Patents Examined by Yevegeny Valenrod
  • Cholecystokinin secretion-promoting composition
    Patent number: 9554990
    Abstract: A method is provided to promote secretion of cholecystokinin (CCK) by administering an active component. The active component includes acrylic acid and/or an unsaturated aldehyde having a main chain of 4 to 12 carbon atoms having a double bond in at least position 2 or 4, where the main chain has 4 to 9 carbon atoms when there is a double bond in only position 2, and the main chain has 9 to 12 carbon atoms when there is a double bond in only position 4. The cholecystokinin secretion-promoting composition can be used as an appetite suppressant. By adding this cholecystokinin secretion-promoting composition to food, appetite-suppressing food products can be provided.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: January 31, 2017
    Assignee: J-Oil Mills, Inc.
    Inventors: Hiroshi Hara, Tohru Hira, Chigusa Nishiyama, Noriko Tokura, Takatoshi Yamashita, Jun Imagi
  • Triscationic amphiphile derivative compounds having a pendent alcohol group, compositions thereof, and methods for making same
    Patent number: 9556109
    Abstract: The inventive subject matter relates to compounds of Formula I, compositions thereof, and processes for making such compounds as further described herein. The inventive compounds and compositions have antimicrobial properties and are useful as environmental disinfectants, topical cleansers such as topical personal care compositions, sanitizers, preservatives, in water treatment, as permanent or erodible coatings for medical devices and appliances, and in therapeutics. Additionally, the compounds of Formula I will serve as synthetic intermediates for making additional novel derivatives of triscationic amphiphile compounds.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: January 31, 2017
    Assignee: JAMES MADISON INNOVATIONS, INC.
    Inventors: Kevin L. Caran, Kyle Seifert
  • Biphenyl esters, their production and their use in the manufacture of plasticizers
    Patent number: 9556103
    Abstract: A biphenyl diester useful as a plasticizer having the formula (I): wherein R1 is an alkyl group having 5 to 15 carbon atoms and R2 is a methyl group or a phenyl group.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: January 31, 2017
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jihad M. Dakka, Wei Tang, Stephen Zushma, Christine A. Costello, Diana Smirnova, Madhavi Vadlamudi, Victor DeFlorio
  • Methyl-substituted biphenyl compounds, their production and their use in the manufacture of plasticizers
    Patent number: 9556087
    Abstract: In a process for producing methyl-substituted biphenyl compounds, a feed comprising at least one aromatic hydrocarbon selected from the group consisting of toluene, xylene and mixtures thereof is contacted with hydrogen in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluenes and/or (dimethylcyclohexyl)xylenes together with dialkylated C21+ compounds. At least part of the dialkylated C21+ compounds is then removed from the hydroalkylation reaction product to produce a dehydrogenation feed; and at least part of the dehydrogenation feed is dehydrogenated in the presence of a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising a mixture of methyl-substituted biphenyl compounds.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: January 31, 2017
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jihad M. Dakka, Lorenzo C. DeCaul, Victor DeFlorio
  • Process for depolymerization of lignin
    Patent number: 9550710
    Abstract: The present invention discloses a process for depolymerization of lignin to yield substituted phenolic monomers using Brönsted ionic liquid as catalyst under mild reaction conditions to obtain an overall yield of monomers up to 97%.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: January 24, 2017
    Assignee: Council of Scientific and Industrial Research
    Inventors: Paresh Laxmikant Dhepe, Ashutosh Anant Kelkar, Babasaheb Mansub Matsagar, Sandip Kumar Singh
  • Process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds
    Patent number: 9550719
    Abstract: The present disclosure provides a process for synthesis of 3-aryl-2-hydroxy propanoic acid derivatives of formula (S)-1. wherein R1 represents H or (C1-C5) alkyl groups and R2 represents (C1-C5) alkyl groups.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: January 24, 2017
    Assignee: Council of Scientific and Industrial Research
    Inventors: Muthukrishnan Murugan, Mujahid Mohammad
  • Catalyst and manufacturing method thereof and method for manufacturing hydrogenated bisphenol A or derivatives thereof using the same
    Patent number: 9545617
