Patents Examined by Yong Chu
  • Process for preparing formic acid
    Patent number: 9428438
    Abstract: Process for obtaining formic acid by thermal separation of a stream comprising formic acid and a tertiary amine (I), in which, in step (a), a liquid stream comprising formic acid, methanol, water and tertiary amine (I) is produced by combining methyl formate, water and tertiary amine (I), from there in step (b), methanol is separated off and in step (c), formic acid is removed by distillation from the liquid stream obtained in a distillation apparatus, wherein, when methyl formate, water and tertiary amine (I) are combined, methyl formate, water and optionally tertiary amine (I) are first introduced in step (a1) in a molar ratio of 0?n(amine to a1)/n(mefo to a1)?0.1, and from 70 to 100% of the hydrolysis equilibrium possible is set and then, in step (a2), tertiary amine (I) is introduced in a molar ratio of 0.1?n(amine to a2)/n(mefo to a1)?2, and the mixture is reacted.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: August 30, 2016
    Assignee: BASF SE
    Inventors: Donata Maria Fries, Klaus-Dieter Mohl, Martin Schäfer, Daniel Schneider, Peter Bassler, Stefan Rittinger, Joaquim Henrique Teles
  • Cocrystals of dimethyl fumarate
    Patent number: 9421182
    Abstract: Disclosed herein are cocrystals of dimethyl fumarate, which is a prodrug of methyl hydrogen fumarate.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: August 23, 2016
    Assignee: XenoPort, Inc.
    Inventors: Chen Mao, Scott L. Childs, Sami Karaborni
  • Catalytic reductive cleavage of a ?-O-4 bond of ethers or polyethers such as lignin
    Patent number: 9422215
    Abstract: The present invention relates to a method of cleaving a ?-O-4 bond to the corresponding C—H bond in a substrate, by use of a hydrogen donor and a metal catalyst in a solvent. Thereby it is possible to depolymerize a polymer having a repeating ?-O-4 bond.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: August 23, 2016
    Assignee: KAT2BIZ AB
    Inventors: Joseph Samec, Maxim Galkin, Joakim Löfstedt
  • 2,4-pyrimidinediamine compounds and their uses
    Patent number: 9416112
    Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: August 16, 2016
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Ankush Argade, Donald Payan, Susan Molineaux, Sacha Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander Rossi
  • Small-molecule inhibitors of dengue virus proteases
    Patent number: 9408813
    Abstract: The present invention concerns methods and compositions involving small molecule inhibitors for the treatment or prophylaxis of flavivirus infection, such as dengue virus and West Nile virus.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: August 9, 2016
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Stanley J. Watowich, Usha Viswanathan
  • Method of production of a methionine salt
    Patent number: 9403764
    Abstract: A method for production of a methionine salt in a reactive rectification column containing a weir having a height of 100 mm or more is provided.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: August 2, 2016
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Hans Joachim Hasselbach, Martin Koerfer, Christof P. Gruener, Franz H. Hanrath, Juergen Stock, Jignesh Gangadwala, Horst Krull
  • Liquid-liquid extraction process for the production of acrylic esters
    Patent number: 9403751
    Abstract: The invention relates to a liquid-liquid extraction process, comprising: the provision of a main input liquid stream, comprising at least one compound of interest and an excess compound; the provision of a liquid scrubbing stream; the extraction of the excess compound from the main input liquid stream by contact with the liquid scrubbing stream, making it possible to collect a main output liquid stream, depleted in excess compound with respect to the main input liquid stream; in which: the main input liquid stream and the liquid scrubbing stream exhibit a difference in density of less than or equal to 50 kg/m3 and also an interfacial tension of less than or equal to 3 dyn/cm; and the extraction stage is carried out in a packed contactor with a ratio by weight as input liquid scrubbing stream/main liquid stream ranging from 0.3 to 0.5.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: August 2, 2016
    Assignee: Arkema France
    Inventors: Serge Tretjak, Stephane Denis
  • Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
    Patent number: 9394264
    Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: July 19, 2016
    Assignee: Receptos, Inc.
