Patents Examined by Yevegeny Valenrod
  • Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
    Patent number: 9617251
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: April 11, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Stefan Peters, Holger Wagner
  • Process for obtaining methionine
    Patent number: 9617209
    Abstract: The invention relates to a method for crystallizing D,L-methionine from aqueous solutions and/or suspensions containing D,L-methionine and D,L-methionine ammonium salts, having a Met content of 70-180 g/kg, an NH4+ content of 1-5 g/kg, in the presence of a crystallization additive, which comprises a nonionic or anionic surfactant or a mixture of various nonionic or anionic surfactants, in which the temperature of the solution and/or suspension is lowered directly or stepwise from T1=85-110° C. to T2=30-50° C., so that D,L-methionine precipitates as a solid.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: April 11, 2017
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Stefan Reichert, Harald Jakob, Hans Joachim Hasselbach, Martin Koerfer
  • Ozonolysis operations for generation of reduced and/or oxidized product streams
    Patent number: 9604898
    Abstract: The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: March 28, 2017
    Assignee: P2 Science, Inc.
    Inventors: Patrick Foley, Yonghua Yang
  • Method for producing dipeptide derivative containing disubstituted amino acid residue
    Patent number: 9605020
    Abstract: A method for producing a dipeptide that has a protected N-terminal and is represented by formula (1) or a salt of the dipeptide, said method comprising condensing an ?-monosubstituted amino acid that has a protected N-terminal and is represented by formula (2) or glycine or a salt thereof with a disubstituted amino acid that is represented by formula (3) or a salt thereof in the presence of a condensing agent [in each of the formulae, substituents are as defined in the description or the like].
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: March 28, 2017
    Assignee: NAGASE & CO., LTD.
    Inventors: Keisuke Matsuyama, Kazuya Kodama
  • Process to prepare treprostinil, the active ingredient in Remodulin®
    Patent number: 9604901
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: March 28, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Heteroarylamide inhibitors of TBK1
    Patent number: 9598424
    Abstract: The present invention provides compounds of formula 1: which are useful as inhibitors of TBK-1, pharmaceutical compositionst thereof, methods for treatment of conditions associated with TBK1, processes for making the compounds and intermediates thereof.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: March 21, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Walter Keung, Lily Kwok, Mark Sabat, Nicholas Scorah, Haixia Wang, Steven John Woodhead, Anthony R Gangloff
  • Quinazolinone derivatives for use in the treatment of chlamydiales infections
    Patent number: 9598406
    Abstract: The present invention relates to a method for treating a Chlamydiae infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof: Wherein, R1, R2, R3, R4 and p are as defined in claim 1.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: March 21, 2017
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Daniel Gillet, Julien Barbier, Jean-Christophe Cintrat, Karen Hinsinger, Thomas Rudel, Jo-Ana Herweg, Annette Fischer
  • Carbonylation process
    Patent number: 9598347
    Abstract: Process for the carbonylation of dimethyl ether with carbon monoxide in the presence of a catalyst to produce methyl acetate reaction product. The carbonylation process is conducted in the presence of hydrogen at a molar ratio of hydrogen to carbon monoxide of greater than 1 and the catalyst is a mordenite zeolite prepared from a synthesis mixture comprising at least one organic structure directing agent.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: March 21, 2017
    Assignee: BP CHEMICALS LIMITED
    Inventors: Evert Jan Ditzel, Bogdan Costin Gagea, David John Law, John Glenn Sunley
  • Process to prepare levulinic acid
    Patent number: 9598341
    Abstract: The invention describes processes to prepare levulinic acid, formic acid and/or hydroxymethyl furfural from various biomass materials.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: March 21, 2017
    Assignee: GFBiochemicals Limited
    Inventors: Brian D. Mullen, Dorie Janine Yontz, Cora M. Leibig
  • Method of treating or reducing the severity of dermatological conditions
    Patent number: 9592188
    Abstract: The present disclosure provides compositions and methods for treating dermatological disorders using a podophyllotoxin formulation.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: March 14, 2017
    Inventor: Yansong Liu
  • Synthesis of intermediates for producing prostacyclin derivatives
    Patent number: 9593061
    Abstract: The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: March 14, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
  • Process to prepare treprostinil, the active ingredient in remodulin®
    Patent number: 9593066
    Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: March 14, 2017
    Assignee: United Therapeutics Corporation
    Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
  • Diindol-3-ylmethanes as potent non-toxic antifouling compounds
    Patent number: 9591855
    Abstract: The present invention provides high potency 3,3?-diindolylmethane (DIM) and analogue compounds as antifouling agents. The present invention further provides methods of preventing or reducing settlement and/or fouling of marine fouling organisms on surfaces of submerged objects by coating the surfaces with the 3,3?-diindolylmethane (DIM) and analogue compounds provided.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: March 14, 2017
    Assignees: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, CHINA OCEAN MINERAL RESOURCES R&D ASSOCIATION
    Inventors: Peiyuan Qian, Ying Xu, Kailing Wang, Changyun Wang
  • Method for producing ester compound
    Patent number: 9586887
    Abstract: A method for producing an ester compound including reacting a compound having at least one cyclic structure of a norbornene ring and a norbornadiene ring with an alcohol and carbon monoxide by using a palladium catalyst and an oxidizing agent, to thereby introduce ester groups to carbon atoms forming a double bond in the cyclic structure and obtain the ester compound, wherein the palladium catalyst comprises a palladium complex having a bipyridyl as a ligand.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: March 7, 2017
    Assignee: JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Daisuke Watanabe, Masaki Noguchi, Akira Shiibashi, Shinichi Komatsu, Takaya Matsumoto
  • Aza-heteroaryl compounds as PI3K-gamma inhibitors
    Patent number: 9586949
    Abstract: The present invention provides aza-heteroaryl derivatives of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, R4, R5, and R6 are defined herein, that inhibit the activity of phosphoinositide 3-kinases-gamma (PI3K?) and are useful in the treatment of diseases related to the activity of PI3K? including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: March 7, 2017
    Assignee: Incyte Corporation
    Inventors: Ge Zou, Andrew P. Combs, Andrew W. Buesking
  • Process for producing acetic acid by introducing a lithium compound
    Patent number: 9580377
    Abstract: Process for producing acetic acid is disclosed in which a lithium compound is added to the reaction medium to maintain a concentration of lithium acetate from 0.3 to 0.7 wt. %. The concentration of the rhodium catalyst is maintained from 300 to 3000 wppm in the reaction medium, the concentration of water is maintained from 0.1 to 4.1 wt. % in the reaction medium, and the concentration of methyl acetate is maintained from 0.6 to 4.1 wt. % in the reaction medium.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: February 28, 2017
    Assignee: CELANESE INTERNATIONAL CORPORATION
    Inventors: Mark O. Scates, Yaw-Hwa Liu
  • Complexes of agomelatine and sulphonic acids, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9573891
    Abstract: Complexes of agomelatine and sulphonic acids of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: February 21, 2017
    Assignees: LES LABORATOIRES SERVIER, SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
    Inventors: Hanbin Shan, Yuhui Shen, Ying Luo, Philippe Letellier, Michael Lynch
  • Polymerizable liquid crystal compound, and compensation film, antireflective film, and display device including the same
    Patent number: 9567524
    Abstract: A polymerizable liquid crystal compound is represented by Chemical Formula 1: wherein, in Chemical Formula 1 groups and variables are the same as defined in the detailed description.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: February 14, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Dmitry Androsov, Sang Ho Park, Won Cheol Jung, Jung Im Han
  • Production of acetic acid with high conversion rate
    Patent number: 9567282
    Abstract: A process for producing acetic acid comprising the steps of reacting carbon monoxide and at least one of methanol and a methanol derivative in a first reactor under conditions effective to produce a crude acetic acid product; separating the crude acetic acid product into at least one derivative stream, at least one of the at least one derivative stream comprising residual carbon monoxide; and reacting at least a portion of the residual carbon monoxide with at least one of methanol and a methanol derivative over a metal catalyst in a second reactor to produce additional acetic acid.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 14, 2017
    Assignee: CELANESE INTERNATIONAL CORPORATION
    Inventors: G. Paull Torrence, Brian W. Hokkanen, Michael O. Nutt, Tianshu Pan, Ronald D. Shaver
  • Methods and compositions for treating androgenetic alopecia
    Patent number: 9561224
    Abstract: A treatment method including: (a) identifying a subject in need of treatment for androgenic alopecia (AGA), and (b) orally administering a physiologically effective amount of cepharanthine (CEP) to the subject according to a dosage regimen.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: February 7, 2017
    Inventor: Moshe Rogosnitzky