    Abstract: A catalyst is provided. The catalyst includes a carrier and a metal Pd. The carrier is represented by a formula: MxAl(1?x)O(3?x)/2, where M is an alkaline earth metal, and x is between 0.09 and 0.24. The metal Pd is loaded on the carrier. A method for manufacturing the catalyst and a method for manufacturing a hydrogenated bisphenol A or derivatives thereof using the catalyst are also provided.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: January 17, 2017
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Kuo-Ching Wu, Chiou-Hwang Lee
  • Inhibitors of the farnesoid X receptor and uses in medicine
    Patent number: 9540415
    Abstract: Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R1, R2, R4, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least Cone compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: January 10, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Penn State Research Foundation
    Inventors: Frank J. Gonzalez, Changtao Jiang, Cen Xie, Andrew D. Patterson, Fei Li, James B. Mitchell
  • Method for producing acrolein and/or acrylic acid from glycerol
    Patent number: 9527791
    Abstract: The invention relates to the production of acrolein and/or acrylic acid from glycerol, and more particularly to a method for continuous production of a stream comprising acrolein by dehydration of glycerol, comprising cycles of reaction and regeneration of a dehydration catalyst.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: December 27, 2016
    Assignee: Arkema France
    Inventors: Jean-Francois Devaux, Michel Fauconet, Nabil Tlili
  • Composition for treating immune diseases containing daurinol compound as active ingredient
    Patent number: 9526717
    Abstract: The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of IL-17 and TNF-?, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive T cells and increasing regulatory T cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the Mongolian medicinal plant Haplophyllum dauricum or Haplophyllum cappadocicum, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: December 27, 2016
    Assignee: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CATHOLIC UNIV. OF KOREA SONGEUI CAMPUS
    Inventors: Mi-La Cho, Dong-Yun Shin, Min-Jung Park, Seon-Yeong Lee, Eun Ji Yang, Eun Kyung Kim, Hye-Jin Son, Eun-Jung Lee, Jae-Kyung Kim, Sung-Hee Lee
  • Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs)
    Patent number: 9527806
    Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: December 27, 2016
    Assignees: STC.UNM, University of Florida Research Foundation, Inc.
    Inventors: David G. Whitten, Kirk S. Schanze, Anand Parthasarathy, Eunkyung Ji, Motokatsu Ogawa, Thomas S. Corbitt, Dimitri Dascier, Ying Wang, Linnea K. Ista, Eric H. Hill
  • Tetrahydroprotoberbine compounds and uses thereof in the treatment of neurological, psychiatric and neurodegenerative diseases
    Patent number: 9526721
    Abstract: Tetrahydroprotoberbine (THPB) compounds and their use in the treatment of neurological, psychiatric and neurodegenerative diseases is provided. The compounds include d-govadine, l-govadine and racemic govadine, as well as d-THPBs of general formula (I). Enantioselective processes for preparing compounds of formula (I), and d- and l-govadine are also provided.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: December 27, 2016
    Inventors: James Jackson Miller, Anthony George Phillips, Christopher Court Lapish, Glenn Martin Sammis
  • Ceramide dispersion composition
    Patent number: 9522110
    Abstract: A ceramide dispersion composition, includes: at least one ceramide represented by Formula (1) or Formula (2); a surfactant; and trisodium ascorbyl palmitate phosphate, wherein in Formula (1), R1 represents an aliphatic hydrocarbon group having at least one unsaturated double bond, R2 represents an alkyl group having 9 or more carbon atoms, and n represents an integer from 20 to 34; and in Formula (2), R3 represents an aliphatic hydrocarbon group having at least one unsaturated double bond, R4 represents an alkyl group having 9 or more carbon atoms, m represents an integer from 20 to 34, and X represents a hydrogen atom or a hydroxyl group.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: December 20, 2016
    Assignee: FUJIFILM Corporation
    Inventors: Terukazu Yanagi, Hiroyuki Kitaoka, Akina Nakaune
  • Lysine-glutamic acid dipeptide derivatives
    Patent number: 9522874
    Abstract: The invention relates to compounds of the formula I. The compounds of formula I are versatile peptide intermediates for the solid phase peptide synthesis (SPPS) of peptide drugs which comprise a Glu-fatty alkyl side chain building block attached to a Lys-part of the peptide chain.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: December 20, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Kurt Puentener
  • Pharmaceutical compositions comprising perillyl alcohol derivatives
    Patent number: 9522918
    Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: December 20, 2016
    Assignee: NeOnc Technologies, Inc.
