Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes at least one optical sensor assembly configured to sense the movement of the pump assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.

Abstract: An insertion device for the insertion of a medical implant into a human and/or animal body. The device has at least one outer shaft, which has a proximal end and a distal end opposite the proximal end. A receiving element is connected to the outer shaft, for the implant. The outer shaft and the receiving element are surrounded at a transition between the outer shaft and receiving element by a locally placed sleeve, which dampens mechanical tensile and/or compressive stresses.

Abstract: Electromechanical substance delivery devices are provided which implement low-power electromechanical release mechanisms for controlled delivery of substances such as drugs and medication. For example, an electromechanical device includes a substrate having a cavity formed in a surface of the substrate, a membrane disposed on the surface of the substrate covering an opening of the cavity, and a seal disposed between the membrane and the surface of the substrate. The seal surrounds the opening of the cavity, and the seal and membrane are configured to enclose the cavity and retain a substance within the cavity. An electrode structure is configured to locally heat a portion of the membrane in response to a control voltage applied to the electrode structure, and create a stress that causes a rupture in the locally heated portion of the membrane to release the substance from within the cavity.

Abstract: An auto-injector comprising an elongate housing containing a syringe. The housing having an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring pushing the needle from a covered position into an advanced position, operating the syringe and covering the needle. An activator arranged to lock the spring prior to manual operation and capable of, upon manual operation, releasing the spring means for injection. A first gear arrangement and a second gear arrangement arranged fro converting torque from a first end and a second end of the torsion spring into a translative force. The first end groundable in the housing while the second end acts on a plunger through the second gear arrangement for advancing the needle and supplying the dose.

Abstract: Methods and devices are provided for various insufflation sealing approaches for a trocar. For example, a trocar is provided that has a housing and a cannula extending therefrom. The housing and the cannula have a tool pathway extending therethrough for receiving a surgical tool, and the housing has an insufflation port therein. A variety of seal elements are provided that seal the insufflation port to prevent fluid flow into the port. The port and seal elements are configured to have a reduced profile to prevent interference between the trocar and a tissue surface during use.

Abstract: A single package infusion set is provided, including one or more of the following inserters: pushbutton-type, squeeze-type, contact-type, skin pinching-type, folding retraction-type, or multistage-type inserter having at least one reusable stage. The infusion set further includes adhesion means with user-selectable degrees of adhesion strength, self-sealing tube connection means, a lens feature to view, a site beneath the set, exemplary tube management and connection elements, insulin supply, adhesion concealment means, finger loops on the inserter and site preparation wipes or sprays, optionally provided as part of the inserter. The system further includes a package which may hold a number of easily released sets, retrievable by an inserter, an exemplary insertion needle handle and shroud, an exemplary squeeze-type latch between an upper portion and a lower portion of the set, and/or a tool removable upper portion of the set.

Abstract: A degradation data generator is used with a scaffold for delivery within a patient. The degradation data generator includes a driving circuit electrically coupled to drive an impedance of the scaffold. A detection circuit generates degradation data based on the impedance of the scaffold or other properties such as RF or lightwave transmission, conductance or absorption. The degradation data indicates an amount of biodegradation of the scaffold. A wireless transmitter is coupled to transmit the degradation data to a wireless degradation data receiver, while the scaffold is within the patient.

Abstract: A safety needle assembly having a first hub attached to a flexible tube and a second hub attached to a needle projecting through the flexible tube. A needle guard is positioned in an interior cavity of the first hub. The needle guard has a proximal wall having an opening and two arms each with an end and wherein the two ends spaced from and biased toward the needle in a ready position. In a particular example, a support is located inside the cavity of the first hub and wherein the two ends of the two arms on the needle guard rest on the support in the ready position.

Abstract: A method for detecting the need for providing assistance to an individual suspected of overdosing on an opiate is provided. The method includes using a wearable device for continuous or intermittent monitoring of one or more physiological parameters of the individual. If the level of one of the one or more physiological parameters exceeds a threshold level specific to that parameter, an alarm is triggered. If the alarm is not aborted, an alert is transmitted to one or more emergency contacts conveying that the individual has overdosed. The method optionally provides for injection of an opioid receptor antagonist into the individual to reverse the effects of the overdose. Also provided is a device for implementing these methods.

Abstract: A microneedle unit includes a liquid holder, a microneedle, and a support member. The liquid holder has an enclosure that holds liquid including a substance to be administered. The microneedle has a base body and protrusions extending from the surface of the base body. The protrusions are of a hardness sufficient to pierce the liquid holder. The support member supports the base body in a state such that the microneedle is arranged at a position in which the tips of the protrusions and the enclosure holding the liquid are opposed to each other with a gap provided therebetween. The tips of the protrusions can be displaced to a position where the tips of the protrusions penetrate through the liquid holder in response to an external force applied to the base body.

