Abstract: The present invention provides methods and devices for treating endovascular disease. Vibrational energy is delivered to change compliance and increase permeability at the treatment area. To improve clinical outcomes, one or more therapeutic drugs may be delivered to the treatment area.

Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.

Abstract: A drug delivery device includes a container for storing a drug, the container having a stopper for expelling the drug; an injection drive comprising an energy source for directly or indirectly acting on the stopper to expel the drug; a sensor for detecting contact between the drug delivery device and a body of a patient; and a user interface (UI) for activating or causing the activation of the injection drive. The device is operative for drawing attention to the UI, if the sensor detects contact between the drug delivery device and the body of the patient, to thereby indicate that the injection drive is ready to be activated, which activation is the next step in the drug administration process.

Abstract: A medicament delivery device and a controller is disclosed. The medicament delivery device includes a medicament container, plunger rod and a resilient member. The plunger rod is in contact with a slidable stopper within the medicament container for expelling a medicament. The resilient member is used for applying a force to the plunger rod upon a delivery of the medicament. In addition, the controller is configured to detect a completion of a delivery stroke of the plunger rod according to an inductive property of the resilient member.

Abstract: Headgear for use with a respiratory mask is described. The headgear comprises a continuous and substantially curved elongate member extending in use below a user's nose and at least two headgear straps capable of attachment to the ends of the elongate member. A mask attachment on the elongate member is disposed to sit below or on one of said user's nose, mouth, upper lip and an inlet to the mask. The attachment is capable of receiving the mask.

Abstract: The invention relates to a glass syringe-side assembly element for providing an interface element between a glass syringe including on its front side a syringe cone part with a syringe needle and including on its rear side a flange part and a glass syringe operating means, where the assembly element can be arranged on the outer contour of the glass syringe, and where the assembly element can be secured to the assembly element relative to the syringe needle in front of the flange part on the glass syringe such that a reference point of the assembly element is always at a defined distance from the needle tip of the syringe needle.

Abstract: An assembly for mixing and dispensing a multi-component fluid includes a sheath having first and second fluid chambers, a chamber coupler, and a flexible tip. The chamber coupler forms first and second fluid channels. Additionally, the flexible tip forms a mixing chamber with a variable mixing volume and an outlet. The flexible tip is coupled to the chamber coupler near a distal end of the sheath. In the presence of an activation force, the flexible tip is forced out of the sheath and positioned in a dispensing state with a maximum mixing volume. In the absence of the activation force, the flexible tip is housed within the sheath and positioned in a non-dispensing state with a minimum mixing volume such that the outlet is substantially closed.

Abstract: The present disclosure relates to a medicament injection device (1) comprising a housing (3) arranged to receive a medicament container (11a), a needle cover (9) movable relative to the housing (3), from a retracted position, in which it engages the housing (3) and enables medicament delivery, to an extended position, a plunger rod (7), and a plunger driver (5) movable relative to the housing (3) from all initial position to a final position, and arranged to actuate the plunger rod (7), wherein the plunger rod (7) has a first guide arrangement and the housing (3) has a second guide arrangement, the first guide arrangement (7d) and the second guide arrangement being arranged to cooperate to guide movement of the plunger rod (7) relative to the housing (3), wherein the first guide arrangement and the second guide arrangement in a first stage provide a linear motion path for the plunger rod (7), enabling the plunger rod (7) to initially move in the axial direction and in a second stage provide a rotation motion

Abstract: A connector to secure a winged needle set to a catheter assembly may include a male luer lock. The male luer lock may include a tapered male discharge nozzle and a locking ring surrounding the tapered male discharge nozzle. The locking ring may be internally threaded. The connector may include a septum configured to prevent flow through the tapered male discharge nozzle. The connector may include an arm, which may include a first end, a second end, and a hinge portion disposed between the first end and the second end. The first end may be coupled to the male luer lock. In response to the hinge portion moving from an open position to a closed position, the arm may be configured to secure the winged needle set to the connector.

Abstract: The present technology is a device for delivering a medicinal agent to a breastfeeding child. One embodiment comprises a first portion configured to be positioned on the breast during breastfeeding a second portion having an agent region and a sealing region. The agent region is configured to house the agent during breastfeeding and has a first cross-sectional area. The sealing region has a second cross-sectional area at least great enough to surround and engage a circumference of the nipple but less than the first cross-sectional area. When the device is positioned on the breast and the child is breastfeeding, the device is configured such that the nipple extends through the sealing region into the agent region and the portion of the delivery device at the sealing region contacts the nipple, thereby reducing or preventing the flow of breast milk and/or the agent through the sealing region to the first portion.

