Abstract: A medicament delivery system configured to reduce the risk of inadvertently injecting medicament directly into a patient during a refill procedure via an external refilling apparatus. The medicament delivery system may include an implantable medical pump having a refillable medicament reservoir accessible via an access port, wherein the refillable medicament reservoir includes a flexible diaphragm having a nonlinear spring rate configured to create a relative vacuum within a medicament chamber when medicament is expelled from the medicament chamber beyond a predefined threshold, so as to spontaneously draw a quantity of medicament into the medicament chamber during the refill procedure to reestablish the predefined threshold, thereby confirming proper placement of a portion of the external refilling apparatus into the access port.

Abstract: Some embodiments of an infusion pump system may be configured to wirelessly communicate with other devices using near field communication (NFC). In particular embodiments, by incorporating near field communication capabilities into the infusion pump system, user communications with the infusion pump system can be enhanced and simplified.

Abstract: The invention provides a syringe for use in an ophthalmic injection. The syringe comprises a body, a stopper and a plunger. The body comprises an outlet at an outlet end and the stopper is arranged within the body such that a front surface of the stopper and the body define a variable volume chamber from which a fluid can be expelled though the outlet. The plunger comprises a plunger contact surface at a first end and a rod extends between the plunger contact surface and a rear portion. The plunger contact surface is arranged to contact the stopper but not couple thereto, such that the plunger can be used to force the stopper towards the outlet end of the body, reducing the volume of the variable volume chamber, but not to move the stopper away from the outlet end.

Abstract: An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are moved by a device (which may be a single pump or two pumps) for moving fluid through a flow path which passes through the dressing and a means for providing simultaneous aspiration and irrigation of the wound. The apparatus also comprises means to apply high frequency vibrational energy, e.g. ultrasound, to the wound bed. The former removes materials deleterious to wound healing, while distributing materials that are beneficial in promoting wound healing over the wound bed. The latter promotes healing. The dressing and a method of treatment using the apparatus.

Abstract: A pump controllably moves a small quantity of fluid from a fluid chamber to an outlet port with a small inexpensive actuator powered for a very short amount of time, thereby optimizing cost, size, and battery efficiency. Multiple pumps can be housed in a single enclosure, allowing multiple drugs to each be injected through a single cannula or needle.

Abstract: The disclosure provides a dose controlled multi-shot injection device comprising a housing and a dose setting mechanism, wherein the dose setting mechanism includes a drive spring, a rotatable dose setting handle adapted to set a dose of medicament, thereby biasing the drive spring, and a ratchet mechanism for maintaining the drive spring in a biased state against a spring force at a set dose.

Abstract: A pressure jacket for use with a fluid injector includes a barrel having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end along a longitudinal axis. The pressure jacket includes at least one engagement member protruding from a terminal portion of the proximal end of the barrel in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end of the barrel. The at least one engagement member engages with a locking mechanism on the fluid injector to releasably lock the pressure jacket with the fluid injector. A taper of the at least one engagement member rotationally guides the barrel into self-alignment with the locking mechanism and axially ejects the barrel upon rotation of the barrel about the longitudinal axis.

Abstract: A medical device and method for the treatment of a sinus opening includes a handle, a guide catheter, a guide wire, a balloon catheter, a guide wire movement mechanism and a balloon catheter movement mechanism. The handle has proximal and distal ends and a longitudinal axis along the length of the handle. The guide catheter is attached to the distal end of the handle and has a catheter lumen. The guide wire and balloon catheter are both disposed at least partially in the handle and catheter lumen. The guide wire movement mechanism and the balloon catheter movement mechanism are both operatively disposed on the handle. In addition, the guide wire movement mechanism is configured for advancement and retraction of the guide wire through the handle and catheter lumen by user operation of the guide wire movement mechanism.

Abstract: A medical connector includes a medical device connection portion communication passage defined by a housing and a valve body to guide a fluid from a first medical device connection portion to a second medical device connection portion. In the medical connector, a male connector inserted into the a connector connection portion presses a head portion of the valve body while contracting and deforming a body portion, and a fluid is guided from the male connector connection portion to the medical device connection portion communication passage, through a gap formed between the head portion and the housing.

Abstract: The present invention provides methods and devices for treating endovascular disease. Vibrational energy is delivered to change compliance and increase permeability at the treatment area. To improve clinical outcomes, one or more therapeutic drugs may be delivered to the treatment area.

Abstract: An infusion pump is provided for pumping fluid through an administrative set at a desired flow rate over a specified duration, and includes a pumping mechanism for releasably receiving and for exerting a pulsing force on the administrative set, thus pressurizing a portion of the set for creating a flow of fluid from a set outlet. A controller is connected to and is configured for operating the pumping mechanism, the controller determines a pulse frequency based on a volume of fluid infused over a portion of the specified duration and the desired flow rate, outputs a control signal to the pumping mechanism for operating the pumping mechanism based on the determined pulse frequency, determines a first pulse frequency based on the desired flow rate; and adjusts the first pulse frequency based on the volume of fluid infused to provide a second pulse frequency being different from the first pulse frequency.