Abstract: A medical delivery device includes a first compartment configured to hold a first substance. The first compartment includes a first wall that includes a first ferrous material, and the first wall is configured to disintegrate and release the first substance into a patient in response to first electromagnetic radiation received by the first ferrous material. The medical delivery device also includes a second compartment attached to the first compartment and configured to hold a second substance. The second compartment includes a second wall that includes a second ferrous material, and the second wall is configured to disintegrate and release the second substance into the patient in response to second electromagnetic radiation received by the second ferrous material.

Abstract: A medical delivery device includes a first compartment configured to hold at least a portion of an activator that activates one or more molecular nanomachines. The first compartment includes a first wall that includes a first ferrous material, where the first wall is configured to disintegrate in response to first electromagnetic radiation received by the first ferrous material such that the activator activates the one or more molecular nanomachines. The device includes a second compartment configured to hold the one or more molecular nanomachines, wherein the second compartment includes a second wall that includes a second ferrous material, and wherein the second wall is configured to disintegrate and release the one or more molecular nanomachines into a patient in response to second electromagnetic radiation received by the second ferrous material.

Abstract: The present invention relates to the titration and delivery of anesthetic and sedative medications to a subject. Further, the present invention relates to a device and methods for titrating and delivering such medications in a semi-automated or fully automated manner and which can be monitoring and controlled remotely. Even still further, the present invention relates to such a device that can perform the titration and delivery of medication in a manner that minimalizes occlusion and prevents back flow of the medication. More particularly, the present invention relates to a device for titration and delivery of medication using a non-concentric pumping mechanism that gradual or progressively increases and decreases occlusion in the medication delivery line within the pump to minimize and/or prevent sudden formation and release of occlusion in order to provide more steady and continuous flow of the medication through the device to the subject.

Abstract: A device for delivering a fluid into a biological tissue includes hollow microneedles (10) projecting from a surface (12) of a substrate (14), and a guide element (18) spaced from the substrate. The guide element provides a tissue-contact surface (20) that defines a tissue contact plane oblique to the surface (12) of the substrate (14).

Abstract: An apparatus and method are disclosed for controlling infusion of liquid into a patient using a peristaltic pump. The liquid infusion apparatus includes a liquid conduit having a proximal segment, a distal segment and an intermediate segment. The liquid infusion apparatus also includes a flow valve in fluid communication with the intermediate and distal segments. The flow valve includes a shuttle member slidably disposed within a housing about the distal segment, the shuttle member being configured for lateral movement relative to an elongated axis of the distal segment. The shuttle member is configured to operate in a first configuration to impede fluid flow through the liquid conduit and in a second configuration for which fluid flow through the liquid conduit is unimpeded. The shuttle member includes a resilient grasper for selectively engaging and disengaging a mating actuator resiliently received by the grasper.

Abstract: Systems, methods and devices for creating an effect using microwave energy to specified tissue are disclosed herein. A system for the application of microwave energy to a tissue can include, in some embodiments, a signal generator adapted to generate a microwave signal having predetermined characteristics, an applicator connected to the generator and adapted to apply microwave energy to tissue, the applicator comprising one or more microwave antennas and a tissue interface, a vacuum source connected to the tissue interface, a cooling source connected to said tissue interface, and a controller adapted to control the signal generator, the vacuum source, and the coolant source. The tissue may include a first layer and a second layer, the second layer below the first layer, and the controller is configured such that the system delivers energy such that a peak power loss density profile is created in the second layer.

Abstract: A medical device is provided, including: a sheath portion (10); a pair of operation wires (30); and a turning operation portion (60) in which the sheath portion (10) is bent in a direction corresponding to the pulled one operation wire (30) through a turning operation. The turning operation portion (60) includes a wire fixation panel (64) around which the operation wires (30) are wound on a side peripheral surface; and a penetration portion (63c) and a closing portion (63d) which are provided further radially outwards than the side peripheral surface of the wire fixation panel (64) and at a position facing the side peripheral surface, so as to be integrated with the wire fixation panel (64).

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure. In one approach, the breast pump assembly includes a breast adapter and a receptacle configured to cup the breast adapter, and the breast adapter is removable from the receptacle.

Abstract: User-friendly attachment mechanisms for pen needles provide improved handling and ease of use, including locking installation and removal features and sensory feedback when a needle-bearing hub is seated on a pen. Embodiments include a needle-bearing hub includes a circumferentially oriented flexible tab that engages a radially inward rib on an outer cover to assist in attaching a pen device to the pen needle.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.