    Inventors: Esther Martinborough, Marcus F. Boehm, Adam Richard Yeager, Junko Tamiya, Liming Huang, Enugurthi Brahmachary, Manisha Moorjani
  • Process for sulfonating halobenzene derivatives with sulfur trioxide
    Patent number: 9394245
    Abstract: A process for sulfonating at least one halobenzene with sulfur trioxide (SO3) comprising the following steps: Step 1. manufacturing a gaseous mixture [mixture (M)] comprising SO3 and at least one additional gas different from SO3 by oxidizing sulfur dioxide in the presence of at least one catalyst, wherein the SO3 content in mixture (M) is from 1 to 95% by volume, relative to the total volume of mixture (M); and step 2 contacting said mixture (M) with said at least one halobenzene.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: July 19, 2016
    Assignee: SOLVAY SPECIALTY POLYMERS USA, LLC.
    Inventors: Mahendra Dosi, Ziad Husein, Ronald Mysona
  • Method for preparing a sulfonimide compound and salts thereof
    Patent number: 9394247
    Abstract: The present invention relates to a method for preparing an aqueous sulfonimide compound of the formula (Rf1—SO2)(Rf2—SO2)NH, wherein Rf1 and Rf2 are independently selected from the group comprising: a fluorine atom and groups having 1 to 10 carbon atoms selected from the perfluoroalkyl, fluoroalkyl, fluoroalkenyl and fluoroallyl groups, from a mixture M1 including (Rf1—SO2)(Rf2—SO2)NH, Rf1SO2H and/or Rf2SO2H, Rf1SO2NH2 and/or Rf2SO2NH2, characterized in that said method includes an oxidation step of said mixture M1 using an oxidizing agent in order to obtain a mixture M2 including (Rf1—SO2)(Rf2—SO2)NH, Rf1SO3H and/or Rf2SO3H and Rf1SO2NH2and/or Rf2SO2NH2.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: July 19, 2016
    Assignee: RHODIA OPERATIONS
    Inventors: Bernard Besson, Francois Metz, Olivier Buisine
  • Method for manufacturing water resistant optically anisotropic film, and water resistant optically anisotropic film
    Patent number: 9387507
    Abstract: A method for manufacturing a water resistant optically anisotropic film capable of suppressing the generation of a defect such as a crack or separation is provided. The method for manufacturing the water resistant optically anisotropic of the present invention includes a water resistant treatment step of bringing an optically anisotropic film containing an organic dye having an anionic group into contact with a water resistant treatment liquid containing a multivalent cationic compound and a monovalent cationic compound, and the mass ratio of the multivalent cationic compound and the monovalent cationic compound contained in the water resistant treatment liquid, monovalent cationic compound/multivalent cationic compound, is 0.01 to 2.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: July 12, 2016
    Assignee: NITTO DENKO CORPORATION
    Inventors: Toru Umemoto, Satoshi Hirata, Sadahiro Nakanishi, Shoichi Matsuda, Tadayuki Kameyama
  • Method for producing ?-fluoroacrylic acid ester
    Patent number: 9388117
    Abstract: The object of the present invention is to provide a process for producing ?-fluoroacrylic acid ester at a high starting material conversion, high selectivity, and high yield. The present invention provides a process for producing the compound represented by the formula (1) wherein R represents alkyl optionally substituted with one or more fluorine atoms, the process comprising step A of reacting a compound represented by the formula (2) wherein X represents a bromine atom or a chlorine atom with an alcohol represented by the formula (3) wherein the symbol is as defined above, and carbon monoxide in the presence of a transition metal catalyst and a base to thereby obtain the compound represented by the formula (1).
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: July 12, 2016
    Assignee: DAIKIN INDUSTRIES, LTD.
    Inventors: Tatsuya Ohtsuka, Akihiro Gotou, Sumi Ishihara, Yoshihiro Yamamoto, Akinori Yamamoto, Yoshichika Kuroki, Yuzo Komatsu, Yousuke Kishikawa
  • Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
    Patent number: 9388147
    Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: July 12, 2016
    Assignee: Celgene International II Sárl
    Inventors: Esther Martinborough, Marcus F. Boehm, Adam Richard Yeager, Junko Tamiya, Liming Huang, Enugurthi Brahmachary, Manisha Moorjani, Gregg Alan Timony, Jennifer L. Brooks, Robert Peach, Fiona Lorraine Scott, Michael Allen Hanson
  • Methods for treatment of pelvic pain and/or comorbid conditions
    Patent number: 9387163
    Abstract: Methods, systems, devices, and medicaments are provided for locally administering to a pelvic-area organ or tissue structure in a patient at least one drug continuously or continually over a treatment period of 24 hours or more in an amount effective to achieve a therapeutic effect in another organ or tissue structure by means of shared or convergent pelvic afferent pathways. The methods systems, devices, and medicaments can be used in the treatment of IC/BPS, chronic pelvic pain, vulvodynia, orchialgia, urethral syndrome, dysparenia, chronic prostatitis, chronic pelvic pain, levator ani syndrome, irritative bowel syndrome, or a combination thereof. The drug may include anesthetic agents, analgesic agents, antispasmodic agents, antimuscarinic agents, and combinations thereof. The drug may be released from a drug delivery device or a sustained release composition deployed inside the bladder.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: July 12, 2016
    Assignee: Allergan, Inc.
