the needle; and a needle guard slidably arranged on the needle, wherein the needle guard is retained in the chamber of the catheter hub when the needle extends through the catheter hub and the catheter, and wherein the needle guard is removable from the catheter hub once the needle tip is received in the needle guard upon withdrawal of the needle from the catheter.

Abstract: A single use pre-filled delivery device is disclosed having a deformable container including a side wall having an inside surface defining a chamber for retaining fluid, a clip element, and a locking element. The deformable container further includes a closed proximal end and an open distal end including a male luer tip having a passageway therethrough providing fluid communication with the chamber. The male luer tip may be removably connectable to a female luer connection of a vascular access device. The clip element includes a distal end, proximal end, and a pivot located between the distal end and the proximal end of the clip element for collapsing the deformable container to drive fluid out of the chamber by movement of the proximal end towards the distal end.

Abstract: An apparatus for treating a tennis elbow by percutaneous intervention, includes: a body having an actuating element, a fixing part arranged to fixably position the body, a positioning device connected to the body, including a positioning part moveable by the actuating element, a holder releasably connected to the positioning part, and including a top part for the releasable connection to the positioning part and a bottom part defining a support surface for supporting an elbow tendon region of a person to be treated, the support surface, the top and bottom parts being connected by one or more connecting members, the holder including a holder part with a number of penetration elements arranged thereon, wherein the top and bottom parts are spaced-apart at such a distance that, before penetration of the elbow tendon, the penetration tips of the penetration elements are covered by the bottom part.

Abstract: Ocular fluid management systems and methods of operating the same. One ocular fluid management system includes a chamber, a diaphragm, a sensor, and a controller. The chamber includes a first portion and a second portion. The first portion is connected to an input line for receiving fluids into the first portion and an output line for discharging fluids from the first portion. The diaphragm is contained in the chamber and changes position based on a pressure difference between the first and second portions. The sensor detects a position of the diaphragm and transmits a signal based on the detected position. The controller is configured to receive the signal and control operation of at least one of a peristaltic pump and a vacuum pump based on the signal to maintain the diaphragm in a predetermined position.