    Inventors: Thomas Chen, Daniel Levin, Satish Pupalli
  • Anti-HIV compounds
    Patent number: 9518022
    Abstract: This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: December 13, 2016
    Assignee: Prosetta Antiviral Inc.
    Inventors: Andy Atuegbu, Dennis Solas, Clarence R. Hurt, Anatoliy Kitaygorodskyy
  • Augmenting moieties for anti-inflammatory compounds
    Patent number: 9512068
    Abstract: Augmented or synergized anti-inflammatory constructs are disclosed including terpenes covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids, amino acids and polyamines; and anti-inflammatory molecules covalently conjugated with specific amino acids. For the latter, further conjugation with a choline bioisostere further augments the anti-inflammatory activity.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 6, 2016
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, LEHIGH UNIVERSITY
    Inventors: Jeffrey D. Laskin, Ned D. Heindel, Diane E. Heck, Carl Jeffrey Lacey, Sherri C. Young
  • Chiral phosphines for palladium-catalyzed asymmetric ?-arylation of ester enolates to produce tertiary stereocenters in high enantioselectivity
    Patent number: 9512155
    Abstract: The disclosure provides new and improved methods for the Pd-catalyzed asymmetric ?-arylation of ester compounds, which produce the corresponding ?-aryl moiety in high enantioselectivity (generally >90% ee). The present methods utilize a palladium catalyst supported by new (R)—H8-BINOL-derived monophosphine ligands. The method is applicable to a wide variety of aryl triflate substrates having variations in both electronic and steric properties. These aryl triflate substrates react with various ?-alkyl (Z)- and/or (E)-0-trimethylsilyl ketene acetals in the presence of a Pd catalyst, (R)—H8-BINOL-derived monophosphine ligand, and a mild activator, for example, LiOAC, to provide the asymmetric ?-arylation of ester compounds in high ee.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: December 6, 2016
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Steve Jianrong Zhou, Zhiyan Huang
  • Method for producing xylylene diisocyanate and system for producing xylylene diisocyanate
    Patent number: 9512067
    Abstract: A method for producing xylylene diisocyanate includes a thermal decomposition step of thermally decomposing xylylene dicarbamate; a first separation step of separating, from the thermal decomposition product obtained in the thermal decomposition step, an isocyanate-containing component containing xylylene diisocyanate as a main component and an alcohol-containing component containing alcohol as a main component and containing xylylene diisocyanate as a subcomponent; a second separation step of separating xylylene dicarbamate and alcohol from the alcohol-containing component obtained in the first separation step; and a returning step of returning xylylene dicarbamate obtained in the second separation step to the thermal decomposition step.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: December 6, 2016
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Koji Takamatsu, Hideki Sone, Masaaki Sasaki
  • Killing of bed bugs
    Patent number: 9512059
    Abstract: Killing of bed bugs is accomplished by bringing the bed bugs into contact with a toxic amount of at least one of the compounds of the structure (I) wherein X is —OH, ?O, or —O(O)CR, wherein R is selected from H and a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 11 carbon atoms; R1 is H or CH3; R2 is H or CH3; R3 is H or a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 11 carbon atoms; and wherein the compounds of structure (I) contain from 6 to 20 total carbon atoms in the compounds.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: December 6, 2016
    Assignee: Bedoukian Research, Inc.
    Inventor: Robert H. Bedoukian