Abstract: An extension for a catheter assembly may include a distal end and a proximal end. The distal end may include one or more cantilever arms and an insertion feature spaced apart from the cantilever arms. The insertion feature may be configured to insert into a lumen of a catheter adapter to provide a fluid connection between the catheter adapter and the extension. The one or more cantilever arms may be configured to engage in a snap-fit with the catheter adapter. The proximal end of the extension may include a female luer fitting.

Abstract: The invention provides a syringe for use in an ophthalmic injection. The syringe comprises a body, a stopper and a plunger. The body comprises an outlet at an outlet end and the stopper is arranged within the body such that a front surface of the stopper and the body define a variable volume chamber from which a fluid can be expelled though the outlet. The plunger comprises a plunger contact surface at a first end and a rod extends between the plunger contact surface and a rear portion. The plunger contact surface is arranged to contact the stopper but not couple thereto, such that the plunger can be used to force the stopper towards the outlet end of the body, reducing the volume of the variable volume chamber, but not to move the stopper away from the outlet end.

Abstract: A microprojection array comprising a substrate with a plurality of microprojections protruding from the substrate wherein the microprojections have a tapering hexagonal shape and comprise a tip and a base wherein the base has two substantially parallel sides with a slight draught angle of approximately 1 to 20 degrees up to a transition point at which point the angle increases to from about 20 degrees to about 70 degrees.

Abstract: The invention provides a syringe for use in an ophthalmic injection. The syringe comprises a body, a stopper and a plunger. The body comprises an outlet at an outlet end and the stopper is arranged within the body such that a front surface of the stopper and the body define a variable volume chamber from which a fluid can be expelled though the outlet. The plunger comprises a plunger contact surface at a first end and a rod extends between the plunger contact surface and a rear portion. The plunger contact surface is arranged to contact the stopper but not couple thereto, such that the plunger can be used to force the stopper towards the outlet end of the body, reducing the volume of the variable volume chamber, but not to move the stopper away from the outlet end.

Abstract: Manual insertion device has retraction spring (202) and hollow septum configuration (224) implemented using barrel-shaped guides (108, 110) and a guiding boss (210) in insertion device housing (106), and provides a fluid path through alignment of septum openings, side-port openings and catheter openings upon complete catheter insertion. Button (200) causes manual insertion of introducer needle (204) and catheter (220) of a first barrel (108) into a skin surface, and loading of retraction spring (202) disposed in an adjacent second barrel (110). Once introducer needle (204) and catheter (220) are fully inserted, the introducer needle hub (206) is released and automatically retracted by release of the retraction spring (202), leaving the catheter (220) in the user's body. Septums (218, 224) and side-port openings (216, 228) in the button (200) and introducer needle (204) are thus aligned, creating an uninterrupted fluid path between a reservoir or pump and catheter (220).

Abstract: A syringe device for ejecting a dose of a medicament, the syringe device comprising: a dose limiting mechanism arranged to interact with a dose ejecting mechanism to prevent ejection of a dose exceeding a set dose, and a safety mechanism, which is arranged such with respect to the dose ejecting mechanism that, if the dose limiting mechanism fails, the safety mechanism prevents ejection of a dose exceeding the set dose.

Abstract: An injector may include a container having a wall with an interior surface defining a closed sterile reservoir filled with a medical fluid or drug product. The injector may also include a fluid delivery system comprising a sterile container needle that is in fluid communication with the container in a delivery state, but may or may not be in fluid communication with the container in a storage state. The sterile container needle is attached to a connector, the connector mechanically coupled to the container to secure the sterile container needle to the container with the needle in the storage state. Further, the injector may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract: A catheter system may comprise an elongated access assist device configured to receive a guidewire during a thrombectomy. The device may include a hemostasis valve coupled to a proximal end of the device, whereby the valve controls fluid flow between a proximal portion and a distal portion of the device. The device may also include a flush port coupled to the proximal portion, where the flush port is configured to couple to a fluid supply source and facilitate the release of fluid from the fluid supply source through the elongated access assist device. The fluid may be configured to be released through a plurality of microperforations located along the body of the device, as well as on a distal tapered portion of the device. The distal tapered portion, combined with the release of fluid through the microperforations, may ease navigation of the system through the vasculature.

Abstract: A kit system has a beginning level kit apparatus, an intermediate level kit apparatus, and an advanced kit apparatus. The beginning level kit apparatus has a first derma roller having a head with a plurality of needles each having a length of five tenths millimeters situated thereon. Additionally, the beginning level kit apparatus has a first chemical compound comprising vitamin A1 at a first potency. The beginning level kit apparatus also has a first red light therapy device that that is configured to emit red light having a wavelength in the range of six hundred ten nanometers to seven hundred nanometers for a predetermined minimum time period of ten minutes. Finally, the beginning level kit apparatus has a beginning level enclosure apparatus that that encloses the first derma roller, the first chemical compound, and the first red light therapy device.