    Inventors: Julie Himes, Dennis Giesing, Cheryl Larrivee-Elkins, Michael J. Cima, Purnanand Sarma, Paul Goldenheim
  • Device useful for hydrogenation reactions (I)
    Patent number: 9381489
    Abstract: The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of specific solid metallic structure which allows cross-flow of the material through the porous element and wherein the porous element is coated by a non-acidic metal oxide which is impregnated by palladium (Pd).
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: July 5, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventor: Werner Bonrath
  • Salts of potassium ATP channel openers and uses thereof
    Patent number: 9381202
    Abstract: Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: July 5, 2016
    Assignee: ESSENTIALIS, INC.
    Inventors: Neil M. Cowen, Khaled A. Yamout
  • Vinyl monomers having chelating functionality
    Patent number: 9376373
    Abstract: The present invention provides novel polymerizable monomers having chelating functionality and processes to make them. In particular, the novel monomers are ethylenically unsaturated aminocarboxylates and are prepared by reacting ethylenediamine triacetic acid or its salt with an ethylenically unsaturated monomer. The ethyleneically unsaturated monomer may be a polymerizable vinyl monomer selected from (o-, p-, m-)DVBMO, allyl glycidyl ether, and glycidyl (meth)acrylate.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: June 28, 2016
    Inventors: Scott Backer, Allen Bulick, Joseph Manna, Cynthia Rand, Jia Xie
  • Method for producing a conjugated Z-alken-yn-yl acetate
    Patent number: 9376368
    Abstract: Provided is a method for industrially producing a conjugated Z-alken-yn-yl acetate such as Z-13-hexadecen-11-yn-yl acetate which is a sex pheromone component of a pine processionary moth, and an intermediate for the conjugated Z-alken-yn-yl acetate under mild conditions at a high yield. More specifically, provided is a method for producing a conjugated Z-alken-yn-yl acetate (5) comprising the steps of: reacting an ?-halo-2-alkynal (1) with an alkylidene triphenylphosphorane (3) through a Wittig reaction to obtain a conjugated Z-alken-yn-yl halide (4), and acetoxylating the conjugated Z-alken-yn-yl halide (4) into a conjugated Z-alken-yn-yl acetate (5).
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: June 28, 2016
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Miyoshi Yamashita, Takehiko Fukumoto, Takeshi Kinsho
  • ?-lactamase inhibitors
    Patent number: 9371337
    Abstract: Disclosed herein inter alia are Boron containing compounds and methods for treating infections related to antibiotic resistant microorganisms.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: June 21, 2016
    Assignees: The Regents of the University of California, Universita' degli Studi di Modena e Reggio Emilia
    Inventors: Brian K. Shoichet, Fabio Prati, Emilia Caselli, Chiara Romagnoli, Oliv Eidam
  • Method for manufacturing tertiary amino group-containing lipid
    Patent number: 9371271
    Abstract: In production of a cationic lipid having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule, isomerization from a cis form to a trans form is suppressed. A compound represented by the following formula (I): R1—X??(I) (in Formula, R1 represents a hydrocarbon group having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule and having the carbon number of 8 to 24 and X represents a releasing group) is reacted with (B) a compound having at least one of each of tertiary amino group and hydroxyl group in the molecule in a saturated hydrocarbon solvent having the carbon number of 5 to 10 in the presence of an alkali catalyst.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: June 21, 2016
    Assignee: NOF CORPORATION
    Inventors: Kazuhiro Kubo, Kota Tange, Masaki Ohta