Abstract: A catheter is disclosed having a distal end portion of a shaft with high breaking strength even if a wall thickness of the distal end portion of the shaft is relatively small. The catheter includes an elongated tube shaped shaft. The shaft has an inner layer having a lumen along a longitudinal direction, an outer layer covering an outer peripheral side of the inner layer, and a reinforcement body disposed on the outer peripheral side of the inner layer. The outer layer has a distal outer layer on a distal end portion of the shaft, an intermediate outer layer proximal to the distal outer layer, and a proximal outer layer proximal to the intermediate outer layer. The intermediate outer layer is more flexible and thicker than the proximal outer layer, and a distal end of the reinforcement body is located proximal to a distal end of the intermediate outer layer.

Abstract: A system for deploying a shape memory catheterization device within a patient, includes a catheter for endovascular insertion of the shape memory catheterization device. A heat source heats the shape memory catheterization device above the transition temperature. A transformation data generator includes a circuit driver for driving a circuit that includes at least one capacitive element of the shape memory catheterization device and a detection circuit for generating transformation data based on a capacitance of the at least one capacitive element, wherein the transformation data indicates a shape transformation of the shape memory catheterization device from a catheterization shape to a transformed shape.

Abstract: Needle assemblies and related methods are disclosed. The needle assemblies can include a catheter hub and a catheter tube and wherein the catheter hub has a low profile to facilitate attaching the catheter hub to the skins of a patient.

Abstract: An assembly for a drug delivery device includes a housing, a rotation member, a drive member and at least one correction member. In a delivery mode, the drive member and the rotation member are coupled such that the drive member follows rotational movement of the rotation member in a first rotational direction. In a correction mode, the rotation member and the drive member are decoupled such that the rotation member is rotatable in the first rotational direction with respect to the drive member. For switching from the delivery mode into the correction mode, the correction member is moveable with respect to the housing, wherein the assembly is configured such that movement of the correction member with respect to the housing is converted into a relative movement between the drive member and the rotation member for decoupling the drive member and the rotation member.

Abstract: A method that includes pumping medical fluid out of or drawing medical fluid into a chamber of a medical fluid cassette, calculating a theoretical volume of fluid pumped out of or drawn into the chamber, and multiplying the theoretical volume of fluid pumped out of or drawn into the chamber by a correction factor to determine a corrected volume of fluid pumped out of or drawn into the chamber.

Abstract: An access device places a medical article within a body space of a patient. The device has a needle that includes an elongated body and a needle hub. The device further includes a dilator disposed on and slideable along the elongated body of the needle and a medical article. The medical article is disposed on and slideable along the dilator. A track extends in a proximal direction from the dilator. The needle hub slides along at least a portion of the track between a first position and a second position. The device further includes a locking mechanism operably disposed between the track and the needle hub so as to inhibit further axial movement of the needle in the proximal direction when the needle hub is in the second position.

Abstract: A therapeutic fluid delivery system including, in various examples, a first reservoir configured to house a first therapeutic fluid, a second reservoir configured to house a second therapeutic fluid, and an inlet port configured to receive a fluid delivery needle is described. The inlet port is configured for fluid communication between the fluid delivery needle and the first reservoir, and the inlet port is further configured for fluid communication between the fluid delivery needle and the second reservoir.

Abstract: Disclosed herein are improved methods and apparatuses for providing hemostasis within a cavity defined by an internal surface of a bleeding tissue space. A catheter comprising a proximal end and a distal end may be advanced into the cavity through a proximal opening of the tissue space into the cavity. A distal balloon coupled to the catheter may be positioned adjacent a distal opening of the tissue space, and expanded to seal the distal opening. A hemostatic agent may be applied from the catheter to the internal surface of the tissue space to inhibit bleeding of the tissue space. The hemostatic agent may be applied without occluding the proximal opening, the distal opening, and a path extending therebetween with the hemostatic agent.

Abstract: A syringe assembly includes a prefilled syringe and a cap. A cap body is configured to be displaced from a first position where a viewing portion is positioned in a cylindrical main body to a second position where the viewing portion protrudes in a distal end direction from an opening of the cylindrical main body. When a mounting tube portion of the cap removed from a syringe body is brought close to a nozzle portion of the syringe body, the cap body is pressed in the distal end direction by the nozzle portion, thereby being displaced from the first position to the second position, and the appearance of an outer peripheral portion of the viewing portion changes.

Abstract: Some embodiments of an infusion pump system can provide an alarm and user instructions in response to an ambient air pressure change or ambient air temperature that exceeds an alarm limit parameter. In some circumstances, the infusion pump system can be configured to monitor the actual ambient air pressure and temperature around the infusion pump system.