Abstract: A microneedle includes a substrate, and projections which extend from a surface of the substrate. Each of the projections includes layers separated from each other in a direction in which the projection extends. The layers include a first layer which contains a polymer which is soluble in water and poorly soluble in oil and a second layer which contains a polymer that is soluble in oil. The first layer and the second layer are adjacent to each other and are formed in the order of the first layer and the second layer from the projection to the substrate.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: An infant and child bonnet for securing a breathing tube includes a cap body and an elastic fixing band. The cap body includes a first opening and a second opening corresponding to each other and includes a first connection portion. The elastic fixing band is connected to the cap body. One end of the elastic fixing band includes a second connection portion flexibly fixing the breathing tube. The second connection portion is joined to the first connection portion. Accordingly, the infant and child bonnet suits various head sizes and shapes and effectively fixes the breathing tube without displacement or detachment.

Abstract: A nasogastric tube (10) including a main lumen (12) having one or more proximal connectors (14) for connecting to a source of substances or pressure, and one or more vacuum lumens (16) peripherally surrounding the main lumen (12), each vacuum lumen (16) including a vacuum sealing portion (24), which includes one or more suction ports (26) for sealingly drawing an inner wall of an esophagus thereagainst.

Abstract: A method and apparatus are provided for providing a plurality of injections from a fluid reservoir. The apparatus includes a fluid controller for controlling the flow of fluid from the fluid reservoir to a needle. An actuator selectively actuates the fluid controller to provide a dose of medicament from the fluid reservoir. The fluid controller also is configured to calculate the volume of fluid in the fluid reservoir required to provide a dose having a desired number of units of medicament for an injection. The apparatus may also include a detector configured to detect a characteristic indicative of the fluid pressure in the needle. The method includes selecting the number of units to be dispensed during an injection, automatically calculating the injection volume required to dispense the selected number of units based on the calculated unit volume and tracking the total number of units dispensed during a series of injections.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure. In one approach, the breast pump assembly includes a breast adapter and a receptacle configured to cup the breast adapter, and the breast adapter is removable from the receptacle.

Abstract: A catheter and a method facilitate insertion into a blood vessel by providing a tubular wall section with a lumen having a longitudinally extending first volume and a second volume extending side-by-side and contiguous with the first volume. A sector of the tubular wall section is extended side-by-side and contiguous with the second volume of the lumen and is constructed of a material enabling the sector to be collapsed diametrically and nested within the first volume so that the section is provided with limited diametric dimensions. Upon insertion of the section into the blood vessel, the sector is expanded to extend diametrically outside the first volume, thereby rendering the section configured with expanded diametric dimensions and the lumen with a total cross-sectional area for accommodating a desired relatively high volumetric flow rate of fluid through the catheter.

Abstract: The present invention relates to a connector system for use in connecting conduits together, such as those used with an extracorporeal blood circulation system. The system has a male and female connector and a seal. The seal is operatively associated with the male and female connectors and forms a fluid tight connection between the male and female connectors. An inner surface of the seal and the inner surfaces of the first and second coupling ends form a continuous and smooth transitional surface.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: A container and methods for storing and mixing a two-component composition is provided. The container includes a body, a first plug and a second plug. The body has a first end, a second end, and a bypass with a length L disposed between the first and second ends. The first and second plugs are slidably disposed in the body and define a first compartment. A second compartment is disposed in the body between the second plug and the second end. The second plug has a first edge, a second edge, and a plurality of spaced-apart primary conduits extending through the second plug. Each primary conduit has a separate first opening. A distance D extends longitudinally from the first edge to the second edge and a distance E extends longitudinally from the first edge to the first opening that is nearest the first edge. D?L and E<L.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: A dilator comprises a guide extending through a tube, and a slidable sleeve exterior to the tube, such that a slit in the tube extending from a first end of the tube to a second end of the tube, opposite of the first end, is closed by a force applied via the slidable sleeve. When closed, the slit does not interfere with the tube being used as a dilator to dilate tissues of a patient through which the guide extends. When opened, the slit allows the tube to be placed onto the guide or removed from the guide.

Abstract: A dual reservoir access port includes a base having proximal and distal fluid reservoirs. The fluid reservoirs each comprise a bottom and a side wall. A dual prong outlet stem projects from a distal end of the base and comprises a first prong and a second prong. A first fluid channel extends through the first prong to the distal reservoir, and a second fluid channel extends through the second prong to the proximal fluid reservoir. A puncture shield is disposed between at least a portion of the second fluid channel and the bottom of the distal fluid reservoir. A needle-penetrable septum is disposed atop of each of the fluid reservoirs. A cap is placed over and around the port base compressing and sealing the septa against the base. A locking collar may be placed over a dual lumen catheter to lock the catheter to the dual prong outlet stem.

Abstract: The invention concerns an ocular iontophoresis device for delivering at least one active substance to an eyeball, comprising: a wall defining a tubular-shaped body delimitating laterally a reservoir configured for receiving the active substance(s), the wall comprising a circular distal end configured for being positioned on an ocular surface of the eyeball and surrounding the cornea and a part of the sclera of the eyeball, a first electrode configured to be positioned in front of the sclera, said first electrode being configured for delivering a first current density to the active substance(s) of the reservoir, the first electrode defining an annular-shaped first surface that is arranged in a peripheral part of the reservoir, a second electrode configured to be positioned in front of the cornea, said second electrode being configured for delivering a second current density to the active substance(s) of the reservoir, the second electrode defining a disk-shaped second surface that is arranged in a central part

Abstract: A system for deploying a shape memory catheterization device within a patient, includes a catheter for endovascular insertion of the shape memory catheterization device. A heat source heats the shape memory catheterization device above the transition temperature. A transformation data generator includes a circuit driver for driving a circuit that includes at least one resistive element of the shape memory catheterization device and a detection circuit for generating transformation data based on a resistance of the at least one resistive element, wherein the transformation data indicates a shape transformation of the shape memory catheterization device from a catheterization shape to a transformed shape.

Abstract: A patient care system has a medical pump for delivering a medicine to a patient, and a processor in communication with the pump. The pump is configured to receive a first input on whether the medicine is a critical medicine, and a second input on a trigger condition that triggers a fail-operate mode for the critical medicine. The processor controls the medical pump to operate in the fail-operate mode, where the fail-operate mode continues delivery of the critical medicine when the trigger condition is triggered.

Abstract: A spray head having multiple openings arranged to provide at spray coverage throughout at least 90 degrees from the spray head central axis. The spray head may be used for applying tissue sealants.

Abstract: A dose setting mechanism for a drug delivery device includes a primary drug delivery assembly and a secondary drug delivery assembly. The dose setting mechanism includes a primary dose dial component for setting a dose in the primary drug delivery assembly and a secondary dose dial component for setting a dose in the secondary drug delivery assembly. The primary dose dial component and the secondary dose dial component are configured to rotate during dose setting. A gear mechanism is configured such that in a first phase of the dose setting, rotation of the primary dose dial component is transferred to the secondary dose dial component and such that in a second phase of the dose setting, the secondary dose dial component is decoupled from the primary dose dial component such that rotation of the primary dose dial component is prevented from being transferred to the secondary dose dial component.